449:
252:
681:
266:
4389:
40:
700:
Elevated PNMT expression is one of the ways that the stress response positively feeds back on itself. An increase in stress hormones or nerve impulses due to stress can cause PNMT to convert more norepinephrine into epinephrine. This increases the potency of the catecholamine response system,
924:
Kitahama K, Pearson J, Denoroy L, Kopp N, Ulrich J, Maeda T, Jouvet M (February 1985). "Adrenergic neurons in human brain demonstrated by immunohistochemistry with antibodies to phenylethanolamine-N-methyltransferase (PNMT): discovery of a new group in the nucleus tractus solitarius".
294:(COMT), though it shares less sequence identity. Several features of the structure like this folding lip suggest that PNMT is a recent adaptation to the catecholamine synthesizing enzyme family, evolving later than COMT, but before other methyltransferases like GNMT.
1195:
Drinkwater N, Vu H, Lovell KM, Criscione KR, Collins BM, Prisinzano TE, et al. (October 2010). "Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors".
1030:
Bart AG, Scott EE. Crystal
Structure of hPNMT in Complex with bisubstrate inhibitor N-(3-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)propyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (Report). RCSB Protein Data
337:
from SAM to norepinephrine, converting it into epinephrine. It works by bringing the cofactor SAM and substrate together in close proximity, so that the reactive methyl group can be attacked by the primary amine of the norepinephrine molecule or another
848:
has also been associated with reduced human PNMT activity in the regions of the brain most associated with degeneration in the disease. There have also been significant associations with PNMT polymorphisms and early onset
Alzheimer's disease.
1798:
Atobe M, Kubota M, Nakagawara M, Kariya T (1996). "Effect of
Phenylethanolamine N-methyltransferase Inhibitor, CGS19281A, on the Alpha-2-Adrenoceptor Function in the Hypothalamus of Rats in Comparison with SKF29661, SKF64139 and Yohimbine".
324:
Human PNMT forms dimers in solution. When PNMT crystals are grown in non-reducing solutions, two disulfide bonds form between cysteines 48 and 139 on opposite chains. This dimerization has no effect on the catalytic activity of the enzyme.
307:(SAM) is a required cofactor. The active site binding region for the cofactor SAM contains a rich number of pi bonds from phenylalanine and tyrosine residues in the active site help to keep it in its binding pocket through
1515:
Cahill AL, Eertmoed AL, Mangoura D, Perlman RL (September 1996). "Differential regulation of phenylethanolamine N-methyltransferase expression in two distinct subpopulations of bovine chromaffin cells".
828:
Two potent PNMT inhibitors (LY134046 and LY78335) were long lasting antagonists of both ethanol intoxication and sedation. This suggests a central role that PNMT and epinephrine play in the synthesis of
1608:
Krizanová O, Micutková L, Jeloková J, Filipenko M, Sabban E, Kvetnanský R (September 2001). "Existence of cardiac PNMT mRNA in adult rats: elevation by stress in a glucocorticoid-dependent manner".
1868:
314:
The residue
Glutamine 185 is necessary in binding the catecholamine substrate. The replacement of this residue another reduces the catalytic efficiency of PNMT by tenfold up to three hundredfold.
2967:
1231:
Gee CL, Nourse A, Hsin AY, Wu Q, Tyndall JD, Grunewald GL, et al. (June 2005). "Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active".
271:
This is a model of the active site of PNMT showing both the distance between amino and sulfur groups, and a proposed area for methyl transfer. It was made using
Chimera and 4MQ4.
1763:
Borchardt RT, Wu YS (March 1975). "Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 3. Modifications of the sugar portion of S-adenosylhomocysteine".
278:
PNMT is a protein whose encoding gene is found on chromosome 17 in humans. It consists of 4 exons and is a 30 kDa protein. It shares many properties found among the other
632:
625:
342:
substrate. The methyl group of SAM is very reactive, so the structure and placement of both norepinephrine and SAM is crucial for correct methylation pattern on the product.
1728:
Mann MB, Wu S, Rostamkhani M, Tourtellotte W, MacMurray J, Comings DE (May 2001). "Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset
Alzheimer disease".
738:
Stress immobilization for a few hours has also been shown to increase PNMT activity in rats. This treatment takes about one week to manifest a difference in PNMT levels.
2287:
1861:
448:
2488:
1137:"Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity"
2960:
2442:
75:
1646:, Wood JM, Pittelkow MR, Buttner G, Swanson N, Korner C, Ehrke C (1996). "Increased monoamine oxidase A activity in the epidermis of patients with vitiligo".
2343:
1854:
873:, a replacement for the cofactor SAM, which resembles it, but is missing the methyl group, so no methyl transfer is possible. Another example is CGS19281A.
2506:
2412:
780:
is produced in small groups of neurons in the human brain which express PNMT; these neurons project from a nucleus that is adjacent (ventrolateral) to the
2607:
741:
SAM not only acts as a cofactor for PNMT, but also helps to stabilize the enzyme and increase the half life by making it more resistant to being cut by
2953:
2386:
1430:
Jiang W, Uht R, Bohn MC (1989). "Regulation of phenylethanolamine N-methyltransferase (PNMT) mRNA in the rat adrenal medulla by corticosterone".
4358:
2617:
4409:
2280:
2571:
4362:
4107:
2997:
2643:
2363:
2359:
2183:
2149:
2135:
1992:
583:
576:
569:
99:
1561:"Phenylethanolamine N-methyltransferase-containing neurons in rat retina: immunohistochemistry, immunochemistry, and molecular biology"
764:
Newer studies are also showing PNMT mRNA and protein to be expressed in other regions of the body as well. Certain neural tracts, the
2676:
2527:
2273:
2144:
87:
3184:
3162:
2602:
2483:
892:
Goldstein M, Fuxe K, Hökfelt T (June 1972). "Characterization and tissue localization of catecholamine synthesizing enzymes".
80:
4366:
4077:
3898:
3197:
2592:
2587:
2511:
2391:
2832:
1267:
4218:
3846:
2368:
2328:
2026:
1941:
350:
291:
4338:
2597:
2437:
2100:
655:
4188:
3726:
2612:
870:
4379:
3907:
3902:
3587:
3215:
3175:
3153:
2976:
1889:
2817:
1836:
3613:
3091:
2933:
2920:
2907:
2894:
2881:
2868:
2855:
2631:
2546:
2456:
2422:
2338:
2309:
2221:
2001:
669:
662:
257:
This is a representation of the disulfide bond made between monomers of PNMT. It was made using
Chimera and 4MQ4.
2827:
2781:
2724:
2475:
2300:
1840:
140:
311:. Among all known PNMT variants in nature there are 7 crucial aromatic residues conserved in the active site.
4150:
2729:
2080:
2061:
1921:
735:
nerve impulses. Nerve impulses increase the synthesis of PNMT mRNA by affecting certain promoter sequences.
