Talk:Enzyme inhibitor - Knowledge (XXG)

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feeling is that historically this is a convenient defintion to complement competitive inhibition. While competitive inhibition only changes the Km non-competitive only changes the Vmax. This is all well and good from a theoretical perspective, but since such inhibitors do not really exist it gets confusing. Personnally I think adding them to the mixed category is a recent academic cop out that is a misschacterisation of non competitive kinetics. What do others feel about this? This is clearly a contentious issue and I have heard many differing opinion from biochemists on this issue. In reality it is quite amazing that this concept is still taught.

2909:) which removes the bottom row. I think the remaining information is very relevant to the lead and does not contain any excess information. The top row depicts what an enyzme does (first paragraph of lead), and the bottom row depicts how an inhibitor works (second paragraph of lead). The current colors do not pass the contrast standards for the color impaired. However the graphic does contain symbols for enzyme (E), substrate (S), product (P), and inhibitor (I). I have added these symbols to the caption. 370: 343: 806:

correct: Mixed inhibition is the most general type of inhibition; competitive, non-competitive and uncompetitive inhibitions are just special cases obtained by setting certain rate constants to zero. See Cleland' series of papers (BBA 67 (1963) 104–137, 173–187, 188–196) for the first modern treatment of enzyme inhibition. This material is also covered in several books (e.g., Bisswanger 2002, Cook & Cleland 2007, Buxbaum 2007) and by a nomenclature draft standard of IUBMB/IUPAC (

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Similary, missing as of dates, sample: "currently approved drugs are enzyme inhibitor". Similarly, but also indicating the article is still dated: "repeated until a sufficiently potent inhibitor is produced. Computer-based methods of predicting the affinity of an inhibitor for an enzyme are also being developed, such as molecular docking" is cited to 2003: "also being developed" still ??? Updates needed. Another example of a

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Irreversible inhibitor sections have not changed that much over the last 20 years. Furthermore I think these sections were well written and organized to begin with. Hence I don't think these sections require a comprehensive rewrite. The main problems with these two sections were lack of citations and jargon, but these has been fixed. Of course, if any additional issues are identified, I will work to correct them.

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The binding of an inhibitor and its effect on the enzymatic activity are two distinctly different things, another problem the traditional equations fail to acknowledge. It is further assumed that noncompetitive inhibition results in 100% inhibition of the enzyme, and fails to consider the possibility

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Reliable secondary sources should be sufficient to support statements about poisons. We are not going to run randomized double blinded clinical studies to confirm that exposure to nerve gas causes deaths in humans. That would obviously be unethical. Animals studies + ancidotal human evidence is more

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There is nowhere here that explains what km and vmax are, and the page on Michaelis–Menten kinetics is too detailed to make it easy to understand the significance of these terms. Their meanings can be deduced from the examples, but that's it. I suggest links to relevant pages. Also, a Lineweaver-Burk

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Is this really true? I would not consider non-competitive inhibition as a sub class of mixed inhibition. We need to be very careful here since non-competitive inhibition is very common in the text books. One might ask why, since it is very rare. In fact, I'm not sure I can even give one example. My

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I don't think this is a realistic option. If it would resort under such a header, I would suggest it to be split into seperate articles. It is indeed an example, but also a topic important enough on itself to deserve an independent article outside gene expression. But I conclude from your remark that

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internal wiki links between text that refer to imgages and the images themselves. Does this work? An alterative would be to include a figure number in each of the captions (figure 1, figure 2, etc.) and refer to the figure number. I cannot find any style guidline that would discourage this, but it

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Thanks SandyGeorgia for your constructive comments. Concerning the lead, for context, it should brefily put in context what an enzyme is and why it is important, but perhaps it could be trimmed back a bit to focus more closely on inhibitors, and that might make it a bit easier to digest. Concerning

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From the article: "Irreversible inhibitors usually react with the enzyme and change it chemically. These inhibitors modify key amino acid residues needed for enzymatic activity. In contrast, reversible inhibitors bind non-covalently and different types of inhibition are produced depending on whether

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I agree that this was ackwardly worded. The general idea is that binding ≠ inhibition. Binding of a molecule to an enzyme does not guarantee it will inhibit, and if it does inhibit, the inhibition may be less than 100%, even if the enzyme is completely occupied by the inhibitor. I have edited this

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There's a couple of paragraphs that do not have citations that concern me. One place is the "Types" section (under "Reversible inhibitors"): uncompetitive inhibition has a citation at the end of its paragraph but the other do not. What is verifying the information in the other three paragraphs, and

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can suggest a couple of editors to take a look at this?) but I'll give some general thoughts below as a non-expert reviewer. I noticed that there's lots of paragraphs that either do not have citations or do not have one at the end. When I write historical bios, I typically require a citation at the

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section had some neutrality issues and also was not up-to-date. This section has been completly rewritten to adress these concerns. I have gone over the rest of the sections and in my opinion, they look like they are in good shape. Basic enzymology concepts that are presented in the Reversible and

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Not sure how to address this. The "Types" and "Examples" subheadings are used twice, but they are under different headings, "Reversible" and "Irreversible", so it is implied that the headings mean "Reversible types", "Irreversible examples", etc. We could spell out the implied meaning, but that

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Unfortunately the entire article is really a mess. The treatment of enzyme kinetics is outdated at best and in places incorrect. I am also not sure why an article for "enzyme inhibitor" largely repeats what is already covered under "enzyme kinetics". But in this one aspect this article is actually

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are clearly related articles, but I think the topics are distinct enough to warrant separate articles. I don't have a problem with both the articles reproducing some information from the other. I think each article with continue to grow and become more thorough and they will gradually diverge in

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This article, thankfully, seems to get the definitions of competitive, non-competitive, uncompetitive, and mixed inhibition exactly right. However, the articles on those specific kinds of inhibition are a mess, largely because there is a lot of misinformation all over the internet about the exact

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Actually, "irreversible inhibitor" is an oxymoron, inhibition is by definition always reversible. Irreversible processes are called "inactivation". Inactivators usually form covalent bonds to the enzyme, but for example the interaction of metal centers with cystein or histidine side chains can be

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Well, enzyme induction is just one particular type of the thousands of changes in gene expression which organisms can make in response to their environment. It seems quite separate from interactions of chemicals with these proteins after they have been synthesised. So yes, I do oppose the merger.

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The lead image has been modified to add a checkerboard pattern to the inhibitor binding site. The substrate and inhibitor can be described by their shapes (rectangle and rounded rectangle respectively). The figure caption has also been modified to supplement the color legend with pattern/shape

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issues; time context is needed for statements like "More recently, an alternative approach has been applied: rational drug design uses the three-dimensional protein structure of an enzyme's active site to predict which molecules" ... something like ... since the 1970s, in the 21st century, etc.

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currently says that a non-competitive inhibitor is any inhibitor that does not bind to the enzyme's active site. That will be fixed in a few minutes, but I could really use some help bringing the other articles in line with the definitions presented here and backing those definitions with solid

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here, as it is only used for enzymes as far as I know. But there isn't actually that much on this here - perhaps there should be a section devoted to this type of inhibition? Aspects like the way the final product inhibits the initial enzyme, preventing the creation toxic intermediates could be

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Some, such as anti-epileptic drugs, alter enzyme activity by causing more or less of the enzyme to be produced. These effects are called enzyme induction and inhibition and are alterations in gene expression, which is unrelated to the type of enzyme inhibition discussed here.

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Thanks again for your constructive criticisms. All issues that have been identified above have been fixed. The introduction section was not as accessibe as it should have been, but it has been extenstively rewritten and now it should be understandable to a wide audience. The

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The L-B plots are only there for historical purposes, since nobody uses them for data interpretation and they are only used occasionally for data presentation. I have never seen a E-H plot in a modern journal article, so I really don't think people will come across them.

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There is too much text uncited that should be cited, inappropriate use of bolding, and while I am not easily frightened by biomedical topics, I can get no sense from the lead of ... anything. The lead needs to be brought down a level, into plainer English, less jargon.

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I think all the concerns raised above have now largely been addressed. If there are any remaining issues, please let me know and I will try to fix them. Just one note in passing. Above it was suggested that we need a medical review. However, with the exception of the

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Thanks for the suggestion. The Encyclopedia of Virology comes in five volumes and I tracked down the chapter "Antiviral Classification" starting on page 129 to volume 5. I agree it is a much better source and as a bonus, that chapter is freely available, so I have

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My guess would be that it was added by somebody who worked on AChE inhibitors and thought they were very important. This is a bit imbalanced, so I've renamed this "pesticides and herbicides" and will add a broader range of examples. 19:22, 20 January 2010

2442:. Your figure is beautiful and a big improvement over the figure that it replaced, but is not as dead simple as it should for the lead of a featured article. I can simplify the caption, but I am not nearly the artist that you are. Something similar to 1932:

This was noticed near the end of 2020, there is a bunch of problems with the articles. Unsourced sentences, the images are laid out messily, the writing needs a overhaul. There are a lot of issues with this article that I don't think will be fixed.

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Feedback inhibition is a function of some reversible inhibitors. Discussion of this function might be expanded a little in the "Metabolic control" section, but it is not mechanistically different from other types of reversible inhibition.

