45:: Zaire Ebola L polymerase, Zaire Ebola membrane-associated protein (VP24), and Zaire Ebola polymerase complex protein (VP35). By down-regulating these three proteins, TKM-Ebola inhibits virus replication and eliminates the infection. The drug was effective in rhesus monkeys infected with Ebola. After the Ebola outbreak in West Africa in 2014, the new variant responsible for it was isolated from several Ebola virus families and the specific genomic sequence was determined. The company re-designed TKM-Ebola and renamed it as "TKM-Ebola-Guinea".
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48:
In
January 2014, Tekmira started a Phase I clinical trial of TKM-Ebola to assess its safety in healthy people with a dose of 0.24 mg/kg/day for seven day treatments. The FDA placed the trial on clinical hold in July 2014 to assess results, after some subjects had flu-like responses. In August,
56:
A Phase II trial started on 11 March 2015 in Sierra Leone, West Africa and stopped enrolling new subjects on 19 June 2015 after it appeared not to work. In July 2015 the company announced it was changing its name to
Arbutus, suspending development of the drug for Ebola and changing its focus to
178:
Thi, Emily P.; Mire, Chad E.; Lee, Amy C. H.; Geisbert, Joan B.; Zhou, Joy Z.; Agans, Krystle N.; Snead, Nicholas M.; Deer, Daniel J.; Barnard, Trisha R.; Fenton, Karla A.; MacLachlan, Ian; Geisbert, Thomas W. (22 April 2015).
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in people infected with Ebola but with the Phase I trial still suspended. In April 2015 the FDA allowed the study to resume at a lower dose.
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34:(formerly Tekmira Pharmaceuticals Corp.) in Vancouver, Canada. The drug candidate was formerly known as Ebola-SNALP.
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181:"Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates"
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Cynthia Koons, Caroline Chen and Robert
Langreth for Bloomberg News. Aug 8, 2014
49:
the FDA changed the status to "partial hold", allowing the drug to be used under
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237:"Tekmira Provides Periodic Update on TKM-Ebola Program (NASDAQ:ABUS)"
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Experimental Ebola drug shelved; study explores virus clearance
364:
138:
FDA Moves On
Tekmira's Ebola Drug While Sarepta's Sits Unused
1266:
279:"FDA modifies partial clinical hold on Tekmira Ebola study"
333:"In setback for potential Ebola drug, company halts trial"
16:
Experimental antiviral drug for Ebola disease that failed
985:
2023 Marburg virus disease outbreak in
Equatorial Guinea
2122:
267:
Ebola Drug by
Tekmira May Be Used on Infected Patients
331:
Vogel, Gretchen; Kupferschmidt, Kai (19 June 2015).
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107:"Tekmira Pharma is Now Arbutus Biopharma (ABUS)"
990:2023 Marburg virus disease outbreak in Tanzania
356:Lisa Schnirring for CIDRAP News. Jul 20, 2015
2142:
1282:
975:2021 Marburg virus disease outbreak in Guinea
380:
306:"New Ebola drug trial starts in Sierra Leone"
8:
980:2022 Marburg virus disease outbreak in Ghana
965:1967 Marburg virus outbreak in West Germany
435:2013−2016 West African Ebola virus epidemic
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1571:Reproductive endocrinology and infertility
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1912:Bachelor of Medicine, Bachelor of Surgery
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41:targeting three of the seven proteins in
516:Recent DR Congo outbreaks and epidemics
908:(2019 miniseries based on Preston book)
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929:Ebola virus disease treatment research
136:David Kroll for Forbes. 7 August 2014
7:
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1811:Physical medicine and rehabilitation
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304:Kupferschmidt, Kai (11 March 2015).
