137:
81:
53:
161:
22:
214:
193:
224:
652:
I'm starting an oral HSP90 inhibitor trial next week at MD Anderson made by
Infinity Pharmaceuticals called IPI-493. I am JAK2 positive and being treated for myelofibrosis. The JAK2 inhibitors worked for one year for me then quit. If you're interested in progress, please feel free to drop me a
379:
On June 4, 2011, at the Annual
Meeting of the American Society for Clinical Oncology (ASCO) a paper was presented on HSP-90 inhibitor ganetespib phase 2 non-small cell lung cancer trial results showing encouraging single agent clinical activity without eye or liver side effects. It is my
879:
According to
Miyazaki et. al. HSP90 (and HSP70) is higher in ALS than controls and remains high through the course of the disease. "The biological source of serum HSPs and the mechanisms mediating the increased expression of serum HSPs in patients with ALS remain unclear."
359:(which is a type of steroid receptor) as an example. In short, Hsp90 is crucial in maintaining steroid receptors in a conformation that is capable of binding hormone and also assists in transporting the receptor from the cytoplasm into the nucleus. I hope this helps.
380:
understanding that ganetespib may be the only current HSP-90 inhibitor that is now showing broad spectrum efficacy with minimal side effects. If so, this remarkable development bears watching and perhaps will merit incorporation in the article.
146:
63:
332:
references this page and labels HSP90 as "Maintenance of steroid receptors and transcription factors." I'm really ignorant about this and was hoping to find this mentioned on this page. Can anybody help?
127:
945:
579:
446:
930:
169:
121:
67:
242:
520:
246:
950:
818:
814:
800:
687:
The lead section claims that Hsp90 assists in tumor repression. Reading through the later sections, it appears to me that the opposite is true: it assists in the
585:
Vague terms of size often are unnecessary and redundant - “some”, “a variety/number/majority of”, “several”, “a few”, “many”, “any”, and “all”. For example, “
97:
745:
impact. A large amount of variation can then be trialled in offspring during long periods of stress, such as when the environment has permanently changed.
925:
876:
Heat shock proteins frequently show up in the research literature on ALS and I wanted to just put in a mention but I could not figure out how to do that.
960:
286:
276:
735:
965:
88:
58:
668:
On a slightly related note. I added a link to a future HSP 90 inhibitor page that I hope with the help of a few students have up in a few days.
627:
575:
940:
466:
151:
786:
251:
174:
955:
796:
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
136:
741:
The suggestion is that Hsp90 plays a very important role in evolution by allowing genetic variation to accumulate without any
691:
of tumors, by stabilizing mutant proteins, growth factor receptors, and signal transduction proteins. This explains why Hsp90
237:
198:
935:
710:
OK, I removed "tumor repression" and instead mentioned its involvement in tumor growth and Hsp90 inhibitors in the intro.
861:
33:
608:
430:
441:. (Note that there might not be an applicable infobox; remember that these suggestions are not generated manually)
817:
to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
313:
852:
778:
450:
434:
408:
356:
774:
635:
337:
836:
If you have discovered URLs which were erroneously considered dead by the bot, you can report them with
824:
438:
39:
777:. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit
622:
Please ensure that the article has gone through a thorough copyediting so that it exemplifies some of
787:
https://web.archive.org/web/20070818224938/http://essays.biochemistry.org/bsessays/040/bse0400041.htm
673:
391:
21:
715:
700:
695:
are investigated as potential cancer medications--why would you want to inhibit a tumor repressor?
385:
329:
309:
654:
96:
on
Knowledge. If you would like to participate, please visit the project page, where you can join
752:
604:
578:
that make the article too wordy instead of being crisp and concise. (You may wish to try Tony1's
507:
470:
469:, headings generally should not repeat the title of the article. For example, if the article was
821:
before doing mass systematic removals. This message is updated dynamically through the template
881:
837:
493:. Certain phrases should specify exactly who supports, considers, believes, etc., such a view.
658:
426:
364:
333:
93:
790:
844:
669:
623:
305:
229:
80:
52:
885:
803:, "External links modified" talk page sections are no longer generated or monitored by
711:
696:
381:
843:
If you found an error with any archives or the URLs themselves, you can fix them with
607:, footnotes usually are located right after a punctuation mark (as recommended by the
919:
748:
490:
417:
360:
160:
420:
image in the top right corner of the article, please try to find and include one.
810:
639:
486:
906:
809:. No special action is required regarding these talk page notices, other than
454:
219:
742:
611:, but not mandatory), such that there is no space in between. For example,
213:
192:
770:
348:
519:
Please make the spelling of
English words consistent with either
736:"How A Fish Unleashed Its Evolutionary Potential And Went Blind"
458:
249:. Please visit the project page for details or ask questions at
523:, depending upon the subject of the article. Examples include:
15:
407:
The following suggestions were generated by a semi-automatic
241:, which recommends that medicine-related articles follow the
453:, years with full dates should be linked; for example, link
159:
135:
889:
866:
756:
719:
704:
677:
662:
642:
411:, and might not be applicable for the article in question.
