841:
1054:
629:
198:
1511:
77:
27:
1275:. The construction of these tubules, which is important for SNX-mediated endosomal sorting, experiments an important acceleration during this transition process; therefore, it is suggested that SNX8 may be involved in the transport of endogenous acid environment-requiring cargo. In addition, as SNX8 interacts with elements of the
1566:. The bar plot on the right shows the proportion of tumor samples from 15 cancer types that have any kind of altering mutations in the given protein. Moreover, some studies seem to draw an important relationship between different type of cancers and SNX8 expression; although most of the patients with
1364:
Several case studies studying deletions in the 7p22.3 genomic region, where the SNX8 gene is located, found that it contributes to neurodevelopmental problems with considerable impairments in the motor, cognitive and socio-emotional areas, with malformations in the heart and craniofacial structures,
2377:
Mastromoro, Gioia; Capalbo, Anna; Guido, Cristiana
Alessia; Torres, Barbara; Fabbretti, Maria; Traversa, Alice; Giancotti, Antonella; Ventriglia, Flavia; Bernardini, Laura; Spalice, Alberto; Pizzuti, Antonio (September 2019). "Small 7p22.3 microdeletion: Case report of Snx8 haploinsufficiency and
1477:
It is suggested that SNX8 participates in the development of the embryonic cardiac tissue since the gene is expressed with cells within the area of heart. This hypothesis is supported by the fact that SNX8 activity has been associated to sortin nexin L, a protein of the same family encoded by the
2286:
Rendu, John; Satre, Véronique; Testard, Hervé; Devillard, Francoise; Vieville, Gaëlle; Fauré, Julien; Amblard, Florence; Jouk, Pierre-Simon; Coutton, Charles (August 2014). "7p22.3 microdeletion disrupting SNX8 in a patient presenting with intellectual disability but no tetralogy of Fallot".
1035:
compartments by acting as an intracellular cholesterol transport inhibitor. On the other hand, SNX8 overexpression induces intracellular clustering of cholesterol under conditions of high cellular cholesterol levels and aggravates abnormal distribution of cholesterol. In relation to the
628:
100:
which are very relevant in relation to its functions. Furthermore, SNX8 study is motivated by its medical significance in relation to diseases such as
Alzheimer's Disease, cancer, neurodevelopmental malformations and to its role in fighting against viral infections.
1498:, one of the most common cyanotic congenital heart defects. Nevertheless, evidence demonstrates the existence of patients with SNX8 deletion whose cardiac tissue development does not experience any alteration. Finally, although cardiac malformation requires SNX8
2060:
Liang, Xiao-Dong; Zhang, Yun-Na; Liu, Chun-Chun; Chen, Jing; Chen, Xiong-Nan; Sattar Baloch, Abdul; Zhou, Bin (1 November 2019). "U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking".
1231:
allows them to assembly in a dose-dependent manner a helical coat with the capacity to detect, promote and stabilize the curvature of endosomal vesicular membranes into tubular profiles during the so-called incidence detection process, specially in
1526:
and trafficking is the main cause of multiple human disorders. For example, some studies suggest that SNX8 deletions might produce cardiac malformations since its function in normal cholesterol levels regulations would be completely impaired.
288:, which is located between amino acids 256 and 440. Its ability to form coatings in membranes in order to induce their curvature is key in SNX8 participation in tubular structures formation. Furthermore, SNX8 C-terminus contains a
1020:: it remains unaltered in conditions of moderate high concentrations of cholesterol, and it experiments a decrease in conditions of restricted levels of cholesterol due to the action of the fungus-derived cholesterol-lowering
394:
by exerting forces on these structures. The biological functions of SNX8 that have been studied, all of which involve its role in intracellular endosomal transport, are explained in more detail in the following sections.
2421:
Vanzo, Rena J.; Martin, Megan M.; Sdano, Mallory R.; Teta, Kathie; South, Sarah T. (August 2014). "Correspondence regarding SNX8 haploinsufficiency and its potential for cardiac anomalies including tetralogy of Fallot".
840:
92:. It is suggested that it acts as an adaptor protein in events related to immune response and cholesterol regulation, for example. As a protein of the SNXs family, the SNX8 is formed of 465 aminoacids and presents a
124:
family of proteins, which mainly contain two functional membrane-binding that allow SNXs to have different roles in endosomal sorting and protein trafficking thanks to its membrane curvature ability. To begin with,
2242:
Richards, Elliott G.; Zaveri, Hitisha P.; Wolf, Varina L.; Kang, Sung-Hae Lee; Scott, Daryl A. (July 2011). "Delineation of a less than 200 kb minimal deleted region for cardiac malformations on chromosome 7p22".
1040:
pathway, SNX8 is not able to successfully reduce the inhibitory impact of cholesterol on SREBP-mediated transcription, but it has an important effect that counteracts the block of this pathway triggered by the
2111:
Xie, Yongzhuang; Niu, Mengxi; Ji, Chengxiang; Huang, Timothy Y.; Zhang, Cuilin; Tian, Ye; Shi, Zhun; Wang, Chen; Zhao, Yingjun; Luo, Hong; Can, Dan; Xu, Huaxi; Zhang, Yun-wu; Zhang, Xian (6 September 2019).
153:
to sense, stabilize and induce membrane curvature. The SNX-BAR proteins that contain both domains are a part of phosphoinositide-enriched, high-curvature tubular micro-domains of the endo-lysosomal network.
2333:
Vanzo, Rena J.; Martin, Megan M.; Sdano, Mallory R.; Teta, Kathie; Aggarwal, Vimla; South, Sarah T. (February 2014). "SNX8: A candidate gene for 7p22 cardiac malformations including tetralogy of fallot".
1053:
1369:
in some cases. This idea is supported by the fact that the overlapping deleted regions of the different patients of these studies contained SNX8, which suggests that it is one of the accountable genes.
80:
Tertiary structure of the SNX9 which gives an idea of the tertiary structure of the SNX8, since primary structure shares 20% sequence identity and 0.3 sequence similarity with SNX8 primary structure.
