Talk:Bupropion - Knowledge (XXG)

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subjects (total sample size = 50) suggesting that bupropion, like caffeine, might be of some abuse liability in about 6% of the smokers (PMID: 15001822). I think that this is important information with respect to estimating the abuse liability of bupropion. That bupropion may be of some abuse liability for some patients/users is supported by an ever-increasing number of case reports reporting abuse (some of which are cited on the Bupropion page in wiki). Anecdotally, some intravenous drug users also do abuse bupropion, although I have no data on that. Therefore, I would like to add that information and the reference to the bupropion page. I did and Doc James removed my text (I already have contacted Doc James and asked him why, he seems to be on vacation). I am a new user, so please advise what I have to do to get that information stably inserted into the bupropion page. Thank you very much! Stoopormundi, April 5, 2016

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associated with a seizure incidence of 0.1% at daily dosages of less than 300 mg of bupropion and 0.4% at 300–400 mg. The immediate release preparation is associated with a seizure incidence of 0.4% for dosages below 450 mg; the incidence climbs to 5% for dosages between 450–600 mg per day. For comparison, the incidence of unprovoked seizure in the general population is 0.07 to 0.09%, and the risk of seizure for a variety of other antidepressants is generally between 0 and 0.6% at recommended dosage levels. Given that clinical depression itself has been reported to increase the occurrence of seizures, it has been suggested that low to moderate doses of antidepressants may not actually increase seizure risk at all. However, this same study found that bupropion and

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available. That basically means the efficacy statements in each section need to be updated to incorporate the findings of (1) the most recent systematic reviews which include a meta-analysis and/or (2) the most recent ordinary meta-analyses, depending upon what's available. Failing that, systematic reviews w/o meta-analysis or just plain review articles of its treatment efficacy would be the only alternative. Once we have a representative sample of newer secondary sources that assess its efficacy, we can update the article's coverage of treatment efficacy

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much of this time. I'm unaware of any quality primary-care literature that ever supported the assertion that bupropion is an effective antidepressant. There were at least 2 unpublished clinical trials the results of which were not published, but which (apparently) showed null effect of bupropion, so there is likely also publication bias. The problem is not that this article hasn't aged well; the problem is that it states many things that were never true.

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to) alopecia ("rare"), concentration disturbance (post marketing reports only, not 1-10%), depression (post marketing reports only, not 1-10%), visual disturbances (postmarketing reports only, not 1-10%). Virtually all of the adverse events in the 0.01% to 0.1% category appear to be from spontaneous postmarketing reports, and thus of unknown causation. These are not Adverse Effects, but Adverse Events of unknown causality.

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only fair to include it as well (50 subjects tested under controlled experimental conditions with the best possible design as opposed to CASE reports). What about the following text, a very brief and concise one: "In a randomized controlled trial, 6% of the bupropion users reported a profound "high", suggesting that bupropion may have abuse liability in some."

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Kindly update the page if you are a moderator with the following research outcome. I oppose the use of the word 'weak' as it is not referenced in any of the articles you have referenced and creates a presumption which is not based on any correlational nor cause and effect methodology. Kindly stick to

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for accessibility). It doesn't state this outright, but based upon the statistical tables, there's insufficient evidence on bupropion augmentation to support its efficacy vs placebo or other any of the other augmentation agents in the study. That's sort of consistent with what the other meta-analysis

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Psychiatric events, including agitation, hostility, and depressed mood have been observed in people using bupropion as an aid to smoking cessation. Though the relative contributions of bupropion and nicotine withdrawal to the emergence of these symptoms is unclear, the U.S. package insert includes a

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This seems like a significant oversight. The Cl group on the phenyl ring is clearly stated as being in the 3 position (3-Chloro-N-tert-butyl-β-keto-α-methylphenethylamine) however in both images representing the chemical structure of bupropion, the Cl group is in the 5 position. Is this intentional?

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A randomized placebo-controlled double-blind crossover study of the subjective effects produced by bupropion (given at a clinical dose, i.e., in its slow-relase form, 150 mg twice daily) vs caffeine in male smokers found subjective effects, i.e., pronounced self-rating of "high" in 6% of the tested

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boxed warning that people should stop taking the drug if these symptoms appear. The package insert further states that people should weigh these risks against the benefits of bupropion in helping people quit smoking, noting that "The health benefits of quitting smoking are immediate and substantial".

