241:
210:
229:
198:
48:
107:
240:
114:
are outgrowths of epithelium, surrounding fibrovascular cores of stroma and at least one blood vessel. In contrast, pseudopapillae (such as in solid pseudopapillary tumours) are nests of proliferating cells that eventually grow to become almost back-to-back, with cells in the centers of nests
97:
Solid pseudopapillary tumours are often asymptomatic and are identified incidentally on imaging performed for unrelated reasons. Less often, they may cause abdominal pain. Solid pseudopapillary tumours tend to occur in women, and most often present in the third decade of life.
592:
Pettinato G, Manivel JC, Ravetto C, et al. (November 1992). "Papillary cystic tumor of the pancreas: A clinicopathologic study of 20 cases with cytologic, immunohistochemical, ultrastructural, and flow cytometric observations, and a review of the literature".
209:
228:
299:
Pitman MB, Centeno BA, Daglilar ES, Brugge WR, Mino-Kenudson M (2014). "Cytological criteria of high-grade epithelial atypia in the cyst fluid of pancreatic intraductal papillary mucinous neoplasms".
159:
positive eosinophilic intracytoplasmic globules. Necrosis is usually present and, as cell death preferentially occurs distant from blood vessels, lead to the formation of pseudopapillae.
755:
55:
Cytopathology of solid pseudopapillary tumour/neoplasm with main findings that distinguish it from pancreatic endocrine neoplasms and acinar cell carcinomas. Diff-Quik stain.
197:
719:
648:
115:
disintegrating, leaving rims of cells lining the periphery of each nest. Discohesive cells and some formations lacking central blood vessels are visual clues.
986:
663:
Wang Y, Miller FH, Chen ZE, Merrick L, Mortele KJ, Hoff FL, et al. (2011). "Diffusion-weighted MR imaging of solid and cystic lesions of the pancreas".
139:
Solid pseudopapillary tumours are typically round, well-demarcated, measuring 2–17 cm in diameter (average 8 cm), with solid and cystic areas with
1011:
748:
1236:
446:"The importance of endoscopic ultrasound fine-needle aspiration in the diagnosis of solid pseudopapillary tumor of the pancreas: two case reports"
1096:
595:
151:
Solid pseudopapillary tumours consist of solid sheets of cells that are focally dyscohesive. The cells in the lesion usually have uniform
1306:
1285:
1241:
741:
569:
552:
273:
249:
immunohistochemistry in solid pseudopapillary tumor, staining the nuclei in 98% of such cases. Cytoplasm is also staining in this case.
278:
848:
1144:
123:
by endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) of the lesion. After surgical excision, the tumor can undergo
1246:
1049:
1006:
977:
957:
1275:
949:
862:
772:
47:
259:
In most cases, solid pseudopapillary tumours should be resected surgically, as there is a risk of malignancy (cancer).
1215:
991:
967:
167:
Solid pseudopapillary tumours show positive nuclear staining for beta catenin, as well as positive immunostaining for
953:
1311:
1231:
972:
826:
156:
234:
Relative incidence of various pancreatic neoplasms, with solid pseudopapillary neoplasm annotated at center right.
1139:
1068:
764:
1091:
945:
553:"Solid and cystic pancreatic tumors. Clinical, histochemical, and electron microscopic features in ten cases"
1280:
1029:
798:
512:"Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas"
184:
1121:
909:
871:
781:
981:
41:
Solid pseudopapillary neoplasm, solid pseudopapillary tumour/neoplasm of the pancreas, Frantz's tumour
1126:
701:
634:
180:
1186:
1168:
1108:
937:
933:
324:
1253:
1205:
1196:
919:
821:
790:
713:
680:
642:
612:
574:
533:
477:
426:
375:
316:
268:
60:
346:"Solid pseudopapillary neoplasm of the pancreas: a single institution experience of 14 cases"
1054:
928:
843:
831:
672:
604:
564:
523:
467:
457:
416:
406:
365:
357:
308:
106:
700:
Pooja Navale, M.D., Omid Savari, M.D., Joseph F. Tomashefski, Jr., M.D., Monika Vyas, M.D.
633:
Pooja Navale, M.D., Omid Savari, M.D., Joseph F. Tomashefski, Jr., M.D., Monika Vyas, M.D.
17:
896:
879:
1210:
1173:
1103:
1001:
941:
884:
813:
803:
472:
445:
421:
394:
370:
345:
215:
152:
128:
124:
1300:
1154:
836:
328:
120:
111:
1116:
188:
246:
219:
119:
The gold standard for diagnosing solid pseudopapillary tumour of the pancreas is
1181:
1134:
1077:
1021:
570:
10.1002/1097-0142(19910315)67:6<1635::aid-cncr2820670627>3.0.co;2-m
1267:
462:
361:
344:
Patil TB, Shrikhande SV, Kanhere HA, Saoji RR, Ramadwar MR, Shukla PJ (2006).