1207:
and tubular structures, it has been demonstrated that sorting involving recycling pathways is mainly tubule-mediated. Therefore, tubular structures building is essential for the activity of
2493:
Chatterjee, Sandipan; Szustakowski, Joseph D.; Nanguneri, Nirmala R.; Mickanin, Craig; Labow, Mark A.; Nohturfft, Axel; Dev, Kumlesh K.; Sivasankaran, Rajeev; Xu, Aimin (21 April 2009).
262:
in positions 95 and 126 that are key in its function in the IFNγ-triggered IKKβ-mediated noncanonical signaling pathway. Overall, the PX domain main function is to target SNX8 mainly to
2009:
Wei, Jin; Lian, Huan; Guo, Wei; Chen, Yun-Da; Zhang, Xia-Nan; Zang, Ru; Zhong, Li; Yang, Qing; Hu, Ming-Ming; Luo, Wei-Wei; Shu, Hong-Bing; Li, Shu; Feng, Pinghui (15 October 2018).
1542:
due to its role in endosomal content sorting. Neuropathic pain is a chronic debilitating pain condition caused by a nervous system lesion or dysfunction, which usually emerges after
2552:
Eberlé, Delphine; Hegarty, Bronwyn; Bossard, Pascale; Ferré, Pascal; Foufelle, Fabienne (November 2004). "SREBP transcription factors: master regulators of lipid homeostasis".
632:
Simplified scheme of DNA-triggered SNX8-mediated association of MITA and VPS34, and its intracellular transport pathway from RE to perinuclear microsomes via Golgi apparatus.
45:
247:, which is located between amino acids 71 and 181. A homology domain with yeast's PX domain is localized between amino acids 75 and 178 within this same domain. As it is a
2163:
Glenner, George G.; Wong, Caine W. (May 1984). "Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein".
659:, a central adaptor protein in the innate immune response to DNA viral infections that activates and onsets the antiviral response, by allowing its association with the
1458:(Sendai virus) through VISA-mediated activation of the IFNβ promoter; murine cells expressing SNX8 under this infection showed a higher expression and secretion of
1101:
processed through two parallel pathways: an amyloidogenic pathway via acidified late endosomes and a non-amyloidogenic or anti-myloidogenic retrograde pathway via
255:
3-phosphate since being specific binding sites, constituting a phosphoinositid binding site with a span of 40 amino acids. Furthermore, it includes a pair of
1469:
in blood and a reduced presence of viral accumulations, which resulted in a reduction of SeV lethality, in comparison to SNX8-negative induced murine cells.
973:. Although its precise mechanism of action remains unknown, data suggests that SNX8 produces changes in cholesterol distribution through regulation of the
1812:
van
Weering, Jan R.T.; Verkade, Paul; Cullen, Peter J. (January 2012). "SNX-BAR-Mediated Endosome Tubulation is Co-ordinated with Endosome Maturation".
783:
197:
786:. Overall, it participates in a series of chemical reactions and molecular interactions that lead to the selective promotion of a particular subset of
2644:
Lin, Tzer-Bin; Lai, Cheng-Yuan; Hsieh, Ming-Chun; Wang, Hsueh-Hsiao; Cheng, Jen-Kun; Chau, Yat-Pang; Chen, Gin-Den; Peng, Hsien-Yu (4 November 2015).
1037:
994:
982:
974:
617:
601:
589:
581:
518:
491:
480:
476:
432:
1005:
compartmentalization through the production of cholesterol cargoes. This last possibility is supported by the fact that the ability of altering
1858:
Dyve, Anne Berit; Bergan, Jonas; Utskarpen, Audrun; Sandvig, Kirsten (December 2009). "Sorting nexin 8 regulates endosome-to-Golgi transport".
856:, resulting in the stimulation of its association with Sxn8 above standard constitutive levels. The link between these two protein within the
2198:
Rosenthal, Samantha L; Wang, Xingbin; Demirci, F Yesim; Barmada, Michael M; Ganguli, Mary; Lopez, Oscar L; Kamboh, M Ilyas (13 August 2012).
529:-mediated antiviral response activation such as the intermediates of this pathway TBK1, IRF3, IκBα or ISRE. IRF3 cooperative activation with
359:
in a retromer-mediated manner. SNX8 is therefore localized in early endosomes, as its colocalization with components of the retromer such as
149:(Bin/amphiphysin/Rvs) domain is a key regulator of phosphoinositide-mediated, tubular-based endosomal sorting. Accordingly, this domain also
844:
Simplified scheme of SNX8 participation in the IFNγ-triggered IKKβ-mediated noncanonical signaling pathway (autophosphorylation not shown).
2587:
Reyes-Gibby, Cielito C.; Wang, Jian; Yeung, Sai-Ching J.; Chaftari, Patrick; Yu, Robert K.; Hanna, Ehab Y.; Shete, Sanjay (8 June 2018).
1514:
This bar plot shows the proportion of tumor samples from 15 cancer types that have any kind of altering mutation(s) in the given protein.
1432:-mediated activation of the IFNβ promoter; murine cells expressing SNX8 under this infection showed a higher expression and secretion of
1664:
Muirhead, Gillian; Dev, Kumlesh K. (2014). "The
Expression of Neuronal Sorting Nexin 8 (SNX8) Exacerbates Abnormal Cholesterol Levels".
1392:-mediated noncanonical signaling pathway; murine cells expressing SNX8 under this infection showed a higher expression and secretion of
880:
436:
1365:
with developmental, intellectual and language delay, with mild intellectual disability and with cognitive impairment associated with
990:
63:
205:
The SNX8 protein, even though is very similar to the other sorting nexins, presents a domain structure which resembles the most to
1546:
treatment. This hypothesis is supported by the fact that other SNXs activity has also been identified with other pain conditions.
710:
whose activation is important in the activation of the IFNβ promoter transcription. This hypothesis is supported by the fact that
1590:
presented low or any concentrations of SNX8. The rationale behind this differential phenotype of SNX8 synthesis remains unclear.
1263:, which is mainly characterized by a retrograde movement from the cell periphery to a juxtanuclear position, an acidification of
1947:
Guo, Wei; Wei, Jin; Zhong, Xuan; Zang, Ru; Lian, Huan; Hu, Ming-Ming; Li, Shu; Shu, Hong-Bing; Yang, Qing (11 September 2019).