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are the most important adverse effect of bupropion. A high incidence of seizures was responsible for the temporary withdrawal of the drug from the market between 1986 and 1989. The risk of seizure is strongly dose-dependent, but also dependent on the preparation. The sustained-release preparation is

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Benzodiazepines lower the seizure threshold. So much so, that they are first-line medications for interrupting seizures. IV lorazepam (Ativan) is typically the first med given for seizures. It is also what is given as needed for patients going through alcohol withdrawal - partly because it decreases

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If the half life is 10-19 hours, which several studies attest to, then why in the figure in the "History" section does it look like the half-life is only ~4-5 hours for the immediate/instant release formulation? Is it two-compartment kinetics? What is more clinically meaningful, the blood level, or

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I've looked at the articles cited as supporting efficacy of bupropion as an antidepressant. I didn't find a quality citation that supported efficacy. I remember the history of bupropion from its time of FDA approval to now, as I was on hospital formulary committees, IRBs, and NBME committees during

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Dear Sizeofint, thank you very much for your help! I understand the meta-analysis / review approach. However, in the bupropion page, I have counted two CASE REPORTS among the references. The trial I was referring to was a randomized placebo-controlled crossover in 50 (FIFTY) smokers. So I think it

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10%) adverse effect" of headache was seen in 26% of people treated with drug and 25% of people treated with placebo in clinical trials. Several other "adverse effects" are listed in the package insert at incidences dramatically different from those in the table. These include (but are not limited

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Low to moderate alcohol intake while taking buprioprion, such that stopping for a while would not precipitate withdrawal, is not contraindicated while taking buproprion. It's still not adivsable when taking buproprion for depression, of course, because alcohol is a CNS depressant. It would tend to

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I looked through this and got rid of most of the primary sources. The only one that i found and couldn't get rid of was the 2002 case report of withdrawal-symptoms. I was tempted to delete that per UNDUE (2 case reports in zillions of uses is really nothing - and i found no reviews talking about

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and behavior in children and adolescents, and 1.5-fold increase in the 18–24 age group. For this analysis the FDA combined the results of 295 trials of 11 antidepressants in order to obtain statistically significant results. Considered in isolation, bupropion was not statistically different from

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Heavier drinkers (and those already in withdrawal) shouldn't take buproprion because 1) heavy drinking with buproprion can increase side effects, and 2) if they decrease their intake substantially (or start to abstain), alcohol withdrawal puts them at higher risk for seizure (lowers their seizure

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review, there have been four suicides per one million prescriptions and one case of suicidal ideation per ten thousand prescriptions of bupropion for smoking cessation in the UK. The review concludes, "Although some suicides and deaths while taking bupropion have been reported, thus far there is

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The section on the MRHA report from 2002 reporting 60 deaths "most of which are explained by the individual's underlying health conditions" is a little long in the tooth, and of questionable relevance if no better source suggesting increased mortality can be found after an additional 13 years of

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Rewriting the depression section with the current sourcing to account for the variation in conclusions actually seems like a bad idea IMO. What this article really needs is an update of its sourcing to reflect conclusions about treatment efficacy from the most recent and highest quality sources

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At least one named reference, "Dwoskin2014", is forwardly-defined, i.e. used as a refname before the reference has been defined. While Knowledge (XXG) permits this, the potential result is that adding a new use of the refname disrupts the reference numbering, spawning unnecessary changes. D A

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I have a problem with the summary where it says: "However, bupropion does not appear to have significant dopaminergic actions in humans under normal clinical circumstances." I had a look in reference it says no such thing. Actually the opposite, so this sentence should be removed.

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page concurrently noting it does not reference what is referenced here. Additionally this page should be frequently updated with regular updates on all science and medical journal publications related to the same (both the medications and the article in reference to the substance.

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The section on contraindications needs to be corrected on the subject of alcohol and benzodiazepines. It is correct that conditions and drugs that lower the seizure threshold would be contraindications to taking buprioprion because buproprion also lowers the seizure threshold.

