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LM11A-31

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29: 587:
Shanks, Hayley R. C.; Börjesson‐Hanson, Anne; Windisch, Manfred; Massa, Stephen M.; Longo, Frank M.; Schmitz, Taylor W. (December 2022). "Age‐dependent effects of the p75 neurotrophin receptor modulator LM11A‐31 on Alzheimer's disease biomarkers in a 26‐week safety and exploratory endpoint trial".
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Nasoohi, Sanaz; Tayefeh Ghahremani, Pargol; Alehossein, Parsa; Elyasizadeh, Siyamak; BaniArdalan, Soha; Ismael, Saifudeen; Vatanpour, Hossein; Ahmadiani, Abolhassan; Ishrat, Tauheed (2023). "The p75 neurotrophin receptor inhibitor, LM11A-31, ameliorates acute stroke injury and modulates astrocytic
504:
Nguyen, Thuy-Vi V.; Crumpacker, Rachel H.; Calderon, Kylie E.; Garcia, Frankie G.; Zbesko, Jacob C.; Frye, Jennifer B.; Gonzalez, Selena; Becktel, Danielle A.; Yang, Tao; Tavera-Garcia, Marco A.; Morrison, Helena W.; Schnellmann, Rick G.; Longo, Frank M.; Doyle, Kristian P. (2021-12-10).
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Simmons, Danielle A.; Mills, Brian D.; Butler III, Robert R.; Kuan, Jason; McHugh, Tyne L.M.; Akers, Carolyn; Zhou, James; Syriani, Wassim; Grouban, Maged; Zeineh, Michael; Longo, Frank M. (2021).
447:
Simmons, Danielle A; James, Michelle L; Belichenko, Nadia P; Semaan, Sarah; Condon, Christina; Kuan, Jason; Shuhendler, Adam J; Miao, Zheng; Chin, Frederick T; Longo, Frank M (2018-08-15).
507:"Post-Stroke Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Attenuates Chronic Changes in Brain Metabolism, Increases Neurotransmitter Levels, and Improves Recovery" 307:"Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway" 449:"TSPO–PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31" 621: 256:"A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression" 364:"Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31" 556:"Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury" 254:
Simmons, Danielle A.; Knowles, Juliet K.; Belichenko, Nadia P.; Banerjee, Gargi; Finkle, Carly; Massa, Stephen M.; Longo, Frank M. (2014-08-25).
554:
Yin, Guo Nan; Ock, Jiyeon; Limanjaya, Anita; Minh, Nguyen Naht; Hong, Soon-Sun; Yang, Tao; Longo, Frank M.; Ryu, Ji-Kan; Suh, Jun-Kyu (2021).
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Elshaer, Sally L.; Alwhaibi, Abdulrahman; Mohamed, Riyaz; Lemtalsi, Tahira; Coucha, Maha; Longo, Frank M.; El-Remessy, Azza B. (2019).
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Journal of Pharmacology and Experimental Therapeutics
211: 178: 173: 153: 128: 106: 69: 53: 48: 40: 35: 142: 115: 8: 19: 622:Experimental drugs for Alzheimer's disease 27: 571: 538: 480: 395: 338: 289: 271: 162: 246: 83: 229:is an experimental drug developed for 18: 7: 133: 98:-(2-morpholin-4-ylethyl)pentanamide 14: 196: 190: 426:10.1016/j.expneurol.2022.114161 560:The Journal of Sexual Medicine 202: 184: 1: 374:(2). Elsevier BV: 1039–1063. 273:10.1371/journal.pone.0102136 648: 590:Alzheimer's & Dementia 573:10.1016/j.jsxm.2020.10.015 380:10.1007/s13311-021-01023-8 174:Chemical and physical data 323:10.1007/s00125-019-4885-2 74: 26: 453:Human Molecular Genetics 523:10.1124/jpet.121.000711 420:. Elsevier BV: 114161. 414:Experimental Neurology 235:Huntington's disease 231:Alzheimer's disease 94:)-2-Amino-3-methyl- 23: 602:10.1002/alz.069079 465:10.1093/hmg/ddy202 121:1243259-19-9 (HCl) 459:(16): 2893–2912. 