1204:
609:
1535:
1429:
1042:
986:
739:
711:
695:
675:
667:
652:
439:
involved in the innate immune response against this type of infections; this process is critical in the recruitment of other
427:-mediated activation of the IFNβ promoter that leads to host defense in a dose-dependent manner. It positively regulates the
787:
637:
409:
315:
protein, the MVP1 encoded by the also homolog gene Mvp1p, which also plays a role by mediating transport of cargo to the
379:). Furthermore, the dynamics of endosomal structures with SNX8-enriched membrane domains are regulated by the opposite
798:
323:
compartments. For this reason, its investigation can lead to a better understanding of SNX8 functions in human cells.
2114:"SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse"
1510:
214:
2468:
2589:"Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer"
1321:
1149:
1137:
1106:
1090:
1082:
1062:
802:
727:
660:
452:
300:, resulting in a phosphothreonine and a phosphoserine. Therefore, there are classified as phosphorylation sites.
1607:
2646:"VPS26A–SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn Neurons Mediates Neuropathic Pain in Rats"
1748:"SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes"
1482:
gene, which plays a role in the development of the embryonic liver. Deletions of chromosome 7p22 that induce
1057:
Simplified scheme of APP traffic and its amyloidogenic and non-amyloidogenic proteolytic degradative pathways
694:. This MITA transport pathway is vital for the immune response to start. SNX8 is suggested to play a role in
1156:
1017:
872:
794:
699:
691:
644:
538:
416:
297:
251:-binding domain, it is important to highlight amino acids 109, 135 and 148 as residues directly related to
221:
shown in the model above. Overall, the SNX8 protein is integrated by one unique peptide chain that has 465
1413:
1380:
1353:
1345:
1337:
1333:
1329:
1317:
1309:
1893:
Hunt, Sylvie D.; Townley, Anna K.; Danson, Chris M.; Cullen, Peter J.; Stephens, David J. (1 June 2013).
1256:(TEN) around the endosomal vacuole, which is an important compartment for successful sorting of cargoes.
1066:
978:
723:
448:
848:
Specifically, the steps of this pathway that are regulated by SNX8 are the following. The reception of
88:
is a sorting nexin protein involved in intracellular molecular traffic from the early endosomes to the
1352:(rs2286206 and rs10249052) within the human SNX8 gene locus have also been associated with late-onset
2600:
2506:
1759:
1543:
1448:
1425:
1233:
1224:
936:
683:
655:-mediated activation of the IFNβ promoter in a dose-dependent manner. It regulates the activation of
514:
487:
428:
348:
267:
252:
248:
130:
2011:"SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA"
1495:
526:
424:
356:
89:
1746:
Wei, Jin; Guo, Wei; Lian, Huan; Yang, Qing; Lin, Heng; Li, Shu; Shu, Hong-Bing (5 December 2017).
2447:
2403:
2359:
2312:
2268:
2086:
1986:
1837:
1689:
1583:
1563:
1499:
1483:
952:
790:
640:
412:
1949:"SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA"
505:
of SNX8 are necessary for this linkage. The formation of the SNX8-VISA complex potentiates VISA
2717:
2693:
2675:
2626:
2569:
2534:
2439:
2395:
2351:
2304:
2260:
2221:
2180:
2145:
2078:
2042:
1978:
1924:
1875:
1829:
1787:
1681:
1575:
1567:
1459:
1433:
1393:
1349:
908:
810:
312:
150:
2665:
2657:
2616:
2608:
2561:
2524:
2514:
2431:
2387:
2343:
2296:
2252:
2211:
2172:
2135:
2125:
2070:
2032:
2022:
1968:
1960:
1914:
1906:
1895:"Microtubule motors mediate endosomal sorting by maintaining functional domain organization"
1867:
1821:
1777:
1767:
1673:
1587:
1491:
1385:
1118:
928:
849:
830:
779:
592:
remains unclear, although two options have been suggested: translocation of viral RNA-bound
1579:
1313:
1272:
1268:
1259:
It is also worth mentioning the existing coupling of tubular structures formation and the
1245:
1188:
1176:
1168:
1160:
1133:
1110:
1102:
1086:
1078:
1074:
993:(SCAP). For example, it is unclear if SNX8 has a direct participation in the transport of
940:
868:
743:
731:
687:
546:
534:
456:
256:
2604:
2510:
1763:
1152:
stability, which is responsible for a longer lifespan, without having any effect in its
189:(Src homology 3) and RA (Ras-associated), are involved in protein-protein interactions.
2670:
2645:
2621:
2588:
2529:
2494:
2216:
2199:
2140:
2113:
2037:
2010:
1973:
1948:
1919:
1894:
1782:
1747:
1571:
1559:
1325:
1126:
1114:
892:
888:
876:
861:
857:
853:
775:
604:
may result in a conformational switch that would increase its affinity for SNX8 or the
585:
522:
510:
440:
352:
226:
2495:"Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity"
2176:
2711:
2407:
2090:
1990:
1825:
1522:
levels regulation is markedly relevant since disruption of intracellular cholesterol
1463:
1437:
1397:
1208:
1153:
1141:
1070:
1010:
1006:
755:
613:
558:
472:
464:
380:
121:
115:
2451:
2363:
1693:
1148:
production (specifically, production of Aβ40 and Aβ42) . In addition, SNX8 improves
2661:
2316:
2272:
1841:
1455:
1341:
1301:
1241:
1145:
1122:
963:
959:
2565:
2519:
2074:
2027:
1519:
1098:
1027:
and the drug U18666a which promotes cytosolic cholesterol clustering within the
970:
955:
924:
573:
340:
296:
in position 456 which can go through post-traductional changes that induces its
2612:
2391:
1871:
1752:
Proceedings of the
National Academy of Sciences of the United States of America
133:(PI)-binding domain. The preferential interaction of this domain with membrane
1964:
1677:
1539:
1523:
1336:. Furthermore, it has been demonstrated that SNX8 overexpression mediated by
1332:. Some studies found that SNX8 levels were drastically lower in patients with
1228:
1212:
1024:
948:
502:
495:
484:
483:
in later stages results in a reduction of this phenomenon). Structurally, the
285:
279:
244:
222:
186:
182:
146:
93:
2130:
1159:. This hypothesis is supported by the fact that SNX8 mainly colocalizes with
467:. Furthermore, RNA viral infections cause the translocation of SNX8 from the
1772:
1421:
1237:
1172:
865:
829:
which present direct antimicrobial activity. In addition, SNX8 enhances the
814:
719:
679:
648:
605:
542:
498:
444:
420:
289:
238:
138:
126:
97:
76:
2679:
2630:
2573:
2538:
2443:
2399:
2355:
2308:
2264:
2225:
2149:
2082:
2046:
1982:
1928:
1879:
1833:
1791:
1685:
2200:"Beta-amyloid toxicity modifier genes and the risk of Alzheimer's disease"
2184:
1710:
141:
the targeting of proteins to phosphatidylinositol-3-phosphate (PI(3)P) to
2435:
2347:
2300:
2256:
1633:"SNX8 - Sorting nexin-8 - Homo sapiens (Human) - SNX8 gene & protein"
1632:
1466:
1440:
1400:
1308:
regions related to memory and cognition are a defining characteristic of
1284:
1280:
1276:
1264:
1260:
1253:
1249:
1236:-enriched regions where they are localized thanks to the affinity of the
1200:
1180:
1164:
1094:
1093:
that reaches the membrane without being severed can be internalized into
1032:
1028:
1002:
998:
912:
806:
759:
735:
562:
530:
460:
320:
263:
259:
142:
1910:
1454:
Finally, SNX8 also plays an antiviral role against RNA viruses such as
1184:
468:
391:
387:
332:
316:
1555:
1506:
Relationship between cardiac malformations and cholesterol regulation
1502:, its deletion is not enough to cause this malformations on its own.