4308:
4354:
4350:
4346:
4193:
4027:
4006:
3130:
2532:
2130:
845:
761:
of most species. PNMT has been localized in most adult mammals to the cytoplasm of these medullary cells.
525:
381:
92:
3911:
3188:
3166:
2750:
2669:
2432:
2249:
2175:
297:
157:
4238:
2822:
4342:
3653:
3643:
2427:
2245:
1987:
721:
1691:"Antagonism of ethanol intoxication in rats by inhibitors of phenylethanolamine N-methyltransferase"
1325:
Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family".
3781:
3505:
2786:
2396:
2041:
2036:
235:
3972:
3569:
3564:
3957:
3938:
3934:
3920:
3916:
3686:
3487:
3139:
2719:
1671:
1643:
1541:
1455:
1117:
950:
362:
279:
3826:
2265:
753:
Epinephrine synthesis and therefore PNMT location has been largely found to be contained in the
4263:
3831:
1135:
Drinkwater N, Gee CL, Puri M, Criscione KR, McLeish MJ, Grunewald GL, Martin JL (August 2009).
724:
of the enzyme in vitro. In animals who have had their pituitary gland removed, the addition of
251:
4414:
4123:
4097:
4067:
3875:
3866:
3836:
3427:
3206:
3202:
3111:
2498:
2313:
2031:
1816:
1780:
1745:
1710:
1663:
1625:
1590:
1533:
1497:
1447:
1412:
1377:
1342:
1304:
1248:
1213:
1174:
1109:
1068:
1020:
999:
942:
901:
773:
562:
388:
354:
3962:
3947:
3943:
3929:
3925:
3691:
3407:
3323:
2982:
2765:
2760:
2734:
2662:
1881:
1808:
1772:
1737:
1702:
1655:
1617:
1580:
1572:
1559:
Park DH, Teitelman G, Evinger MJ, Woo JI, Ruggiero DA, Albert VR, et al. (April 1986).
1525:
1489:
1439:
1404:
1369:
1334:
1296:
1240:
1205:
1164:
1156:
1148:
1099:
1058:
1047:"Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT"
989:
981:
934:
535:
416:
152:
357:
which adds a methyl group in a different location, in turn producing the inactive compound
145:
4288:
4253:
3884:
3343:
3180:
2812:
2796:
2709:
2550:
2187:
1946:
1395:
Wurtman RJ (June 2002). "Stress and the adrenocortical control of epinephrine synthesis".
754:
725:
717:
705:
219:
181:
161:
1360:
Wang X, Li J, Dong G, Yue J (February 2014). "The endogenous substrates of brain CYP2D".
1846:
1529:
796:
PNMT's normal function and defects are associated with multiple diseases and disorders.
4393:
3880:
3812:
3746:
3696:
3602:
3433:
3171:
3050:
2850:
2791:
2241:
1706:
1585:
1576:
1560:
1169:
1136:
994:
969:
858:
809:
785:
769:
713:
518:
494:
377:
223:
1621:
1063:
1046:
4403:
4183:
3629:
3293:
3273:
3238:
3046:
2755:
2714:
2460:
2202:
2057:
1493:
1443:
1300:
938:
834:
817:
781:
758:
709:
457:
433:
339:
1675:
1545:
1459:
1121:
290:). It also shares many structural properties like the shape of the folding lip with
4208:
3987:
3893:
3771:
3706:
3458:
3438:
3333:
3328:
3318:
3243:
3158:
2704:
2378:
2167:
1287:
Broadley KJ (March 2010). "The vascular effects of trace amines and amphetamines".
954:
358:
334:
2945:
1373:
1244:
968:
Wang Y, Lin WK, Crawford W, Ni H, Bolton EL, Khan H, et al. (January 2017).
116:
4248:
4166:
3889:
3816:
3701:
3597:
3448:
3377:
3372:
3367:
3263:
3253:
3149:
3081:
3034:
2928:
2863:
2699:
2296:
1968:
1104:
1087:
805:
777:
701:
increasing the sympathetic output and making the stress response more profound.
441:
437:
392:
373:
346:
308:
227:
191:
4388:
1338:
265:
4318:
4268:
4203:
4198:
4062:
4043:
3977:
3967:
3776:
3761:
3756:
3711:
3555:
3550:
3545:
3530:
3525:
3520:
3515:
3497:
3492:
3468:
3463:
3453:
3397:
3387:
3382:
3362:
3313:
3308:
3288:
3268:
3258:
3248:
3233:
3101:
3071:
3067:
3055:
2979:
2114:
1480:
Ciaranello RD (1978). "Regulation of phenylethanolamine N-methyltransferase".
862:
732:
555:
545:
487:
404:
400:
123:
1088:"Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo"
4304:
4273:
4258:
4234:
4173:
4141:
4127:
4093:
4016:
4012:
3992:
3982:
3786:
3540:
3443:
3423:
3415:
3338:
3303:
3298:
3283:
3278:
3211:
3096:
3086:
3041:
3029:
2902:
2876:
2556:
2122:
2118:
1902:
1898:
1408:
318:
1749:
1629:
1416:
1381:
1346:
1308:
1252:
1217:
1178:
1072:
1003:
685:
PNMT plays an important role in trace amine and catecholamine biosynthesis.
1820:
1784:
1714:
1667:
1594:
1537:
1451:
1113:
946:
905:
365:
are very common in the catecholamine synthesis and deactivation pathways.
4057:
3862:
3766:
3742:
3716:
3669:
3633:
3593:
3535:
3402:
3228:
3193:
3062:
3020:
2163:
1964:
1960:
1501:
813:
511:
501:
467:
412:
128:
1776:
4278:
3510:
3419:
3411:
2635:
2198:
1659:
1209:
1152:
1045:
Martin JL, Begun J, McLeish MJ, Caine JM, Grunewald GL (October 2001).
866:
830:
742:
1812:
1741:
1160:
1024:
985:
3673:
3013:
2915:
2685:
2465:
2417:
1877:
765:
641:
477:
231:
215:
111:
1690:
776:
in the hearts are now being elucidated as sites of PNMT expression.
17:
4047:
3871:
3392:
3025:
2889:
2179:
1610:
American
Journal of Physiology. Heart and Circulatory Physiology
680:
287:
104:
2949:
2658:
2269:
1850:
39:
3797:
345:
While PNMT methylates norepinephrine into the active compound
1233:
Biochimica et
Biophysica Acta (BBA) - Proteins and Proteomics
321:
group is bound to the active site to stabilize this region.
4108:
2998:
2654:
1689:
Mefford IN, Lister RG, Ota M, Linnoila M (February 1990).
1320:
1318:
1282:
1280:
1086:
Wong DL, Lesage A, Siddall B, Funder JW (November 1992).
728:
significantly lengthens the half life of PNMT enzymes.
716:'s positive influence on the maintenance of PNMT mRNA.
