33:
65:
47:
514:
1048:
397:. It is present as an introduced species in North America. In the British Isles, female plants are rarely found outside central and northern England and the species may be naturalized as clonal populations outside this area, propagating via rhizome fragments. The preferred habitats are moist, fertile soils often by rivers, streams, and in
533:
The adverse effects of butterbur reported in clinical trials include mainly gastrointestinal problems, such as nausea, flatulence, and belching. In 2015, the
American Academy of Neurology withdrew its original endorsement of butterbur due to safety concerns.
927:"Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: [RETIRED]: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society"
537:
Long-term health effects and interaction of butterbur with other drugs have not been well documented. However, it can theoretically interact with certain blood pressure and heart medications, as well as with drugs that can induce a liver
380:
clustered on a 5–20 cm (2–8 in) stem. The leaves are large, on stout 80–120 cm (31–47 in) tall stems, round, with a diameter of 40–70 cm (16–28 in) with petioles up to 1.5 m (4 ft 11 in).
814:
Wu, Arthur W.; Gettelfinger, John D.; Ting, Jonathan Y.; Mort, Claudia; Higgins, Thomas S. (2020-02-27). "Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method".
480:
traditional medicine internally (as tea or cold maceration in ethanol) and externally (as compresses or maceration in vinegar) for treatment of infections, fever, flu, colds, hay-fever, and allergies.
866:
Sylvia Vogl; Paolo Picker; Judit Mihaly-Bison; Nanang
Fakhrudin; Atanas G. Atanasov; Elke H. Heiss; Christoph Wawrosch; Gottfried Reznicek; Verena M. Dirsch; Johannes Saukel; Brigitte Koppa (2013).
365:, the male and female flowers being borne on separate plants. In Britain, the male flowers are widespread, but the female flowers have a restricted distribution in northern and central England.
1273:
1348:
530:
have been found to contain hepatotoxic pyrrolizidine alkaloids at the retail level. These extracts are not recommended during pregnancy or breastfeeding.
721:, LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, US National Institute of Diabetes and Digestive and Kidney Diseases, 2012,
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413:, preparations are sold in some countries as a dietary supplement. There is no evidence that butterbur is useful for treating
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457:
Although there have been studies of butterbur root or leaf extracts as possible therapies for symptoms of hay fever (
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327:
986:"Hepatobiliary Events in Migraine Therapy with Herbs—The Case of Petadolex, A Petasites Hybridus Extract"
643:. National Center for Complementary and Integrative Health, US National Institutes of Health. 1 July 2020
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546:. Prior cases of liver damage have been reported from people taking butterbur, with cases varying in
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796:
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925:
Holland, S.; Silberstein, S. D.; Freitag, F.; Dodick, D. W.; Argoff, C.; Ashman, E. (2012-04-24).
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may have derived from the use of leaves to wrap butter centuries ago. It is also called
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Although some preliminary studies indicate that butterbur may reduce the frequency of
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to treat various disorders, there are no approved medical uses, but it is sold as a
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756:(Fourth ed.). Middlewood Green, Suffolk, U.K.: C & M Floristics.
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803:. Biological Records Centre and Botanical Society of Britain and Ireland.
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461:), the results were insufficient to determine effectiveness and safety.
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It is native to central Europe, extending from the
British Isles to the
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anti-inflammatory activities of 71 Austrian traditional herbal drugs"
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associations do not recommend it because of concerns of possible
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618:. Copenhagen, Denmark: Global Biodiversity Information System.
409:
As there are no approved clinical uses of butterbur or its
16:
Species of flowering plant in the daisy family
Asteraceae
872:
studies on
Austria's folk medicine – an unexplored lore
330:
in butterbur limit its use in human and animal studies.
1498:
1073:
326:. Concerns about the potential toxic effects of
797:"Online Atlas of the British and Irish Flora,
499:in its leaves and roots. Also present are the
984:Anderson, Nora; Borlak, Jürgen (2019-05-10).
372:are produced in the early spring, before the
8:
817:International Forum of Allergy and Rhinology
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376:appear. They are pale pink, with several
785:. Naturhistoriska riksmuseet, Stockholm.
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783:(L.) P. Gaertn., B. Mey. & Scherb"
616:(L.) G. Gaertn., B. Mey. & Scherb"
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604:
573:
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393:, and from southern Italy to southern
635:
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7:
1364:7c20ec61-cdc8-4021-8019-6558e96e02fa
583:(L.) G.Gaertn., B.Mey. & Scherb"
589:. Royal Botanic Gardens, Kew. 2023
14:
441:in adults and children, clinical
1581:urn:lsid:ipni.org:names:256913-1
1439:urn:lsid:ipni.org:names:237374-1
1046:
318:Although used over centuries in
63:
405:Dietary supplement and research
754:New Flora of the British Isles
510:, isopetasin, and neopetasin.