1487:
1408:
1366:
1021:
1016:
It has been observed that variation in cholesterol levels alter SNX8
944:
904:
826:
822:
751:
715:
703:
671:
663:
383:
368:
293:
201:
SNX8 primary structure highlighting relevant domains and amino acids.
158:
1711:"SNX8 sorting nexin 8 [Homo sapiens (human)] - Gene - NCBI"
935:(Sterol Regulatory Element Binding Proteins), which is a family of
1538:(single nucleotide polymorphisms) in the SNX8 gene are related to
1479:
1444:
1404:
1305:
1287:
and the generation of tubular profiles from vesicular structures.
1052:
967:
932:
839:
818:
747:
593:
569:
554:
550:
506:
372:
309:
185:(postsynaptic density protein-95, discs-large, zona occludens-1),
178:
134:
1125:(Aβ) peptide that accumulates in extracellular locations forming
475:. During the early stage of the infection, SNX8 association with
1451:
lethality, in comparison to SNX8-negative induced murine cells.
1417:
lethality, in comparison to SNX8-negative induced murine cells.
1389:
1220:
1216:
900:
896:
884:
834:
771:
707:
656:
597:
577:
376:
364:
360:
218:
210:
206:
174:
170:
166:
162:
1140:
levels, a stimulated distribution throughout the outer face of
907:
in position 177 (as SNX8 lacks enzymatic activity) and further
612:
of one of these proteins allowing the translocation of SNX8 to
443:
components. Although SNX8's standard localization includes the
390:, both of which allow SNX8-mediated cargo movement through the
20:
1554:
Some mutations of SNX8 have been related to certain types of
1494:, dysmorphic features and cardiac malformations encompassing
698:'s activation through this transport pathway, modulating its
1261:
maduration processes from early endosomes to late endosomes
766:
IFNγ-triggered IKKβ-mediated noncanonical signaling pathway
805:, which participate in host defense against intracellular
966:; this results in an overall regulation of intracellular
1136:
to other cellular locations, leading to an increase of
981:
events rather than by interacting with proteins of the
885:
inhibitor of nuclear factor-kappa-B kinase subunit beta
521:
activation, its accumulation allows the recruitment of
41:
161:
genome contains 12 genes coding for SNX-BAR proteins (
1348:
mice. It is also important mentioning that a pair of
375:
has been demonstrated by some studies (and also with
1578:
showed high levels of SNX8, almost any patient with
682:, which are induced by infection of viruses such as
479:
increases above constitutive levels (degradation of
217:
remains unknown, it theoretically resembles that of
2165:
1860:
1132:SNX8 promotes non-amyloidogenic transport from the
1081:soluble fragment sAPPα is produced as a product of
674:translocation complex; this linkage is crucial for
36:
may be too technical for most readers to understand
1420:In addition, SNX8 plays an antiviral role against
782:, which takes places parallelly to the more known
580:-mediated activation of the IFNβ promoter, since
327:Biological functions and its molecular mechanisms
1279:, it is important to highlight the role of both
1443:in blood and a decreased presence of cerebral
1328:and suppresses cognitive impairment caused by
742:. Examples of genes whose DNA virus-triggered
2204:American Journal of Neurodegenerative Disease
666:-containing translocon machinery to form the
8:
1486:of SNX8 among other genes (FTSJ2, NUDTI and
1344:levels and reversed cognitive impairment in
1144:, an enhanced sAPPα secretion and a reduced
1121:, resulting in production of the neurotoxic
1065:(APP) is consecutively transported from the
1009:curvature is shared by some proteins of the
636:SNX8 is a key component in the induction of
537:leads to the induction of the IFNβ promoter
408:SNX8 is a key component in the induction of
2424:American Journal of Medical Genetics Part A
2336:American Journal of Medical Genetics Part A
2289:American Journal of Medical Genetics Part A
2245:American Journal of Medical Genetics Part A
1403:in blood and lower presence of bacteria in
1227:-mediated endosomal sorting proteins. This
1049:Intracellular non-amyloidogenic APP traffic
181:, SNX32 and SNX33). Other domains, such as
903:activation through autophosphorylation at
2669:
2620:
2528:
2518:
2215:
2139:
2129:
2036:
2026:
1972:
1918:
1781:
1771:
64:Learn how and when to remove this message
48:, without removing the technical details.