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discussed re: bupropion as an add-on therapy. I might add something on the lack of evidence on effectiveness as an add-on therapy within the next week, citing both meta-analyses, but I need to finish adding content in 2 other articles before I get around to summarizing that.

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I'm curious why the list of adverse effects of bupropion is in a separate article. I suggest that this separate article be merged into the main bupropion article. I would simply make this change, but this is a featured article, so thought I'd ask here on the talk page

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their withdrawal symptoms (because many of the pharmacologic effects are similar to alcohol), and because it decreases their risk of seizure. Abrupt withdrawal from regular benzodiazepine usage, however, does lower the seizure threshold - similar to alchol.

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to generate a citation template for sources with a PMID number. All you need to do is click the "Add ref tag" check box, copy/paste an article's PMID number into the text field, and hit submit; it will provide you with a formatted citation template.

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Here's the reference: Casey, E.R.; Scott, M.G.; Tang, S.; Mullins, M.E. (2011) "Frequency of false positive amphetamine screens due to bupropion using the Syva EMIT II immunoassay." J Med Toxicol 7:105–108 DOI 10.1007/s13181-010-0131-5

3004:, I found 23 potentially relevant meta-analyses, including the recent Bayesian one (i.e., the 2nd entry in this list). I'll go through it now and see what we have. If anyone has a better idea for a search string, feel free to tell me! 1486:

Common adverse events seen in clinical trials with an incidence at least 5% greater in people treated with bupropion compared to people treated with a sugar pill include agitation, anxiety, insomnia, weight loss, dry mouth, and nausea.

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FWIW, I don't think this article is FA-quality at all anymore. The OD and synthesis sections are hardly comprehensive and there's noticeable prose issues like the numerous of 1–2 sentence paragraphs scattered throughout the article.

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these 4 assess the efficacy of bupropion for MDD/"depression", seasonal affective disorder, and treatment-resistant depression. Haven't gone through them yet. I'm going to see if there's any relevant ones from 6-8 years ago first.

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Until we have newer sources on hand to update each sub-section, I think just dating the statements that are cited to recent reviews/meta-analyses and including the update banner in the medical uses section is the best approach.

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We can wait for this to be discussed in a review. If it is important in the field, it will be; there are lots of reviews on smoking cessation and if this is really a significant side effect and it will be addressed. There is

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talks about this a bit. We should judge content on its own merits and not based on the existence of similar content. Actually, if you could point out the references we can try to replace them with better sources if necessary.

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Methodologically more robust trials support the superiority of bupropion over placebo, and most head-to-head antidepressant trials showed an equivalent effectiveness, though some of these are hindered by a lack of a placebo

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This meta-analysis indicates that it's superior to placebo for depression. There's a massive discussion and comparative analysis with other drugs, but it's not really summarized well in the paper. The abstract just states

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I would suggest adding the following sentence at the end of Pharmacokinetics paragraph: "However, a 2011 study found that therapeutic use of bupropion could and did appear to cause false positives for amphetamines."

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http://web.archive.org/web/20101019032042/http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm169988.htm

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Certain generics are considered generic Zyban while others are considered generic wellbutrin. I’ve noticed 150mg SR being zyban and 200mg SR being wellbutrin. It’s likely just manufacturer/insurance oddities.

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science, as well expand the matter due to the number of related deaths being claimed in the USA in specific jurisdictions being that this is a point of reference for many, additionally consider updating the

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INN. I felt I should raise this issue here, instead of just editing the article accordingly off the bat because I felt anyone that made these changes must have had a decent reason which should be heard.

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The paragraph on "bupropion induced psychosis" is based on a case report and documents stating that causation is not completely clear. The causative role of bupropion is presented as an established fact

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Alper K, Schwartz KA, Kolts RL, Khan A (August 2007). "Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports".

135: 3661: 150: 2185:. Welcome to the editing side of Knowledge (XXG)! I hope we haven't damped your enthusiasm. Most articles on Knowledge (XXG) require reliable sources for their content, as you are probably aware ( 1929: 1455:

The list of "Adverse effects" is inaccurate and misleading, as these are not "adverse effects" but "adverse events". The former phrase implies causality. But for example, the "Very common (: -->

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Correct, though I don't see where the article makes that mistake (quote it for us?). Also, welcome to Knowledge (XXG)! Here's a tutorial on how to edit (register to keep track of your edits)

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has the details). Essentially, we prefer meta-analyses and review articles to individual studies. The reason being that individuals studies often have conflicting conclusions. Hope this helps!