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I wonder if the intro should focus so much on what is 'not an enzyme inhibitor'. It seems to take up a lot of space. I am considering moving it to the drug section in the article and reducing it to a short disclaimer in the introduction.

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While this terminology results in a simplified way of dealing with kinetic effects relating to the maximum velocity of the Michaelis–Menten equation, it highlights potential problems with the term used to describe effects relating to the

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I think there's confusion between non-competitive, uncompetitive, and mixed. Some literature uses non-competitive and mixed interchangeably. Regardless, uncompetitive inhibition should be including, especially it's Lineweaver-Burk plot.

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I updated the lead to make it more accessible for laypeople and corrected some minor misspellings and whatnot. Surprisingly, „interfers“ is not (yet) accepted British spelling. But I daresay it will be someday, as a posher variant of

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section, the entire section was out-of-date and read like an advertisement for virtual screening. While virtual screening is useful, it is only one many strategies that are used in modern drug disocovery. Therefore I have completely

577:, but at the genetic level, and relates more to pharmacology. This was really necessary because a lot of pharmacology articles had redlinks to enzyme induction and enzyme inhibition, the latter referring to the article I started. 580:

In the introduction of the article I started, I mention the problem and have a redirect to the other article. I created a redirect to enzyme induction from enzyme inhibition, which he changed (in good faith) to enzyme inhibitor.

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OK, thanks for the hint. I have removed all the links to images and replaced with reference to image headers. I have also searched for "see", "above", "below", and "right". Hopefully all references to images have been fixed.

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end of the every paragraph, minimum, to verify the preceding information. I'm not sure how it is with MED articles, as there are formulas involved, so instead I will post some of these paragraphs without citations below:

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Does anyone else see an absolutely disgusting picture of a very weird looking penis that blocks the top of the article? I tried to edit it out but I can't find the source of it. --Surelyican 03:51, 15 December 2006 (UTC)

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Weight-for-weight, tetrodotoxin is ten times as deadly as the venom of the many-banded krait of S.E. Asia. Tetrodotoxin is 10 to 100 times as lethal as black widow spider venom, and more than 10,000 times deadlier than

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There may be confusion if you say a compound blocks "catalysis" as this could be read either to be blocking turnover, or just the catalytic step. I'd prefer activity, which can't be interpreted in this specific way.

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content. If they are merged now, it would make a good article, but in the near future there will be probably end up being a split anyway. So I would suggest just having the two articles refer to each other. --

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Under "Quantitative description" there are paragraphs between formulas that are not cited. I am confused about which sources are verifying this information. Is there a way that citations can be added to these

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Merging or disambiguation is fine when the ultimate article contains the information the user seeks. In this article, however, there is only scant mention of induction at all! In fact, the only mention is:

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can often be difficult, and not a reason alone for opposing an image, it is awkward to have a lead image that breaches MOS:COLOR and that contains excess information. A simpler lead image is still needed.

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Thanks SandyGeorgia for your comments. Most material is now supported by citations, inappropriate bolding removed, and the lead has undergone signficant copyedits, so hopefully it is now more accesssible.

420: 2175:... maximum reaction rate catalyzed by the enzyme) and Km (the concentration of substrate resulting in half maximal enzyme activity) as the concentration of the enzyme's substrate is varried.: 132–167 1605:

redirect to this article? Feedback control is the name of a large field of technology related to electronics and robotics and essentially unrelated to enzyme inhibitors. I would suggest a redirect to

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I also clarified the text regarding the Lineweaver-Burk plots, to make it easier to recognize which diagrams are meant and how they illustrate the type of inhibition (competitive vs. non-competitive).

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How about we change the word from activity in the first paragraph to "catalysis"? Its far more scientific and in the wikipedia definition, catalysis includes biological catalysts, which are enzymes.

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than sufficient. Statements such as 1/3 of currently approved drugs are enzyme inhibitors are uncontroversial and are backed up by reliable secondary sources already included in the article.

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I've been going through Knowledge (XXG) articles and removing the phrase "term used to describe" where I can since it's usually unhelpful fluff; sometimes, I simply change it to "term used to

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reveals a number of duplicate links, but they are probably justifiable by the complexity of the topic; I have rejigged to avoid some Easter egg links, and that should be checked throughout.

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paper - parallel lines that do not intersect. This is a very rare mode of inhibition, so isn't included in the diagrams on this page, but we should probably have a diagram of this in the

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I have reordered a few of the sections, corrected a few inaccuracies, improved the image layout, and have added a few citations. I will add more as I find time. Any additional problems?

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It's on the list for me. Although I should note that I'm not going to be very scientific-literate (my wife was shocked to find out that I don't know how many chromosomes a human has).

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In the references, the article names are in italics and the journals names are not. It should be the other way around, according to convention. Is there a special reason for this here?

60: 1841:, etc.) section. Also the sources throughout need to be updated and the images with black background should be replaced with transparent backgrounds. What other problems are there? 4224: 3096:. Wiktionary has it as "splitting", while regular dictionaries have it as "adhering to". Which is the case here? Can a parenthetical be inserted on first occurrence of the word 64: 3312: 177: 2798:. Throughout, the text refers to image placement with words such as "on the right", etc. Images display in different places on different browers; this needs to be redone. 4234: 4022:

is not the best. It is poorly written, has numerous grammatical errors and is difficult even for me to understand. (Please forgive my immodesty). This one is much better:

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descriptions. I experimented with adding pattern to the substrate and inhibitor, but the results were not very aesthetic. Hopefully the shape descriptions are adequate.

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Links to "sections above" won't work on Knowledge (XXG) mirrors, and need to be spelled out, as do things like "discussed above (where)? I have added inline queries.

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No worries! I might also try to make something for metabolic regulation within pathways (including end-product regulation) as I think it's easiest when visualised.

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are not explaining to the layreader what an enzyme inhibitor is, rather providing too much detail that isn't helpful to the lay reader, who will access the lead.

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this section based on more recent secondary sources. Hopefully the section is now more balanced. It needs some additional copy edits and I am working on this.

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are immune to the toxin due to a single point mutation in their sodium channel that prevents the specific binding of the toxin. Another ion channel inhibitor is

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for alternate suggestion to use the title header on images, and refer to those. What is done now is a GREAT start, but doesn't work on Knowledge (XXG) mirrors.

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are enzyme inhibitors. The article mentions this indirectly in the lead but it is not followed up in the body. I think the article needs a paragraph on this.

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I'm not sure what you mean, do you want to know how a particular binding site is selected and why inhibitors don't bind randomly onto the surface of enzymes?

4229: 2739:(don't repeat heading titles in every subheading). Alternatively, a synomyn could be used, but I cannot think of any good synomyms to use in this context. 2309:(for example, natural poisons and drugs) contains biomedical/health statements that I don't feel qualified to assess; the article needs a medical reviewer. 4269: 3673:

Another problem the traditional equations fail to acknowledge is that the binding of an inhibitor and its effect on the enzymatic activity are distinct.

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I am going to be traveling for my son's wedding, and won't be able to follow progress on this nom for several weeks, but on a quick final glance I see:

1920: 1122: 499: 377: 348: 611:, I think. But then the explanation about enzyme inhibitors would kinda not fit under this title. As you can see I'm struggling, please help out! :-) 1870: 1801:

This featured article, last reviewed in 2006, has turned into quite a wreck since Tim Vickers stopped editing; unless someone is able to bring it to

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However, I think your suggestion of a disambiguation page could work very well, since these terms sound quite similar and could indeed be confused.--

4259: 2033:, is fairly technical, and the only support I could find was in a predatory source. Prehaps it would be best to delete this material altogether. 4209: 2983:, missing as of date, is: "An estimated 29% of currently approved drugs are enzyme inhibitors of which approximately 1/3 are kinase inhibitors." 2228:. I will work on adding more citations to other parts of the article and remove citation overkill. Congrats to your son and enjoy your trip! 3028:

compliance and comprehensive rewrite has not yet been done. Shall we MOVE to FARC or is someone able to do a comprehensive check and update?

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I don't think we need much more. We should stress that the enzymes inhibited are mainly virus-encoded and not host ones. Also this citation,

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It seems like this could be changed to "term referring to" but I honestly don't know what that sentence is talking about. Could someone who

3677:?? The equations assume that noncompetitive inhibition results in 100% inhibition of the enzyme, and fail to account for partial inhibition. 490: 467: 4244: 2047:

I do not have the subject-area expertise to comment on what should and should not be in the article, so I will defer to other's judgement.

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I'd forgotton i wrot ethe above since most of the discussion was on the FA nomination page. What you just did is exactly what was needed.

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What is the best way to solve this problem? I can think of various ways but I'm not sure what is the best option, so I wanted to ask here.

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section has now been added to provide a more complete description of what enzyme inhibitor are composed of (small molecules and proteins).

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with many symptoms, including heart arhythmia, nevertheless, it has been widely used in the treatment of various heart conditions such as

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Your figure of non compeditive inhibition is wrong you may want to correct this. The slope i.e (Vmax/Km) does not change in this plot

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Definitely looks improved from the previous version. Gonna need another take from someone more seasoned with medical articles at least.