2060:
2121:. You can help Knowledge (XXG) by
1947:Medical Scientist Training Program
970:2017 Uganda Marburg virus outbreak
455:United Nations Ebola Response Fund
14:
71:Atoltivimab/maftivimab/odesivimab
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1937:Doctor of Osteopathic Medicine
1371:Oral and maxillofacial surgery
37:TKM-Ebola is a combination of
1:
159:. BioCentury Publications Inc
1917:Bachelor of Medical Sciences
1684:Neurosurgical anesthesiology
764:Jean-Jacques Muyembe-Tamfum
460:Operation United Assistance
2199:
2100:
57:developing treatments for
2035:
1236:
445:Reported cases and deaths
1871:Transplantation medicine
1762:Clinical neurophysiology
1679:Obstetric anesthesiology
1599:Interventional radiology
1359:Digestive system surgery
1742:Intensive care medicine
1716:Mass gathering medicine
1561:Maternal–fetal medicine
241:investor.arbutusbio.com
1334:Cardiothoracic surgery
39:small interfering RNAs
30:that was developed by
1985:Personalized medicine
1844:Reproductive medicine
1769:Occupational medicine
1723:Evolutionary medicine
1223:Huangjiao thamnovirus
1083:Marburg virus disease
604:Taï Forest ebolavirus
564:Bundibugyo ebolavirus
2005:Traditional medicine
1965:Alternative medicine
1832:Addiction psychiatry
1646:Transfusion medicine
1641:Medical microbiology
1556:Gynecologic oncology
1408:Reproductive surgery
1007:Marburg marburgvirus
22:was an experimental
2027:History of medicine
2010:Veterinary medicine
1817:Preventive medicine
1669:Adolescent medicine
1511:Infectious diseases
924:Ebola virus disease
430:1976 Zaire outbreak
425:1976 Sudan outbreak
337:news.sciencemag.org
205:10.1038/nature14442
197:2015Natur.521..362T
1975:Molecular oncology
1932:Doctor of Medicine
1922:Master of Medicine
1839:Radiation oncology
1711:Emergency medicine
1664:Addiction medicine
1631:Clinical chemistry
1626:Clinical pathology
1418:Transplant surgery
1376:Orthopedic surgery
1354:Colorectal surgery
796:Thomas Eric Duncan
247:on 8 December 2015
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1927:Master of Surgery
1891:
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1876:Tropical medicine
1822:Prison healthcare
1737:Hospital medicine
1701:Disaster medicine
1691:Aviation medicine
1506:Hospital medicine
1413:Surgical oncology
1398:Pediatric surgery
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1339:Endocrine surgery
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1199:
1198:
1190:Xilang striavirus
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1120:Lloviu cuevavirus
1096:
1095:
942:
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791:Pauline Cafferkey
754:Ebola researchers
694:
578:Reston ebolavirus
505:Ouse to Ouse Tock
59:hepatitis B virus
32:Arbutus Biopharma
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2183:Immunology stubs
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618:Zaire ebolavirus
590:Sudan ebolavirus
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243:. Archived from
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191:(7552): 362–65.