4078:
230:(adrenaline). It is also expressed in small groups of
4377:
4219:
3847:
869:. Inhibition can also be produced by the addition of
712:. One way that it can regulate PNMT expression is by
919:
917:
915:
425:
4287:
4217:
4149:
4140:
4106:
4076:
4026:
4005:
3845:
3795:
3727:
3725:
3652:
3612:
3586:
3110:
2996:
2989:
2841:
2805:
2774:
2743:
2692:
2630:
2580:
2564:
2545:
2520:
2497:
2474:
2455:
2405:
2377:
2352:
2321:
2308:
2230:
2210:
2197:
2162:
2113:
2089:
2069:
2056:
2015:
1976:
1959:
1930:
1910:
1897:
1888:
1432:
International
Journal of Developmental Neuroscience
187:
177:
172:
151:
139:
134:
122:
110:
98:
86:
74:
66:
58:
53:
32:
234:in the human brain and in selected populations of
3614:
2489:3-methyl-2-oxobutanoate hydroxymethyltransferase
4151:
784:and from a nucleus in the dorsal region of the
4028:
3802:Tooltip Phenylethanolamine N-methyltransferase
3131:
1695:Alcoholism: Clinical and Experimental Research
887:
885:
804:Decreased levels of PNMT activity measured by
731:Elevated PNMT levels can also be triggered by
2961:
2670:
2443:Cyclopropane-fatty-acyl-phospholipid synthase
2281:
1862:
1475:
1473:
1471:
1469:
368:PNMT is also involved in the biosynthesis of
8:
3654:
2344:Phosphatidylethanolamine N-methyltransferase
1190:
1188:
820:, which normally have higher PNMT activity.
317:In the absence of an inhibitor or ligand, a
4113:Tooltip Acetylserotonin O-methyltransferase
3003:Tooltip Aromatic L-amino acid decarboxylase
2507:Phosphoribosylglycinamide formyltransferase
2413:Phosphatidyl ethanolamine methyltransferase
1040:
1038:
349:, norepinephrine can also be methylated by
4146:
4023:
3609:
3140:
3121:
2993:
2968:
2954:
2946:
2677:
2663:
2655:
2608:3-hydroxymethylcephem carbamoyltransferase
2561:
2471:
2318:
2288:
2274:
2266:
2207:
2066:
1973:
1907:
1894:
1869:
1855:
1847:
169:
3112:
1839:at the U.S. National Library of Medicine
1584:
1168:
1103:
1062:
993:
4384:
4289:
881:
282:. It is closest in sequence to glycine-
27:Mammalian protein found in Homo sapiens
4083:Tooltip Serotonin N-acetyl transferase
2618:N-acetylornithine carbamoyltransferase
2387:Betaine-homocysteine methyltransferase
2334:Phenylethanolamine N-methyltransferase
2007:Phenylethanolamine N-methyltransferase
1837:Phenylethanolamine+N-Methyltransferase
1015:
1013:
33:phenylethanolamine N-methyltransferase
29:
4224:Tooltip Histamine N-methyltransferase
3852:Tooltip Catechol-O-methyl transferase
812:is seen in the skin of patients with
720:have also been shown to increase the
7:
2572:methylmalonyl-CoA carboxytransferase
1730:American Journal of Medical Genetics
3732:Tooltip Dopamine beta-monooxygenase
2644:Arginine:glycine amidinotransferase
2364:Acetylserotonin O-methyltransferase
2360:5-hydroxyindole-O-methyltransferase
2150:Acetylserotonin O-methyltransferase
1648:Archives of Dermatological Research
1530:10.1046/j.1471-4159.1996.67031217.x
837:induced sedation and intoxication.
1707:10.1111/j.1530-0277.1990.tb00446.x
1577:10.1523/JNEUROSCI.06-04-01108.1986
1327:Trends in Pharmacological Sciences
25:
3619:Tooltip Phenylalanine hydroxylase
1622:10.1152/ajpheart.2001.281.3.H1372
704:PNMT is known to be regulated by
333:PNMT catalyzes the transfer of a
48:-methyltransferase monomer, Human
4387:
2528:Glutamate formimidoyltransferase
2145:Aralkylamine N-acetyltransferase
1362:European Journal of Pharmacology
1301:10.1016/j.pharmthera.2009.11.005
857:Classic PNMT inhibitors include
679:
447:
264:
250:
38:
4156:Tooltip Histidine decarboxylase
2603:Putrescine carbamoyltransferase
2484:Serine hydroxymethyltransferase
1289:Pharmacology & Therapeutics
4033:Tooltip Tryptophan hydroxylase
3813:Norepinephrine (noradrenaline)
3747:Norepinephrine (Noradrenaline)
3172:Norepinephrine (noradrenaline)
3136:Tooltip Aldehyde dehydrogenase
2593:Ornithine carbamoyltransferase
2588:Aspartate carbamoyltransferase
2512:Inosine monophosphate synthase
2392:Homocysteine methyltransferase
1765:Journal of Medicinal Chemistry
871:S-deoxyadenosyl L-homocysteine
1:
4359:Monoamine reuptake inhibitors
4339:Receptor/signaling modulators
2369:Catechol-O-methyl transferase
2329:Histamine N-methyltransferase
2027:Catechol-O-methyl transferase
1942:Histamine N-methyltransferase
1064:10.1016/s0969-2126(01)00662-1
351:catechol-O-methyl transferase
292:catechol-O-methyl transferase
4410:Genes on human chromosome 17
3659:Tooltip Tyrosine hydroxylase
2598:Oxamate carbamoyltransferase
2438:Thiopurine methyltransferase
2101:4-aminobutyrate transaminase
1494:10.1016/0006-2952(78)90002-3
1444:10.1016/0736-5748(89)90010-5
1374:10.1016/j.ejphar.2013.12.025
1245:10.1016/j.bbapap.2005.03.006
939:10.1016/0304-3940(85)90555-5
4319:Pimagedine (aminoguanidine)
4189:Alpha-Fluoromethylhistidine
2613:Lysine carbamoyltransferase
2299:: one carbon transferases (
1565:The Journal of Neuroscience
1105:10.1096/fasebj.6.14.1426768
4431:
4363:Monoamine releasing agents
3129:Substrates→Products (with
1339:10.1016/j.tips.2005.03.007
432:Biosynthetic pathways for
4331:
3477:
3352:
3124:
3117:Tooltip Monoamine oxidase
2833:Michaelis–Menten kinetics
2423:Histone methyltransferase
2339:Amine N-methyltransferase
2222:Choline acetyltransferase
2140:-amino acid decarboxylase
2002:Dopamine beta-hydroxylase
1997:-amino acid decarboxylase
1518:Journal of Neurochemistry
970:"+ Cells in Murine Heart"
168:
37:
3817:Epinephrine (adrenaline)
3150:Epinephrine (adrenaline)
2725:Diffusion-limited enzyme
2476:Hydroxymethyltransferase
1841:Medical Subject Headings
1482:Biochemical Pharmacology
4294:Tooltip Diamine oxidase
2081:Glutamate decarboxylase
1922:Histidine decarboxylase
1409:10.1053/meta.2002.33185
1198:The Biochemical Journal
1141:The Biochemical Journal
894:Pharmacological Reviews
840:
218:found primarily in the
4194:Histidine methyl ester
2533:Aminomethyltransferase
2131:Tryptophan hydroxylase
4367:Monoamine neurotoxins
4309:Imidazole acetic acid
2818:Eadie–Hofstee diagram
2751:Allosteric regulation
2433:DNA methyltransferase
2250:Butyrylcholinesterase
2176:Nitric oxide synthase
1268:"The Adrenal Medulla"
529:-Methylphenethylamine
385:-methylphenethylamine
286:-methyl transferase (
4302:Substrates→Products:
4232:Substrates→Products:
4164:Substrates→Products:
4121:Substrates→Products:
4091:Substrates→Products:
4041:Substrates→Products:
3860:Substrates→Products:
3810:Substrates→Products:
3740:Substrates→Products:
3667:Substrates→Products:
3644:3,4-Dihydroxystyrene
3627:Substrates→Products:
3011:Substrates→Products:
2828:Lineweaver–Burk plot
2428:Thymidylate synthase
2246:Acetylcholinesterase
1988:Tyrosine hydroxylase
927:Neuroscience Letters
824:Ethanol intoxication
722:biological half life
3782:Phenopicolinic acid
3506:Desmethylselegiline
2397:Methionine synthase
1777:10.1021/jm00237a018
1403:(6 Suppl 1): 11–4.