1707: 821: 1448:, where it could be explained why enzyme inhibition is a case of dissociation, or dissociation a process competitive to dissociation? 221: 1616: 1126: 627:

Enzyme induction is an example of the control of gene expression. I think the Enzyme Induction page should therefore be merged with

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How can this article be considered the authoritative source for information about enzymatic induction when it never discusses it?

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I assume this means irreversible inhibitors bond covalently. I think it's safe to assume, but I'd like to be absolutely certain.

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sources. I suspect it could be a contentious issue as there are tons of sources out there that back the incorrect definitions.

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Since we have Lineweaver-Burk plots of the different inhibitions up, should we also include their Eadie-Hofstee plots as well?

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Kausar S, Said Khan F, Ishaq Mujeeb Ur Rehman M, Akram M, Riaz M, Rasool G, Hamid Khan A, Saleem I, Shamim S, Malik A (2021).

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I have added a number of wiki links for technical terms and provided explained what a dissociation constant is in this

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nomenclature, but it's used inconsistently and more complex inhibitor suituations use a different nomenclature again (

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The article did a good job explaining what enzyme inhibitors do, but only in passing mentioned what they are. A new

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The new graphics are perfect! Both dead simple and visually pleasing. Also thanks for your other edits. Cheers.

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I agree - It probably makes sens to have a highly sinplified variant for the lead image. I'll get on it this week.

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Thanks Z1720 for your comments. I am gradually adding more citations to the sections that you mention. Under the

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on the DFP reaction diagram; can it be redone to use a schematic other than color? See, for example, the maps at

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Uncompetitive is when the inhibitor will only bind to the ES complex, the L-B plot is shown in figures 2 and 3 of

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does not seem to be widely practiced. Disadvantages of this aproach are maintenance and longer figure captions.

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Oh, I forgot to give a reason. The articles are on subjects that don't overlap much. Length is also an issue.

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I certainly agree its absense would be obvious. And it is clearly present in the text books for that reason.

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Sorry, it's summer and I have wound down my Knowledge (XXG) reading so I haven't done any deep reading here.

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isn't even described, but merely used. Should the entry be converted to some kind of lk to a new section of

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doesn't even get mentioned above the third heading (4 screens down from the top of the page), AFAI can see K

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No, you're quite welcome to format these with the cite template. Not a task I'm keen on taking up myself!

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I think it's reasonable to repeat subheadings under different headings in this context, and the shorter

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I've also done a quick scan through the article to find mistakes, but not yet a thorough read-through.

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you think it has little to do with inhibition at the enzyme level, and that you oppose to the merger? --

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on Knowledge (XXG). If you would like to participate, please visit the project page, where you can join

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on Knowledge (XXG). If you would like to participate, please visit the project page, where you can join

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might get the point across more clearly. Can you make something similar? In addition, something like

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The first paragraph in "Measuring" does not have citations. Is citation 33 verifying this information?

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Sounds a good idea, particularly the stuff on induction/repression. I've moved this to Chemotherapy.

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I think including it is a useful pedagogical trick, but it doesn't have many practical applications.

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section, the second half of the section was added after the the article was promoted to FA in this

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Put an explanation of the two levels in the inhibitor article, with a referral to enzyme induction.

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Great! I would not hold up a FAC or FAR over this, but we should try to fix it when it's doable.

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I've added some updated figures throughout, aiming to use similar colour schemes to those used in

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The second paragraph in "Antibiotics" does not have citations. What is verifying this information?

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The first paragraph in "Applications" does not have citations. What is verifying this information?

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Can you be a little more specific? This is one area that I am somewhat familar with. I think the

1755:" since terms don't normally describe. This effort has brought me to in this article (as well as 1403: 4094: 4061: 4049: 3951: 3935: 3921: 3886: 3870: 3850: 3566: 3547: 3523: 3120: 2855: 2839: 2784: 2196: 1784: 1322: 982: 869: 845: 792: 768: 678: 3391:

Much better ... I like it! But you still have to ctrl-f on WHERE? ... there are still several.

3025: 2529:) I've also tried to make the italicisation consistent, but please do check if I've missed any! 2007:

I hope this gives a good start in things to consider. Please ping me if you have any questions.

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The first paragraph in "Pesticides" does not have citations. What is verifying this information?

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It's in the templates and images - been going on for several days. Admins are working on it.

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know tell me if that change would be wrong and, if so, what "term" means in that sentence? —

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strong enough to be virtually irreversible. I have written my PhD thesis about such a case.

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Also, you can do a ctrl-f search on WHERE? to locate the other instances that need fixin'.

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I have removed external jumps from image captions and completed incomplete image captions:

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since it mimics the hydrated sodium ion and blocks the pores. According to William Light:

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nomenclature) as I think it's more common these days. A number of publications use the α

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but probably HDAC inhibitors are not important enough to be mentioned. Any idea why

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I'm on wikibreak myself starting from tomorrow, so I'll catch up at the end of July.

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Acronyms are used before they are defined (eg, ATH, NADH); check throughout needed.

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The same could be done in a "see also" section, but this is not the option I prefer.

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This article appeared on Knowledge (XXG)'s Main Page as Today's featured article on

3795: 3735: 2795: 2151: 1830: 1783: 1318:? Are you sure you're not mixing up uncompetitive inhibition with non competitive? 922: 891: 733: 495: 2195:

I won't be available to help bring this one over the line. Perhaps you can enlist

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standard (and fix the image layout mess, too), the article should be submitted to

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The Na/K-ATPase-mediated signal transduction as a target for new drug development.

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section was also rewritten to bring it up-to-date and to broaden its scope. The

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Paragraphing in the lead makes no sense and it is still not lay-reader friendly.

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Synthesis and structure-activity relationships of neuromuscular blocking agents.

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Sorry for the late reply but I'm perfectly fine with closing without an FARC.

4041: 4001: 3730:(which don't have Wikilinks); the "above" has to be explicitly named in text: 3578: 3509: 3190:) in both American and British English. Now fixed. Thanks for catching this. 2809: 2048: 2008: 1504: 1478: 1451: 1237: 4157:, but there may be a delay in bot processing of the close. Please leave the 2774:

It is a bit problematic though, as it messes with section linking processes.

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seems like an obvious addition. An image of one already exists on that page.

807: 3799: 2998:, I specified when. Concerning molecular docking which was mentioned in the 2878: 963: 958: 4017: 1083: 1064: 1030: 1011: 288:) and some terms that are used in it may be different or absent from other 4180: 4140: 4116: 4102: 4088: 4069: 3977: 3959: 3943: 3929: 3907: 3875: 3855: 3832: 3816: 3787: 3767: 3716: 3696: 3651: 3636: 3617: 3599: 3571: 3555: 3540: 3498: 3479: 3440: 3419: 3405: 3386: 3371: 3352: 3329: 3306: 3283: 3262: 3243: 3218: 3199: 3177: 3147: 3128: 3114: 3085: 3067: 3042: 3016: 2965: 2947: 2918: 2896: 2860: 2844: 2828: 2789: 2769: 2748: 2729: 2708: 2690: 2665: 2643: 2616: 2594: 2564: 2551: 2537: 2498: 2472: 2459: 2428: 2405: 2381: 2363: 2338: 2323: 2301: 2274: 2256: 2237: 2213: 2159: 2129: 2091: 2076: 2056: 2042: 2016: 1965: 1954: 1939: 1850: 1823: 1791: 1741: 1715: 1694: 1680:

these inhibitors bind the enzyme, the enzyme-substrate complex, or both."

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I am aware of the current bad title for enzyme induction, which should be

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Knowledge (XXG) talk:Featured article review/Enzyme inhibitor/archive1#HF

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Knowledge (XXG) does not seem to have anything to link to for clarifying

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with "symbol for" as a shot in the dark. It's still not acceptable, bcz K

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Toxins that block ion channels can also interfere with neural function.

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which gives more examples of this process and mentions how it happens.--

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of inhibitors on enzymes is most commonly the same site that binds the

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Marine toxins and nonmarine toxins: convergence or symbiotic organisms?

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Knowledge (XXG) talk:Featured article review/Enzyme inhibitor/archive1

3290:

Knowledge (XXG) talk:Featured article review/Enzyme inhibitor/archive1

3187: 978:

The natural poisons section does look more balanced with its absence.

944:

It is interesting to note that although this toxin is associated with

3585:. It should not be difficult to do that without dependence on color. 2504: 1098:

I meant to revert TO MisfitToys, not past. Thanks for putting back. –

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for Knowledge (XXG)'s health content are defined in the guideline

3885:, thank you Boghog, and Hog Farm for the heavy lifting. Perhaps 1869:

Further comments should be made on the article's talk page or at

962:), that competes with potassium ions for the binding site on the 588:

Merger of the two articles. This is probably the option I prefer.

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Put a message above each article referring to the other article.

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See, I thought that many drugs period are enzyme inhibitors...

3163:

If so, can we add an inline comment so others won't change it?

2794:

I have addressed that issue; there are still remaining issues.

810:). The German Knowledge (XXG) on enzyme kinetics is also nice ( 305: 246: 161: 1047:

The Magazine of the California Academy of Sciences. 1998 51:3

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My preference would be something similar to option 4 above.