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stating that antidepressants may increase the risk of suicide in persons younger than 25. This warning is based on a statistical analysis conducted by the FDA which found a 2-fold increase in

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Is true that bupropion causes a higher risk of seizures compared to other antidepressants? A reference would be good if that is the case: I see some sources saying that is a myth.

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http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm169988.htm

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in the British Columbia Medical Journal "Bupropion toxicity with unintentional exposure or abuse: More common than you think" may be worth mentioning in this article.

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Use of alcohol or benzodiazepines while taking buproprion does not lower the seizure threshold. Abrupt withdrawal from these drugs lowers the seizure threshold.

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Comparative Efficacy, Acceptability, and Tolerability of Augmentation Agents in Treatment-Resistant Depression: Systematic Review and Network Meta-Analysis

1882:) while bupropion hydrochloride is the USAN for this salt specifically (no USAN for freebase bupropion is mentioned, in this source). Amfepramone was the 3691: 3681: 2794:

FWIW, this article really does need an update of its sources for clinically relevant statements. A number of them appear to be 10–15 years old. As with

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after the link to keep me from modifying it, if I keep adding bad data, but formatting bugs should be reported instead. Alternatively, you can add

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the level in tissue? I'm confused... By the way, I have taken immediate release, and the chief effects seem to diminish after a few hours..

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So, this basically says that the evidence suggests it has comparable effectiveness to other drugs, but some of that evidence is low-quality.

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undermine the effects of buproprion. Buproprion can also decrease one's alcohol tolerance (so one would be impaired with less alcohol).

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the same search with a modified date range found these 2 from 2011 that assess the efficacy for dysthymia and "late-life depression".

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Suicidal thought and behavior are rare in clinical trials, and the FDA requires all antidepressants, including bupropion, to carry a

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When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

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There are several opportunities for improvement in this section. I outline these below followed by a proposed change in the text.

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Many of the refs are old. Some of the conclusions appear a little too positive. Needs updating and removal of primary sources.

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Bupropion is technically of the amphetamine "class" or "family"... Moralistic hysteria does not require us to self-censor...

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I don't know how to make changes, but bupropion is NOT an SSRI. According to this article's own source, it is an NDRI.

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Hi, I've noticed that the lead has picked up some erroneous naming info. Bupropion is the INN and BAN (according to

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Pisani F, Oteri G, Costa C, Di Raimondo G, Di Perri R (2002). "Effects of psychotropic drugs on seizure threshold".

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Any reason why the Cl group in the skeletal/ball-and-stick model is in the 5 position instead of the 3 position?

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to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the

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to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the

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to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the

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Suicidal behavior is less of a concern when bupropion is prescribed for smoking cessation. According to a 2007

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https://web.archive.org/web/20070928041150/http://www.biospace.com/news_story.aspx?StoryID=18222420&full=1

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you mention should be able to interconvert by rotation about the benzene-carbonyl C-C single bond, providing

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http://web.archive.org/web/20101227032032/http://www.gsk.com/media/pressreleases/2007/2007_01_16_GSK956.htm

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this. it is also hard to find reviews b/c the search is messed up by the nicotine dependence use...).

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to keep me off the page altogether, but should be used as a last resort. I made the following changes:

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Typically we try to use secondary sources and major textbooks rather than primary sources for content.

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Insurance still covers in the US. But they might not cover if you're already taking a similar drug ?

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http://web.archive.org/web/20070927173339/http://www.gsk.com/investors/reports/gsk_q22006/q22006.pdf

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http://web.archive.org/web/20070927173339/http://www.gsk.com/investors/reports/gsk_q22006/q22006.pdf

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were unique among antidepressants in that they were associated with increased incidence of seizures.

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Package insert doesn't say it's an antidepressant anymore, some insurance won't pay for it now

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Hughes JR, Stead LF, Lancaster T (2007). Hughes JR (ed.). "Antidepressants for smoking cessation".

