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connected the cytoplasmic multi-PDZ domain protein GRIP1, an interaction partner of Eph/ephrin proteins and other molecules, with the rare but severe human congenital disease Fraser
Syndrome. They also demonstrated that Junctional Adhesion Molecules (JAMs) are critical regulators of cell polarity.
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Several of their discoveries are directly relevant for human pathologies. For example, they were the first to show that the Eph receptor ligand ephrin-B1 controls skeletal morphogenesis and that defects in the human gene (EFNB1) lead to
Craniofrontonasal Syndrome (CFNS). A different project has
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After his move to the Max Planck
Institute for Molecular Biomedicine in the year 2008, Adams found that the Notch ligand Jagged1 antagonizes the function of Dll4 and thereby acts as an important pro-angiogenic switch in endothelial cells. His team also discovered that the transmembrane protein
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and an important regulator of blood vessel morphogenesis in the developing embryo. Together with his collaborator Dr A. Nebrada, he also demonstrated that the p38α mitogen-activated protein kinase is required for the formation of the vascular network inside the placenta.
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Although his work has addressed many important aspects of tissue and organ morphogenesis, the interaction of different cells and cell types during the formation of new blood vessels is a central research interest in the laboratory of Dr Adams.
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in
Biochemistry for his work at the Max Planck Institute for Brain Research in Frankfurt (Germany), which includes the discovery of several novel semaphorin family molecules and the characterization of their role in axon guidance.
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Dr Adams and his co-workers have made significant achievements by combining genetic approaches in the mouse with a wide range of cell and molecular biology methods.
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Since 2007 Adams is
Professor for ‘Vascular Biology’ at the Westfälische Wilhelms University and Director at the MPI for Molecular Biomedicine in Münster, Germany.
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during the years 1996 to 2000, he was among the first to discover that ephrin-B2, a ligand for Eph receptor tyrosine kinases, is a marker for arterial
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London
Research Institute (formerly, Imperial Cancer Research Fund) and Honorary Senior Research Fellow at the
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As a postdoctoral research fellow with Dr R. Klein at the
European Molecular Biology Laboratory in
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Website of Adams' Department at the Max Planck
Institute for Molecular Biomedicine
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ephrin-B2 controls endothelial cell motility and VEGF receptor endocytosis.
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In 2000 Adams became head of the
Vascular Development Laboratory at the
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from the article and its talk page, especially if potentially
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and head of the Department of Tissue Morphogenesis in
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