228:
36:
320:
128:
209:
According to reviews, it is thought that senolytics can be administered intermittently while being as effective as continuous administration. This could be an advantage of senolytic drugs and decrease adverse effects, for instance circumventing potential off-target effects.
163:
and improve health in humans. A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases. Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging.
671:(SA-Ξ²-gal) staining of senescent cells. To help neutralize their low pH, senescent cells produce high levels of GLS1; inhibiting the activity of this enzyme exposes senescent cells to unsurvivably severe internal acidity, leading to cell death.
213:
Recently, artificial intelligence has been used to discover new senolytics, resulting in the identification of structurally distinct senolytic compounds with more favorable medicinal chemistry properties than previous senolytic candidates.
2489:
Suda M, Shimizu I, Katsuumi G, Yoshida Y, Hayashi Y, Ikegami R, et al. (December 2021). "Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice".
2279:
Shoemaker AR, Mitten MJ, Adickes J, Ackler S, Refici M, Ferguson D, et al. (June 2008). "Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models".
3071:
2435:
Johmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, et al. (January 2021). "Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders".
238:
46:
3135:
1140:
2131:"Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease"
634:
Gene
Knockout. Crispr/Cas9 is used to trigger apoptosis in relation to a specified gene sequence such as a cancer gene sequence or damage marker sequences.
3152:
1175:
Hu, Qinchao; Peng, Jianmin; Jiang, Laibo; Li, Wuguo; Su, Qiao; Zhang, Jiayu; Li, Huan; Song, Ming; Cheng, Bin; Xia, Juan; Wu, Tong (28 October 2020).
880:
937:
668:
439:
2327:"Elimination of senescent cells by Ξ²-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice"
1719:
Wong F, Omori S, Donghia NM, Zheng EJ, Collins JJ (May 2023). "Discovering small-molecule senolytics with deep neural networks".
203:
408:. A peptide that binds with FOXO4 disrupts the p53-FOXO4 interaction, releasing p53 into the cytosol and triggering cell death.
1177:"Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma"
3162:
2585:
Triana-MartΓnez F, Picallos-Rabina P, Da Silva-Γlvarez S, Pietrocola F, Llanos S, Rodilla V, et al. (October 2019).
1930:
Li W, Qin L, Feng R, Hu G, Sun H, He Y, Zhang R (July 2019). "Emerging senolytic agents derived from natural products".
1822:
Ge M, Hu L, Ao H, Zi M, Kong Q, He Y (April 2021). "Senolytic targets and new strategies for clearing senescent cells".
299:
107:
879:β modulate properties of senescent cells without eliminating them, suppressing phenotypes of senescence, including the
246:
54:
948:
271:
79:
257:
242:
65:
50:
278:
86:
2533:
L'HΓ΄te V, Courbeyrette R, Pinna G, Cintrat JC, Le Pavec G, Delaunay-Moisan A, et al. (September 2021).
2082:"Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity"
2028:"Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential"
2383:
Gene By CRISPR/Cas9 Induces
Apoptosis And Inhibits Cell Proliferation In Leukemic Cell Lines, HL60 And KG1"
285:
93:
1977:
1876:"Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging"
2230:
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, et al. (October 2018).
3129:
2535:"Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy"
2129:
Hickson LJ, Langhi Prata LG, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, et al. (September 2019).
922:
736:
2918:
Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, et al. (August 2021).
2178:
Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, et al. (February 2019).
267:
75:
2709:
2598:
2444:
2180:"Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study"
1775:
1499:
1440:
1094:
696:). A protein that enrich senescent cells studied as molecular target for a senolytic vaccine in mice.
3157:
2854:
Al-Mansour F, Alraddadi A, He B, Saleh A, Poblocka M, Alzahrani W, Cowley S, Macip S (2023-03-28).
953:
405:
160:
3089:
3058:
2959:
2895:
2515:
2468:
2304:
2008:
1955:
1847:
1744:
1554:
Robbins PD, Jurk D, Khosla S, Kirkland JL, LeBrasseur NK, Miller JD, et al. (January 2021).
1311:
606:
199:
1762:
Smer-Barreto V, Quintanilla A, Elliott RJ, Dawson JC, Sun J, Campa VM, et al. (June 2023).
3050:
3002:
2951:
2887:
2836:
2787:
2735:
2673:
2624:
2564:
2507:
2460:
2414:
2356:
2296:
2261:
2209:
2160:
2111:
2059:
2000:
1947:
1905:
1839:
1801:
1736:
1701:
1649:
1585:
1525:
1468:
1409:
1360:
1303:
1268:
1206:
1157:
1120:
1063:
1014:
477:
Src tyrosine kinase inhibitors: dasatinib β see "Combination of dasatinib and quercetin" below
3019:
Zhu Y, Prata LG, Gerdes EO, Netto JM, Pirtskhalava T, Giorgadze N, et al. (March 2022).