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seem to have created two related but not identical articles.

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Thanks! I can follow from iPad, but can't do much to help.

1722:

Help with related articles on types of reversible inhibition

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Non-competitive inhibition is a sub-set of mixed inhibition.

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Featured articles that have appeared on the main page twice

2925:

A jargon check/wikilinking check is needed throughout; eg,

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Unique sub-headings: the heading "Examples" is used twice.

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OK, the "Antiviral Classification" chapter is sufficient.

3990:

International Journal of Immunopathology and Pharmacology

2629:. Unsure if that should be a cite web or a cite journal. 2450:

figure would be great further down the article. Cheers.

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the single bolded term that is not in the lead sentence,

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the source. What volume/chapter does page 11 refer to?

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will always go to the first use of the section heading.

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I am going to pu this up for Peer review as soon as the

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Hopefully I caught all the remainder in this series of

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Could someone please answer the above question. Cheers

178:

Knowledge (XXG):Identifying reliable sources (medicine)

131: 112: 93: 898:, that is the source of arrow poison and was used for 4215:

Featured articles that have appeared on the main page

3024:

This issues indicates that a top-to-bottom check for

2507:. I've also edited the kinetic mechanisms to use the 2489:" figures, but please feel free to replace. Cheers. 2224:

is a redirect, and hence is an allowed exception to

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Still some text that is uncited that needs citation.

494:, a collaborative effort to improve the coverage of 381:, a collaborative effort to improve the coverage of 4250:

WikiProject Molecular and Cellular Biology articles

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clinical publications about evidence-based medicine