846:Alzheimer's disease
841:Alzheimer's disease
226:(noradrenaline) to
204:Phenylethanolamine
44:Phenylethanolamine
3958:2-Hydroxyestradiol
3939:4-Methoxyestradiol
3935:4-Hydroxyestradiol
3921:2-Methoxyestradiol
3917:2-Hydroxyestradiol
3687:2-Hydroxyestradiol
2787:Enzyme superfamily
2720:Enzyme promiscuity
1801:Neuropsychobiology
1660:10.1007/bf02505037
1210:10.1042/bj20100651
1153:10.1042/bj20090702
974:Scientific Reports
363:Methyltransferases
280:methyltransferases
208:-methyltransferase
4375:
4374:
4370:
4327:
4326:
4239:N-Methylhistamine
4169:
4136:
4135:
4124:N-Acetylserotonin
4098:N-Acetylserotonin
4068:Telotristat ethyl
4063:Fenclonine (PCPA)
4020:
4001:
4000:
3876:Homovanillic acid
3867:3-Methoxytyramine
3676:
3606:
3582:
3581:
3578:
3577:
3559:
3500:
3428:tetrahydroharmine
3408:Harmala alkaloids
3203:3-Methoxytyramine
3058:
3037:
3016:
2943:
2942:
2652:
2651:
2626:
2625:
2541:
2540:
2499:Formyltransferase
2451:
2450:
2263:
2262:
2259:
2258:
2158:
2157:
2139:
2109:
2108:
2052:
2051:
2032:Monoamine oxidase
1996:
1955:
1954:
1882:neurotransmission
1813:10.1159/000119297
1742:10.1002/ajmg.1363
986:10.1038/srep40687
692:
691:
563:3-Methoxytyramine
480:
470:
460:
389:positional isomer
376:: it metabolizes
355:methyltransferase
304:
201:
200:
197:
196:
16:(Redirected from
4422:
4392:
4391:
4383:
4333:
4295:
4291:
4225:
4221:
4167:
4157:
4153:
4147:
4114:
4110:
4084:
4080:
4034:
4030:
4024:
4010:
3963:2-Hydroxyestrone
3948:4-Methoxyestrone
3944:4-Hydroxyestrone
3930:2-Methoxyestrone
3926:2-Hydroxyestrone
3853:
3849:
3803:
3799:
3733:
3729:
3692:2-Hydroxyestrone
3677:-DOPA (levodopa)
3674:
3660:
3656:
3620:
3616:
3610:
3591:
3557:
3498:
3485:MAO-B selective:
3360:MAO-A-selective:
3324:Phenoxypropazine
3146:
3142:
3137:
3133:
3122:
3118:
3114:
3056:
3035:
3017:-DOPA (levodopa)
3014:
3004:
3000:
2994:
2970:
2963:
2956:
2947:
2823:Hanes–Woolf plot
2766:Enzyme activator
2761:Enzyme inhibitor
2735:Enzyme catalysis
2679:
2672:
2665:
2656:
2562:
2472:
2319:
2290:
2283:
2276:
2267:
2235:
2215:
2208:
2137:
2094:
2074:
2067:
2020:
1994:
1981:
1974:
1935:
1915:
1908:
1895:
1871:
1864:
1857:
1848:
1825:
1824:
1795:
1789:
1788:
1760:
1754:
1753:
1725:
1719:
1718:
1686:
1680:
1679:
1640:
1634:
1633:
1605:
1599:
1598:
1588:
1556:
1550:
1549:
1512:
1506:
1505:
1477:
1464:
1463:
1427:
1421:
1420:
1392:
1386:
1385:
1357:
1351:
1350:
1322:
1313:
1312:
1284:
1275:
1274:
1272:
1263:
1257:
1256:
1228:
1222:
1221:
1192:
1183:
1182:
1172:
1132:
1126:
1125:
1107:
1083:
1077:
1076:
1066:
1042:
1033:
1032:
1027:
1017:
1008:
1007:
997:
965:
959:
958:
921:
910:
909:
889:
683:
682:
672:
665:
658:
651:
644:
635:
628:
621:
620:
614:
613:
607:
606:
600:
599:
593:
586:
579:
572:
565:
558:
551:
541:
531:
521:
514:
507:
497:
490:
483:
478:
473:
468:
463:
458:
451:
426:
353:(COMT), another
302:
268:
254:
170:
42:
30:
21:
4430:
4429:
4425:
4424:
4423:
4421:
4420:
4419:
4400:
4399:
4398:
4386:
4378:
4376:
4371:
4323:
4293:
4283:
4254:Diphenhydramine
4223:
4213:
4155:
4132:
4112:
4102:
4082:
4072:
4032:
4009:
3997:
3885:Normetanephrine
3851:
3841:
3801:
3791:
3731:
3721:
3658:
3648:
3618:
3601:
3590:
3588:Phenethylamines
3574:
3473:
3348:
3344:Tranylcypromine
3181:Normetanephrine
3144:
3135:
3116:
3106:
3002:
2985:
2974:
2944:
2939:
2851:Oxidoreductases
2837:
2813:Enzyme kinetics
2801:
2797:List of enzymes
2770:
2739:
2710:Catalytic triad
2688:
2683:
2653:
2648:
2622:
2576:
2554:
2537:
2516:
2493:
2464:
2447:
2401:
2373:
2348:
2304:
2294:
2264:
2255:
2231:
2226:
2211:
2193:
2154:
2105:
2090:
2085:
2070:
2048:
2016:
2011:
1977:
1951:
1947:Diamine oxidase
1931:
1926:
1911:
1884:
1875:
1833:
1828:
1797:
1796:
1792:
1762:
1761:
1757:
1727:
1726:
1722:
1688:
1687:
1683:
1644:Schallreuter KU
1642:
1641:
1637:
1607:
1606:
1602:
1558:
1557:
1553:
1514:
1513:
1509:
1479:
1478:
1467:
1429:
1428:
1424:
1394:
1393:
1389:
1359:
1358:
1354:
1324:
1323:
1316:
1286:
1285:
1278:
1270:
1265:
1264:
1260:
1230:
1229:
1225:
1194:
1193:
1186:
1134:
1133:
1129:
1085:
1084:
1080:
1044:
1043:
1036:
1029:
1019:
1018:
1011:
967:
966:
962:
923:
922:
913:
891:
890:
883:
879:
855:
843:
826:
802:
794:
755:adrenal medulla
751:
726:glucocorticoids
718:Glucocorticoids
706:glucocorticoids
698:
693:
688:
687:
686:
684:
676:
675:
674:
673:
668:
666:
661:
659:
654:
652:
649:
647:
645:
640:
638:
636:
631:
629:
624:
622:
618:
617:
615:
611:
610:
608:
604:
603:
601:
597:
596:
594:
591:
589:
587:
582:
580:
575:
573:
568:
566:
561:
559:
554:
552:
544:
542:
539:-Methyltyramine
534:
532:
524:
522:
517:
515:
510:
508:
500:
498:
493:
491:
486:
484:
476:
474:
466:
464:
456:
452:
444:
420:-methyltyramine
331:
276:
275:
274:
273:
272:
269:
260:
259:
258:
255:
244:
220:adrenal medulla
49:
28:
23:
22:
15:
12:
11:
5:
4428:
4426:
4418:
4417:
4412:
4402:
4401:
4397:
4396:
4373:
4372:
4332:
4329:
4328:
4325:
4324:
4322:
4321:
4312:
4311:
4298:
4296:
4285:
4284:
4282:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4242:
4241:
4228:
4226:
4215:
4214:
4212:
4211:
4206:
4201:
4196:
4191:
4186:
4177:
4176:
4160:
4158:
4144:
4138:
4137:
4134:
4133:
4131:
4130:
4117:
4115:
4104:
4103:
4101:
4100:
4087:
4085:
4074:
4073:
4071:
4070:
4065:
4060:
4051:
4050:
4037:
4035:
4021:
4003:
4002:
3999:
3998:
3996:
3995:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3951:
3950:
3941:
3932:
3923:
3914:
3905:
3896:
3887:
3881:Norepinephrine
3878:
3869:
3856:
3854:
3843:
3842:
3840:
3839:
3834:
3829:
3820:
3819:
3806:
3804:
3793:
3792:
3790:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3750:
3749:
3736:
3734:
3723:
3722:
3720:
3719:
3714:
3709:
3704:
3699:
3697:3-Iodotyrosine
3694:
3689:
3680:
3679:
3663:
3661:
3650:
3649:
3647:
3646:
3637:
3636:
3623:
3621:
3607:
3603:norepinephrine
3584:
3583:
3580:
3579:
3576:
3575:
3573:
3572:
3567:
3562:
3553:
3548:
3543:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3503:
3495:
3490:
3478:
3475:
3474:
3472:
3471:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3434:Methylene blue
3431:
3405:
3400:
3395:
3393:CX157 (Tyrima)
3390:
3385:
3380:
3375:
3370:
3365:
3353:
3350:
3349:
3347:
3346:
3341:
3336:
3331:
3326:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3236:
3231:
3226:Non-selective:
3219:
3218:
3209:
3200:
3191:
3178:
3169:
3156:
3125:
3119:
3108:
3107:
3105:
3104:
3099:
3094:
3089:
3084:
3075:
3074:
3065:
3053:
3051:Phenethylamine
3044:
3032:
3023:
3007:
3005:
2991:
2987:
2986:
2975:
2973:
2972:
2965:
2958:
2950:
2941:
2940:
2938:
2937:
2924:
2911:
2898:
2885:
2872:
2859:
2845:
2843:
2839:
2838:
2836:
2835:
2830:
2825:
2820:
2815:
2809:
2807:
2803:
2802:
2800:
2799:
2794:
2789:
2784:
2778:
2776:
2775:Classification
2772:
2771:
2769:
2768:
2763:
2758:
2753:
2747:
2745:
2741:
2740:
2738:
2737:
2732:
2727:
2722:
2717:
2712:
2707:
2702:
2696:
2694:
2690:
2689:
2684:
2682:
2681:
2674:
2667:
2659:
2650:
2649:
2647:
2646:
2640:
2638:
2628:
2627:
2624:
2623:
2621:
2620:
2615:
2610:
2605:
2600:
2595:
2590:
2584:
2582:
2578:
2577:
2575:
2574:
2568:
2566:
2559:
2543:
2542:
2539:
2538:
2536:
2535:
2530:
2524:
2522:
2518:
2517:
2515:
2514:
2509:
2503:
2501:
2495:
2494:
2492:
2491:
2486:
2480:
2478:
2469:
2453:
2452:
2449:
2448:
2446:
2445:
2440:
2435:
2430:
2425:
2420:
2415:
2409:
2407:
2403:
2402:
2400:
2399:
2394:
2389:
2383:
2381:
2375:
2374:
2372:
2371:
2366:
2356:
2354:
2350:
2349:
2347:
2346:
2341:
2336:
2331:
2325:
2323:
2316:
2306:
2305:
2295:
2293:
2292:
2285:
2278:
2270:
2261:
2260:
2257:
2256:
2254:
2253:
2242:Cholinesterase
2238:
2236:
2228:
2227:
2225:
2224:
2218:
2216:
2205:
2195:
2194:
2192:
2191:
2172:
2170:
2160:
2159:
2156:
2155:
2153:
2152:
2147:
2142:
2133:
2127:
2125:
2111:
2110:
2107:
2106:
2104:
2103:
2097:
2095:
2087:
2086:
2084:
2083:
2077:
2075:
2064:
2054:
2053:
2050:
2049:
2047:
2046:
2045:
2044:
2039:
2029:
2023:
2021:
2013:
2012:
2010:
2009:
2004:
1999:
1990:
1984:
1982:
1971:
1957:
1956:
1953:
1952:
1950:
1949:
1944:
1938:
1936:
1928:
1927:
1925:
1924:
1918:
1916:
1905:
1892:
1886:
1885:
1876:
1874:
1873:
1866:
1859:
1851:
1845:
1844:
1832:
1831:External links
1829:
1827:
1826:
1790:
1755:
1720:
1681:
1635:
1616:(3): H1372-9.
