Knowledge (XXG)

Postpolypectomy coagulation syndrome

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PPCS is caused by an electrocautery-induced injury to the wall of the colon that occurs during removal of colon polyps. PPCS occurs when the electric current extends beyond the mucosa, entering the muscularis propria and serosa, resulting in a full thickness (transmural) burn injury. The transmural
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PPCS occurs about 1% of cases following polypectomy with electrocautery. Risk factors for PPCS include right colon polypectomy, large polyp size (>2 cm), non-polypoid lesions (laterally spreading lesions), and hypertension.
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PPCS may resemble perforation. Recognition of PPCS is important, since treatment usually does not require surgery, unlike gastrointestinal perforation. Laboratory studies may show elevated white blood cell count
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PPCS causes abdominal pain and fever. The condition usually onsets within 1–5 days after colonoscopy with polypectomy using electrocautery. Physical examination may show evidence of peritonitis.
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Shin, YJ; Kim, YH; Lee, KH; Lee, YJ; Park, JH (October 2016). "CT findings of post-polypectomy coagulation syndrome and colonic perforation in patients who underwent colonoscopic polypectomy".
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Treatment of PPCS consists of intravenous fluids, antibiotics, and avoiding any oral intake of food, water, etc. until symptoms improve.
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La Regina, D; Mongelli, F; Fasoli, A; Lollo, G; Ceppi, M; Saporito, A; Garofalo, F; Di Giuseppe, M; Ferrario di Tor Vajana, A (2020).
172: 320:"Clinical Adverse Events after Endoscopic Resection for Colorectal Lesions: A Meta-Analysis on the Antibiotic Prophylaxis" 213:. CT scan of the abdomen may show severe mural thickening, without air present outside the gastrointestinal tract. 500: 95: 160: 90: 85:, right colon polypectomy, large polyp size (>2 cm), non-polypoid lesions (laterally spreading lesions) 264:
Hirasawa, K; Sato, C; Makazu, M; Kaneko, H; Kobayashi, R; Kokawa, A; Maeda, S (10 September 2015).
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Waye, JD (June 1993). "Management of complications of colonoscopic polypectomy".
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Some low quality evidence suggests that antibiotic prophylaxis may prevent PPCS.
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burn results in localized inflammation of the peritoneum (peritonitis).
336: 319: 168: 159:, which results in a burn injury to the wall of the 127: 117: 109: 101: 89: 76: 68: 60: 50: 38: 26: 21: 8: 209:) and elevated inflammatory markers such as 270:World Journal of Gastrointestinal Endoscopy 259: 257: 255: 253: 251: 18: 403: 335: 291: 281: 313: 311: 113:IV fluids, antibiotics, nothing by mouth 324:Digestive Diseases (Basel, Switzerland) 247: 148:) is a condition that occurs following 373: 371: 369: 367: 365: 363: 7: 138:Postpolypectomy coagulation syndrome 22:Postpolypectomy coagulation syndrome 14: 173:elevated white blood cell count 72:Polypectomy during colonoscopy 1: 163:. The condition results in 517: 441:10.1016/j.crad.2016.03.010 64:1-5 days after polypectomy 30:Transmural burn syndrome, 32:Postpolypectomy syndrome 396:10.5946/ce.2014.47.3.205 283:10.4253/wjge.v7.i12.1055 142:Postpolypectomy syndrome 464:The Gastroenterologist 161:gastrointestinal tract 105:Antibiotic prophylaxis 91:Differential diagnosis 56:Abdominal pain, fever 378:Kim, HW (May 2014). 