3986:"A review: Mechanism of action of antiviral drugs" 2933:doesn't seem to be linked. Pls check throughout. 2284:section, this article is more within the scope of 4225:Knowledge (XXG) articles that use British English 4188:The above discussion is preserved as an archive. 3410:Missed your inline comments. Now working on it. 2833:I'll give it a read-through over my lunch break. 2814:do you find the lead accessible to a layperson? 1024:Hemlock alkaloids from Socrates to poison aloes. 569:explains inhibition at the protein level, while 1873:. No further edits should be made to this page. 3778:with a reference to the section heading name. 1986:should there be a citation at the end of them? 1044:Eye of Newt, Skin of Toad, Bile of Pufferfish. 4194:No further edits should be made to this page. 4167:template in place on the talk page until the 1859:The following is an archived discussion of a 931:), is a particularly potent inhibitor of the 395:Knowledge (XXG):WikiProject Molecular Biology 8: 4024:Bamford, Dennis; Zuckerman, Mark A. (2021). 3424:Switched them so they will be easier to see 1871:Knowledge (XXG) talk:Featured article review 948:, it appears to be synthesised by bacteria. 43:. Even so, if you can update or improve it, 39:as one of the best articles produced by the 33:; it (or a previous version of it) has been 3707:paragraph and hopefully it is now clearer. 1026:Phytochemistry. 2005 Jun;66(12):1399-1406. 4054:: CS1 maint: location missing publisher ( 1727:definitions. For example, the article on 808:http://www.chem.qmul.ac.uk/iubmb/kinetics/ 456: 337: 264:, which has its own spelling conventions ( 72: 15: 4235:Mid-importance Molecular Biology articles 4008: 3743: 1551:Certainly not! I'm taking down the tags. 894:, a competitive neuromuscular blocker of 440:the Molecular and Cell Biology task force 3734:Proteins can also be natural poisons or 3728:will not work on Knowledge (XXG) mirrors 3608:may be a solution. I am working on it. 1833:section needs to be complemented with a 1207:How do you control inhibitors on enzymes 887:Moved until I can find where to put it. 508:Knowledge (XXG):WikiProject Pharmacology 309: 203:review articles from the past five years 4255:All WikiProject Molecular Biology pages 2757:subheadings are definitely better than 2265:Could we get an update on status here? 1582:No, receptors are not usually enzymes. 1391:In place of this entry at the Dab'n pg 1007:Curr Med Chem. 2002 Aug;9(16):1507-36. 996: 458: 339: 4047: 3950:I can write the section if you agree. 3228:The lead says AIDS, the body says HIV. 2514:' making system (rather than the old K 398:Template:WikiProject Molecular Biology 4093:I don't know where I got "11" from. 2674:why each item is included in See also 2485:Thanks! I have put in place holder " 1432:(AFAI can see) the article isn't on K 296:, this should not be changed without 7: 4265:Mid-importance pharmacology articles 2901:The bottom row of the lead graphic ( 2648:It is both a journal citation and a 2581:I have inserted a simplifed figure ( 1079:Front Biosci. 2005 Sep 1;10:3100-9. 812:http://de.wikipedia.org/Enzymkinetik 488:This article is within the scope of 375:This article is within the scope of 231:Centre for Reviews and Dissemination 4230:FA-Class Molecular Biology articles 4028:(4th ed.). Amsterdam. pp. 11, 129. 3864:, my concerns have been addressed. 3671:"Two distinctly different"? --: --> 2627:this citation needs to be completed 1060:J Nat Prod. 2004 Aug;67(8):1211-5. 890:Other familiar neurotoxins include 328:It is of interest to the following 3055:Discovery and design of inhibitors 3000:Discovery and design of inhibitors 2599:I have also added a second figure 2188:A complete read-through is needed. 591:Creation of a disambiguation page. 14: 4270:WikiProject Pharmacology articles 4210:Knowledge (XXG) featured articles 1977:I am not a medical expert (maybe 1925:talk page notification 2020-12-13 1406:bcz of the piping, i put instead 896:nicotinic acetylcholine receptors 511:Template:WikiProject Pharmacology 228:Other potential sources include: 1473:Should this page should mention 1371:I've added one to that article. 751:As the article currently reads: 481: 460: 368: 341: 310: 250: 165: 52: 19: 2601:File:Enzyme inhibitor types.svg 1759:) with the following sentence: 935:in nerve membranes. This halts 609:enzyme induction and inhibition 528:This article has been rated as 415:This article has been rated as 4260:FA-Class pharmacology articles 3182:That is a typo. It is spelled 3133:Thanks, parenthetical added. 2931:Acetylcholinesterase inhibitor 2759:Types of reversible inhibitors 2222:covalent reversible inhibitors 1645:17:56, 16 September 2009 (UTC) 1625:17:05, 16 September 2009 (UTC) 986:20:16, 20 September 2006 (UTC) 873:20:20, 20 September 2006 (UTC) 861:20:09, 20 September 2006 (UTC) 849:16:45, 18 September 2006 (UTC) 796:20:12, 20 September 2006 (UTC) 784:20:09, 20 September 2006 (UTC) 772:16:39, 18 September 2006 (UTC) 1: 3604:Technically challenging, but 3119:Yes, "splitting" is correct. 2101:I haven't read through yet. 1824:20:54, 13 December 2020 (UTC) 1716:19:45, 23 November 2010 (UTC) 1524:Merge w/ receptor antagonist? 1487:18:19, 30 November 2008 (UTC) 1402:which is clearly contrary to 1316:Image:Inhibition_diagrams.png 1199:16:21, 15 December 2006 (UTC) 1177:03:53, 15 December 2006 (UTC) 1150:04:24, 15 December 2006 (UTC) 1135:03:22, 15 December 2006 (UTC) 1110:00:54, 15 December 2006 (UTC) 933:voltage-gated sodium channels 830:19:38, 23 November 2010 (UTC) 502:and see a list of open tasks. 437:This article is supported by 389:and see a list of open tasks. 378:WikiProject Molecular Biology 189:sources of information about 2907:File:Enzyme inhibitors 2.svg 1894:) 2:32, 6 August 2022 (UTC) 1792:22:53, 5 December 2012 (UTC) 1695:01:42, 14 October 2010 (UTC) 1592:01:29, 25 January 2009 (UTC) 1575:11:36, 25 January 2009 (UTC) 1561:00:26, 25 January 2009 (UTC) 1546:00:21, 25 January 2009 (UTC) 1513:04:07, 20 January 2010 (UTC) 1326:07:57, 16 October 2007 (UTC) 1308:15:43, 13 October 2007 (UTC) 1288:Problem with your inhibition 4245:Mid-importance MCB articles 3968:. Feel to expand and edit. 3893:would you like to revisit? 2849:I found it comprehensible. 956:, from the foxglove plant ( 742:01:16, 17 August 2008 (UTC) 717:22:20, 29 August 2006 (UTC) 4286: 4181:02:32, 6 August 2022 (UTC) 2903:File:Enzyme inhibitors.svg 2438:Evolution and evolvability 2257:17:28, 21 April 2022 (UTC) 2238:16:15, 21 April 2022 (UTC) 2214:13:52, 21 April 2022 (UTC) 2160:10:38, 16 April 2022 (UTC) 1966:04:44, 29 March 2022 (UTC) 1955:14:23, 26 March 2022 (UTC) 1940:23:02, 25 March 2022 (UTC) 1851:00:43, 26 March 2022 (UTC) 1807:WP:Featured article review 1729:non-competitive inhibition 1491:I guess it would be under 1282:16:25, 2 August 2007 (UTC) 1271:07:24, 2 August 2007 (UTC) 747:Non-competitive inhibition 534:project's importance scale 401:Molecular Biology articles 120:Featured article candidate 4141:06:05, 31 July 2022 (UTC) 4117:19:02, 22 July 2022 (UTC) 4103:17:02, 22 July 2022 (UTC) 4089:16:45, 22 July 2022 (UTC) 4070:15:47, 22 July 2022 (UTC) 4002:10.1177/20587384211002621 3978:12:59, 22 July 2022 (UTC) 3960:22:13, 21 July 2022 (UTC) 3944:21:08, 21 July 2022 (UTC) 3930:17:52, 21 July 2022 (UTC) 3908:15:29, 21 July 2022 (UTC) 3876:13:20, 21 July 2022 (UTC) 3856:04:42, 19 July 2022 (UTC) 3833:11:02, 16 July 2022 (UTC) 3817:04:27, 16 July 2022 (UTC) 3794:Substrate is a dab: "The 3788:11:02, 16 July 2022 (UTC) 3768:05:17, 15 July 2022 (UTC) 3717:11:02, 16 July 2022 (UTC) 3697:05:14, 15 July 2022 (UTC) 3652:15:45, 16 July 2022 (UTC) 3637:15:56, 14 July 2022 (UTC) 3618:12:40, 14 July 2022 (UTC) 3600:18:38, 13 July 2022 (UTC) 3572:23:13, 12 July 2022 (UTC) 3556:15:11, 12 July 2022 (UTC) 3541:14:51, 12 July 2022 (UTC) 3506:Noting my queries above, 3499:21:35, 12 July 2022 (UTC) 3480:14:37, 12 July 2022 (UTC) 3441:15:55, 14 July 2022 (UTC) 3420:12:40, 14 July 2022 (UTC) 3406:20:39, 13 July 2022 (UTC) 3387:20:27, 13 July 2022 (UTC) 3372:19:25, 13 July 2022 (UTC) 3353:19:18, 13 July 2022 (UTC) 3330:18:30, 13 July 2022 (UTC) 3307:18:25, 13 July 2022 (UTC) 3292:, Samples of linking ... 