1600:
1571:(4): 1108–13.
1551:
1524:(3): 1217–24.
1507:
1488:(15): 1895–7.
1465:
1422:
1387:
1352:
1333:(5): 274–281.
1314:
1295:(3): 363–375.
1276:
1258:
1223:
1184:
1127:
1098:(14): 3310–5.
1078:
1057:(10): 977–85.
1034:
1009:
960:
911:
900:(2): 293–309.
880:
878:
875:
859:benzimidazoles
854:
851:
842:
839:
825:
822:
810:norepinephrine
801:
798:
793:
790:
786:solitary tract
768:, and in both
750:
747:
714:corticosterone
697:
694:
690:
689:
678:
677:
667:
660:
653:
646:
637:
630:
623:
616:
609:
602:
595:
588:
581:
574:
567:
560:
553:
543:
533:
523:
519:Norepinephrine
516:
509:
499:
495:Phenethylamine
492:
485:
475:
465:
461:-Phenylalanine
455:
454:
453:
446:
445:
434:catecholamines
431:
430:
429:
424:
378:phenethylamine
330:
327:
270:
263:
262:
261:
256:
249:
248:
247:
246:
245:
243:
240:
236:cardiomyocytes
224:norepinephrine
222:that converts
199:
198:
195:
194:
189:
185:
184:
179:
175:
174:
166:
165:
155:
149:
148:
143:
137:
136:
132:
131:
126:
120:
119:
114:
108:
107:
102:
96:
95:
90:
84:
83:
78:
72:
71:
68:
64:
63:
60:
56:
55:
51:
50:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4427:
4416:
4413:
4411:
4408:
4407:
4405:
4395:
4390:
4385:
4381:
4369:
4368:
4364:
4360:
4356:
4355:Serotonergics
4352:
4351:Melatonergics
4348:
4347:Dopaminergics
4344:
4340:
4337:
4330:
4320:
4317:
4314:
4313:
4310:
4306:
4303:
4300:
4299:
4297:
4292:
4286:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4244:
4243:
4240:
4236:
4233:
4230:
4229:
4227:
4222:
4216:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4179:
4178:
4175:
4171:
4165:
4162:
4161:
4159:
4154:
4148:
4145:
4143:
4139:
4129:
4125:
4122:
4119:
4118:
4116:
4111:
4105:
4099:
4095:
4092:
4089:
4088:
4086:
4081:
4075:
4069:
4066:
4064:
4061:
4059:
4056:
4053:
4052:
4049:
4045:
4042:
4039:
4038:
4036:
4031:
4025:
4022:
4018:
4014:
4008:
4004:
3994:
3991:
3989:
3986:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3953:
3952:
3949:
3945:
3942:
3940:
3936:
3933:
3931:
3927:
3924:
3922:
3918:
3915:
3913:
3909:
3906:
3904:
3900:
3897:
3895:
3891:
3888:
3886:
3882:
3879:
3877:
3873:
3870:
3868:
3864:
3861:
3858:
3857:
3855:
3850:
3844:
3838:
3835:
3833:
3830:
3828:
3825:
3822:
3821:
3818:
3814:
3811:
3808:
3807:
3805:
3800:
3794:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3752:
3751:
3748:
3744:
3741:
3738:
3737:
3735:
3730:
3724:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3682:
3681:
3678:
3671:
3668:
3665:
3664:
3662:
3657:
3651:
3645:
3642:
3639:
3638:
3635:
3631:
3630:Phenylalanine
3628:
3625:
3624:
3622:
3617:
3611:
3608:
3604:
3599:
3595:
3589:
3585:
3571:
3568:
3566:
3563:
3561:
3554:
3552:
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3496:
3494:
3491:
3489:
3486:
3483:
3480:
3479:
3476:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3429:
3425:
3421:
3417:
3413:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3358:
3355:
3354:
3351:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3294:Metfendrazine
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3274:Isocarboxazid
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3239:Echinopsidine
3237:
3235:
3232:
3230:
3227:
3224:
3221:
3220:
3217:
3213:
3210:
3208:
3204:
3201:
3199:
3195:
3192:
3190:
3186:
3182:
3179:
3177:
3173:
3170:
3168:
3164:
3160:
3157:
3155:
3151:
3148:
3143:
3134:
3127:
3126:
3123:
3120:
3115:
3109:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3085:
3083:
3080:
3077:
3076:
3073:
3069:
3066:
3064:
3060:
3054:
3052:
3048:
3047:Phenylalanine
3045:
3043:
3039:
3033:
3031:
3027:
3024:
3022:
3018:
3012:
3009:
3008:
3006:
3001:
2995:
2992:
2988:
2984:
2981:
2978:
2971:
2966:
2964:
2959:
2957:
2952:
2951:
2948:
2935:
2931:
2930:
2925:
2922:
2918:
2917:
2912:
2909:
2905:
2904:
2899:
2896:
2892:
2891:
2886:
2883:
2879:
2878:
2873:
2870:
2866:
2865:
2860:
2857:
2853:
2852:
2847:
2846:
2844:
2840:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2810:
2808:
2804:
2798:
2795:
2793:
2792:Enzyme family
2790:
2788:
2785:
2783:
2780:
2779:
2777:
2773:
2767:
2764:
2762:
2759:
2757:
2756:Cooperativity
2754:
2752:
2749:
2748:
2746:
2742:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2715:Oxyanion hole
2713:
2711:
2708:
2706:
2703:
2701:
2698:
2697:
2695:
2691:
2687:
2680:
2675:
2673:
2668:
2666:
2661:
2660:
2657:
2645:
2642:
2641:
2639:
2637:
2633:
2629:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2585:
2583:
2579:
2573:
2570:
2569:
2567:
2563:
2560:
2558:
2552:
2548:
2544:
2534:
2531:
2529:
2526:
2525:
2523:
2519:
2513:
2510:
2508:
2505:
2504:
2502:
2500:
2496:
2490:
2487:
2485:
2482:
2481:
2479:
2477:
2473:
2470:
2468:- and Related
2467:
2462:
2461:Hydroxymethyl
2458:
2454:
2444:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2410:
2408:
2404:
2398:
2395:
2393:
2390:
2388:
2385:
2384:
2382:
2380:
2376:
2370:
2367:
2365:
2361:
2358:
2357:
2355:
2351:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2326:
2324:
2320:
2317:
2315:
2311:
2307:
2302:
2298:
2291:
2286:
2284:
2279:
2277:
2272:
2271:
2268:
2251:
2247:
2243:
2240:
2239:
2237:
2234:
2229:
2223:
2220:
2219:
2217:
2214:
2209:
2206:
2204:
2203:Acetylcholine
2200:
2196:
2189:
2185:
2181:
2177:
2174:
2173:
2171:
2169:
2165:
2161:
2151:
2148:
2146:
2143:
2141:
2134:
2132:
2129:
2128:
2126:
2124:
2120:
2116:
2112:
2102:
2099:
2098:
2096:
2093:
2088:
2082:
2079:
2078:
2076:
2073:
2068:
2065:
2063:
2059:
2055:
2043:
2040:
2038:
2035:
2034:
2033:
2030:
2028:
2025:
2024:
2022:
2019:
2014:
2008:
2005:
2003:
2000:
1998:
1991:
1989:
1986:
1985:
1983:
1980:
1975:
1972:
1970:
1966:
1962:
1958:
1948:
1945:
1943:
1940:
1939:
1937:
1934:
1929:
1923:
1920:
1919:
1917:
1914:
1909:
1906:
1904:
1900:
1896:
1893:
1891:
1887:
1883:
1879:
1872:
1867:
1865:
1860:
1858:
1853:
1852:
1849:
1842:
1838:
1835:
1834:
1830:
1822:
1818:
1814:
1810:
1806:
1802:
1794:
1791:
1786:
1782:
1778:
1774:
1770:
1766:
1759:
1756:
1751:
1747:
1743:
1739:
1735:
1731:
1724:
1721:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1685:
1682:
1677:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1639:
1636:
1631:
1627:
1623:
1619:
1615:
1611:
1604:
1601:
1596:
1592:
1587:
1582:
1578:
1574:
1570:
1566:
1562:
1555:
1552:
1547:
1543:
1539:
1535:
1531:
1527:
1523:
1519:
1511:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1476:
1474:
1472:
1470:
1466:
1461:
1457:
1453:
1449:
1445:
1441:
1438:(5): 513–20.