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76:Zaire ebolavirus
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2178:Abandoned drugs
2168:Antiviral drugs
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2020:Chief physician
1953:
1898:
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1881:Travel medicine
1866:Sports medicine
1849:Sexual medicine
1789:Palliative care
1784:Pain management
1728:Family medicine
1706:Diving medicine
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1542:
1535:
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1403:Plastic surgery
1349:General surgery
1329:Cardiac surgery
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1029:Drug candidates
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848:Richard Preston
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833:Popular culture
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811:Matthew Lukwiya
806:Sheik Umar Khan
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633:Drug candidates
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545:2021 North Kivu
485:in Sierra Leone
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113:. 3 August 2015
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846:(1995 book by
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1479:Endocrinology
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1076:Miscellaneous
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917:Miscellaneous
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801:Salome Karwah
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645:Brincidofovir
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540:2020 Équateur
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535:Kivu epidemic
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531:
530:2018 Équateur
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79:(Ebola virus)
78:
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54:
52:
46:
44:
40:
35:
33:
29:
28:Ebola disease
25:
21:
2123:expanding it
2112:
2097:
2095:
1995:Rural health
1980:Nanomedicine
1531:Rheumatology
1462: /
1381:Hand surgery
1366:Neurosurgery
1221:
1204:
1188:
1171:
1157:Mengla virus
1139:
1118:
1101:
1063:The Hot Zone
1061:
1005:
949:Marburgvirus
947:
904:The Hot Zone
902:
892:
880:(1996 novel)
874:
864:
854:
842:The Hot Zone
840:
786:Kent Brantly
689:
616:
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405:
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352:
340:. Retrieved
336:
326:
314:. Retrieved
309:
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287:. Retrieved
282:
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249:. Retrieved
245:the original
240:
231:
188:
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161:. Retrieved
156:
115:. Retrieved
110:
101:
74:
55:
47:
36:
19:
18:
2065:Wikiproject
1854:Venereology
1799:Neonatology
1696:Dermatology
1551:Gynaecology
1543:gynaecology
1526:Pulmonology
1344:Eye surgery
1306:Specialties
1256:Wikispecies
1206:Thamnovirus
1141:Dianlovirus
1067:(1995 book)
934:Ebola River
898:(2016 film)
888:(2014 meme)
870:(1996 film)
860:(1995 film)
698:Triazavirin
655:Favipiravir
397:Filoviridae
251:30 November
153:"TKM-Ebola"
83:Favipiravir
43:Ebola virus
2162:Categories
2115:immunology
1827:Psychiatry
1813:(PM&R)
1806:Phlebology
1794:Pediatrics
1621:Anatomical
1586:Diagnostic
1566:Obstetrics
1516:Nephrology
1501:Hematology
1496:Geriatrics
1489:Hepatology
1474:Cardiology
1464:Immunology
1173:Striavirus
1103:Cuevavirus
885:Ebola-chan
769:Peter Piot
736:rVSV-ZEBOV
713:cAd3-ZEBOV
680:Lamivudine
480:in Nigeria
470:in Liberia
407:Ebolavirus
157:BioCentury
94:References
2015:Physician
1899:education
1757:Neurology
1752:Narcology
1616:Pathology
1594:Radiology
1469:Angiology
1433:Andrology
958:Outbreaks
690:TKM-Ebola
500:in the UK
495:in the US
465:in Guinea
450:Responses
417:Outbreaks
20:TKM-Ebola
2045:Category
1521:Oncology
1452:medicine
1450:Internal
1298:Medicine
856:Outbreak
731:Vaccines
708:Vaccines
693:(failed)
490:in Spain
440:Timeline
316:1 August
289:1 August
223:25901685
163:1 August
65:See also
2085:Outline
2055:Commons
2000:Therapy
1897:Medical
1460:Allergy
1428:Urology
1321:Surgery
1246:Commons
1215:Species
1182:Species
1150:Species
1112:Species
1088:Marburg
1046:FGI-106
1041:FGI-103
1036:BCX4430
999:Species
894:93 Days
670:FGI-106
665:FGI-104
660:FGI-103
640:BCX4430
556:Species
475:in Mali
342:24 June
283:Reuters
214:4467030
193:Bibcode
2075:Portal
1942:MD–PhD
1159:(MLAV)
685:mAb114
312:. AAAS
221:
211:
185:Nature
117:16 May
2173:Ebola
2113:This
1657:Other
724:Drugs
703:ZMapp
675:JK-05
650:DZNep
583:RESTV
88:ZMapp
2119:stub
1125:LLOV
1018:RAVV
1013:MARV
623:EBOV
610:TAFV
596:SUDV
570:BDBV
525:2017
520:2014
344:2015
318:2015
291:2015
253:2015
219:PMID
165:2015
119:2016
26:for
1391:ENT
1309:and
209:PMC
201:doi
189:521
2164::
1730:/
335:.
308:.
281:.
239:.
217:.
207:.
199:.
187:.
183:.
155:.
144:^
127:^
109:.
61:.
2150:e
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1123:(
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388:e
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293:.
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203::
195::
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121:.
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