3284:14:34, 12 July 2022 (UTC) 3263:09:34, 13 July 2022 (UTC) 3244:14:15, 12 July 2022 (UTC) 3219:09:37, 13 July 2022 (UTC) 3200:09:24, 13 July 2022 (UTC) 3178:14:06, 12 July 2022 (UTC) 3148:14:06, 12 July 2022 (UTC) 3129:14:04, 12 July 2022 (UTC) 3115:14:01, 12 July 2022 (UTC) 3086:11:59, 12 July 2022 (UTC) 3068:09:09, 26 June 2022 (UTC) 3043:15:28, 20 June 2022 (UTC) 3017:11:20, 25 June 2022 (UTC) 2966:11:11, 25 June 2022 (UTC) 2948:15:19, 20 June 2022 (UTC) 2919:10:13, 24 June 2022 (UTC) 2897:15:16, 20 June 2022 (UTC) 2861:17:37, 20 June 2022 (UTC) 2845:15:11, 20 June 2022 (UTC) 2829:15:10, 20 June 2022 (UTC) 2790:13:38, 20 June 2022 (UTC) 2770:12:18, 13 June 2022 (UTC) 2583:File:Enzyme inhibitor.svg 2565:12:46, 13 June 2022 (UTC) 2552:10:36, 13 June 2022 (UTC) 2538:07:56, 13 June 2022 (UTC) 2130:13:43, 9 April 2022 (UTC) 2092:12:13, 9 April 2022 (UTC) 2077:00:28, 4 April 2022 (UTC) 2057:15:30, 3 April 2022 (UTC) 2043:10:24, 3 April 2022 (UTC) 2017:03:30, 3 April 2022 (UTC) 1742:03:52, 2 April 2012 (UTC) 1597:Feedback Control redirect 1462:01:41, 13 July 2008 (UTC) 1381:19:44, 5 March 2008 (UTC) 1366:05:34, 5 March 2008 (UTC) 1343:02:24, 5 March 2008 (UTC) 1251:18:06, 24 July 2007 (UTC) 1241:18:02, 24 July 2007 (UTC) 1226:02:07, 4 March 2007 (UTC) 1216:19:00, 3 March 2007 (UTC) 1003:Tuba Z, Maho S, Vizi ES. 712:article is off the list. 700:10:14, 31 July 2006 (UTC) 527: 476: 436: 414: 363: 336: 152: 75: 71: 41:Knowledge (XXG) community 4191:Please do not modify it. 4026:Encyclopedia of virology 2749:09:23, 5 June 2022 (UTC) 2730:19:31, 3 June 2022 (UTC) 2709:19:25, 3 June 2022 (UTC) 2691:21:11, 1 June 2022 (UTC) 2666:19:25, 3 June 2022 (UTC) 2644:21:06, 1 June 2022 (UTC) 2617:09:33, 5 June 2022 (UTC) 2595:19:45, 4 June 2022 (UTC) 2499:16:58, 5 June 2022 (UTC) 2473:10:04, 5 June 2022 (UTC) 2460:18:44, 3 June 2022 (UTC) 2429:20:56, 1 June 2022 (UTC) 2406:20:54, 1 June 2022 (UTC) 2389:User:Evad37/duplinks-alt 2382:10:19, 5 June 2022 (UTC) 2364:20:53, 1 June 2022 (UTC) 2339:19:09, 5 June 2022 (UTC) 2324:21:10, 1 June 2022 (UTC) 2027:Quantitative description 1866:Please do not modify it. 1658:uncompetitive inhibition 1354:uncompetitive inhibition 683:13:11, 8 July 2006 (UTC) 656:20:27, 3 July 2006 (UTC) 646:19:57, 3 July 2006 (UTC) 636:19:23, 3 July 2006 (UTC) 622:18:39, 3 July 2006 (UTC) 491:WikiProject Pharmacology 4162:featured article review 3668:of partial inhibition. 2672:A short description of 2302:06:54, 7 May 2022 (UTC) 2275:04:20, 7 May 2022 (UTC) 1861:featured article review 1747:"Term used to describe" 1670:16:01, 2 May 2010 (UTC) 883:Section on ion-channels 139:Featured article review 2974:Review throughout for 2776:Enzyme inhibitor#Types 2412:lead image and caption 2282:Enzyme_inhibitor#Drugs 1773: 1631:I've redirected it to 730: 433: 318:This article is rated 4240:FA-Class MCB articles 3996:: 20587384211002621. 2877:While complying with 2652:entry. Added both in 1761: 1675:Clarification request 1477:? and if so, where ? 1446:Dissociation constant 1398:*], enzyme inhibition 1125:comment was added by 725: 565:, started earlier by 514:pharmacology articles 432: 322:on Knowledge (XXG)'s 3889:would have a look. 3583:Great Fire of London 3526:are you satisfied ? 2173:WP:CITATION OVERKILL 2140:— looks better on a 1532:be merged with this 1497:Acetylcholinesterase 1314:You mean this one: 294:relevant style guide 290:varieties of English 209:free review articles 185:. Here are links to 101:Good article nominee 3964:I agree. I made a 3840:Comments posted at 1530:receptor antagonist 1263:feedback inhibition 1257:Feedback inhibition 1183:Eadie-Hofstee Plots 972:atrial fibrillation 966:pump. Digoxin is a 925:, from pufferfish ( 292:. According to the 3740:trypsin inhibitors 3074:Structural classes 2676:would be helpful. 434: 324:content assessment 181:and are typically 113:September 20, 2006 76:Article milestones 4151:removal candidate 4034:978-0-12-814516-6 3464:should be linked? 2766: 2650:Protein Data Bank 2561: 2534: 2469: 2109:British spelling? 1928: 1917:Molecular Biology 1788: 1706:comment added by 1615:comment added by 1310: 1298:comment added by 1138: 968:cardiac glycoside 937:action potentials 820:comment added by 693:Steven Fruitsmaak 691:Option 4 it is!-- 643:Steven Fruitsmaak 619:Steven Fruitsmaak 575:enzyme inhibition 548: 547: 544: 543: 540: 539: 455: 454: 451: 450: 392:Molecular Biology 383:Molecular Biology 349:Molecular Biology 304: 303: 245: 244: 160: 159: 148: 147: 61:December 15, 2006 4277: 4193: 4166: 4160: 4138: 4059: 4053: 4045: 4021: 4012: 3918:anti-viral drugs 3900: 3809: 3802:of the enzyme." 3760: 3689: 3629: 3592: 3533: 3522:for a new look. 3521: 3491: 3472: 3433: 3398: 3364: 3345: 3299: 3276: 3255: 3236: 3211: 3170: 3140: 3107: 3035: 2940: 2889: 2821: 2813: 2764: 2722: 2683: 2636: 2559: 2532: 2467: 2441: 2421: 2398: 2356: 2316: 2249: 2206: 2122: 2069: 1976: 1963: 1937: 1909: 1903:Enzyme inhibitor 1878:The article was 1868: 1835:targeted therapy 1816: 1790: 1785: 1718: 1651:Useful additions 1627: 1609:instead. ~~me 1603:Feedback control 1534:enzyme inhibitor 1421:enzyme inhibitor 1418:effectiveness of 1293: 1261:I've redirected 1120: 1102: 1086: 1073: 1067: 1054: 1048: 1039: 1033: 1020: 1014: 1001: 943: 832: 670:enzyme induction 666:Enzyme inhibitor 617:kind regards, -- 571:enzyme induction 563:Enzyme inhibitor 516: 515: 512: 509: 506: 485: 478: 477: 472: 464: 457: 421:importance scale 403: 402: 399: 396: 393: 372: 365: 364: 359: 356: 345: 338: 321: 315: 314: 306: 257:This article is 254: 247: 191:Enzyme inhibitor 169: 162: 155:Featured article 153:Current status: 134: 115: 96: 73: 56: 31:featured article 27:Enzyme inhibitor 23: 16: 4285: 4284: 4280: 4279: 4278: 4276: 4275: 4274: 4200: 4199: 4198: 4189: 4164: 4158: 4136: 4046: 4035: 4023: 3983: 3898: 3874: 3854: 3807: 3758: 3687: 3663:This loses me: 3627: 3590: 3570: 3531: 3507: 3489: 3470: 3431: 3396: 3362: 3343: 3297: 3274: 3253: 3248:Fixed, struck. 3234: 3209: 3168: 3138: 3105: 3033: 2938: 2887: 2859: 2843: 2819: 2799: 2788: 2720: 2681: 2634: 2524: 2517: 2513: 2435: 2419: 2396: 2354: 2314: 2247: 2204: 2120: 2067: 1970: 1961: 1935: 1906: 1864: 1814: 1799: 1787: 1770: 1757:enzyme kinetics 1749: 1724: 1701: 1677: 1653: 1610: 1599: 1526: 1475:HDAC inhibitors 1471: 1469:HDAC inhibitors 1443: 1439: 1435: 1431: 1415: 1389: 1387:Dab entry at Ki 1290: 1259: 1234: 1209: 1185: 1160: 1121:—The preceding 1117: 1100: 1096: 1091: 1090: 1089: 1074: 1070: 1055: 1051: 1040: 1036: 1021: 1017: 1002: 998: 940: 885: 838: 815: 749: 710:Enzyme kinetics 629:gene expression 603:Another option? 553: 513: 510: 507: 504: 503: 470: 400: 397: 394: 391: 390: 357: 351: 319: 298:broad consensus 261:British English 187:possibly useful 183:review articles 130: 111: 94:August 29, 2006 92: 12: 11: 5: 4283: 4281: 4273: 4272: 4267: 4262: 4257: 4252: 4247: 4242: 4237: 4232: 4227: 4222: 4217: 4212: 4202: 4201: 4197: 4196: 4184: 4183: 4171:goes through. 4132: 4131: 4130: 4129: 4128: 4127: 4126: 4125: 4124: 4123: 4122: 4121: 4120: 4119: 4033: 3948: 3947: 3946: 3911: 3910: 3883:Close w/o FARC 3879: 3878: 3868: 3862:Close w/o FARC 3848: 3838: 3837: 3836: 3835: 3792: 3791: 3790: 3752: 3751: 3738:, such as the 3724: 3723: 3722: 3721: 3720: 3719: 3681: 3680: 3679: 3678: 3674: 3661: 3660: 3659: 3658: 3657: 3656: 3655: 3654: 3575: 3574: 3564: 3558: 3504: 3503: 3502: 3501: 3484:Done, struck. 