34:Coagulation syndrome 175:and elevated serum 429:Clinical Radiology 384:Clinical Endoscopy 211:C-reactive protein 183:Signs and symptoms 177:C-reactive protein 337:10.1159/000502055 135: 134: 16:Medical condition 508: 501:Gastroenterology 480: 479: 459: 453: 452: 424: 418: 417: 407: 375: 358: 357: 339: 315: 306: 305: 295: 285: 261: 45:Gastroenterology 19: 516: 515: 511: 510: 509: 507: 506: 505: 486: 485: 484: 483: 461: 460: 456: 426: 425: 421: 377: 376: 361: 317: 316: 309: 276:(12): 1055–61. 263: 262: 249: 244: 235: 227: 219: 202: 193: 185: 33: 31: 17: 12: 11: 5: 514: 512: 504: 503: 498: 488: 487: 482: 481: 454: 435:(10): 1030–6. 419: 359: 307: 246: 245: 243: 240: 234: 231: 226: 223: 218: 215: 201: 198: 192: 189: 184: 181: 165:abdominal pain 154:electrocautery 133: 132: 129: 125: 124: 121: 115: 114: 111: 107: 106: 103: 99: 98: 93: 87: 86: 80: 74: 73: 70: 66: 65: 62: 58: 57: 54: 48: 47: 42: 36: 35: 28: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 513: 502: 499: 497: 494: 493: 491: 477: 473: 470:(2): 158–64. 469: 465: 458: 455: 450: 446: 442: 438: 434: 430: 423: 420: 415: 411: 406: 401: 397: 393: 389: 385: 381: 374: 372: 370: 368: 366: 364: 360: 355: 351: 347: 343: 338: 333: 329: 325: 321: 314: 312: 308: 303: 299: 294: 289: 284: 279: 275: 271: 267: 260: 258: 256: 254: 252: 248: 241: 239: 232: 230: 224: 222: 216: 214: 212: 208: 199: 197: 190: 188: 182: 180: 178: 174: 170: 166: 162: 158: 155: 151: 147: 143: 139: 130: 126: 122: 120: 116: 112: 108: 104: 100: 97: 94: 92: 88: 84: 81: 79: 75: 71: 67: 63: 59: 55: 53: 49: 46: 43: 41: 37: 29: 25: 20: 467: 463: 457: 432: 428: 422: 390:(3): 205–6. 387: 383: 330:(1): 15–22. 327: 323: 273: 269: 236: 233:Epidemiology 228: 220: 207:leukocytosis 203: 194: 186: 145: 141: 137: 136: 83:Hypertension 78:Risk factors 157:polypectomy 150:colonoscopy 96:Perforation 61:Usual onset 27:Other names 490:Categories 242:References 225:Prevention 102:Prevention 496:Endoscopy 354:199573818 217:Treatment 200:Diagnosis 128:Frequency 123:Excellent 119:Prognosis 110:Treatment 40:Specialty 449:27085213 414:24944980 346:31408875 302:26380051 191:Etiology 52:Symptoms 476:8049888 405:4058534 293:4564832 474:  447:  412:  402:  352:  344:  300:  290:  69:Causes 350:S2CID 169:fever 152:with 472:PMID 445:PMID 410:PMID 342:PMID 298:PMID 146:PPCS 437:doi 400:PMC 392:doi 332:doi 288:PMC 278:doi 144:or 492:: 466:. 443:. 433:71 431:. 408:. 398:. 388:47 386:. 382:. 362:^ 348:. 340:. 328:38 326:. 322:. 310:^ 296:. 286:. 272:. 268:. 250:^ 179:. 171:, 167:, 131:1% 478:. 468:1 451:. 439:: 416:. 394:: 356:. 334:: 304:. 280:: 274:7 205:( 140:(

Index

Specialty
Gastroenterology
Symptoms
Risk factors
Hypertension
Differential diagnosis
Perforation
Prognosis
colonoscopy
electrocautery
polypectomy
gastrointestinal tract
abdominal pain
fever
elevated white blood cell count
C-reactive protein
leukocytosis
C-reactive protein





"Coagulation syndrome: Delayed perforation after colorectal endoscopic treatments"
doi
10.4253/wjge.v7.i12.1055
PMC
4564832
PMID
26380051

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