140:
733:
1163:
1086:
904:
608:
528:
411:
222:. This case also shows the key feature of intracytoplasmic hyaline globules.
684:
537:
481:
430:
379:
320:
616:
578:
86:
1226:
676:
176:
82:
78:
65:
511:
312:
155:
with occasional nuclear grooves, eosinophilic or clear cytoplasm and
1223:
172:
168:
737:
395:"Solid pseudopapillary tumor: a rare neoplasm of the pancreas"
551:
Stömmer P, Kraus J, Stolte M, Giedl J (March 1991).
499:. Vol. I (3rd ed.). Elsevier. p. 478.
1266:
1195:
1153:
1076:
1067:
1042:
1020:
918:
895:
870:
861:
812:
789:
780:
771:
59:
37:
32:
89:architecture that typically afflicts young women.
334:Images and annotations: Mikael Häggström, M.D.
749:
203:Histopathology of solid pseudopapillary tumor
8:
718:: CS1 maint: multiple names: authors list (
647:: CS1 maint: multiple names: authors list (
1073:
867:
786:
777:
756:
742:
734:
46:
29:
1012:Hereditary nonpolyposis colorectal cancer
568:
527:
471:
461:
420:
410:
369:
105:
1237:Intraductal papillary mucinous neoplasm
290:
193:
711:
640:
596:American Journal of Clinical Pathology
7:
1286:Desmoplastic small round cell tumor
510:Serra S, Chetty R (November 2008).
497:Diagnostic Histopathology of Tumors
274:Pancreatic mucinous cystic neoplasm
218:of a solid pseudopapillary tumour.
987:Polymerase proofreading-associated
279:Serous cystadenoma of the pancreas
25:
849:Hereditary diffuse gastric cancer
690:Diagram by Mikael Häggström, M.D.
110:Papillae vs pseudopapillae: True
1145:Nodular regenerative hyperplasia
724:Last author update: 4 March 2022
702:"Solid pseudopapillary neoplasm"
653:Last author update: 4 March 2022
635:"Solid pseudopapillary neoplasm"
239:
227:
208:
196:
450:Journal of Medical Case Reports
297:Source for mentioned findings:
1247:Solid pseudopapillary neoplasm
1050:Gastrointestinal stromal tumor
1007:Familial adenomatous polyposis
629:Image by Mikael Häggström, MD.
1:
1055:Krukenberg tumor (metastatic)
1276:Primary peritoneal carcinoma
950:traditional serrated adenoma
75:solid pseudopapillary tumour
33:Solid pseudopapillary tumour
1216:Pancreatic ductal carcinoma
18:Solid pseudopapillary tumor
1328:
1307:Digestive system neoplasia
1232:Serous microcystic adenoma
827:Signet ring cell carcinoma
765:Digestive system neoplasia
1140:Focal nodular hyperplasia
463:10.1186/s13256-018-1585-3
444:De Moura, D.T.H. (2018).
362:10.1080/13651820510035721
77:is a low-grade malignant
54:
45:
1242:Mucinous cystic neoplasm
1092:Hepatocellular carcinoma
946:sessile serrated adenoma
631:Reference for features:
393:Shuja, Asim (May 2014).
191:and pancreatic enzymes.
187:; they are negative for
1281:Peritoneal mesothelioma
1030:Squamous cell carcinoma
799:Squamous cell carcinoma
529:10.1136/jcp.2008.057828
399:Gastroenterol Rep (Oxf)
185:neuron specific enolase
1122:Hepatocellular adenoma
910:Pseudomyxoma peritonei
116:
609:10.1093/ajcp/98.5.478
495:Fletcher CDM (2007).
412:10.1093/gastro/gou006
109:
1127:Cavernous hemangioma
978:Familial adenomatous
965:Polyposis syndromes:
677:10.1148/rg.313105174
163:Immunohistochemistry
181:alpha 1-antitrypsin
1187:Gallbladder cancer
1169:Cholangiocarcinoma
1109:Liver angiosarcoma
1043:Upper and/or lower
992:Serrated polyposis
706:Pathology Outlines
313:10.1002/cncy.21344
117:
93:Signs and symptoms
1312:Pancreatic cancer
1294:
1293:
1262:
1261:
1254:Pancreatoblastoma
1206:exocrine pancreas
1063:
1062:
1038:
1037:
857:
856:
822:Gastric carcinoma
301:Cancer Cytopathol
269:Pancreatic cancer
143:on cut sections.