3457: 3456: 3455: 3454: 3453: 3452: 3451: 3450: 3449: 3448: 3447: 3446: 3445: 3444: 3443: 3355: 3311:Based on this 3267: 3266: 3265: 3225: 3224: 3223: 3222: 3221: 3154: 3153: 3152: 3151: 3150: 3089: 3088: 3070: 3022: 3021: 3020: 3019: 2985: 2984: 2971: 2970: 2969: 2968: 2923: 2922: 2921: 2875: 2874: 2873: 2872: 2871: 2870: 2869: 2868: 2867: 2866: 2865: 2864: 2863: 2853: 2837: 2782: 2735:would violate 2713: 2712: 2711: 2670: 2669: 2668: 2623: 2622: 2621: 2620: 2619: 2597: 2578: 2577: 2576: 2575: 2574: 2573: 2572: 2571: 2570: 2569: 2568: 2567: 2522: 2515: 2511: 2478: 2477: 2476: 2475: 2408: 2386: 2385: 2384: 2347: 2346: 2345: 2344: 2343: 2342: 2341: 2262: 2261: 2260: 2259: 2190: 2189: 2186: 2179: 2176: 2170: 2163: 2162: 2148: 2145: 2114: 2113: 2110: 2099: 2098: 2097: 2096: 2095: 2094: 2024: 2023: 2022: 2021: 2020: 2019: 2005: 2004: 2003: 2000: 1997: 1994: 1991: 1987: 1930: 1929: 1905: 1900: 1899: 1876: 1875: 1855: 1854: 1853: 1798: 1795: 1786: 1768: 1748: 1745: 1723: 1720: 1676: 1673: 1662:143.239.192.26 1652: 1649: 1648: 1647: 1607:Control Theory 1598: 1595: 1580: 1579: 1578: 1577: 1525: 1522: 1521: 1520: 1470: 1467: 1465: 1449: 1441: 1437: 1433: 1429: 1426: 1425: 1424: 1423: 1413: 1400: 1399: 1388: 1385: 1384: 1383: 1346: 1345: 1329: 1328: 1300:134.53.132.215 1289: 1286: 1285: 1284: 1258: 1255: 1254: 1253: 1233: 1232:The references 1230: 1229: 1228: 1208: 1205: 1204: 1203: 1202: 1201: 1184: 1181: 1180: 1179: 1159: 1156: 1155: 1154: 1153: 1152: 1116: 1113: 1095: 1092: 1088: 1087: 1075:Xie Z, Xie J. 1068: 1049: 1034: 1015: 995: 994: 990: 989: 988: 912:poison hemlock 884: 881: 880: 879: 878: 877: 876: 875: 837: 836:Not inhibitors 834: 803: 802: 801: 800: 799: 798: 761: 760: 759: 758: 748: 745: 720: 719: 705: 704: 703: 702: 686: 685: 662: 661: 660: 659: 658: 605: 604: 601: 598: 595: 592: 589: 573:also explains 552: 549: 546: 545: 542: 541: 538: 537: 530:Mid-importance 526: 520: 519: 517: 500:the discussion 486: 474: 473: 471:Mid‑importance 465: 453: 452: 449: 448: 445:Mid-importance 435: 425: 424: 417:Mid-importance 413: 407: 406: 404: 387:the discussion 373: 361: 360: 358:Mid‑importance 346: 334: 333: 327: 316: 302: 301: 255: 243: 242: 241: 240: 226: 213: 194: 170: 158: 157: 150: 149: 146: 145: 142: 135: 132:August 6, 2022 127: 126: 123: 116: 108: 107: 104: 97: 89: 88: 85: 82: 78: 77: 69: 68: 65:March 28, 2023 57: 49: 48: 24: 13: 10: 9: 6: 4: 3: 2: 4282: 4271: 4268: 4266: 4263: 4261: 4258: 4256: 4253: 4251: 4248: 4246: 4243: 4241: 4238: 4236: 4233: 4231: 4228: 4226: 4223: 4221: 4218: 4216: 4213: 4211: 4208: 4207: 4205: 4195: 4192: 4186: 4185: 4182: 4178: 4174: 4170: 4163: 4156: 4152: 4148: 4145: 4144: 4143: 4142: 4139: 4118: 4114: 4110: 4106: 4105: 4104: 4100: 4096: 4095:Graham Beards 4092: 4091: 4090: 4086: 4082: 4078: 4073: 4072: 4071: 4067: 4063: 4062:Graham Beards 4057: 4051: 4043: 4040: 4036: 4031: 4027: 4019: 4016: 4011: 4007: 4003: 3999: 3995: 3991: 3987: 3981: 3980: 3979: 3975: 3971: 3967: 3963: 3962: 3961: 3957: 3953: 3952:Graham Beards 3949: 3945: 3941: 3937: 3936:Jo-Jo Eumerus 3933: 3932: 3931: 3927: 3923: 3922:Graham Beards 3919: 3915: 3914: 3913: 3912: 3909: 3905: 3901: 3897: 3892: 3888: 3887:Graham Beards 3884: 3881: 3880: 3877: 3873: 3872: 3867: 3863: 3860: 3859: 3858: 3857: 3853: 3852: 3847: 3843: 3834: 3830: 3826: 3823: 3820: 3819: 3818: 3814: 3810: 3806: 3801: 3797: 3793: 3789: 3785: 3781: 3777: 3774: 3773: 3772: 3771: 3770: 3769: 3765: 3761: 3757: 3749: 3745: 3741: 3737: 3736:antinutrients 3733: 3732: 3731: 3729: 3718: 3714: 3710: 3705: 3704: 3703: 3702: 3701: 3700: 3699: 3698: 3694: 3690: 3686: 3675: 3670: 3669: 3666: 3665: 3664: 3653: 3649: 3645: 3640: 3639: 3638: 3634: 3630: 3626: 3621: 3620: 3619: 3615: 3611: 3607: 3603: 3602: 3601: 3597: 3593: 3589: 3584: 3580: 3577: 3576: 3573: 3569: 3568: 3563: 3559: 3557: 3553: 3549: 3548:Jo-Jo Eumerus 3545: 3544: 3543: 3542: 3538: 3534: 3530: 3525: 3524:Jo-Jo Eumerus 3519: 3515: 3511: 3500: 3496: 3492: 3488: 3483: 3482: 3481: 3477: 3473: 3469: 3465: 3463: 3458: 3442: 3438: 3434: 3430: 3426: 3423: 3422: 3421: 3417: 3413: 3409: 3408: 3407: 3403: 3399: 3395: 3390: 3389: 3388: 3384: 3380: 3375: 3374: 3373: 3369: 3365: 3361: 3356: 3354: 3350: 3346: 3342: 3337: 3333: 3332: 3331: 3327: 3323: 3318: 3314: 3310: 3309: 3308: 3304: 3300: 3296: 3291: 3287: 3286: 3285: 3281: 3277: 3273: 3268: 3264: 3260: 3256: 3252: 3247: 3246: 3245: 3241: 3237: 3233: 3229: 3226: 3220: 3216: 3212: 3208: 3203: 3202: 3201: 3197: 3193: 3189: 3185: 3181: 3180: 3179: 3175: 3171: 3167: 3162: 3160: 3155: 3149: 3145: 3141: 3137: 3132: 3131: 3130: 3126: 3122: 3121:Jo-Jo Eumerus 3118: 3117: 3116: 3112: 3108: 3104: 3099: 3095: 3091: 3090: 3087: 3083: 3079: 3075: 3071: 3069: 3065: 3061: 3056: 3052: 3047: 3046: 3045: 3044: 3040: 3036: 3032: 3027: 3018: 3014: 3010: 3006: 3001: 2997: 2993: 2989: 2988: 2987: 2986: 2982: 2977: 2973: 2972: 2967: 2963: 2959: 2955: 2951: 2950: 2949: 2945: 2941: 2937: 2932: 2928: 2927:isomerization 2924: 2920: 2916: 2912: 2908: 2904: 2900: 2899: 2898: 2894: 2890: 2886: 2880: 2876: 2862: 2858: 2857: 2852: 2848: 2847: 2846: 2842: 2841: 2836: 2832: 2831: 2830: 2826: 2822: 2818: 2811: 2807: 2803: 2797: 2793: 2792: 2791: 2787: 2786: 2781: 2777: 2773: 2772: 2771: 2768: 2760: 2756: 2752: 2751: 2750: 2746: 2742: 2738: 2733: 2732: 2731: 2727: 2723: 2719: 2714: 2710: 2706: 2702: 2698: 2694: 2693: 2692: 2688: 2684: 2680: 2675: 2671: 2667: 2663: 2659: 2655: 2651: 2647: 2646: 2645: 2641: 2637: 2633: 2628: 2624: 2618: 2614: 2610: 2606: 2602: 2598: 2596: 2592: 2588: 2584: 2580: 2579: 2566: 2563: 2555: 2554: 2553: 2549: 2545: 2541: 2540: 2539: 2536: 2528: 2521: 2510: 2506: 2502: 2501: 2500: 2496: 2492: 2488: 2484: 2483: 2482: 2481: 2480: 2479: 2474: 2471: 2463: 2462: 2461: 2457: 2453: 2449: 2445: 2439: 2434: 2433: 2432: 2431: 2430: 2426: 2422: 2418: 2413: 2409: 2407: 2403: 2399: 2395: 2390: 2387: 2383: 2379: 2375: 2371: 2367: 2366: 2365: 2361: 2357: 2353: 2348: 2340: 2336: 2332: 2327: 2326: 2325: 2321: 2317: 2313: 2308: 2305: 2304: 2303: 2299: 2295: 2291: 2287: 2283: 2278: 2277: 2276: 2272: 2268: 2264: 2263: 2258: 2254: 2250: 2246: 2241: 2240: 2239: 2235: 2231: 2227: 2223: 2218: 2217: 2216: 2215: 2211: 2207: 2203: 2198: 2197:Graham Beards 2194: 2187: 2184: 2180: 2177: 2174: 2171: 2168: 2167: 2166: 2161: 2157: 2153: 2149: 2146: 2143: 2139: 2134: 2133: 2132: 2131: 2127: 2123: 2119: 2111: 2108: 2104: 2103: 2102: 2093: 2089: 2085: 2080: 2079: 2078: 2074: 2070: 2066: 2060: 2059: 2058: 2054: 2050: 2046: 2045: 2044: 2040: 2036: 2032: 2028: 2018: 2014: 2010: 2006: 2001: 1998: 1995: 1992: 1988: 1984: 1983: 1980: 1974: 1969: 1968: 1967: 1964: 1958: 1957: 1956: 1952: 1948: 1944: 1943: 1942: 1941: 1938: 1927: 1926: 1922: 1918: 1914: 1908: 1907: 1904: 1901: 1898: 1896: 1893: 1889: 1885: 1881: 1874: 1872: 1867: 1862: 1857: 1856: 1852: 1848: 1844: 1840: 1836: 1832: 1828: 1827: 1826: 1825: 1821: 1817: 1813: 1808: 1804: 1796: 1794: 1793: 1789: 1782: 1778: 1772: 1767: 1760: 1758: 1754: 1746: 1744: 1743: 1739: 1735: 1730: 1721: 1719: 1717: 1713: 1709: 1708:207.42.135.25 1705: 1697: 1696: 1692: 1688: 1684: 1681: 1674: 1672: 1671: 1667: 1663: 1659: 1650: 1646: 1642: 1638: 1634: 1630: 1629: 1628: 1626: 1622: 1618: 1614: 1608: 1604: 1596: 1594: 1593: 1589: 1585: 1576: 1572: 1568: 1564: 1563: 1562: 1558: 1554: 1550: 1549: 1548: 1547: 1543: 1539: 1538:Temporal User 1535: 1531: 1523: 1517: 1516: 1515: 1514: 1510: 1506: 1502: 1498: 1494: 1489: 1488: 1484: 1480: 1476: 1468: 1466: 1464: 1463: 1457: 1453: 1447: 1422: 1419: 1416:, symbol for 1411: 1410: 1409: 1408: 1407: 1405: 1397: 1396: 1395: 1394: 1386: 1382: 1378: 1374: 1370: 1369: 1368: 1367: 1363: 1359: 1355: 1351: 1344: 1340: 1336: 