1437:
1433:
1426:
1423:
1418:
1414:
1410:
1406:
1402:
1398:
1391:
1388:
1383:
1379:
1375:
1371:
1367:
1363:
1356:
1353:
1348:
1344:
1340:
1336:
1332:
1328:
1321:
1319:
1315:
1310:
1306:
1302:
1298:
1294:
1290:
1283:
1281:
1277:
1269:
1262:
1259:
1254:
1250:
1246:
1242:
1238:
1234:
1227:
1224:
1219:
1215:
1211:
1207:
1203:
1199:
1191:
1189:
1185:
1180:
1176:
1171:
1166:
1162:
1158:
1154:
1150:
1147:(3): 463–71.
1146:
1142:
1138:
1131:
1128:
1123:
1119:
1115:
1111:
1106:
1101:
1097:
1093:
1092:FASEB Journal
1089:
1082:
1079:
1074:
1070:
1065:
1060:
1056:
1052:
1048:
1041:
1039:
1035:
1026:
1022:
1016:
1014:
1010:
1005:
1001:
996:
991:
987:
983:
979:
975:
971:
964:
961:
956:
952:
948:
944:
940:
936:
932:
928:
920:
918:
916:
912:
907:
903:
899:
895:
888:
886:
882:
876:
874:
872:
868:
864:
860:
852:
850:
847:
838:
836:
835:pentobarbital
832:
823:
821:
819:
818:keratinocytes
815:
811:
807:
799:
797:
791:
789:
787:
783:
782:area postrema
779:
775:
771:
767:
762:
760:
759:adrenal gland
756:
748:
746:
744:
739:
736:
734:
729:
727:
723:
719:
715:
711:
710:adrenal gland
707:
702:
695:
671:
664:
657:
643:
634:
627:
585:
578:
571:
564:
557:
550:
548:
540:
538:
530:
528:
520:
513:
506:
504:
496:
489:
482:
472:
462:
450:
443:
439:
435:
428:
427:
423:
421:
419:
414:
410:
406:
402:
398:
394:
390:
386:
384:
379:
375:
371:
366:
364:
360:
356:
352:
348:
343:
341:
340:catecholamine
336:
328:
326:
322:
320:
315:
312:
310:
306:
300:
295:
293:
289:
285:
281:
267:
253:
241:
239:
237:
233:
229:
225:
221:
217:
213:
209:
207:
193:
190:
186:
183:
180:
176:
171:
167:
164:
163:
159:
156:
154:
150:
147:
144:
142:
138:
133:
130:
127:
125:
121:
118:
115:
113:
109:
106:
103:
101:
97:
94:
91:
89:
85:
82:
79:
77:
73:
69:
65:
61:
57:
52:
47:
41:
36:
31:
19:
4335:
4334:
4315:
4301:
4245:
4231:
4209:Tritoqualine
4180:
4163:
4120:
4090:
4054:
4040:
3988:Quinalizarin
3973:Neluxicapone
3954:
3894:Metanephrine
3859:
3823:
3809:
3796:
3772:Fusaric acid
3753:
3739:
3707:Bulbocapnine
3683:
3666:
3640:
3626:
3570:Tisolagiline
3565:Sembragiline
3556:Selegiline (
3484:
3481:
3459:Sercloremine
3439:Metralindole
3359:
3356:
3334:Procarbazine
3329:Pivhydrazine
3319:Pheniprazine
3244:Furazolidone
3225:
3222:
3159:Metanephrine
3128:
3078:
3010:
2990:Non-specific
2929:Translocases
2926:
2913:
2900:
2887:
2874:
2864:Transferases
2861:
2848:
2705:Binding site
2379:Homocysteine
2333:
2232:
2212:
2091:
2071:
2017:
2006:
1978:
1932:
1912:
1880:involved in
1807:(2): 82–89.
1804:
1800:
1793:
1771:(3): 300–4.
1768:
1764:
1758:
1736:(4): 312–6.
1733:
1729:
1723:
1698:
1694:
1684:
1651:
1647:
1638:
1613:
1609:
1603:
1568:
1564:
1554:
1521:
1517:
1510:
1485:
1481:
1435:
1431:
1425:
1400:
1396:
1390:
1365:
1361:
1355:
1330:
1326:
1292:
1288:
1261:
1239:(1): 82–92.
1236:
1232:
1226:
1204:(1): 51–61.
1201:
1197:
1144:
1140:
1130:
1095:
1091:
1081:
1054:
1050:
980:(1): 40687.
977:
973:
963:
933:(3): 303–8.