1509:
1283:in the coordinated relationship between
627:
588:. The mechanism for SNX8 recruitment to
196:
75:
1599:
1244:. In particular, SNX8 colocalizes with
977:transcriptional activity by modulating
947:needed for the synthesis and uptake of
899:complex. This linkage is essential for
784:IFNγ-induced JAK-STAT1 mediated pathway
568:In addition, SNX8 also plays a role in
997:pathway components or if it regulates
624:Cytosolic DNA virus-triggered response
404:Cytosolic RNA virus-triggered response
2463:
2461:
2328:
2326:
2237:
2235:
2106:
2104:
2102:
2100:
2004:
2002:
2000:
1853:
1851:
1705:
1703:
1378:SNX8 plays an antiviral role against
1105:. The amyloidogenic pathway leads to
883:by permitting the recruitment of the
678:transport from the ER to perinuclear
661:class III phosphatylinositol 3 kinase
46:make it understandable to non-experts
7:
2380:European Journal of Medical Genetics
1942:
1940:
1938:
1807:
1805:
1803:
1801:
1741:
1739:
1737:
1735:
1733:
1731:
1659:
1657:
1655:
1653:
1627:
1625:
1623:
1621:
1326:Aβ plaques and deposit accumulations
1320:: it enhances the non-amyloidogenic
1953:Cellular & Molecular Immunology
1447:, which resulted in a reduction of
1411:, which resulted in a reduction of
706:in position 366 and recruiting the
447:and other compartments such as the
351:of intracellular proteins from the
337:endosome-to-Golgi transport pathway
2118:Frontiers in Cellular Neuroscience
1069:after its synthesis to the plasma
584:works as an intermediate for both
213:'s; for this reason, although its
14:
1666:Journal of Molecular Neuroscience
1291:Medical and clinical significance
991:SREBP cleavage-activating protein
746:is stimulated by SNX8 are IFNB1,
728:ER-Golgi intermediate compartment
453:ER-Golgi intermediate compartment
284:SNX contains a BAR domain in its
243:SNX8 contains a PX domain in its
1826:10.1111/j.1600-0854.2011.01297.x
1324:pathway and, hence, reduces the
1195:Construction of tubular profiles
758:(being IFNB1 and IL6 related to
722:, and that SNX8 localization in
610:post-translational modifications
561:(being IL6 and IFNB1 related to
525:components which play a role in
274:BAR Domain-containing C-terminus
25:
680:microsomal punctuate structures
463:, it is partially localized at
345:endosomal sorting and signaling
233:PX Domain-containing N-terminus
2694:"Expression of SNX8 in cancer"
2662:10.1523/JNEUROSCI.2587-15.2015
881:adaptor or scaffolding protein
879:-SNX, and the SNX8 acts as an
871:in positions 95 and 126. This
1:
2177:10.1016/S0006-291X(84)80190-4
2566:10.1016/j.biochi.2004.09.018
2520:10.1371/journal.pone.0005197
2075:10.1016/j.vetmic.2019.108436
2028:10.1371/journal.ppat.1007336
1360:Neurodevelopmental disorders
1281:subcomplexes of the retromer
837:in a dose-dependent manner.
266:and other membranes rich in
1300:Insoluble accumulations of
1077:; during this traffic, the
833:-induced activation of the
270:3-phosphate phospholipids.
137:makes the main function of
2734:
2613:10.1038/s41598-018-27070-4
2392:10.1016/j.ejmg.2019.103772
1872:10.1016/j.bbrc.2009.09.076
1043:insulin-induced gene INSIG
770:SNX8 is a component of an
549:is stimulated by SNX8 are
541:. Examples of genes whose
531:NF-κB transcription factor
353:early endosome compartment
277:
236:
113:
1965:10.1038/s41423-019-0285-2
1678:10.1007/s12031-013-0209-z
1254:tubular endosomal network
1063:amyloid precursor protein
708:transcription factor IRF3
651:, as it is necessary for
616:for its interaction with
423:, as it is necessary for
331:SNX8 is thought to be an
145:. On the other hand, the
2378:neurological findings".
2131:10.3389/fncel.2019.00410
1310:Alzheimer's Disease (AD)
1267:lumen and a switch from
335:protein involved in the
2698:The Human Protein Atlas
2650:Journal of Neuroscience
2063:Veterinary Microbiology
1899:Journal of Cell Science
1773:10.1073/pnas.1713462114
1295:
923:SNX8 protein regulates
774:-mediated noncanonical
1612:SWISS-MODEL Repository
1515:
1414:Listeria monocytogenes
1381:Listeria monocytogenes
1338:adeno-associated virus
1242:membrane phospholipids
1058:
919:Cholesterol regulation
845:
738:is similar to that of
633:
399:Innate immune response
292:in position 452 and a
202:
81:
1513:
1473:Cardiac malformations
1252:membranes and at the
1201:endosomal compartment
1056:
979:intracellular traffic
937:transcription factors
860:-SNX8 complex allows
843:
692:intracellular traffic
631:
200:
110:Sorting nexins (SNXs)
79:
2436:10.1002/ajmg.a.36572
2348:10.1002/ajmg.a.36242
2301:10.1002/ajmg.a.36566
2257:10.1002/ajmg.a.34041
1715:www.ncbi.nlm.nih.gov
1544:head and neck cancer
1285:endosomal maturation
799:IFNγ-induced GTPases
488:transmembrane domain
386:containing LIC1 and
349:retrograde transport
268:phosphatidylinositol
253:phosphatidylinositol
120:SNX8 belongs to the
2656:(44): 14943–14955.
2605:2018NatSR...8.8789R
2511:2009PLoSO...4.5197C
2473:www.phosphosite.org
1764:2017PNAS..11413000W
1758:(49): 13000–13005.
1496:tetralogy of Fallot
1484:happloinsufficiency
1296:Alzheimer's disease
1173:recycling endosomes
1167:and partially with
1075:trans-Golgi network
864:to catalyse SNX8's
357:trans-Golgi network
347:. It downregulates
339:, participating in
90:trans-golgi network
2593:Scientific Reports
1911:10.1242/jcs.122317
1564:endometrial cancer
1516:
1500:haploinsufficiency
1374:Antiviral activity
1059:
846:
811:secretion proteins
718:colocalize in the
634:
586:signaling pathways
431:and activation of
215:terciary structure
203:
82:
1959:(11): 1126–1135.
1905:(11): 2493–2501.
960:triacylglycerides
939:that control the
778:triggered by the
776:signaling pathway
74:
73:
66:
2725:
2702:
2701:
2690:
2684:
2683:
2673:
2641:
2635:
2634:
2624:
2584:
2578:
2577:
2549:
2543:
2542:
2532:
2522:
2490:
2484:
2483:
2481:
2479:
2465:
2456:
2455:
2430:(8): 2136–2137.