1331: 1330: 1327: 1324: 1321: 1317: 1313: 1312: 1311: 1309: 1305: 1301: 1297: 1287: 1283: 1280: 1275: 1274: 1273: 1272: 1269: 1264: 1256: 1252: 1249: 1245: 1244: 1243: 1242: 1239: 1231: 1227: 1224: 1220: 1219: 1218: 1217: 1214: 1206: 1200: 1197: 1192: 1191: 1190: 1189: 1188: 1182: 1178: 1174: 1170: 1166: 1165: 1164: 1157: 1151: 1148: 1143: 1142: 1141: 1140: 1139: 1136: 1132: 1128: 1124: 1114: 1112: 1111: 1108: 1107: 1103: 1093: 1085: 1082: 1078: 1072: 1069: 1066: 1063: 1059: 1053: 1050: 1046: 1045: 1038: 1035: 1032: 1029: 1025: 1019: 1016: 1013: 1010: 1006: 1000: 997: 993: 987: 984: 981: 977: 976: 975: 973: 969: 965: 961: 960: 955: 951: 947: 938: 934: 930: 929: 924: 919: 917: 913: 909: 905: 901: 897: 893: 888: 882: 874: 871: 868: 864: 863: 862: 859: 855: 854: 853: 852: 851: 850: 847: 844: 835: 833: 831: 827: 823: 822:207.42.135.25 819: 813: 809: 797: 794: 791: 787: 786: 785: 782: 778: 777: 776: 775: 774: 773: 770: 767: 756: 755: 754: 753: 752: 746: 744: 743: 739: 735: 729: 724: 718: 715: 711: 707: 706: 701: 698: 694: 690: 689: 688: 687: 684: 680: 676: 671: 667: 663: 657: 654: 649: 648: 647: 644: 639: 638: 637: 634: 630: 626: 625: 624: 623: 620: 615: 612: 610: 602: 599: 596: 593: 590: 587: 586: 585: 582: 578: 576: 572: 568: 567:User:Edgar181 564: 560: 556: 550: 535: 531: 525: 522: 521: 518: 501: 497: 493: 492: 487: 484: 480: 479: 475: 469: 466: 463: 459: 446: 443:(assessed as 442: 441: 431: 427: 426: 422: 418: 412: 409: 408: 405: 388: 384: 380: 379: 374: 371: 367: 366: 362: 355: 350: 347: 344: 340: 335: 331: 325: 317: 313: 308: 307: 299: 295: 291: 287: 283: 279: 275: 271: 267: 263: 262: 256: 253: 249: 248: 239: 238: 233: 232: 227: 224: 223: 218: 217:TRIP database 214: 211: 210: 205: 204: 199: 196: 195: 192: 188: 184: 180: 179: 174: 173:Ideal sources 171: 168: 164: 163: 156: 151: 143: 141: 140: 136: 133: 129: 128: 124: 122: 121: 117: 114: 110: 109: 105: 103: 102: 98: 95: 91: 90: 86: 83: 80: 79: 74: 70: 66: 62: 58: 55: 51: 50: 46: 42: 38: 37: 32: 28: 25: 22: 18: 17: 4190: 4187: 4154: 4147:Closing note 4146: 4133: 4025: 3993: 3989: 3895: 3882: 3869: 3861: 3849: 3839: 3821: 3804: 3796:binding site 3755: 3753: 3747: 3727: 3725: 3684: 3682: 3662: 3624: 3587: 3565: 3528: 3505: 3486: 3467: 3459: 3428: 3393: 3359: 3340: 3294: 3271: 3250: 3231: 3227: 3206: 3183: 3165: 3158: 3156: 3135: 3102: 3097: 3093: 3030: 3023: 2935: 2926: 2884: 2854: 2838: 2816: 2796:MOS:SEEIMAGE 2783: 2763:T.Shafee(Evo 2758: 2754: 2717: 2678: 2631: 2558:T.Shafee(Evo 2531:T.Shafee(Evo 2519: 2508: 2466:T.Shafee(Evo 2416: 2393: 2351: 2311: 2307:This section 2244: 2201: 2191: 2164: 2117: 2115: 2106: 2100: 2064: 1979:SandyGeorgia 1931: 1921:Pharmacology 1910: 1879: 1877: 1865: 1858: 1831:chemotherapy 1811: 1800: 1797:WP:URFA/2020 1776: 1774: 1765: 1762: 1752: 1750: 1725: 1698: 1685: 1682: 1678: 1654: 1600: 1581: 1527: 1500: 1496: 1492: 1490: 1472: 1459: 1427: 1417: 1401: 1390: 1347: 1291: 1260: 1235: 1210: 1186: 1161: 1118: 1105: 1097: 1076: 1071: 1057: 1052: 1042: 1041:Light, W.H. 1037: 1023: 1022:Reynolds T. 1018: 1004: 999: 991: 957: 949: 945: 926: 923:Tetrodotoxin 920: 892:tubocurarine 889: 886: 839: 804: 762: 750: 731: 726: 721: 616: 613: 606: 583: 579: 574: 557: 554: 529: 505:Pharmacology 496:Pharmacology 489: 468:Pharmacology 438: 416: 376: 330:WikiProjects 285: 281: 277: 273: 269: 265: 258: 235: 229: 220: 207: 201: 190: 186: 176: 172: 154: 137: 118: 100: 99: 45:please do so 34: 26: 3742:(discussed 2992:MOS:CURRENT 2990:Concerning 2981:MOS:CURRENT 2976:MOS:CURRENT 2181:Still some 1990:paragraphs? 1702:—Preceding 1687:Blafreniere 1637:Tim Vickers 1617:204.4.70.37 1611:—Preceding 1584:Tim Vickers 1373:Tim Vickers 1358:Tim Vickers 1294:—Preceding 1279:Tim Vickers 1266:discussed. 1248:Tim Vickers 1127:68.6.230.65 964:Na/K ATPase 900:anaesthesia 816:—Preceding 259:written in 4204:Categories 4173:Nikkimaria 4137:GamerPro64 4042:1240584737 3891:GamerPro64 3672:?? --: --> 3579:MOS:COLOUR 3514:GamerPro64 3313:suggestion 3188:wikt:repel 2994:, in this 2267:Nikkimaria 2193:GamerPro64 2185:wonkiness. 1962:GamerPro64 1936:GamerPro64 1913:TimVickers 1911:Notified: 1884:Nikkimaria 1567:Narayanese 1553:Narayanese 1268:Richard001 1223:TimVickers 1196:TimVickers 1147:TimVickers 992:References 858:TimVickers 781:TimVickers 714:TimVickers 653:TimVickers 633:TimVickers 206:(limit to 106:Not listed 36:identified 4153:has been 4050:cite book 3800:substrate 3315:, I have 3005:rewritten 2879:MOS:COLOR 2695:Added in 2107:interfers 1656:plot for 1601:Why does 1356:article. 1158:Vandalism 1115:Activity? 1056:Daly JW. 959:Digitalis 910:found in 270:travelled 219:provides 200:provides 63:, and on 4149:: This 4018:33726557 3866:Hog Farm 3846:Hog Farm 3776:Replaced 3562:Hog Farm 3518:Hog Farm 3204:Struck, 3026:WP:WIAFA 2851:Hog Farm 2835:Hog Farm 2806:Hog Farm 2780:Hog Farm 2603:in this 2226:MOS:BOLD 2183:MOS:BOLD 2144:, no? ;) 1839:imatinib 1803:WP:WIAFA 1753:refer to 1704:unsigned 1633:Feedback 1613:unsigned 1320:David D. 1296:unsigned 1213:Ahadland 1123:unsigned 1101:Outriggr 1084:15970564 1065:15332834 1031:15955542 1012:12171561 980:David D. 942:cyanide. 916:Socrates 908:alkaloid 867:David D. 843:David D. 818:unsigned 790:David D. 766:David D. 679:Edgar181 320:FA-class 282:artefact 125:Promoted 4077:updated 4010:7975490 3899:Georgia 3808:Georgia 3759:Georgia 3688:Georgia 3676:--: --> 3628:Georgia 3591:Georgia 3532:Georgia 3516:, and 3490:Georgia 3471:Georgia 3432:Georgia 3397:Georgia 3363:Georgia 3344:Georgia 3298:Georgia 3275:Georgia 3254:Georgia 3235:Georgia 3210:Georgia 3169:Georgia 3139:Georgia 3106:Georgia 3034:Georgia 2939:Georgia 2888:Georgia 2820:Georgia 2808:, and 2761:etc. 2737:WP:HEAD 2721:Georgia 2682:Georgia 2635:Georgia 2527:example 2487:pac-man 2420:Georgia 2397:Georgia 2355:Georgia 2315:Georgia 2248:Georgia 2205:Georgia 2121:Georgia 2068:Georgia 1837:(e.g., 1815:Georgia 1528:Should 954:digoxin 904:Coniine 734:Gjbloom 555:Hello! 532:on the 419:on the 286:analyse 278:defence 84:Process 4109:Boghog 4081:Boghog 3970:Boghog 3825:Boghog 3780:Boghog 3709:Boghog 3644:Boghog 3610:Boghog 3460:Which 3412:Boghog 3379:Boghog 3322:Boghog 3192:Boghog 3161:BrEng? 3159:repell 3098:cleave 3094:cleave 3078:Boghog 3060:Boghog 3009:Boghog 2958:Boghog 2911:Boghog 2802:Buidhe 2741:Boghog 2701:Boghog 2699:edit. 2658:Boghog 2656:edit. 2609:Boghog 2587:Boghog 2544:Boghog 2505:enzyme 2491:Boghog 2452:Boghog 2374:Boghog 2331:Boghog 2294:Boghog 2290:WP:MED 2286:WP:MCB 2230:Boghog 2152:Willow 2142:résumé 2138:gofers 2084:Boghog 2035:Boghog 1973:Boghog 1947:Boghog 1888:FACBot 1843:Boghog 1781:Æµ§œš¹ 1460:& 1458:01:37 1404:MoSDab 1335:Dooser 1323:(Talk) 983:(Talk) 870:(Talk) 846:(Talk) 793:(Talk) 769:(Talk) 326:scale. 274:centre 266:colour 198:PubMed 87:Result 3966:start 3916:Many 3896:Sandy 3822:fixed 3805:Sandy 3756:Sandy 3748:above 3744:above 3726:This 3685:Sandy 3625:Sandy 3588:Sandy 3529:Sandy 3510:Z1720 3487:Sandy 3468:Sandy 3462:dimer 3429:Sandy 3394:Sandy 3360:Sandy 3341:Sandy 3317:added 3295:Sandy 3272:Sandy 3251:Sandy 3232:Sandy 3207:Sandy 3184:repel 3166:Sandy 3136:Sandy 3103:Sandy 3051:Drugs 3031:Sandy 2936:Sandy 2885:Sandy 2817:Sandy 2810:Z1720 2765:& 2755:Types 2718:Sandy 2679:Sandy 2632:Sandy 2560:& 2533:& 2468:& 2417:Sandy 2394:Sandy 2370:edits 2352:Sandy 2312:Sandy 2288:than 2245:Sandy 2202:Sandy 2118:Sandy 2065:Sandy 2049:Z1720 2009:Z1720 1812:Sandy 1519:(UTC) 1505:Rod57 1479:Rod57 1452:Jerzy 1238:Pixie 1169:Sandy 906:, an 551:Merge 29:is a 4177:talk 4155:kept 4113:talk 4099:talk 4085:talk 4066:talk 4056:link 4039:OCLC 4030:ISBN 4015:PMID 3974:talk 3956:talk 3940:talk 3926:talk 3904:Talk 3871:Talk 3851:Talk 3829:talk 3813:Talk 3784:talk 3764:Talk 3713:talk 3693:Talk 3648:talk 3633:Talk 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