3117:
3079:
3040:
3032:
2992:
2984:
2941:
2931:
2877:
2867:
2826:
2818:
2777:
2769:
2725:
2717:
2663:
2655:
2614:
2606:
2554:
2546:
2499:
2452:
2404:
2394:
2346:
2338:
2288:
2251:
2243:
2199:
2191:
2150:
2142:
2101:
2093:
2049:
2039:
1992:
1939:
1895:
1887:
1874:
Baar MP, Brandt RM, Putavet DA, Klein JD, Derks KW, Bourgeois BR, et al. (March 2017).
1831:
1791:
1783:
1728:
1691:
1683:
1639:
1631:
1575:
1567:
1515:
1507:
1458:
1448:
1399:
1391:
1350:
1342:
1295:
1258:
1250:
1196:
1188:
1149:
1110:
1102:
1053:
1045:
1004:
996:
927:
917:
184:
1571:
2758:"The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice"
1138:
Chambers ES, Akbar AN (2020). "Can blocking inflammation enhance immunity during aging?".
876:
2642:
Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, et al. (November 2019).
2882:
2855:
2713:
2696:
Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton ZS, et al. (February 2022).
2602:
2448:
1796:
1779:
1763:
1503:
1444:
1098:
3045:
3021:"Orally-active, clinically-translatable senolytics restore Ξ±-Klotho in mice and humans"
3020:
2997:
2972:
2946:
2919:
2831:
2806:
2782:
2757:
2730:
2697:
2668:
2643:
2619:
2586:
2559:
2534:
2409:
2378:
2351:
2326:
2256:
2231:
2204:
2179:
2155:
2130:
2106:
2081:
2054:
2027:
1900:
1875:
1696:
1671:
1644:
1619:
1580:
1555:
1520:
1487:
1404:
1379:
1355:
1330:
1263:
1238:
1201:
1176:
1115:
1082:
1058:
1033:
1009:
984:
932:
897:
765:
361:
292:
176:
156:
152:
100:
1486:
Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, et al. (July 2020).
202:
have been found to be highly expressed on senescent cells, leading researchers to use
175:
Possible senolytic agents are under preliminary research, including some which are in
3146:
3105:
3093:
3062:
2963:
2899:
2519:
2472:
1959:
1851:
1748:
907:
472:
2308:
1315:
404:(programmed cell death). Instead, retention of p53 in the nucleus by FOXO4 promotes
2012:
431:
389:
385:
2822:
2587:"Identification and characterization of Cardiac Glycosides as senolytic compounds"
2292:
1395:
985:"Cellular senescence in aging and age-related disease: from mechanisms to therapy"
2698:"Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types"
3036:
3012:
2247:
2195:
2146:
1049:
943:
864:
656:
598:
180:
3121:
2936:
2773:
2721:
2610:
2503:
1891:
1787:
1732:
1635:
1453:
1428:
1192:
1153:
3084:
2659:
2342:
1996:
1943:
1835:
1687:
1511:
1299:
958:
902:
573:
192:
143:
2044:
1620:"Cellular senescence in ageing: from mechanisms to therapeutic opportunities"
2456:
1106:
892:
872:
860:
664:
524:
520:
447:
435:
401:
355:
188:
3054:
3006:
2955:
2891:
2856:"Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic"
2840:
2791:
2739:
2677:
2628:
2568:
2511:
2464:
2418:
2360:
2300:
2265:
2213:
2164:
2115:
2063:
2004:
1951:
1909:
1843:
1805:
1740:
1705:
1653:
1589:
1529:
1472:
1463:
1413:
1364:
1307:
1272:
1210:
1161:
1124:
1067:
1018:
2872:
2399:
1618:
Di Micco R, Krizhanovsky V, Baker D, d'Adda di
Fagagna F (February 2021).
1556:"Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span"
17:
1549:
1547:
1545:
1543:
1541:
1539:
868:
832:
347:
2920:"Invariant Natural Killer T cells coordinate removal of senescent cells"
2080:
He Y, Li W, Lv D, Zhang X, Zhang X, Ortiz YT, et al. (March 2020).
667:
content and leaking lysosomal membranes. This low pH forms the basis of
2988:
2550:
2097:
1254:
1034:"Clinical strategies and animal models for developing senolytic agents"
602:
550:
443:
397:
393:
256:
if you can. Unsourced or poorly sourced material may be challenged and
167:
A related concept is "senostatic", which means to suppress senescence.
