20:
326:
of all cells was using an ancient Wood–Ljungdahl pathway in a hydrothermal setting, but more recent work challenges this conclusion as they argued that the previous study had "undersampled protein families, resulting in incomplete
877:
Preiner, Martina; Igarashi, Kensuke; Muchowska, Kamila B.; Yu, Mingquan; Varma, Sreejith J.; Kleinermanns, Karl; Nobu, Masaru K.; Kamagata, Yoichi; Tüysüz, Harun; Moran, Joseph; Martin, William F. (April 2020).
749:
540:
Paul A. Lindahl "Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon
Monoxide Dehydrogenases" Met. Ions Life Sci. 2009, volume 6, pp. 133–150.
1028:
Xavier, Joana C.; Gerhards, Rebecca E.; Wimmer, Jessica L. E.; Brueckner, Julia; Tria, Fernando D. K.; Martin, William F. (2021-03-26).
248:
278:
reactions of the reductive acetyl-CoA pathway. Recent experiments have tried to replicate this pathway by attempting to reduce CO
149:
302:(10 μM). Joseph Moran and colleagues state that "it has been proposed that either the complete or “horseshoe” forms of the r
175:
Not to be confused with the Wood-Ljungdahl pathway, an evolutionarily related but biochemically distinct pathway named the
473:
661:"Function and regulation of isoforms of carbon monoxide dehydrogenase/acetyl-CoA synthase in Methanosarcina acetivorans"
981:"A new analysis of archaea-bacteria domain separation: Variable phylogenetic distance and the tempo of early evolution"
1186:
307:
79:
879:
743:
275:
936:
M. C. Weiss; et al. (2016). "The physiology and habitat of the last universal common ancestor".
478:
169:
122:
506:
Ragsdale
Stephen W (2006). "Metals and Their Scaffolds To Promote Difficult Enzymatic Reactions".
1165:
1128:
961:
918:
590:
191:
141:
1157:
1120:
1067:
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953:
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792:
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328:
260:
75:
48:
1149:
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1057:
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1000:
992:
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894:
846:
830:
776:
721:
680:
672:
631:
621:
574:
541:
515:
440:
407:
398:
Ljungdahl LG (1986). "The autotrophic pathway of acetate synthesis in acetogenic bacteria".
378:
268:
118:
306:
may have once been united with the acetyl CoA pathway in an ancestral, possibly prebiotic,
19:
468:
291:
90:
445:
428:
382:
1062:
1029:
1005:
980:
851:
814:
813:
Varma, Sreejith J.; Muchowska, Kamila B.; Chatelain, Paul; Moran, Joseph (2018-04-23).
685:
660:
636:
609:
483:
295:
220:
199:
180:
67:
63:
880:"A hydrogen-dependent geochemical analogue of primordial carbon and energy metabolism"
1180:
922:
659:
Matschiavelli, N.; Oelgeschlager, E.; Cocchiararo, B.; Finke, J.; Rother, M. (2012).
340:
1132:
1169:
965:
594:
411:
283:
264:
102:
83:
557:
Spormann, Alfred M.; Thauer, Rudolf K. (1988). "Anaerobic acetate oxidation to CO
137:
and the latter combines the resulting CO with a methyl group to give acetyl-CoA.
949:
764:
545:
287:
176:
94:
1115:
1090:
1045:
780:
614:
Proceedings of the
National Academy of Sciences of the United States of America
253:
It has been proposed that the reductive acetyl-CoA pathway might have begun at
898:
834:
726:
709:
257:
187:
110:
44:
24:
1053:
996:
906:
842:
788:
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303:
271:
126:
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957:
914:
860:
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735:
694:
645:
527:
454:
1161:
1124:
419:
390:
347:
of the common ancestors of archaea and bacteria support that LUCA fixed CO
336:
254:
98:
52:
36:
676:
1153:
578:
332:
231:
209:
194:
183:
165:
161:
145:
519:
319:
114:
130:
40:
429:"A life with acetogens, thermophiles, and cellulolytic anaerobes"
298:(< 30 μM), and even less so under hydrothermal settings with H
144:
bacteria use the Wood–Ljungdahl pathway in reverse to break down
323:
1140:
Diekert G, Wohlfarth G (1994). "Metabolism of homoacetogens".