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Weird I wonder what country you live it its still covered in the United States by my insurance

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before doing mass systematic removals. This message is updated dynamically through the template

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before doing mass systematic removals. This message is updated dynamically through the template

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before doing mass systematic removals. This message is updated dynamically through the template

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The fourth trial (i.e., the 2018 meta-analysis) is already in the article; I really just need

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I would suggest an edit to the beginning of the contraindication section along the lines of:

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http://web.archive.org/web/20070630052951/http://www3.cnn.com/HEALTH/library/DI/00069.html

2074: 1672: 1008: 789: 2950: 2186: 177: 3478: 3306:"Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant" 2189:). For medical and health related content the standard for a reliable source is higher ( 3619: 3397: 3329: 3305: 2622:, "External links modified" talk page sections are no longer generated or monitored by 2514:, "External links modified" talk page sections are no longer generated or monitored by 2386:, "External links modified" talk page sections are no longer generated or monitored by 1418: 1158: 2712: 2662:

If you found an error with any archives or the URLs themselves, you can fix them with

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If you found an error with any archives or the URLs themselves, you can fix them with

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If you found an error with any archives or the URLs themselves, you can fix them with

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If you found an error with any archives or the URLs themselves, you can fix them with

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here and high quality sourcing is important to maintain. 06:06, 9 April 2016 (UTC)

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for how we handle it when meta-analyses and clinical guidelines are in tension.

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Patel K, Allen S, Haque MN, Angelescu I, Baumeister D, Tracy DK (April 2016).

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The Cochrane review on bupropion for SAD has a somewhat depressing conclusion.

2628:. No special action is required regarding these talk page notices, other than 2520:. No special action is required regarding these talk page notices, other than 2392:. No special action is required regarding these talk page notices, other than 863: 779: 165: 3437: 3321: 3608: 2887:. NICE for example has this drug as first line for smoking cessation. See 2795: 2589: 2461: 2303: 2255:

Editors aren't always aware of MEDRS so lower quality sources can sneak in.

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OK, just did that for the depression section and smoking cessation section.

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Clinical trial suggesting abuse liability of bupropion in 6% of smokers

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Meh. I'll go through the other 5 tomorrow. This is a lot of reading.

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An editor has reviewed this edit and fixed any errors that were found.

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http://www.biospace.com/news_story.aspx?StoryID=18222420&full=1

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The use of Bupropion in Methamphetamine dependence and or recovery

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New(er) Research on Bupropion and False-Positives for Amphetamines

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for Knowledge (XXG)'s health content are defined in the guideline

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Haven’t forgotten about this. Will include the relevant findings

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http://www.gsk.com/media/pressreleases/2007/2007_01_16_GSK956.htm

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I feel as though this could lead to some confusion. Any input?

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insufficient evidence to suggest they were caused by bupropion."

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I suggest replacing this entire section with the following text:

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Knowledge (XXG):WikiProject Psychoactive and Recreational Drugs

141: 1137: 401: 236: 228: 15: 1650:. Washington, DC: American Psychiatric Publishing, Inc. 2003. 801:, which recommends that medicine-related articles follow the 2487:

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http://us.gsk.com/products/assets/us_wellbutrin_tablets.pdf

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Featured articles that have appeared on the main page once

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for additional information. I made the following changes:

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http://www.gsk.com/investors/reports/gsk_q22006/q22006.pdf

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for additional information. I made the following changes:

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for additional information. I made the following changes:

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The references support the dopaminergic action in humans.

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Good point. Yes, those too are high-quality references.

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http://drugabuse.gov/NIDA_notes/NNvol20N5/Bupropion.html

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This article appeared on Knowledge (XXG)'s Main Page as

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Knowledge (XXG):Identifying reliable sources (medicine)

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Featured articles that have appeared on the main page

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916165/

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The American Psychiatric Press Textbook of Psychiatry

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https://en.wikipedia.org/Alcohol_withdrawal#Treatment

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clinical publications about evidence-based medicine

