197:. Her main goal is to understand how this virus enters a cell and also to come up with a subunit vaccine that will expand upon and improve the current vaccine for variola, which can have serious side effects and may not be used on pregnant women or individuals with an impaired immune system. She is directing her focus to the entry protein L1, which she believes is the receptor binding protein for vaccina and will be able to improve limitations of the current vaccine for smallpox.
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173:, or genes that retain the same function, of three glycoproteins. These glycoproteins gB, gH, and gL play important roles in how a virus enters a cell and how it spreads when inside of a cell. Eisenberg is interested in the fact that glycoproteins gH, gL and gB are very protected in all herpesviruses, especially in the large number of animal herpesviruses, which can cause disease in small, farm, and zoo animals.
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Xiao, Yuhong; Aldaz-Carroll, Lydia; Ortiz, Alexandra; Whitbeck, Charles; Alexander, Edward; Lou, Huan; Davis, Heather; Braciale, Thomas; Eisenberg, Roselyn; Cohen, Gary; Isaacs, Stuart (26 January 2007).
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Heldwein, Ekaterina; Lou, Haun; Bender, Florent; Cohen, Gary; Eisenberg, Roselyn; Harrison, Stephen (14 July 2006). "Crystal
Structure of Glycoprotein B from Herpes Simplex Virus 1".
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Eisenberg studies how molecular events mediate a virus' entry into a cell. Her research is focused mainly on the herpes simplex virus (herpesviridea) and the poxvirus.
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She has contributed research and information to 264 articles and has been cited 784 times. Below is a list of some of the publications she has taken part in.
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from 1965 to 1968. She works closely beside Dr. Gary H. Cohen, who is a professor and the chair of the
Department of Microbiology at Penn Dental Medicine.
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and a member of the
University's School of Veterinary Medicine and School of Dental Medicine. The majority of Eisenberg's research is focused on the
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Lazear, E.; Whitbeck, C.J.; Ponce-de-Leon, M.; Cairns, T.M.; Willis, S.H.; Zuo, Y.; Krummenacher, C.; Cohen, G.H.; Eisenberg, R.J. (February 2012).
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485:"Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion"
215:"Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion"
436:"A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost"
212:"A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost"
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593:"Antibody-induced conformational changes in herpes simplex virus glycoprotein gD reveal new targets for virus neutralization"
221:"Antibody-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein gD Reveal New Targets for Virus Neutralization"
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544:"The myristate moiety and amino terminus of vaccinia virus l1 constitute a bipartite functional region needed for entry"
218:"The Myristate Moiety and Amino Terminus of Vaccinia Virus L1 Constitute a Bipartite Functional Region Needed for Entry"
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Eisenberg, R.J.; Atanasiu, D.; Cairns, T.M.; Gallagher, J.R.; Krummenacher, C.; Cohen, G.H. (May 10, 2012).
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Foo, C.H.; Whitbeck, J.C.; Ponce-de-Leon, M.; Saw, W.T.; Cohen, G.H.; Eisenberg, R.J. (7 March 2012).
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Cairns, T.; Whitbeck, C.; Lou, H.; Heldwein, E.; Chowdary, T.; Eisenberg, R.; Cohen, G. (July 2011).
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Atanasiu, D; Whitbeck, J.C; Cairns, T.M; Reilly, B; Cohen, G; Eisenberg, R (14 November 2007).
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to honor her contributions and leadership. She is a member of the editorial board for the
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Biology, Bryn Mawr
College, 1960 PhD, Microbiology, University of Pennsylvania, 1965
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Research of herpes simplex virus and poxvirus and how they enter susceptible cells
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Eisenberg was elected to the
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209:"Crystal Structure of Glycoprotein B from Herpes Simplex Virus 1"
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and how they enter into susceptible cells. She also studies
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153:Research contributions
80:Microbiology, virology
697:. Journal of Virology
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