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21-alpha-hydroxylase deficiency. There were some mentions pressure in some websites (that do not list sources) about low blood pressure in most severe salt-losing forms, but these symptoms are no longer found in most recent articles, reviews and practical guidelines about 21-hydroxylase deficiency.
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I found references (PMID 9809193 and 36807213) to support the claim that in 11-beta-hydroxylase deficiency, 11-deoxycortisol levels increase dramatically, causing hypertension (as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids).
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However, I cannot find the explicit reference for the second part of the addition "(as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids)". I could not find an article that clearly states that hypotension is a symptom in
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The disputed addition is (quote): "In 11-beta-hydroxylase deficiency, 11-deoxycortisol levels increase dramatically, causing hypertension (as opposed to 21-alpha-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids)."
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In fact, in 11-beta-hydroxylase deficiency, it is 11-deoxycorticosterone that leads to hypertension, although it raises together with 11-deoxycortisol, but 11-deoxycortisol itself does not lead to hypertension. I have corrected this and added a reference.
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On 29 May 2009‎ an unauthenticated user from the IP address 146.203.126.113 added a brief note on clinical relevance of 11-deoxycortisol
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for that content in the latter page, and it must not be deleted as long as the latter page exists.
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