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94:. It is vesiculopustular rash made up of 1–3 mm fluid-filled lesions that rupture, leaving behind a collarette of scale and a brown macule. The lesions are fragile and with no surrounding erythema. This rash occurs only in the newborn stage, usually appearing a few days after birth, but pigmented macules are sometimes already present at birth. The rash usually fades over three to four weeks but may linger for up to three months after birth. It can occur anywhere on the body, including the palms and soles.
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Transient neonatal pustular melanosis is diagnosed clinically, based on appearance alone, with no need for special testing. Proper identification is important to distinguish it from other serious, infectious neonatal diseases and to help avoid unnecessary diagnostic testing and treatments.
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The incidence of TNPM is 0.6% in white infants and 4.4% in
African-American infants in the United States. This rash also generally has a higher incidence in non-African-American infants with skin of color.
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No treatment is needed except for parental reassurance. The rash spontaneously resolves, usually in three to four weeks, but the pigmented macules may linger for up to three months after birth.
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There is significant regional variation and the incidence can vary widely in other nations. For example, in Brazil, transient neonatal pustular melanosis occurs in 9.6% of all newborns.
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On histopathology, the pigmented macules will show basal and supra-basal increase in pigmentation without any pigmentary incontinence. Bacterial culture will be negative.
383:
Ferrándiz, C; Coroleu, W; Ribera, M; Lorenzo, JC; Natal, A (1992). "Sterile transient neonatal pustulosis is a precocious form of erythema toxicum neonatorum".
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Ramamurthy, RS; Reveri, M; Esterly, NB; Fretzin, DF; Pildes, RS (May 1976). "Transient neonatal pustular melanosis".
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Increased frequency of placental squamous metaplasia has been reported in the mothers of some of these infants.
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or a "precocious" form of erythema toxicum neonatorum. No treatment is needed except for parental reassurance.
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A smear of the pustular contents will show polymorphic neutrophils and occasional eosinophils on
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Genetic influence is unlikely as it has been reported in only one of pairs of identical twins.
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The cause of TNPM is unknown. It has been suggested that TNPM is merely a variant of
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Transient neonatal pustular melanosis was clearly identified in 1976 by
Ramamurthy
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KagoTague, Daniel A.; Sunjah, Frida; Kenfack, Kelly; Chiabi, Andreas (2017).
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423:"Transient neonatal pustular melanosis: A frequent misdiagnosis in neonates"
509:"Transient Neonatal Pustular Melanosis: Background, Etiology, Epidemiology"
490:"Transient Neonatal Pustular Melanosis: Background, Etiology, Epidemiology"
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Transient neonatal pustular melanosis was initially described in 1961 as
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and as such was not fully distinguished from other similar rashes.
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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It has been suggested that TNPM is merely a precocious form of
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James, William; Berger, Timothy; Elston, Dirk (2005).
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Araújo, Tami de; Schachner, Lawrence (August 2006).
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327:: CS1 maint: DOI inactive as of September 2024 (
527:"Erupções vesicopustulosas benignas no neonato"
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279:"Neonatal pustular dermatosis: an overview"
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61:Transient neonatal pustular melanosis
33:Transient neonatal pustular melanosis
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180:TNPM occurs equally in both sexes.
90:that is a transient rash common in
565:Disturbances of human pigmentation
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531:Anais Brasileiros de Dermatologia
237:. St. Louis: Mosby. p. 476.
347:"Frequent newborn skin diseases"
544:10.1590/S0365-05962006000400009
427:The Journal of Medical Research
128:The cause of TNPM is unknown.
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468:10.1016/S0022-3476(76)81126-2
283:Indian Journal of Dermatology
42:Transient neonatal pustulosis
18:Transient neonatal pustulosis
193:List of cutaneous conditions
364:10.11138/cderm/2016.4.3.082
133:erythema toxicum neonatorum
99:erythema toxicum neonatorum
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87:neonatal pustular eruption
235:Dermatology: 2-Volume Set
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296:10.4103/0019-5154.152558
215:. (10th ed.). Saunders.
299:(inactive 2024-09-13).
277:Ghosh, S (March 2015).
71:Dermatology, pediatrics
440:10.31254/jmr.2017.3102
80:(TNPM), also known as
456:Journal of Pediatrics
111:lentigines neonatorum
46:lentigines neonatorum
351:Clinical Dermatology
345:Patrizi, A (2016).
82:pustular melanosis
397:10.1159/000247396
244:978-1-4160-2999-1
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67:Specialty
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187:See also
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105:History
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239:ISBN
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