395:
368:
341:
317:
791:
http://essays.biochemistry.org/bsessays/040/bse0400041.htm
781:
for additional information. I made the following changes:
506:
might be weasel words, and should be provided with proper
355:
discusses the role of Hsp90 in normal cells and uses the
510:(if they already do, or are not weasel terms, please
92:, a collaborative effort to improve the coverage of
946:
WikiProject
Molecular and Cellular Biology articles
813:using the archive tool instructions below. Editors
172:, a task force which is currently considered to be
126:This article has not yet received a rating on the
245:and that biomedical information in any article
799:This message was posted before February 2018.
931:Unknown-importance Molecular Biology articles
243:Manual of Style for medicine-related articles
8:
907:https://www.ncbi.nlm.nih.gov/pubmed/27112486
769:I have just modified one external link on
187:
47:
147:the Molecular and Cell Biology task force
951:All WikiProject Molecular Biology pages
899:
189:
106:Knowledge:WikiProject Molecular Biology
49:
19:
872:Hsp90 in Amyotrophic Lateral Sclerosis
738:and thought I should mention it here.
628:User:Tony1/How to satisfy Criterion 1a
109:Template:WikiProject Molecular Biology
7:
467:Knowledge:Manual of Style (headings)
235:This article is within the scope of
168:This article is within the scope of
86:This article is within the scope of
429:for this article. For example, see
252:Knowledge talk:WikiProject Medicine
38:It is of interest to the following
926:B-Class Molecular Biology articles
14:
773:. Please take a moment to review
613:the sun is larger than the moon .
961:Mid-importance medicine articles
617:the sun is larger than the moon.
591:pigs are pink, so we thought of
489:in this article- please observe
247:use high-quality medical sources
222:
212:
191:
79:
51:
20:
634:You may wish to browse through
485:There are a few occurrences of
473:, instead of using the heading
281:This article has been rated as
966:All WikiProject Medicine pages
261:Knowledge:WikiProject Medicine
1:
757:20:24, 13 December 2013 (UTC)
720:00:13, 25 February 2012 (UTC)
705:23:43, 18 February 2012 (UTC)
264:Template:WikiProject Medicine
170:the Cell Signaling task force
144:This article is supported by
100:and see a list of open tasks.
89:WikiProject Molecular Biology
867:19:58, 7 November 2017 (UTC)
521:American or British spelling
342:11:34, 29 January 2008 (UTC)
941:Mid-importance MCB articles
643:12:06, 20 August 2007 (UTC)
638:for further ideas. Thanks,
425:There may be an applicable
982:
830:(last update: 5 June 2024)
766:Hello fellow Wikipedians,
431:Template:Infobox Biography
287:project's importance scale
112:Molecular Biology articles
956:B-Class medicine articles
890:13:02, 3 March 2019 (UTC)
663:04:39, 12 June 2010 (UTC)
597:ways to turn them green.”
369:06:13, 30 June 2008 (UTC)
318:15:09, 17 June 2006 (UTC)
280:
207:
167:
143:
125:
74:
46:
396:01:07, 5 June 2011 (UTC)
762:External links modified
678:16:30, 9 May 2011 (UTC)
451:Knowledge:Build the web
435:Template:Infobox School
357:glucocorticoid receptor
636:User:AndyZ/Suggestions
615:is usually written as
475:==Magellan's journey==
351:to this article which
164:
140:
28:This article is rated
648:HSP90 Inhibitor Trial
624:Knowledge's best work
439:Template:Infobox City
403:Automated peer review
304:cut & paste from
163:
139:
936:B-Class MCB articles
811:regular verification
580:redundancy exercises
238:WikiProject Medicine
801:After February 2018
732:National Geographic
330:heat shock proteins
855:InternetArchiveBot
806:InternetArchiveBot
471:Ferdinand Magellan
416:If there is not a
409:javascript program
354:
165:
141:
34:content assessment
831:
730:I read Ed Yong's
726:Role in evolution
683:Tumor repression?
447:Knowledge:Context
352:
324:Steroid Receptors
320:
301:
300:
297:
296:
293:
292:
267:medicine articles
186:
185:
182:
181:
103:Molecular Biology
94:Molecular Biology
59:Molecular Biology
973:
909:
904:
865:
856:
829:
828:
807:
596:
590:
399:
303:
269:
268:
265:
262:
259:
232:
227:
226:
225:
216:
209:
208:
203:
195:
188:
128:importance scale
114:
113:
110:
107:
104:
83:
76:
75:
70:
55:
48:
31:
25:
24:
16:
981:
980:
976:
975:
974:
972:
971:
970:
916:
915:
914:
913:
912:
905:
901:
874:
859:
854:
822:
815:have permission
805:
779:this simple FaQ
764:
728:
685:
650:
592:
586:
567:(B) (American:
551:(B) (American:
405:
389:
377:
347:I have added a
328:The article on
326:
266:
263:
260:
257:
256:
230:Medicine portal
228:
223:
221:
201:
111:
108:
105:
102:
101:
61:
32:on Knowledge's
29:
12:
11:
5:
979:
977:
969:
968:
963:
958:
953:
948:
943:
938:
933:
928:
918:
917:
911:
910:
898:
897:
893:
873:
870:
849:
848:
841:
794:
793:
785:Added archive
763:
760:
727:
724:
723:
722:
684:
681:
667:
649:
646:
632:
631:
620:
600:
599:
598:
572:
559:(A) (British:
543:(A) (British:
535:(A) (British:
527:(A) (British:
517:
516:
515:
514:this comment).