2418:
2412:
2411:
2374:
2368:
2367:
2330:
2321:
2320:
2295:(8): 2133–2135.
2283:
2277:
2276:
2251:(7): 1729–1734.
2239:
2230:
2229:
2219:
2195:
2189:
2188:
2160:
2154:
2153:
2143:
2133:
2108:
2095:
2094:
2057:
2051:
2050:
2040:
2030:
2021:(10): e1007336.
2006:
1995:
1994:
1976:
1944:
1933:
1932:
1922:
1890:
1884:
1883:
1855:
1846:
1845:
1809:
1796:
1795:
1785:
1775:
1743:
1726:
1725:
1723:
1721:
1707:
1698:
1697:
1661:
1648:
1647:
1645:
1643:
1629:
1616:
1615:
1604:
1588:carcinoid cancer
1531:Neuropathic pain
1492:craniosynostosis
1490:) seem to cause
1316:role related to
1225:phosphoinositide
815:chemokine family
780:interferon gamma
249:phosphoinositide
131:phosphoinositide
69:
62:
58:
55:
49:
29:
28:
21:
2733:
2732:
2728:
2727:
2726:
2724:
2723:
2722:
2708:
2707:
2706:
2705:
2692:
2691:
2687:
2643:
2642:
2638:
2586:
2585:
2581:
2560:(11): 839–848.
2551:
2550:
2546:
2492:
2491:
2487:
2477:
2475:
2467:
2466:
2459:
2420:
2419:
2415:
2376:
2375:
2371:
2332:
2331:
2324:
2285:
2284:
2280:
2241:
2240:
2233:
2197:
2196:
2192:
2162:
2161:
2157:
2110:
2109:
2098:
2059:
2058:
2054:
2008:
2007:
1998:
1946:
1945:
1936:
1892:
1891:
1887:
1857:
1856:
1849:
1811:
1810:
1799:
1745:
1744:
1729:
1719:
1717:
1709:
1708:
1701:
1663:
1662:
1651:
1641:
1639:
1637:www.uniprot.org
1631:
1630:
1619:
1606:
1605:
1601:
1596:
1558:, specially to
1552:
1533:
1508:
1475:
1376:
1362:
1314:neuroprotective
1298:
1293:
1265:early endosomes
1250:early endosomes
1234:phosphoinosited
1203:is composed of
1197:
1189:Golgi apparatus
1165:early endosomes
1134:Golgi apparatus
1103:Golgi apparatus
1099:proteolytically
1097:in order to be
1079:neuroprotective
1051:
921:
913:oligomerization
873:phosphorylation
869:phosphorylation
768:
700:phosphorylation
647:in response to
643:antiviral gene
626:
535:phosphorylation
457:Golgi apparatus
437:adaptor protein
419:in response to
415:antiviral gene
406:
401:
329:
306:
298:phosphorylation
282:
276:
264:early endosomes
241:
235:
195:
118:
112:
107:
70:
59:
53:
50:
42:help improve it
39:
30:
26:
19:
12:
11:
5:
2731:
2729:
2721:
2720:
2710:
2709:
2704:
2703:
2685:
2636:
2579:
2544:
2485:
2469:"SNX8 (human)"
2457:
2413:
2369:
2342:(2): 554–556.
2322:
2278:
2231:
2210:(2): 191–198.
2190:
2171:(3): 885–890.
2155:
2096:
2052:
2015:PLOS Pathogens
1996:
1934:
1885:
1866:(1): 109–114.
1847:
1797:
1727:
1699:
1672:(1): 125–134.
1649:
1617:
1598:
1597:
1595:
1592:
1551:
1548:
1532:
1529:
1507:
1504:
1474:
1471:
1375:
1372:
1361:
1358:
1340:(AVV) reduced
1297:
1294:
1292:
1289:
1196:
1193:
1181:late endosomes
1127:senile plaques
1109:processing by
1050:
1047:
920:
917:
875:activates the
854:Janus kinase 1
767:
764:
625:
622:
576:-mediated and
511:polymerization
405:
402:
400:
397:
381:motor proteins
328:
325:
305:
302:
278:Main article:
275:
272:
257:phosphorylable
237:Main article:
234:
231:
229:of 52.569 Da.
227:molecular mass
194:
191:
129:is a distinct
114:Main article:
111:
108:
106:
103:
72:
71:
33:
31:
24:
17:
13:
10:
9:
6:
4:
3:
2:
2730:
2719:
2716:
2715:
2713:
2699:
2695:
2689:
2686:
2681:
2677:
2672:
2667:
2663:
2659:
2655:
2651:
2647:
2640:
2637:
2632:
2628:
2623:
2618:
2614:
2610:
2606:
2602:
2598:
2594:
2590:
2583:
2580:
2575:
2571:
2567:
2563:
2559:
2555:
2548:
2545:
2540:
2536:
2531:
2526:
2521:
2516:
2512:
2508:
2504:
2500:
2496:
2489:
2486:
2474:
2470:
2464:
2462:
2458:
2453:
2449:
2445:
2441:
2437:
2433:
2429:
2425:
2417:
2414:
2409:
2405:
2401:
2397:
2393:
2389:
2386:(4): 103772.
2385:
2381:
2373:
2370:
2365:
2361:
2357:
2353:
2349:
2345:
2341:
2337:
2329:
2327:
2323:
2318:
2314:
2310:
2306:
2302:
2298:
2294:
2290:
2282:
2279:
2274:
2270:
2266:
2262:
2258:
2254:
2250:
2246:
2238:
2236:
2232:
2227:
2223:
2218:
2213:
2209:
2205:
2201:
2194:
2191:
2186:
2182:
2178:
2174:
2170:
2166:
2159:
2156:
2151:
2147:
2142:
2137:
2132:
2127:
2123:
2119:
2115:
2107:
2105:
2103:
2101:
2097:
2092:
2088:
2084:
2080:
2076:
2072:
2068:
2064:
2056:
2053:
2048:
2044:
2039:
2034:
2029:
2024:
2020:
2016:
2012:
2005:
2003:
2001:
1997:
1992:
1988:
1984:
1980:
1975:
1970:
1966:
1962:
1958:
1954:
1950:
1943:
1941:
1939:
1935:
1930:
1926:
1921:
1916:
1912:
1908:
1904:
1900:
1896:
1889:
1886:
1881:
1877:
1873:
1869:
1865:
1861:
1854:
1852:
1848:
1843:
1839:
1835:
1831:
1827:
1823:
1820:(1): 94–107.