64:
if you can. Unsourced or poorly sourced material may be challenged and
1346:
2756:
Xu Q, Fu Q, Li Z, Liu H, Wang Y, Lin X, et al. (December 2021).
451:
330:
Hypothetical candidates for senolytics based on early-stage research
1000:
27:
Type of molecule that may be able to induce death of senescent cells
2325:
Cai Y, Zhou H, Zhu Y, Sun Q, Ji Y, Xue A, et al. (July 2020).
2805:
Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD (2018-05-03).
963:
912:
810:
788:
743:
693:
631:
374:
1488:"Senolytic CAR T cells reverse senescence-associated pathologies"
498:
2232:"Fisetin is a senotherapeutic that extends health and lifespan"
1672:"Cellular senescence: at the nexus between ageing and diabetes"
179:. The majority of candidate senolytic compounds are repurposed
3072:"Could getting rid of old cells turn back the clock on aging?"
2225:
2223:
983:
Childs BG, Durik M, Baker DJ, van
Deursen JM (December 2015).
381:
221:
29:
2807:"Hsp90 inhibitors as senolytic drugs to extend healthy aging"
2751:
2749:
2580:
2578:
2484:
2482:
1869:
1867:
1865:
1863:
1861:
1670:
Palmer AK, Gustafson B, Kirkland JL, Smith U (October 2019).
1613:
1611:
1609:
1607:
1605:
1603:
1601:
1599:
450:
induce apoptosis by inhibition of the anti-apoptotic protein
2320:
2318:
1925:
1923:
1921:
1919:
1817:
1815:
660:
2430:
2428:
2372:
2370:
1286:
Baumann K (September 2018). "Rejuvenating senolytics".
253:
61:
1380:"Could cancer drugs provide ammunition against aging?"
2075:
2073:
159:
to determine if they can selectively induce death of
1976:
Hernandez-Segura A, Nehme J, Demaria M (June 2018).
1232:
1230:
1228:
1226:
1224:
1222:
1220:
3106:"How to kill the 'zombie' cells that make you age"
2644:"Cardiac glycosides are broad-spectrum senolytics"
1331:"Selective anti-cancer agents as anti-aging drugs"
2973:"Senolytic drugs: from discovery to translation"
1764:"Discovery of senolytics using machine learning"
1239:"Senolytic drugs: from discovery to translation"
438:proteins. Studies of cell cultures of senescent
200:urokinase plasminogen activator surface receptor
2387:Blood and Lymphatic Cancer: Targets and Therapy
1971:
1969:
1665:
1663:
1378:Slack C, Alic N, Partridge L (6 January 2016).
692:Glycoprotein nonmetastatic melanoma protein B (
2377:Narimani M, Sharifi M, Jalili A (2019-11-27).
1141:The Journal of Allergy and Clinical Immunology
341:Tests as senolytic have been conducted in ...
252:Please review the contents of the section and
60:Please review the contents of the article and
8:
3134:: CS1 maint: DOI inactive as of June 2024 (
3015:and features a list of senolytics candidates
1560:Annual Review of Pharmacology and Toxicology
1083:"Senolytic therapies for healthy longevity"
903:DNA repair Β§ Senescence and apoptosis
597:Senescence-specific killing compound 1: A
501:(ubiquitin-specific processing protease 7)
388:, which prevents it from interacting with
328:
3083:
3044:
2996:
2971:Kirkland JL, Tchkonia T (November 2020).
2945:
2935:
2881:
2871:
2830:
2781:
2729:
2691:
2689:
2687:
2667:
2618:
2558:
2408:
2398:
2350:
2255:
2203:
2154:
2105:
2053:
2043:
1899:
1795:
1695:
1643:
1579:
1519:
1462:
1452:
1429:"T cells engineered to target senescence"
1403:
1354:
1262:
1237:Kirkland JL, Tchkonia T (November 2020).
1200:
1114:
1057:
1008:
938:Senescence-associated beta-galactosidase
928:Klotho (biology) Β§ Effects on aging
669:senescence-associated beta-galactosidase
1032:Kirkland JL, Tchkonia T (August 2015).
975:
430:Inhibitors of different members of the
3127:
1624:Nature Reviews. Molecular Cell Biology
1572:10.1146/annurev-pharmtox-050120-105018
1288:Nature Reviews. Molecular Cell Biology
746:in multiple human and mouse cell types
530:Combination of dasatinib and quercetin
440:human umbilical vein endothelial cells
206:to eliminate senescent cells in mice.
7:
2817:(9). Informa UK Limited: 1048β1055.
2026:Rivera-Torres J, San JosΓ© E (2019).