71:
70:
27:Medical condition
16:(Redirected from
1319:
1074:
973:MUTYH-associated
958:Cronkhite–Canada
929:Colorectal polyp
868:
844:Linitis plastica
832:Gastric lymphoma
787:
778:
758:
751:
744:
735:
725:
723:
717:
709:
697:
691:
688:
660:
654:
652:
646:
638:
627:
621:
620:
589:
583:
582:
572:
548:
542:
541:
531:
507:
501:
500:
492:
486:
485:
475:
465:
441:
435:
434:
424:
414:
390:
384:
383:
373:
341:
335:
332:
295:
243:
231:
212:
200:
135:Gross morphology
50:
30:
21:
1327:
1326:
1322:
1321:
1320:
1318:
1317:
1316:
1297:
1296:
1295:
1290:
1258:
1191:
1149:
1059:
1034:
1016:
914:
891:
880:Duodenal cancer
872:Small intestine
853:
808:
767:
762:
731:
729:
728:
710:
699:
698:
694:
689:
662:
661:
657:
639:
632:
630:
628:
624:
591:
590:
586:
550:
549:
545:
516:J. Clin. Pathol
509:
508:
504:
494:
493:
489:
443:
442:
438:
392:
391:
387:
343:
342:
338:
333:
298:
296:
292:
287:
265:
257:
250:
244:
235:
232:
223:
213:
204:
201:
165:
149:
147:Histomorphology
137:
127:evaluation for
104:
95:
28:
23:
22:
15:
12:
11:
5:
1325:
1323:
1315:
1314:
1309:
1299:
1298:
1292:
1291:
1289:
1288:
1283:
1278:
1272:
1270:
1264:
1263:
1260:
1259:
1257:
1256:
1250:
1249:
1244:
1239:
1234:
1219:
1218:
1213:
1211:Adenocarcinoma
1201:
1199:
1193:
1192:
1190:
1189:
1177:
1176:
1174:Klatskin tumor
1171:
1159:
1157:
1151:
1150:
1148:
1147:
1142:
1130:
1129:
1124:
1112:
1111:
1106:
1104:Hepatoblastoma
1101:
1100:
1099:
1082:
1080:
1071:
1065:
1064:
1061:
1060:
1058:
1057:
1052:
1046:
1044:
1040:
1039:
1036:
1035:
1033:
1032:
1026:
1024:
1018:
1017:
1015:
1014:
1009:
1004:
1002:Adenocarcinoma
995:
994:
989:
984:
975:
970:
961:
960:
924:
922:
916:
915:
913:
912:
907:
901:
899:
893:
892:
890:
889:
888:
887:
885:Adenocarcinoma
876:
874:
865:
859:
858:
855:
854:
852:
851:
846:
841:
840:
839:
829:
824:
818:
816:
810:
809:
807:
806:
804:Adenocarcinoma
801:
795:
793:
784:
775:
769:
768:
763:
761:
760:
753:
746:
738:
727:
726:
692:
655:
622:
584:
563:(6): 1635–41.
543:
522:(11): 1153–9.
502:
487:
436:
405:(2): 145–149.
385:
336:
289:
288:
286:
283:
282:
281:
276:
271:
264:
261:
256:
253:
252:
251:
245:
238:
236:
233:
226:
224:
216:Histopathology
214:
207:
205:
202:
195:
164:
161:
148:
145:
136:
133:
129:cancer staging
125:histopathology
103:
100:
94:
91:
69:
68:
63:
57:
56:
52:
51:
43:
42:
39:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1324:
1313:
1310:
1308:
1305:
1304:
1302:
1287:
1284:
1282:
1279:
1277:
1274:
1273:
1271:
1269:
1265:
1255:
1252:
1251:
1248:
1245:
1243:
1240:
1238:
1235:
1233:
1229:
1228:
1225:
1221:
1220:
1217:
1214:
1212:
1209:
1207:
1203:
1202:
1200:
1198:
1194:
1188:
1185:
1183:
1179:
1178:
1175:
1172:
1170:
1167:
1165:
1161:
1160:
1158:
1156:
1155:Biliary tract
1152:
1146:
1143:
1141:
1138:
1136:
1132:
1131:
1128:
1125:
1123:
1120:
1118:
1114:
1113:
1110:
1107:
1105:
1102:
1098:
1097:Fibrolamellar
1095:
1094:
1093:
1090:
1088:
1084:
1083:
1081:
1079:
1075:
1072:
1070:
1066:
1056:
1053:
1051:
1048:
1047:
1045:
1041:
1031:
1028:
1027:
1025:
1023:
1019:
1013:
1010:
1008:
1005:
1003:
1000:
997:
996:
993:
990:
988:
985:
983:
979:
976:
974:
971:
969:
966:
963:
962:
959:
955:
954:Peutz–Jeghers
951:
947:
943:
939:
935:
932:
930:
926:
925:
923:
921:
917:
911:
908:
906:
903:
902:
900:
898:
894:
886:
883:
882:
881:
878:
877:
875:
873:
869:
866:
864:
860:
850:
847:
845:
842:
838:
837:MALT lymphoma
835:
834:
833:
830:
828:
825:
823:
820:
819:
817:
815:
811:
805:
802:
800:
797:
796:
794:
792:
788:
785:
783:
779:
776:
774:
770:
766:
759:
754:
752:
747:
745:
740:
739:
736:
732:
721:
715:
707:
703:
696:
693:
686:
682:
678:
674:
671:(3): E47-64.