930:
926:
897:
893:
856:
844:
827:
803:
795:
763:
752:
749:Localization
740:
737:
730:
708:made in the
703:
699:
546:
536:
526:
502:
438:trace amines
417:
408:
396:
382:
374:trace amines
372:-methylated
369:
367:
359:metanephrine
344:
335:methyl group
332:
323:
316:
313:
298:
296:
283:
277:
211:
205:
203:
202:
160:
67:Alt. symbols
45:
4343:Adrenergics
4316:Inhibitors:
4249:Amodiaquine
4246:Inhibitors:
4181:Inhibitors:
4055:Inhibitors:
4007:Tryptamines
3955:Inhibitors:
3890:Epinephrine
3824:Inhibitors:
3754:Inhibitors:
3702:Aquayamycin
3684:Inhibitors:
3641:Inhibitors:
3598:epinephrine
3488:Adarigiline
3482:Inhibitors:
3449:Moclobemide
3378:Brofaromine
3373:Befloxatone
3368:Bazinaprine
3357:Inhibitors:
3264:Iproclozide
3254:Hydralazine
3223:Inhibitors:
3145:Tooltip ALR
3082:Benserazide
3079:Inhibitors:
2700:Active site
2297:Transferase
2233:catabolism:
2092:catabolism:
2018:catabolism:
1969:epinephrine
1933:catabolism:
1701:(1): 53–7.
1654:(1): 14–8.
1368:: 211–218.
806:epinephrine
778:Epinephrine
549:-Octopamine
488:Epinephrine
442:human brain
393:amphetamine
347:epinephrine
309:pi stacking
305:-methionine
228:epinephrine
182:Swiss-model
54:Identifiers
4404:Categories
4269:Quinacrine
4204:Naringenin
4199:Meciadanol
4170:-Histidine
4044:Tryptophan
3978:Nitecapone
3968:Entacapone
3827:CGS-19281A
3777:Nepicastat
3762:Disulfiram
3757:Bupicomide
3712:Metirosine
3560:-Deprenyl)
3551:Safinamide
3546:Rasagiline
3531:Mofegiline
3526:Milacemide
3521:Lazabemide
3516:Ladostigil
3493:Almoxatone
3469:Toloxatone
3464:Tetrindole
3454:Pirlindole
3398:Eprobemide
3388:Clorgiline
3383:Cimoxatone
3363:Amiflamine
3314:Phenelzine
3309:Paraxazone
3289:Mebanazine
3269:Iproniazid
3259:Indantadol
3249:Guineesine
3234:Caroxazone
3102:Methyldopa
3072:Tryptamine
3068:Tryptophan
3038:-Histidine
2983:modulators
2980:metabolism
2903:Isomerases
2877:Hydrolases
2744:Regulation
2213:anabolism:
2115:tryptophan
2072:anabolism:
1979:anabolism:
1913:anabolism:
1397:Metabolism
1161:1808/26489
877:References
863:quinolones
853:Inhibition
774:ventricles
745:protease.
733:splanchnic
696:Regulation
556:Synephrine
405:synephrine
401:octopamine
301:-adenosyl-
178:Structures
173:Search for
135:Other data
4336:See also:
4305:Histamine
4274:SKF-91488
4264:Metoprine
4259:Harmaline
4235:Histamine
4174:Histamine
4142:Histamine
4128:Melatonin
4094:Serotonin
4017:melatonin
4013:serotonin
3993:Tolcapone
3983:Opicapone
3832:SKF-64139
3787:Tropolone
3541:Pargyline
3501:-Deprenyl
3444:Minaprine
3424:norharman
3416:harmaline
3339:Safrazine
3304:Octamoxin
3299:Nialamide
3284:Linezolid
3279:Isoniazid
3212:Serotonin
3097:Genistein
3087:Carbidopa
3059:-Tyrosine
3042:Histamine
3030:Serotonin
2977:Monoamine
2782:EC number
2581:Carbamoyl
2557:Carbamoyl
2136:Aromatic
2123:melatonin
2119:serotonin
2058:glutamate
1993:Aromatic
1903:histamine
1899:histidine
1890:monoamine
1051:Structure
1028:;
505:-Tyramine
471:-Tyrosine
329:Mechanism
319:phosphate
242:Structure
141:EC number
117:NM_002686
76:NCBI gene
4415:EC 2.1.1
4184:Catechin
4058:AGN-2979
3863:Dopamine
3837:SKF-7698
3767:Dopastin
3743:Dopamine
3717:Oudenone
3670:Tyrosine
3634:Tyrosine
3594:dopamine
3536:Nicotine
3403:Esuprone
3229:Benmoxin
3194:Dopamine
3063:Tyramine
3021:Dopamine
2806:Kinetics
2730:Cofactor
2693:Activity
2164:arginine
1965:dopamine
1961:tyrosine
1750:11378842
1676:31646987
1630:11514309
1546:26602827
1460:24803398
1417:12040535
1382:24374199
1347:15860375
1309:19948186
1266:Brandt.
1253:15893506
1218:20642456
1179:19570037
1122:23761885
1073:11591352
1004:28084430
814:vitiligo
800:Vitiligo
512:Dopamine
413:tyramine
214:) is an
192:InterPro
146:2.1.1.28
4394:Biology
4279:Tacrine
3511:Ethanol
3412:harmine
3410:(e.g.,
2916:Ligases
2686:Enzymes
2636:Amidine
2565:Carboxy
2551:Carboxy
2314:Methyl-
2199:choline
1878:Enzymes
1821:8904737
1785:1133821
1715:2178473
1668:8750929
1595:2871139
1586:6568425
1538:8752129
1452:2816488
1170:5940352
1114:1426768
995:5234027
955:2578817
947:3885079
906:4564603
867:purines
831:ethanol
816:in the
792:Disease
743:trypsin
650:pathway
592:pathway
590:primary
440:in the
232:neurons
188:Domains
162:q21-q22
158:Chr. 17
124:UniProt
4380:Portal
3420:harman
3216:5-HIAA
2890:Lyases
2466:Formyl
2418:DNMT3B
1843:(MeSH)
1819:
1783:
1748:
1713:
1674:
1666:
1628:
1593:
1583:
1544:
1536:
1502:708473
1500:
1458:
1450:
1415:
1380:
1345:
1307:
1251:
1216:
1177:
1167:
1120:
1112:
1071:
1002:
992:
953:
945:
904:
865:, and
766:retina
642:CYP2D6
407:, and
216:enzyme
129:P11086
112:RefSeq
105:171190
59:Symbol
4079:AANAT
4048:5-HTP
3903:MOPEG
3899:DOPEG
3872:DOPAC
3198:DOPAC
3026:5-HTP
2842:Types
2632:2.1.4
2547:2.1.3
2521:Other
2457:2.1.2
2406:Other
2310:2.1.1
1672:S2CID
1542:S2CID
1456:S2CID
1271:(PDF)
1118:S2CID
1031:Bank.
951:S2CID
770:atria
648:minor
639:brain
481:-DOPA
415:into
403:into
380:into
153:Locus
4220:HNMT
4109:ASMT
3908:DOMA
3848:COMT
3798:PNMT
3185:MHPG
3176:DHMA
3163:MHPG
3154:DHMA
3132:ALDH
3092:DFMD
2999:AAAD
2934:list
2927:EC7
2921:list
2914:EC6
2908:list
2901:EC5
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