1819:
1815:
1808:
1806:
1804:
1802:
1798:
1793:
1789:
1784:
1779:
1774:
1769:
1765:
1761:
1757:
1753:
1749:
1742:
1740:
1738:
1736:
1734:
1732:
1728:
1716:
1712:
1706:
1704:
1700:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1667:
1660:
1658:
1656:
1654:
1650:
1638:
1634:
1628:
1626:
1624:
1622:
1618:
1613:
1609:
1603:
1600:
1593:
1591:
1589:
1585:
1581:
1577:
1576:testis cancer
1573:
1569:
1565:
1561:
1557:
1549:
1547:
1545:
1541:
1537:
1530:
1528:
1525:
1521:
1518:SNX8 role in
1512:
1505:
1503:
1501:
1497:
1493:
1489:
1485:
1481:
1472:
1470:
1468:
1465:
1461:
1457:
1452:
1450:
1446:
1442:
1439:
1435:
1431:
1427:
1423:
1418:
1416:
1415:
1410:
1406:
1402:
1399:
1395:
1391:
1387:
1383:
1382:
1373:
1371:
1368:
1359:
1357:
1355:
1351:
1350:polymorphisms
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1312:. SNX8 has a
1311:
1307:
1303:
1290:
1288:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1257:
1255:
1251:
1247:
1243:
1239:
1235:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1199:Although the
1194:
1192:
1190:
1186:
1182:
1178:
1174:
1170:
1166:
1162:
1158:
1157:transcription
1155:
1151:
1147:
1143:
1142:cell membrane
1139:
1135:
1130:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1100:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1055:
1048:
1046:
1044:
1039:
1034:
1030:
1026:
1023:
1019:
1018:transcription
1014:
1012:
1008:
1004:
1000:
996:
992:
988:
985:pathway like
984:
980:
976:
972:
969:
965:
964:phospholipids
961:
957:
954:
950:
946:
942:
938:
934:
930:
927:levels as an
926:
918:
916:
914:
910:
906:
902:
898:
894:
890:
886:
882:
878:
874:
870:
867:
863:
859:
855:
851:
842:
838:
836:
835:IRF1 promoter
832:
828:
824:
820:
816:
812:
808:
804:
800:
796:
795:transcription
792:
789:
785:
781:
777:
773:
765:
763:
761:
757:
753:
749:
745:
741:
737:
733:
729:
725:
721:
717:
713:
709:
705:
701:
697:
693:
689:
685:
681:
677:
673:
669:
665:
662:
658:
654:
650:
646:
645:transcription
642:
639:
630:
623:
621:
619:
615:
611:
607:
603:
599:
595:
591:
587:
583:
579:
575:
571:
566:
564:
560:
556:
552:
548:
544:
540:
539:transcription
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
497:
493:
489:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
417:transcription
414:
411:
403:
398:
396:
393:
389:
385:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
326:
324:
322:
318:
314:
311:
304:MVP1 ortholog
303:
301:
299:
295:
291:
287:
281:
273:
271:
269:
265:
261:
258:
254:
250:
246:
240:
232:
230:
228:
224:
220:
216:
212:
208:
199:
192:
190:
188:
184:
180:
176:
172:
168:
164:
160:
155:
152:
148:
144:
140:
136:
132:
128:
123:
122:sorting nexin
117:
116:Sorting nexin
109:
104:
102:
99:
95:
91:
87:
78:
68:
65:
57:
47:
43:
37:
34:This article
32:
23:
22:
16:
2697:
2688:
2653:
2649:
2639:
2596:
2592:
2582:
2557:
2553:
2547:
2505:(4): e5197.
2502:
2498:
2488:
2476:. Retrieved
2472:
2427:
2423:
2416:
2383:
2379:
2372:
2339:
2335:
2292:
2288:
2281:
2248:
2244:
2207:
2203:
2193:
2168:
2164:
2158:
2121:
2117:
2066:
2062:
2055:
2018:
2014:
1956:
1952:
1902:
1898:
1888:
1863:
1859:
1817:
1813:
1755:
1751:
1718:. Retrieved
1714:
1669:
1665:
1640:. Retrieved
1636:
1611:
1602:
1553:
1534:
1517:
1476:
1453:
1445:viral titers
1428:through the
1419:
1412:
1384:through the
1379:
1377:
1363:
1299:
1258:
1223:or SNX8) as
1198:
1131:
1123:amyloid beta
1115:β-secretases
1111:γ-secretases
1087:α-secretases
1085:cleavage by
1060:
1015:
922:
909:dimerization
847:
797:that encode
769:
762:secretion).
635:
614:mitochondria
567:
565:secretion).
473:mitochondria
465:mitochondria
407:
344:
336:
330:
307:
283:
242:
204:
156:
119:
85:
83:
60:
54:October 2019
51:
35:
15:
2599:(1): 8789.
1584:endometrial
1520:cholesterol
1422:DNA viruses
1388:-triggered
1304:peptide in
1273:Rab7 GTPase
1269:Rab5 GTPase
1213:BAR domains
1211:containing
1011:SNXs family
971:homeostasis
956:cholesterol
949:fatty acids
925:cholesterol
714:, SNX8 and
649:DNA viruses
608:may induce
574:CARD domain
572:containing
545:-triggered
515:aggregation
429:aggregation
421:RNA viruses
341:endocytosis
308:SNX8 has a
223:amino acids
2478:25 October
2069:: 108436.