1932:Mechanisms of Ageing and Development
1824:Mechanisms of Ageing and Development
191:and the experimental small molecule
151:, "destroying") is among a class of
659:(GLS1). Senescent cells have a low
3076:Knowable Magazine | Annual Reviews
1978:"Hallmarks of Cellular Senescence"
25:
3153:Senescence in non-human organisms
2866:(9). Impact Journals: 2373β2394.
1329:Blagosklonny MV (December 2013).
204:chimeric antigen receptor T cells
964:YPEL3 Β§ Cellular senescence
318:
226:
126:
34:
605:that is activated by lysosomal
601:(a cytotoxic chemotherapeutic)
742:25-hydroxycholesterol targets
254:add the appropriate references
62:add the appropriate references
1:
2823:10.1080/15384101.2018.1475828
2293:10.1158/1078-0432.CCR-07-4622
1427:Wagner V, Gil J (July 2020).
1396:10.1080/15384101.2015.1118905
3104:Wong, Carissa (2024-05-15).
2977:Journal of Internal Medicine
1335:Cancer Biology & Therapy
1243:Journal of Internal Medicine
609:(a common senescence marker)
3037:10.1016/j.ebiom.2022.103912
2248:10.1016/j.ebiom.2018.09.015
2196:10.1016/j.ebiom.2018.12.052
2147:10.1016/j.ebiom.2019.08.069
1081:van Deursen JM (May 2019).
1050:10.1016/j.exger.2014.10.012
949:Sirtuin-activating compound
239:reliable medical references
47:reliable medical references
3179:
3122:10.1038/d41586-024-01370-4
2937:10.1016/j.medj.2021.04.014
2774:10.1038/s42255-021-00491-8
2722:10.1016/j.isci.2022.103848
2611:10.1038/s41467-019-12888-x
2504:10.1038/s43587-021-00151-2
1892:10.1016/j.cell.2017.02.031
1788:10.1038/s41467-023-39120-1
1733:10.1038/s43587-023-00415-z
1636:10.1038/s41580-020-00314-w
1454:10.1038/d41586-020-01759-x
1193:10.1038/s41419-020-03126-0
1154:10.1016/j.jaci.2020.03.016
923:Invariant NKT (iNKT) cells
867:β with candidates such as
384:protein retains it in the
3085:10.1146/knowable-122122-1
2660:10.1038/s42255-019-0122-z
2343:10.1038/s41422-020-0314-9
2032:Frontiers in Pharmacology
1997:10.1016/j.tcb.2018.02.001
1944:10.1016/j.mad.2019.05.001
1836:10.1016/j.mad.2021.111468
1688:10.1007/s00125-019-4934-x
1512:10.1038/s41586-020-2403-9
1300:10.1038/s41580-018-0047-5
657:kidney-type glutaminase 1
340:
337:
334:
245:or relies too heavily on
53:or relies too heavily on
2281:Clinical Cancer Research
2045:10.3389/fphar.2019.01011
1181:Cell Death & Disease
1038:Experimental Gerontology
863:senescent cells whereas
454:(a bcl-2 family member).
396:where it would activate
177:early-stage human trials
2457:10.1126/science.abb5916
1107:10.1126/science.aaw1299
183:molecules, such as the
3124:(inactive 2024-06-08).
3070:Dance A (2022-12-21).
1985:Trends in Cell Biology
3163:Anti-aging substances
2873:10.18632/aging.204616
2591:Nature Communications
2400:10.2147/BLCTT.S230383
1768:Nature Communications
940:, used as a biomarker
737:25-hydroxycholesterol
442:have shown that both
218:Senolytic candidates
3011:, a review that is
2714:2022iSci...25j3848L
2603:2019NatCo..10.4731T
2449:2021Sci...371..265J
1780:2023NatCo..14.3445S
1504:2020Natur.583..127A
1445:2020Natur.583...37W
1099:2019Sci...364..636V
954:Unity Biotechnology
406:cellular senescence
331:
2989:10.1111/joim.13141
2551:10.1111/acel.13447
2098:10.1111/acel.13117
1886:(1): 132β147.e16.
1255:10.1111/joim.13141
877:rapalog Everolimus
714:Cardiac glycosides
689:Anti-GPNMB vaccine
663:due to their high
655:Target the enzyme
335:Medication/target
329:
3116:(8012): 518β520.
2768:(12): 1706β1726.
2762:Nature Metabolism
2654:(11): 1074β1088.
2648:Nature Metabolism
2498:(12): 1117β1126.
2443:(6526): 265β270.
2287:(11): 3268β3277.
1682:(10): 1835β1841.
1498:(7814): 127β132.
1347:10.4161/cbt.27350
1341:(12): 1092β1097.
1093:(6441): 636β637.