368:Neurotherapeutics 224: 223: 16:Experimental drug 639: 606: 605: 584: 578: 577: 575: 551: 545: 544: 542: 501: 495: 494: 484: 444: 438: 437: 408: 402: 401: 399: 359: 353: 352: 342: 317:(8): 1488–1500. 302: 296: 295: 293: 275: 251: 219: 204: 198: 192: 186: 166: 146: 136: 135: 119: 31: 24: 22: 647: 646: 642: 641: 640: 638: 637: 636: 612: 611: 610: 609: 586: 585: 581: 553: 552: 548: 503: 502: 498: 446: 445: 441: 410: 409: 405: 361: 360: 356: 304: 303: 299: 253: 252: 248: 243: 217: 207: 201: 195: 189: 169: 149: 132: 124: 120: 102: 99: 82: 81: 65: 62:Investigational 17: 12: 11: 5: 645: 643: 635: 634: 629: 624: 614: 613: 608: 607: 579: 546: 496: 439: 403: 354: 297: 266:(8): e102136. 245: 244: 242: 239: 222: 221: 215: 209: 208: 205: 199: 193: 187: 182: 176: 175: 171: 170: 168: 167: 159: 157: 151: 150: 148: 147: 139: 137: 126: 125: 123: 122: 112: 110: 104: 103: 101: 100: 85: 77: 76: 75: 72: 71: 67: 66: 64: 63: 59: 57: 51: 50: 46: 45: 42: 38: 37: 33: 32: 15: 13: 10: 9: 6: 4: 3: 2: 644: 633: 630: 628: 625: 623: 620: 619: 617: 603: 599: 595: 591: 583: 580: 574: 569: 565: 561: 557: 550: 547: 541: 536: 532: 528: 524: 520: 516: 512: 508: 500: 497: 492: 488: 483: 478: 474: 470: 466: 462: 458: 454: 450: 443: 440: 435: 431: 427: 423: 419: 415: 407: 404: 398: 393: 389: 385: 381: 377: 373: 369: 365: 358: 355: 350: 346: 341: 336: 332: 328: 324: 320: 316: 312: 308: 301: 298: 292: 287: 283: 279: 274: 269: 265: 261: 257: 250: 247: 240: 238: 236: 232: 228: 216: 214: 210: 183: 181: 177: 172: 165: 161: 160: 158: 156: 152: 145: 141: 140: 138: 131: 127: 118: 114: 113: 111: 109: 105: 97: 93: 89: 84: 80: 73: 68: 61: 60: 58: 56: 52: 47: 43: 39: 36:Clinical data 34: 30: 25: 632:Carboxamides 593: 589: 582: 566:(1): 17–28. 563: 559: 549: 514: 510: 499: 456: 452: 442: 417: 413: 406: 371: 367: 357: 314: 311:Diabetologia 310: 300: 263: 259: 249: 226: 225: 95: 91: 87: 55:Legal status 49:Legal status 627:Morpholines 220: g·mol 117:102562-74-3 70:Identifiers 41:Other names 616:Categories 241:References 213:Molar mass 164:Y9GUF3B7Q7 108:CAS Number 79:IUPAC name 531:0022-3565 473:0964-6906 434:0014-4886 412:proNGF". 388:1878-7479 331:0012-186X 282:1932-6203 44:LM-11A-31 540:11048261 491:29860333 349:31073629 260:PLoS ONE 227:LM11A-31 144:18604758 21:LM11A-31 596:(S10). 482:6077813 397:8423954 340:8808141 291:4143160 218:243.351 180:Formula 130:PubChem 537:  529:  489:  479:  471:  432:  394:  386:  347:  337:  329:  288:  280:  527:ISSN 487:PMID 469:ISSN 430:ISSN 384:ISSN 345:PMID 327:ISSN 278:ISSN 233:and 155:UNII 598:doi 568:doi 535:PMC 519:doi 515:380 477:PMC 461:doi 422:doi 418:359 392:PMC 376:doi 335:PMC 319:doi 286:PMC 268:doi 134:CID 618:: 594:18 592:. 564:18 562:. 558:. 533:. 525:. 513:. 509:. 485:. 475:. 467:. 457:27 455:. 451:. 428:. 416:. 390:. 382:. 372:18 370:. 366:. 343:. 333:. 325:. 315:62 313:. 309:. 284:. 276:. 262:. 258:. 237:. 194:25 188:12 90:,3 86:(2 604:. 600:: 576:. 570:: 543:. 521:: 493:. 463:: 436:. 424:: 400:. 378:: 351:. 321:: 294:. 270:: 264:9 206:2 203:O 200:3 197:N 191:H 185:C 96:N 92:S 88:S

Index


Legal status
IUPAC name
CAS Number
102562-74-3
PubChem
18604758
UNII
Y9GUF3B7Q7
Formula
Molar mass
Alzheimer's disease
Huntington's disease
"A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression"
doi
10.1371/journal.pone.0102136
ISSN
1932-6203
PMC
4143160
"Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway"
doi
10.1007/s00125-019-4885-2
ISSN
0012-186X
PMC
8808141
PMID
31073629
"Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31"

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