1720:26 October
1642:25 October
1594:References
1568:colorectal
1540:neuropathy
1524:metabolism
1240:for these
1229:BAR domain
1089:. Lately,
953:endogenous
941:expression
887:(IKKβ) to
852:activates
803:GBP family
788:downstream
744:expression
638:downstream
547:expression
503:C-terminus
496:N-terminus
485:C-terminus
410:downstream
286:C-terminus
280:BAR domain
245:N-terminus
94:BAR domain
2554:Biochimie
2408:203624241
2091:204882235
1991:202558274
1467:cytokines
1441:cytokines
1401:cytokines
1302:β-amyloid
1238:PX domain
1215:(such as
1205:vesicular
1183:and with
1095:endosomes
1033:lysosomal
1029:endosomal
1025:mevinolin
1003:lysosomal
999:endosomal
929:activator
866:tyrosines
807:pathogens
736:endosomes
720:cytoplasm
690:mediated
606:RNA virus
543:RNA virus
523:signaling
499:PX domain
494:and both
461:endosomes
445:cytoplasm
441:signaling
388:kinesin-1
321:lysosomal
290:threonine
260:tyrosines
239:PX domain
159:mammalian
157:The
151:dimerizes
143:endosomes
105:Structure
98:PX domain
2718:Proteins
2712:Category
2680:26538661
2631:29884837
2574:15589694
2539:19381295
2499:PLOS ONE
2452:39609715
2444:24733602
2400:31568860
2364:31142228
2356:24311514
2309:24715298
2265:21671376
2226:22984654
2150:31551717
2083:31648726
2047:30321235
1983:31511639
1929:23549789
1880:19782049
1834:21973056
1792:29180417
1694:14668542
1686:24362679
1608:"Q9Y5X2"
1580:prostate
1424:such as
1277:retromer
1117:such as
1073:via the
1071:membrane
1007:membrane
817:such as
791:effector
760:cytokine
641:effector
563:cytokine
533:through
517:. After
435:, a key
413:effector
384:dynein-1
317:vacuolar
313:ortholog
2671:6605230
2622:5993794
2601:Bibcode
2530:2668173
2507:Bibcode
2317:8191354
2273:7570369
2217:3560458
2185:6375662
2141:6743354
2124:: 410.
2038:6188873
1974:7784681
1920:3679488
1842:7295814
1814:Traffic
1783:5724276
1760:Bibcode
1572:stomach
1560:stomach
1409:spleens
1185:Giantin
1175:, with
945:enzymes
931:of the
891:in the
813:of the
801:of the
471:to the
469:cytosol
392:cytosol
355:to the
333:adaptor
225:with a
209:'s and
40:Please
18:Protein
2678:
2668:
2629:
2619:
2572:
2537:
2527:
2450:
2442:
2406:
2398:
2362:
2354:
2315:
2307:
2271:
2263:
2224:
2214:
2183:
2148:
2138:
2089:
2081:
2045:
2035:
1989:
1981:
1971:
1927:
1917:
1878:
1840:
1832:
1790:
1780:
1692:
1684:
1556:cancer
1550:Cancer
1488:MAD1L1
1367:autism
1022:statin
933:SREBPs
905:serine
895:-SNX8-
827:CXCL11
825:, and
823:CXCL10
809:, and
752:CXCL10
704:serine
686:, via
509:-like
455:, the
451:, the
294:serine
139:SNX-PX
135:lipids
127:SNX-PX
96:and a
2448:S2CID
2404:S2CID
2360:S2CID
2313:S2CID
2269:S2CID
2087:S2CID
1987:S2CID
1838:S2CID
1690:S2CID
1480:SNX21
1449:HSV-1
1426:HSV-1
1405:liver
1306:brain
1119:BACE1
1038:SREBP
995:SREBP
987:INSIG
983:SREBP
975:SREBP
968:lipid
819:CXCL9
793:gene
748:ISG56
732:Golgi
716:VPS34
688:Golgi
684:HSV-1
672:Vps34
664:VPS34
594:RIG-I
570:RIG-I
555:ISG56
551:IFNB1
507:prion
373:Vps35
369:Vps26
310:yeast
179:SNX18
2676:PMID
2627:PMID
2570:PMID
2535:PMID
2480:2019
2440:PMID
2396:PMID
2352:PMID
2305:PMID
2261:PMID
2222:PMID
2181:PMID
2146:PMID
2079:PMID
2043:PMID
1979:PMID
1925:PMID
1876:PMID
1830:PMID
1788:PMID
1722:2019
1682:PMID
1644:2019
1562:and
1536:SNPs
1462:and
1460:IFNβ
1436:and
1434:IFNβ
1430:MITA
1407:and
1396:and
1394:IFNβ
1390:IKKβ
1386:IFNγ
1246:Rab5
1221:SNX4
1217:SNX1
1209:SNXs
1177:Rab7
1169:Rab4
1161:Rab5
1154:mRNA
1113:and
1061:The
1031:and
1001:and
962:and
911:and
901:IKKβ
897:IKKβ
893:JAK1
889:JAK1
877:JAK1
862:JAK1
858:JAK1
850:IFNγ
831:IFNγ
772:IKKβ
754:and
740:MITA
734:and
712:MITA
696:MITA
676:MITA
668:MITA
657:MITA
653:MITA
618:VISA
602:VISA
598:MDA5
590:VISA
582:VISA
578:MDA5
557:and
519:VISA
513:and
501:and
492:VISA
481:VISA
477:VISA
433:VISA
377:EEA1
371:and
365:SNX2
361:SNX1
343:and
319:and
219:SNX9
211:SNX9
207:SNX1
193:SNX8
175:SNX9
171:SNX4
167:SNX2
163:SNX1
86:SNX8
84:The
2666:PMC
2658:doi
2617:PMC
2609:doi
2562:doi
2525:PMC
2515:doi
2432:doi
2428:164
2388:doi
2344:doi
2340:164
2297:doi
2293:164
2253:doi
2249:155
2212:PMC
2173:doi
2169:120
2136:PMC
2126:doi
2071:doi
2067:238
2033:PMC
2023:doi
1969:PMC
1961:doi
1915:PMC
1907:doi
1903:126
1868:doi
1864:390
1822:doi
1778:PMC
1768:doi
1756:114
1674:doi
1586:or
1574:or
1464:IL6
1456:SeV
1438:IL6
1398:IL6
1322:APP
1271:to
1248:at
1187:at
1179:at
1171:at
1163:at
1150:APP
1138:APP
1107:APP
1091:APP
1083:APP
989:or
943:of
756:IL6
702:at
600:to
596:or
559:IL6
527:RLR
490:of
459:or
425:RLR
187:SH3
183:PDZ
147:BAR
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