670:
666:
665:Radiographics
659:
656:
650:
644:
636:
626:
623:
618:
614:
610:
606:
603:(5): 478–88.
602:
598:
597:
588:
585:
580:
576:
571:
566:
562:
558:
554:
547:
544:
539:
535:
530:
525:
521:
517:
513:
506:
503:
498:
491:
488:
483:
479:
474:
469:
464:
459:
455:
451:
447:
440:
437:
432:
428:
423:
418:
413:
408:
404:
400:
396:
389:
386:
381:
377:
372:
367:
363:
359:
356:(2): 148–50.
355:
351:
347:
340:
337:
330:
326:
322:
318:
314:
310:
306:
302:
294:
291:
284:
280:
277:
275:
272:
270:
267:
266:
262:
260:
254:
248:
242:
237:
230:
225:
221:
220:H&E stain
217:
211:
206:
199:
194:
192:
190:
186:
182:
178:
174:
170:
162:
160:
158:
154:
146:
144:
142:
134:
132:
130:
126:
122:
121:cytopathology
113:
108:
101:
99:
92:
90:
88:
84:
80:
76:
67:
64:
62:
58:
53:
49:
44:
40:
36:
31:
19:
1222:
1204:
1180:
1162:
1133:
1115:
1085:
998:
964:
938:hyperplastic
927:
920:Colon/rectum
730:
705:
695:
668:
664:
658:
625:
600:
594:
587:
560:
556:
546:
519:
515:
505:
496:
490:
456:(107): 107.
453:
449:
439:
402:
398:
388:
353:
349:
339:
304:
300:
293:
258:
189:chromogranin
166:
150:
138:
118:
96:
74:
72:
1182:gallbladder
1135:hyperplasia
307:(1): 40–7.
38:Other names
1301:Categories
1268:Peritoneum
285:References
255:Management
141:hemorrhage
1227:neoplasms
1164:bile duct
1087:malignant
1069:Accessory
999:Neoplasm:
982:Gardner's
905:Carcinoid
791:Esophagus
329:205677185
247:β-catenin
102:Diagnosis
87:papillary
61:Specialty
1197:Pancreas
968:Juvenile
942:juvenile
897:Appendix
773:GI tract
714:cite web
685:21721197
643:cite web
538:18708424
482:29695287
431:24759340
380:18333264
321:23939829
263:See also
177:vimentin
112:papillae
83:pancreas
79:neoplasm
66:Oncology
934:adenoma
814:Stomach
617:1283055
579:1900454
473:5918898
422:4020125
371:2131425
81:of the
1224:cystic
1117:benign
683:
615:
577:
557:Cancer
536:
480:
470:
429:
419:
378:
368:
327:
319:
183:, and
153:nuclei
1078:Liver
863:Lower
782:Upper
325:S2CID
1022:Anus
720:link
681:PMID
649:link
613:PMID
575:PMID
534:PMID
478:PMID
427:PMID
376:PMID
317:PMID
173:CD56
169:CD10
673:doi
605:doi
565:doi
524:doi
468:PMC
458:doi
417:PMC
407:doi
366:PMC
358:doi
350:HPB
309:doi
305:122
157:PAS
85:of
1303::
1230::
956:,
952:,
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940:,
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712:{{
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669:31
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601:98
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561:67
559:.
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532:.
520:61
518:.
514:.
476:.
466:.
454:12
452:.
448:.
425:.
415:.
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397:.
374:.
364:.
352:.
348:.
323:.
315:.
303:.
179:,
175:,
171:,
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687:.
675::
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619:.
607::
581:.
567::
540:.
526::
484:.
460::
433:.
409::
403:2
382:.
360::
354:8
331:.
311::
20:)
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