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I looked at a few 947:Psychoactive and Recreational Drugs 910:Psychoactive and Recreational Drugs 23:for discussing improvements to the 1100:. For more information, visit the 1025:Knowledge (XXG):WikiProject Autism 633:This article has been listed as a 14: 3692:Mid-importance chemicals articles 3682:WikiProject Pharmacology articles 3657:Knowledge (XXG) featured articles 2592:. Please take a moment to review 2464:. Please take a moment to review 2306:. Please take a moment to review 2059:. Please take a moment to review 1794:U.S. Food and Drug Administration 1497:Lowering of the seizure threshold 1204:Other potential sources include: 707:Template:WikiProject Neuroscience 488:Template:WikiProject Pharmacology 50:New to Knowledge (XXG)? Welcome! 3712:Mid-importance medicine articles 3450: 3445: 3428:and found both conformers (e.g. 3147: 2963:<ref name="pmid24402784": --> 2711: 2113: 1960: 1700:10.2165/00002018-200225020-00004 1141: 1084: 1066: 994: 973: 927: 902: 866: 807:use high-quality medical sources 782: 772: 745: 677: 656: 554: 540: 526: 458: 437: 406: 315: 282: 240: 45:Click here to start a new topic. 3757:WikiProject Disability articles 3633:Confused about half life figure 2959:<ref name=pmid24402784/: --> 1117:Template:WikiProject Disability 1045:This article has been rated as 841:This article has been rated as 724:This article has been rated as 611:This article has been rated as 505:This article has been rated as 3742:Low-importance Autism articles 3732:All WikiProject Medicine pages 3727:Psychiatry task force articles 3697:FA-Class neuroscience articles 3672:FA-Class pharmacology articles 2083:Attempted to fix sourcing for 1824:10.1002/14651858.CD000031.pub3 1751:10.1016/j.biopsych.2006.09.023 594:Template:WikiProject Chemicals 424:It is of interest to multiple 1: 3628:08:15, 11 February 2023 (UTC) 3582:06:44, 21 December 2021 (UTC) 2686:16:31, 11 November 2017 (UTC) 2042:06:19, 16 December 2015 (UTC) 2013:01:36, 11 December 2015 (UTC) 1582:16:23, 21 December 2014 (UTC) 1439:23:24, 22 November 2014 (UTC) 1410:04:33, 20 November 2014 (UTC) 1165:sources of information about 1019:and see a list of open tasks. 879:This article is supported by 824:Template:WikiProject Medicine 698:and see a list of open tasks. 479:and see a list of open tasks. 253:for general discussion about 42:Put new text under old text. 3752:FA-Class Disability articles 3717:FA-Class psychiatry articles 3536:19:17, 7 February 2022 (UTC) 3507:07:41, 24 January 2021 (UTC) 2993:Pubmed-indexed meta-analyses 1280:00:04, 23 January 2014 (UTC) 3747:WikiProject Autism articles 3687:FA-Class chemicals articles 3410:17:24, 30 August 2020 (UTC) 2745:04:39, 6 January 2018 (UTC) 2706:13:25, 5 January 2018 (UTC) 1028:Template:WikiProject Autism 585:for details on the project. 3773: 3707:FA-Class medicine articles 3643:12:12, 26 March 2023 (UTC) 3563:12:12, 26 March 2023 (UTC) 3553:00:37, 17 April 2023 (UTC) 3365:04:37, 14 March 2019 (UTC) 2649:(last update: 5 June 2024) 2585:Hello fellow Wikipedians, 2541:(last update: 5 June 2024) 2457:Hello fellow Wikipedians, 2413:(last update: 5 June 2024) 2299:Hello fellow Wikipedians, 2156:20:57, 30 March 2016 (UTC) 2077:|deny=InternetArchiveBot}} 2052:Hello fellow Wikipedians, 1913:06:50, 30 April 2015 (UTC) 1816:Cochrane Database Syst Rev 1051:project's importance scale 847:project's importance scale 730:project's importance scale 617:project's importance scale 511:project's importance scale 360:Featured article candidate 3597:02:37, 25 July 2023 (UTC) 3513:Still an antidepressant? 