995:(12): 1424β1435.
852:
851:
380:FOXO4 binding to
377:-related peptides
346:human cell lines
327:
326:
303:
135:
134:
111:
16:(Redirected from
3170:
3139:
3133:
3125:
3097:
3087:
3066:
3048:
3010:
3000:
2967:
2949:
2939:
2904:
2903:
2885:
2875:
2851:
2845:
2844:
2834:
2802:
2796:
2795:
2785:
2753:
2744:
2743:
2733:
2693:
2682:
2681:
2671:
2639:
2633:
2632:
2622:
2582:
2573:
2572:
2562:
2530:
2524:
2523:
2486:
2477:
2476:
2432:
2423:
2422:
2412:
2402:
2374:
2365:
2364:
2354:
2322:
2313:
2312:
2276:
2270:
2269:
2259:
2227:
2218:
2217:
2207:
2175:
2169:
2168:
2158:
2126:
2120:
2119:
2109:
2077:
2068:
2067:
2057:
2047:
2023:
2017:
2016:
1982:
1973:
1964:
1963:
1927:
1914:
1913:
1903:
1871:
1856:
1855:
1819:
1810:
1809:
1799:
1759:
1753:
1752:
1716:
1710:
1709:
1699:
1667:
1658:
1657:
1647:
1615:
1594:
1593:
1583:
1551:
1534:
1533:
1523:
1483:
1477:
1476:
1466:
1456:
1424:
1418:
1417:
1407:
1375:
1369:
1368:
1358:
1326:
1320:
1319:
1283:
1277:
1276:
1266:
1234:
1215:
1214:
1204:
1172:
1166:
1165:
1148:(5): 1323β1331.
1135:
1129:
1128:
1118:
1078:
1072:
1071:
1061:
1029:
1023:
1022:
1012:
980:
918:Immunosenescence
427:BCL-2 inhibitors
369:phase III trial
332:
322:
321:
313:
310:
304:
302:
261:
230:
229:
222:
185:chemotherapeutic
141:(from the words
130:
129:
121:
118:
112:
110:
69:
38:
37:
30:
21:
3178:
3177:
3173:
3172:
3171:
3169:
3168:
3167:
3143:
3142:
3126:
3103:
3100:
3069:
3018:
2970:
2917:
2913:
2911:Further reading
2908:
2907:
2853:
2852:
2848:
2804:
2803:
2799:
2755:
2754:
2747:
2695:
2694:
2685:
2641:
2640:
2636:
2584:
2583:
2576:
2532:
2531:
2527:
2488:
2487:
2480:
2434:
2433:
2426:
2376:
2375:
2368:
2324:
2323:
2316:
2278:
2277:
2273:
2229:
2228:
2221:
2177:
2176:
2172:
2128:
2127:
2123:
2079:
2078:
2071:
2025:
2024:
2020:
1980:
1975:
1974:
1967:
1929:
1928:
1917:
1873:
1872:
1859:
1821:
1820:
1813:
1761:
1760:
1756:
1718:
1717:
1713:
1669:
1668:
1661:
1617:
1616:
1597:
1553:
1552:
1537:
1485:
1484:
1480:
1439:(7814): 37β38.
1426:
1425:
1421:
1377:
1376:
1372:
1328:
1327:
1323:
1285:
1284:
1280:
1236:
1235:
1218:
1174:
1173:
1169:
1137:
1136:
1132:
1080:
1079:
1075:
1031:
1030:
1026:
1001:10.1038/nm.4000
989:Nature Medicine
982:
981:
977:
972:
889:
857:
652:GLS1 inhibitors
607:Ξ²-galactosidase
494:USP7 inhibitors
366:phase II trial
323:
319:
314:
308:
305:
262:
251:
247:primary sources
231:
227:
220:
173:
161:senescent cells
153:small molecules
131:
127:
122:
116:
113:
70:
59:
55:primary sources
39:
35:
28:
23:
22:
15:
12:
11:
5:
3176:
3174:
3166:
3165:
3160:
3155:
3145:
3144:
3141:
3140:
3099:
3098:
3067:
3016:
2983:(5): 518β536.
2968:
2930:(8): 938β950.
2914:
2912:
2909:
2906:
2905:
2846:
2797:
2745:
2683:
2634:
2574:
2525:
2478:
2424:
2366:
2337:(7): 574β589.
2314:
2271:
2219:
2170:
2121:
2069:
2018:
1991:(6): 436β453.
1965:
1915:
1857:
1811:
1754:
1727:(6): 734β750.
1711:
1659:
1595:
1566:(1): 779β803.
1535:
1478:
1419:
1390:(2): 153β155.
1370:
1321:
1278:
1249:(5): 518β536.