504:
499:
483:
462:
443:
422:
404:
401:
394:comment added
376:
373:
372:
371:
325:
322:
310:TenOfAllTrades
299:
298:
295:
294:
291:
290:
283:Mid-importance
279:
273:
272:
270:
234:
233:
217:
205:
204:
202:Mid‑importance
196:
184:
183:
180:
179:
166:
156:
155:
152:Mid-importance
142:
132:
131:
124:
118:
117:
115:
98:the discussion
84:
72:
71:
68:Cell Signaling
56:
44:
43:
37:
26:
13:
10:
9:
6:
4:
3:
2:
978:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
923:
921:
908:
903:
900:
896:
892:
891:
887:
883:
877:
871:
869:
868:
863:
858:
857:
846:
842:
839:
835:
834:
833:
826:
820:
816:
812:
808:
802:
797:
792:
788:
784:
783:
782:
780:
776:
772:
767:
761:
759:
758:
754:
750:
746:
744:
739:
737:
733:
725:
721:
717:
713:
709:
708:
707:
706:
702:
698:
694:
690:
682:
680:
679:
675:
671:
665:
664:
660:
656:
647:
645:
644:
641:
637:
629:
625:
621:
619:
618:
614:
610:
606:
601:
595:
589:
584:
583:
581:
577:
573:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
513:
509:
505:
503:
502:is considered
500:
498:
495:
494:
492:
488:
484:
482:
480:
476:
472:
468:
463:
460:
456:
452:
448:
444:
442:
440:
436:
432:
428:
423:
421:
419:
414:
413:
412:
410:
402:
400:
397:
393:
387:
383:
374:
370:
366:
362:
358:
350:
346:
345:
344:
343:
339:
335:
331:
323:
321:
319:
315:
311:
307:
288:
284:
278:
275:
274:
271:
254:
253:
248:
244:
240:
239:
231:
220:
218:
215:
211:
210:
206:
200:
197:
194:
190:
177:
176:
171:
162:
158:
157:
153:
150:(assessed as
149:
148:
138:
134:
133:
129:
123:
120:
119:
116:
99:
95:
91:
90:
85:
82:
78:
77:
73:
69:
65:
60:
57:
54:
50:
45:
41:
35:
27:
23:
18:
17:
902:
894:
878:
875:
853:
850:
825:source check
804:
798:
795:
768:
765:
747:
740:
731:
729:
692:
688:
686:
666:
651:
633:
616:
612:
602:
593:
587:
576:redundancies
568:
564:
560:
556:
552:
548:
544:
540:
536:
532:
528:
524:
511:
501:
496:
487:weasel words
478:
474:
464:
424:
415:
406:
388:)frankatca
378:
334:doctorwolfie
327:
302:
282:
250:
236:
173:
145:
87:
40:WikiProjects
689:maintenance
626:. See also
605:WP:FOOTNOTE
603:As done in
594:a number of
479:==Journey==
390:—Preceding
349:new section
920:Categories
895:References
862:Report bug
743:phenotypic
693:inhibitors
670:Jasoninkid
574:Watch for
561:signalling
497:apparently
455:January 15
375:Ganetespib
845:this tool
838:this tool
712:AxelBoldt
697:AxelBoldt
653:line. --
557:signaling
529:recognise
525:recognize
508:citations
382:Frankatca
308:removed.
851:Cheers.—
749:Yaris678
734:article
565:any more
418:free use
258:Medicine
199:Medicine
175:inactive
775:my edit
655:Saalanc
569:anymore
553:ization
549:isation
545:isation
541:ization
537:realise
533:realize
427:infobox
392:undated
361:Boghog2
353:briefly
285:on the
30:B-class
640:Tirkfl
512:strike
491:WP:AWT
477:, use
36:scale.
882:dawot
771:Hsp90
437:, or
886:talk
753:talk
716:talk
701:talk
674:talk
659:talk
465:Per
459:2006
449:and
445:Per
386:talk
365:talk
338:talk
314:talk
306:Fink
819:RfC
789:to
609:CMS
588:All
582:.)
563:),
555:),
547:),
539:),
531:),
277:Mid
122:???
64:MCB
922::
888:)
832:.
827:}}
823:{{
755:)
718:)
703:)
676:)
661:)
571:).
457:,
433:,
367:)
340:)
316:)
154:).
66:/
62::
884:(
864:)
860:(
847:.
840:.
751:(
714:(
699:(
672:(
657:(
630:.
481:.
461:.
398:.
384:(
363:(
336:(
312:(
289:.
255:.
178:.
130:.
42::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