1:
690:. Drugs.com. 14 February 2022
990:Journal of Clinical Medicine
944:10.1212/WNL.0b013e3182535d0c
881:Journal of Ethnopharmacology
299:, is a herbaceous perennial
1653:Taxa named by Carl Linnaeus
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587:Plants of the World Online
894:10.1016/j.jep.2013.06.007
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190:
60:Scientific classification
58:
53:
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23:
1648:Plants described in 1753
423:urinary tract infections
497:pyrrolizidine alkaloids
328:pyrrolizidine alkaloids
868:"Ethnopharmacological
518:
429:, or other disorders.
516:
262:Petasites officinalis
1057:at Wikimedia Commons
472:leaves were used in
465:Traditional medicine
320:traditional medicine
295:, also known as the
517:Petasin's structure
470:Petasites hybridus
254:Tussilago petasites
1400:Petasites_hybridus
1139:petasites-hybridus
1105:Petasites hybridus
1075:Petasites hybridus
1054:Petasites hybridus
1003:10.3390/jcm8050652
799:Petasites hybridus
781:Petasites hybridus
614:Petasites hybridus
581:Petasites hybridus
558:to liver failure.
522:Potential toxicity
519:
489:Petasites hybridus
439:migraine headaches
324:dietary supplement
307:that is native to
292:Petasites hybridus
278:Petasites vulgaris
201:Petasites hybridus
25:Petasites hybridus
1630:
1629:
1500:Tussilago hybrida
1385:Open Tree of Life
1067:Taxon identifiers
1051:Media related to
937:(17): 1346–1353.
829:10.1002/alr.22488
777:Anderberg, Arne.
763:978-1-5272-2630-2
459:allergic rhinitis
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801:(Butterbur)"
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750:Stace, C. A.
730:, retrieved
717:
692:. Retrieved
645:. Retrieved
613:
591:. Retrieved
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385:Distribution
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1323:NatureServe
1248:iNaturalist
1099:Wikispecies
688:"Butterbur"
641:"Butterbur"
552:cholestasis
493:senecionine
399:wet meadows
395:Scandinavia
357:Description
347:Devil's hat
343:bog rhubarb
241:(L.) Bernh.
159:Senecioneae
103:Angiosperms
1637:Categories
1413:gcc-143847
1408:Plant List
996:(5): 652.
562:References
526:Butterbur
419:bronchitis
305:Asteraceae
149:Asteraceae
1643:Petasites
1515:Q21877665
1012:2077-0383
953:0028-3878
931:Neurology
853:211538121
837:2042-6976
718:Butterbur
491:contains
443:neurology
433:Migraines
363:dioecious
339:Butterbur
297:butterbur
213:G.Gaertn.
177:Species:
170:Petasites
139:Asterales
73:Kingdom:
1594:50233438
1589:Tropicos
1568:256913-1
1509:Wikidata
1459:VASCAN:
1447:Tropicos
1397:PalDat:
1328:2.133231
1279:10907661
1266:237374-1
1146:BioLib:
1126:286-82-1
1084:Wikidata
1030:31083451
971:22529203
912:23770053
874:in vitro
870:in vitro
845:32104974
752:(2019).
727:31643329
528:extracts
474:Austrian
453:Rhinitis
411:extracts
391:Caucasus
229:Synonyms
145:Family:
129:Asterids
116:Eudicots
54:Foliage
1620:1178636
1542:3088302
1488:1114946
1452:2710849
1227:3088301
1170:Ecocrop
1090:Q375620
1021:6572430
962:3335449
903:3791396
542:called
508:petasin
370:flowers
221:Scherb.
165:Genus:
155:Tribe:
135:Order:
77:Plantae
1555:413415
1421:PLANTS
1390:533782
1361:NZOR:
1354:278673
1292:116220
1240:413414
1214:160476
1188:468820
1134:ARKive
1123:APSA:
1116:222617
1113:APDB:
1028:
1018:
1010:
969:
959:
951:
910:
900:
851:
843:
835:
760:
725:
612:"GBIF
544:CYP3A4
540:enzyme
504:esters
427:asthma
374:leaves
349:, and
309:Europe
219:&
217:B.Mey.
1615:WoRMS
1529:7CYKG
1483:WoRMS
1462:27171
1305:36056
1274:IRMNG
1253:55850
1209:EUNIS
1201:PEDHY
1175:15851
1162:4FCZK
1149:41448
849:S2CID
732:5 May
694:5 May
647:5 May
593:3 May
550:from
478:Czech
281:Desf.
123:Clade
110:Clade
97:Clade
84:Clade
1576:POWO
1563:IPNI
1550:GRIN
1537:GBIF
1434:POWO
1426:PEHY
1377:7696
1349:NCBI
1300:ITIS
1261:IPNI
1235:GRIN
1222:GBIF
1196:EPPO
1026:PMID
1008:ISSN
967:PMID
949:ISSN
908:PMID
841:PMID
833:ISSN
758:ISBN
734:2022
723:PMID
696:2022
649:2022
595:2023
554:and
476:and
368:The
313:Asia
1602:WFO
1524:CoL
1470:WFO
1336:NBN
1315:421
1287:ISC
1183:EoL
1157:CoL
1016:PMC
998:doi
957:PMC
939:doi
898:PMC
890:doi
886:149
825:doi
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