1216:
1167:
1130:
1073:
1024:
974:
973:
971:
968:
967:
966:
961:
956:
951:
946:
941:
935:
933:Life extension
930:
925:
920:
915:
910:
905:
900:
898:Biogerontology
895:
888:
885:
856:
853:
850:
849:
847:
845:
843:
841:
839:
837:
835:
829:
828:
826:
824:
822:
820:
818:
816:
814:
807:
806:
804:
802:
800:
798:
796:
793:
791:
785:
784:
782:
780:
778:
776:
773:
770:
768:
766:Procyanidin C1
762:
761:
759:
757:
755:
753:
750:
747:
740:
733:
732:
730:
728:
726:
723:
720:
717:
715:
711:
710:
708:
706:
704:
702:
699:
697:
690:
686:
685:
683:
681:
679:
677:
675:
672:
653:
649:
648:
646:
644:
642:
640:
638:
635:
628:
627:BIRC5 knockout
624:
623:
621:
619:
617:
615:
612:
610:
595:
591:
590:
588:
586:
583:
580:
578:
576:
570:
569:
567:
565:
563:
561:
558:
555:
553:
547:
546:
544:
542:
539:
537:
534:
531:
528:
517:
516:
514:
512:
510:
508:
505:
502:
497:Inhibitors of
495:
491:
490:
488:
486:
484:
482:
480:
478:
475:
473:Src inhibitors
469:
468:
466:
464:
462:
460:
458:
455:
428:
424:
423:
421:
419:
417:
415:
412:
409:
378:
371:
370:
367:
364:
359:
353:
350:
343:
342:
339:
336:
325:
324:
317:
315:
309:September 2023
234:
232:
225:
219:
216:
172:
169:
157:basic research
133:
132:
125:
123:
42:
40:
33:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3175:
3164:
3161:
3159:
3156:
3154:
3151:
3150:
3148:
3137:
3131:
3123:
3119:
3115:
3111:
3107:
3102:
3101:
3095:
3091:
3086:
3081:
3077:
3073:
3068:
3064:
3060:
3056:
3052:
3047:
3042:
3038:
3034:
3030:
3026:
3022:
3017:
3014:
3008:
3004:
2999:
2994:
2990:
2986:
2982:
2978:
2974:
2969:
2965:
2961:
2957:
2953:
2948:
2943:
2938:
2933:
2929:
2925:
2921:
2916:
2915:
2910:
2901:
2897:
2893:
2889:
2884:
2879:
2874:
2869:
2865:
2861:
2857:
2850:
2847:
2842:
2838:
2833:
2828:
2824:
2820:
2816:
2812:
2808:
2801:
2798:
2793:
2789:
2784:
2779:
2775:
2771:
2767:
2763:
2759:
2752:
2750:
2746:
2741:
2737:
2732:
2727:
2723:
2719:
2715:
2711:
2708:(2): 103848.
2707:
2703:
2699:
2692:
2690:
2688:
2684:
2679:
2675:
2670:
2665:
2661:
2657:
2653:
2649:
2645:
2638:
2635:
2630:
2626:
2621:
2616:
2612:
2608:
2604:
2600:
2596:
2592:
2588:
2581:
2579:
2575:
2570:
2566:
2561:
2556:
2552:
2548:
2545:(9): e13447.
2544:
2540:
2536:
2529:
2526:
2521:
2517:
2513:
2509:
2505:
2501:
2497:
2493:
2485:
2483:
2479:
2474:
2470:
2466:
2462:
2458:
2454:
2450:
2446:
2442:
2438:
2431:
2429:
2425:
2420:
2416:
2411:
2406:
2401:
2396:
2392:
2388:
2384:
2382:
2379:"Knockout Of
2373:
2371:
2367:
2362:
2358:
2353:
2348:
2344:
2340:
2336:
2332:
2331:Cell Research
2328:
2321:
2319:
2315:
2310:
2306:
2302:
2298:
2294:
2290:
2286:
2282:
2275:
2272:
2267:
2263:
2258:
2253:
2249:
2245:
2241:
2237:
2233:
2226:
2224:
2220:
2215:
2211:
2206:
2201:
2197:
2193:
2189:
2185:
2181:
2174:
2171:
2166:
2162:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2125:
2122:
2117:
2113:
2108:
2103:
2099:
2095:
2092:(3): e13117.
