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1083:, thanks for your input and addition to the article. IIRC, there was a three-strand DNA structure proposed by Linus Pauling before Watson and Crick's model was published, which had protonated phosphates at the centre, linked by hydrogen bonds. I don't recall if it was a helix, though. Do you think this and other early DNA structures belong here, rather than just a focus on the 1970s work and since?
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So I've been looking up the history of this area and doing some updates to the organisation of the article to focus a bit more on the historical context of why the theories were initially proposed in the '70s. I think it's probably worthwhile separating which elements are obsolete models before the
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I would say that self-citation is justified to support non-controversial statements, however they shouldn't be the sole support for any contentious claim. Such citations could be appropriate as part of a section discussing the modern incarnations of anti-helicism as a fringe theory, but not to
452:, and the implications for unwinding in bacterial chromosome replication. We need to have a section about that. These topics definitely have to be areas of intense ongoing research right now; any sources or background from anyone familiar with these topics would be greatly appreciated.
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I'm not sure that expanding the scope of this article to include the
Pauling structure is a good idea, since the two are completely unrelated except for both being obsolete. In fact, I think there's a good opportunity to create a new article on
821:
Yes, ironically, the current incarnation as a fringe theory is sufficiently fringe that it'd probably be non-notable in the absence of the historical relevance. The most recent publication on the topic in 2018 was in a journal that also
164:
764:
B-DNA became overwhelming, and which are modern day fringe theories (though there's probably no hard boundary between the two). As well as how to structure the
History section, it will also affect whether the article is just in
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I've found this to be a fascinating topic since I came across it. I think it's telling that the non-helical models were taken seriously enough in the 1970s that Crick felt the need to write a paper specifically to refute it
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885:, which is new to me as a publisher doing peer review after publication. Two reviewers raised issues needing change with that paper and the third rejected it outright. The book chapter by Xu is published by
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I'll first have a go at stripping it back to re-balance first. If possible, I prefer to preserve the history, but TNT can be a backup option if it still ends up accumulating fringe or POV material.
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It's an odd mix I agree. The page was originally just the contemporary 'anti-helicist' material, and the historical work (like
Pauling's triplex) was added later. However, the Pauling triplex
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is to consider an article 'published' (and included in pubmed) only if it has two ticks or one tick and two question marks and the author has not responded to those. In this case,
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800:, but I haven't really looked. The treatment of the Wu and Xu papers is undue; they probably each deserve a sentence or two in the context of it being a fringe theory.
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1140:. Both of these edits relate directly to the topic in this thread, so I wonder if you would like to make any comments on the various issues raised here? Thanks.
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For the more recent fringe-science incarnation, I wonder how many third-party sources there are about it? The only one I'm aware of is the
Gautham comment
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article, MDPI is a very mixed bag publisher. Although I've certainly found high-quality articles in their journals, but plenty of very dodgy ones.
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My opinion is that due weight would be to summarise the post-1970s information to a paragraph or two about the persistence of the fringe theory.
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834:) across multiple internet forums and a kickstarter campaign, so not sure that aspect is notable despite being an interesting phenomenon.
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I will cross-post requesting help from the
Science RD thread, and the Chemistry, Genetics, and Molecular and Cell Biology WikiProjects.
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826:! For contemporary general public discussion, I've done some google and google-news searches, but only found posts by a single person (
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IIRC gives a good historical perspective on this. There's a lot of room to improve this article to give the details of this debate.
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Coelho, P. A.; Queiroz-Machado, J.; Carmo, A. M.; Moutinho-Pereira, S.; Maiato, H.; Sunkel, C. E. (2008). Pellman, David (ed.).
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lists the article, when I click on it I get a "File Not Exists" notice... and the same for other articles I've tried.
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Kim, R. A.; Wang, J. C. (1989). "Function of DNA topoisomerases as replication swivels in
Saccharomyces cerevisiae".
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If user Ycxu2019 is in fact the author Xu You Cheng of references 21, 34, 35, 37, and 38, then we appear to have
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issue. In correcting the refs, I noticed that reference 36, on which Xu has commented (reference 37), is from
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Nitiss, J. L. (1998). "Investigating the biological functions of DNA topoisomerases in eukaryotic cells".
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So, the reason that mainstream scientists lost interest in the non-helical structure was the discovery of
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on
Knowledge (XXG). If you would like to participate, please visit the project page, where you can join
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for that content in the latter page, and it must not be deleted as long as the latter page exists.
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Untangling the Double Helix. DNA Entanglement and the Action of the DNA Topoisomerases
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Wang, J. C. (2002). "Cellular roles of dna topoisomerases: A molecular perspective".
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I am going to start collecting some sources below; please feel free to add more.
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should be treated as a preprint with significant concerns raised by reviewers.
544:"Dual Role of Topoisomerase II in Centromere Resolution and Aurora B Activity"
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Champoux JJ (2001). "DNA topoisomerases: structure, function, and mechanism".
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Biochimica et
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Kresge, Nicole; Simoni, Robert D.; Hill, Robert L. (1 June 2007).
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A Commons file used on this page has been nominated for deletion
706:. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
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I note that reference 21 refers to a red-linked journal (the
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or worse? It's not my area but I thought the discovery of
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the edits and selectively restore what's salvageable.
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597:Gellert, M. (1981). "DNA Topoisomerases".
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