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Studies of phenotype of mice showed that having a loss of an allele resulted in obesity and poor metabolic profiles.
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57:
286:"WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake"
333:
Ducos E, Vergès V, Dugé de
Bernonville T, Blanc N, Giglioli-Guivarc'h N, Dutilleul C (September 2017).
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335:"Remarkable Evolutionary Conservation of Antiobesity ADIPOSE/WDTC1 Homologs in Animals and Plants"
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C-terminus. Reduced expression or disruption of WDTC1 gene is associated with obesity, increased
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Lai CQ, Parnell LD, Arnett DK, García-Bailo B, Tsai MY, Kabagambe EK, et al. (March 2009).
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expression of the WDTC1 gene in mice showed the opposite effect with mice having less adipose.
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435:"The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase"
386:"The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase"
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acting as a suppressor in lipid accumulation. WDTC1 protein consists of seven
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Suh JM, Zeve D, McKay R, Seo J, Salo Z, Li R, et al. (September 2007).
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protein-protein interaction domains, DDB1 binding elements, and a
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Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y (May 2016).
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Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y (May 2016).
217:"Adipose is a conserved dosage-sensitive antiobesity gene"
186:, and ROC1 that restricts transcription in adipogenesis.
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Born lucky: Scientists discover "skinny gene" - MSNBC
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178:. WDTC1 is a factor in a complex composed of
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147:("Adipose") is a gene associated with
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265:"ScienceDaily: 'Skinny Gene' Exists"
164:transient receptor potential channel
22:WD and tetratricopeptide repeats 1
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154:WDTC1 is a gene that codes for a
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501:Genes on human chromosome 1
352:10.1534/genetics.116.198382
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233:10.1016/j.cmet.2007.08.001
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451:10.15252/embr.201540500
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16:Protein found in humans
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174:accumulation, and
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268:. Retrieved
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176:adipogenesis
172:triglyceride
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123:Swiss-model
27:Identifiers
270:2007-09-05
202:References
196:Transgenic
168:prenylated
119:Structures
114:Search for
88:Other data
70:NM_015023
41:NCBI gene
495:Category
469:27113764
420:27113764
371:28663238
339:Genetics
320:19238144
251:17767906
133:InterPro
460:5341520
411:5341520
362:5586369
311:2874970
290:Obesity
242:2587167
156:protein
149:obesity
129:Domains
77:UniProt
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99:Chr. 1
82:Q8N5D0
65:RefSeq
32:Symbol
145:WDTC1
103:p35.3
94:Locus
58:29175
46:23038
35:WDTC1
465:PMID
416:PMID
367:PMID
316:PMID
247:PMID
184:CUL4
180:DDB1
160:WD40
53:HGNC
455:PMC
447:doi
406:PMC
398:doi
357:PMC
347:doi
343:207
306:PMC
298:doi
237:PMC
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