2091:
2087:
2083:
2076:
2074:
2070:
2065:
2061:
2056:
2051:
2046:
2041:
2037:
2033:
2029:
2022:
2019:
2014:
2010:
2006:
2002:
1998:
1994:
1990:
1986:
1979:
1972:
1970:
1966:
1961:
1957:
1953:
1949:
1945:
1941:
1937:
1933:
1926:
1924:
1922:
1920:
1916:
1911:
1907:
1902:
1897:
1893:
1889:
1885:
1881:
1877:
1870:
1868:
1866:
1864:
1862:
1858:
1853:
1849:
1845:
1841:
1837:
1833:
1829:
1825:
1818:
1816:
1812:
1807:
1803:
1798:
1793:
1789:
1785:
1781:
1777:
1773:
1769:
1765:
1758:
1755:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1722:
1715:
1712:
1707:
1703:
1698:
1693:
1689:
1685:
1681:
1677:
1673:
1666:
1664:
1660:
1655:
1651:
1646:
1641:
1637:
1633:
1629:
1625:
1621:
1614:
1612:
1610:
1608:
1606:
1604:
1602:
1600:
1596:
1591:
1587:
1582:
1577:
1573:
1569:
1565:
1561:
1557:
1550:
1548:
1546:
1544:
1542:
1540:
1536:
1531:
1527:
1522:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1489:
1482:
1479:
1474:
1470:
1465:
1464:10044/1/80980
1460:
1455:
1450:
1446:
1442:
1438:
1434:
1430:
1423:
1420:
1415:
1411:
1406:
1401:
1397:
1393:
1389:
1385:
1381:
1374:
1371:
1366:
1362:
1357:
1352:
1348:
1344:
1340:
1336:
1332:
1325:
1322:
1317:
1313:
1309:
1305:
1301:
1297:
1293:
1289:
1282:
1279:
1274:
1270:
1265:
1260:
1256:
1252:
1248:
1244:
1240:
1233:
1231:
1229:
1227:
1225:
1223:
1221:
1217:
1212:
1208:
1203:
1198:
1194:
1190:
1186:
1182:
1178:
1171:
1168:
1163:
1159:
1155:
1151:
1147:
1143:
1142:
1134:
1131:
1126:
1122:
1117:
1112:
1108:
1104:
1100:
1096:
1092:
1088:
1084:
1077:
1074:
1069:
1065:
1060:
1055:
1051:
1047:
1043:
1039:
1035:
1028:
1025:
1020:
1016:
1011:
1006:
1002:
998:
994:
990:
986:
979:
976:
969:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
939:
936:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
908:Geroprotector
906:
904:
901:
899:
896:
894:
891:
890:
886:
884:
882:
878:
874:
870:
866:
862:
854:
848:
846:
844:
842:
840:
838:
836:
834:
831:
830:
827:
825:
823:
821:
819:
817:
815:
812:
809:
808:
805:
803:
801:
799:
797:
794:
792:
790:
787:
786:
783:
781:
779:
777:
774:
771:
769:
767:
764:
763:
760:
758:
756:
754:
751:
748:
745:
741:
738:
735:
734:
731:
729:
727:
724:
721:
718:
716:
713:
712:
709:
707:
705:
703:
700:
698:
695:
691:
688:
687:
684:
682:
680:
678:
676:
673:
670:
666:
662:
658:
654:
651:
650:
647:
645:
643:
641:
639:
636:
633:
629:
626:
625:
622:
620:
618:
616:
613:
611:
608:
604:
600:
596:
593:
592:
589:
587:
584:
581:
579:
577:
575:
572:
571:
568:
566:
564:
562:
559:
556:
554:
552:
549:
548:
545:
543:
540:
538:
535:
532:
529:
526:
522:
519:
518:
515:
513:
511:
509:
506:
503:
500:
496:
493:
492:
489:
487:
485:
483:
481:
479:
476:
474:
471:
470:
467:
465:
463:
461:
459:
456:
453:
449:
445:
441:
437:
433:
429:
426:
425:
422:
420:
418:
416:
413:
410:
407:
403:
400:, leading to
399:
395:
391:
387:
383:
379:
376:
373:
372:
368:
365:
363:
362:phase I trial
360:
357:
354:
351:
349:
345:
344:
333:
316:
312:
301:
298:
294:
291:
287:
284:
280:
277:
273:
270: β
269:
265:
264:Find sources:
259:
255:
249:
248:
244:
240:
235:This section
233:
224:
223:
217:
215:
211:
207:
205:
201:
196:
194:
190:
186:
182:
178:
170:
168:
165:
162:
158:
154:
150:
146:
145:
140:
124:
120:
109:
106:
102:
99:
95:
92:
88:
85:
81:
78: β
77:
73:
72:Find sources:
67:
63:
57:
56:
52:
48:
43:This article
41:
32:
31:
19:
3130:cite journal
3113:
3109:
3075:
3028:
3025:eBioMedicine
3024:
2980:
2976:
2927:
2923:
2863:
2859:
2849:
2814:
2810:
2800:
2765:
2761:
2705:
2701:
2651:
2647:
2637:
2594:
2590:
2542:
2538:
2528:
2495:
2492:Nature Aging
2491:
2440:
2436:
2390:
2386:
2380:
2334:
2330:
2284:
2280:
2274:
2239:
2236:eBioMedicine
2235:
2187:
2184:eBioMedicine
2183:
2173:
2138:
2135:eBioMedicine
2134:
2124:
2089:
2085:
2035:
2031:
2021:
1988:
1984:
1935:
1931:
1883:
1879:
1827:
1823:
1771:
1767:
1757:
1724:
1721:Nature Aging
1720:
1714:
1679:
1676:Diabetologia
1675:
1630:(2): 75β95.