3468:23:17, 5 March 2021 (UTC) 3281:18:50, 29 July 2018 (UTC) 3243:11:29, 20 July 2018 (UTC) 3184:01:06, 18 July 2018 (UTC) 3137:06:47, 15 July 2018 (UTC) 3109:06:41, 15 July 2018 (UTC) 3072:06:37, 15 July 2018 (UTC) 3026:06:12, 15 July 2018 (UTC) 2988:04:02, 15 July 2018 (UTC) 2927:04:05, 15 July 2018 (UTC) 2901:03:57, 15 July 2018 (UTC) 2880:03:41, 15 July 2018 (UTC) 2866:03:15, 15 July 2018 (UTC) 2835:02:57, 15 July 2018 (UTC) 2820:02:36, 15 July 2018 (UTC) 2790:01:49, 15 July 2018 (UTC) 2780:What clinical guideline? 2775:01:03, 15 July 2018 (UTC) 2576:21:29, 10 July 2016 (UTC) 2285:12:07, 9 April 2016 (UTC) 2270:07:16, 9 April 2016 (UTC) 2242:04:56, 9 April 2016 (UTC) 2203:18:02, 5 April 2016 (UTC) 2176:15:49, 5 April 2016 (UTC) 1954:18:29, 18 June 2015 (UTC) 1938:18:17, 18 June 2015 (UTC) 1374:13:58, 7 March 2014 (UTC) 1079: 1044: 989: 922: 882:the Psychiatry task force 862: 840: 767: 723: 672: 641:featured article criteria 632: 610: 549: 504: 453: 432: 392: 334: 330: 304:Knowledge (XXG) community 80:Be welcoming to newcomers 3737:FA-Class Autism articles 3568:Higher risk of seizures? 3322:10.1177/2045125316629071 2448:19:38, 4 July 2016 (UTC) 1859:"www.accessdata.fda.gov" 1628:"www.accessdata.fda.gov" 687:WikiProject Neuroscience 569:, a daughter project of 468:WikiProject Pharmacology 324:Today's featured article 3422:the barrier to rotation 2885:and clinical guidelines 2763:Oseltamivir#Medical_use 2581:External links modified 2453:External links modified 2295:External links modified 2048:External links modified 1788:Levenson M, Holland C. 1094:is within the scope of 379:Featured article review 1097:WikiProject Disability 859: 629: 414:This article is rated 75:avoid personal attacks 2257:WP:Other stuff exists 1874:Source of naming info 858: 710:neuroscience articles 628: 572:WikiProject Chemistry 565:WikiProject Chemicals 491:pharmacology articles 418:on Knowledge (XXG)'s 326:on December 21, 2007. 123:Find medical sources: 100:Neutral point of view 2949:You may want to use 2630:regular verification 2522:regular verification 2394:regular verification 1970:D Anthony Patriarche 1185:free review articles 1161:. 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1716: 1708: 1705: 1701: 1697: 1694:(2): 91–110. 1693: 1689: 1682: 1679: 1674: 1657: 1649: 1643: 1641: 1637: 1629: 1623: 1620: 1616: 1609: 1608: 1602: 1601: 1600: 1588: 1587: 1586: 1583: 1579: 1575: 1571: 1567: 1554: 1553: 1552: 1551: 1544: 1540: 1539: 1538: 1537: 1530: 1526: 1525:boxed warning 1522: 1520: 1517: 1516: 1515: 1514: 1508: 1503: 1500: 1498: 1495: 1494: 1493: 1492: 1485: 1483: 1480: 1479: 1478: 1477: 1473: 1472: 1467: 1466: 1463:clinical use. 1461: 1460: 1454: 1453: 1452: 1446: 1440: 1436: 1432: 1428: 1424: 1422: 1416: 1415: 1414: 1413: 1412: 1411: 1407: 1405: 1401: 1397: 1391: 1387: 1380: 1378: 1375: 1371: 1367: 1363: 1359: 1351: 1350: 1346: 1342: 1337: 1333: 1329: 1325: 1322: 1319: 1316: 1309: 1303: 1299: 1295: 1291: 1284: 1283: 1282: 1281: 1277: 1273: 1269: 1265: 1263: 1253: 1245: 1242: 1240: 1237: 1235: 1232: 1231: 1230: 1229: 1224: 1215: 1214: 1209: 1208: 1203: 1200: 1199: 1194: 1193:TRIP database 1190: 1187: 1186: 1181: 1180: 1175: 1172: 1171: 1168: 1164: 1160: 1156: 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