1627:
1623:
1563:
1559:
1495:
1491:
1481:
1436:
1432:
1422:
1387:
1383:
1373:
1338:
1334:
1324:
1291:
1287:
1281:
1246:
1242:
1184:
1180:
1170:
1145:
1139:
1133:
1090:
1086:
1076:
1041:
1037:
1027:
992:
988:
978:
865:senomorphics
858:
855:Senomorphics
630:Crispr/Cas9
432:bcl-2 family
390:mitochondria
352:mice models
338:Description
306:
296:
289:
282:
275:
263:
243:verification
236:
212:
208:
197:
174:
166:
148:
142:
138:
136:
117:January 2022
114:
104:
97:
90:
83:
71:
51:verification
44:
3013:open access
2597:(1): 4731.
2190:: 554β563.
2141:: 446β456.
1774:(1): 3445.
1187:(10): 925.
944:Senotherapy
859:Senolytics
599:gemcitabine
268:"Senolytic"
237:needs more
181:anti-cancer
76:"Senolytic"
45:needs more
3158:Senescence
3147:Categories
3031:: 103912.
2811:Cell Cycle
2539:Aging Cell
2086:Aging Cell
1830:: 111468.
1384:Cell Cycle
1294:(9): 543.
970:References
959:Venetoclax
813:inhibitors
574:Navitoclax
279:newspapers
193:navitoclax
144:senescence
87:newspapers
18:Senolytics
3094:255055238
3063:247443187
2964:236546883
2900:257804078
2520:245068564
2473:231606800
2393:: 53β61.
2242:: 18β28.
1960:147704626
1852:232246367
1749:258506382
1044:: 19β25.
893:Autophagy
873:Rapamycin
861:eliminate
722:xenograft
665:lysosomal
582:xenograft
525:Quercetin
521:Dasatinib
448:quercetin
436:apoptotic
402:apoptosis
356:xenograft
189:dasatinib
139:senolytic
3055:35292270
3007:32686219
2956:34617070
2892:36988504
2883:10120895
2841:29886783
2792:34873338
2740:35198901
2702:iScience
2678:31799499
2629:31636264
2569:34355491
2512:37117524
2465:33446552
2419:31819702
2361:32341413
2309:15786367
2301:18519752
2266:30279143
2214:30616998
2165:31542391
2116:32064756
2064:31619990
2038:: 1011.
2005:29477613
1952:31077707
1910:28340339
1844:33741395
1806:37301862
1797:10257182
1741:37142829
1706:31451866
1654:33328614
1590:32997601
1530:32555459
1473:32601490
1414:26587873
1365:24345884
1316:51726136
1308:30054558
1273:32686219
1211:33116117
1162:32386656
1125:31097655
1068:25446976
1019:26646499
887:See also
869:Apigenin
833:CUDC-907
434:of anti-
398:caspases
348:in vitro
198:Soluble
171:Research
3046:9034457
2998:7405395
2947:8491998
2832:6110594
2783:8688144
2731:8851282
2710:Bibcode
2669:6887543
2620:6803708
2599:Bibcode
2560:8564827
2445:Bibcode
2437:Science
2410:6885567
2352:7184167
2257:6197652
2205:6412088
2156:6796530
2107:7059172
2055:6759511
2013:3534989
1938:: 1β6.
1901:5556182
1776:Bibcode
1697:6731336
1645:8344376
1581:7790861
1521:7583560
1500:Bibcode
1441:Bibcode
1405:4825846
1356:3912031
1264:7405395
1202:7595194
1116:6816502
1095:Bibcode
1087:Science
1059:4412760
1010:4748967
603:prodrug
551:Fisetin
444:fisetin
394:cytosol
392:in the
386:nucleus
293:scholar
258:removed
101:scholar
66:removed
3110:Nature
3092:
3061:
3053:
3043:
3005:
2995:
2962:
2954:
2944:
2898:
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