1030:"The metabolic network of the last bacterial common ancestor"
819:
to intermediates and end-products of the acetyl-CoA pathway"
365:
Ljungdahl LG (1969). "Total synthesis of acetate from CO
117:
participate on the carbon monoxide side of the pathway:
708:
Lyu, Z.; Shao, N.; Akinyemi, T.; Whitman, WB. (2018).
322:
of a set of bacteria and archaea suggested that the
16:
A set of biochemical reactions used by some bacteria
109:) and then combined with the carbon monoxide and
168:. When operating in the reverse direction, the
51:. This pathway enables these organisms to use
35:is a set of biochemical reactions used by some
172:is sometimes called acetyl-CoA decarbonylase.
89:In this pathway carbon dioxide is reduced to
8:
748:: CS1 maint: multiple names: authors list (
765:"The rocky roots of the acetyl-CoA pathway"
101:(R−CH=O), the formyl group is reduced to a
152:(SRB) transform acetate completely into CO
1114:
1061:
1004:
850:
725:
684:
635:
625:
444:
226:
215:
58:
18:
495:
741:
501:
499:
335:family evolution". However geological
324:last universal common ancestor (LUCA)
7:
979:S. J. Berkemer; et al. (2021).
872:
870:
808:
806:
113:to produce acetyl-CoA. Two specific
763:Russell, M. J.; Martin, W. (2004).
610:"The Wolfe cycle comes full circle"
446:10.1146/annurev.micro.091208.073617
383:10.1146/annurev.mi.23.100169.002503
14:
1099:as a source of carbon and energy"
197:, the Wolfe Cycle functions as a
985:Molecular Biology and Evolution
887:Nature Ecology & Evolution
823:Nature Ecology & Evolution
769:Trends in Biochemical Sciences
412:10.1146/annurev.micro.40.1.415
314:Last universal common ancestor
160:coupled with the reduction of
1:
474:Carbon monoxide dehydrogenase
433:Annual Review of Microbiology
400:Annual Review of Microbiology
371:Annual Review of Microbiology
563:Desulfotomaculum acetoxidans
369:by heterotrophic bacteria".
249:Iron–sulfur world hypothesis
950:10.1038/nmicrobiol.2016.116
546:10.1039/9781847559159-00133
179:occurs exclusively in some
97:(HCOOH) or directly into a
1203:
1116:10.1096/fasebj.5.2.1900793
1046:10.1038/s42003-021-01918-4
781:10.1016/j.tibs.2004.05.007
608:Thauer, Rudolf K. (2012).
246:
39:. It is also known as the
1089:Wood HG (February 1991).
899:10.1038/s41559-020-1125-6
835:10.1038/s41559-018-0542-2
727:10.1016/j.cub.2018.05.021
150:sulfate-reducing bacteria
567:Archives of Microbiology
243:Relevance to abiogenesis
1142:Antonie van Leeuwenhoek
815:"Native iron reduces CO
665:Journal of Bacteriology
627:10.1073/pnas.1213193109
343:reconstructions of the
1034:Communications Biology
997:10.1093/molbev/msaa089
33:Wood–Ljungdahl pathway
28:
427:Ljungdahl LG (2009).
359:Historical references
331:which do not reflect
22:
318:A 2016 study of the
1091:"Life with CO or CO
938:Nature Microbiology
677:10.1128/JB.00881-12
620:(38): 15084–15085.
479:Syngas fermentation
282:, with very little
170:acetyl-CoA synthase
123:acetyl-CoA synthase
43:acetyl-coenzyme A (
1187:Metabolic pathways
1154:10.1007/BF00871640
579:10.1007/BF00408310
329:phylogenetic trees
261:hydrothermal vents
223:such as hydrogen (
29:
720:(13): R727–R732.
520:10.1021/cr0503153
345:metabolic network
269:transition metals
76:electron acceptor
1194:
1173:
1136:
1118:
1076:
1075:
1065:
1025:
1019:
1018:
1008:
991:(8): 2332–2340.
976:
970:
969:
944:(16116): 16116.
933:
927:
926:
884:
874:
865:
864:
854:
829:(6): 1019–1024.
810:
801:
800:
760:
754:
753:
747:
739:
729:
710:"Methanogenesis"
705:
699:
698:
688:
656:
650:
649:
639:
629:
605:
599:
598:
554:
548:
538:
532:
531:
514:(8): 3317–3337.
503:
458:
448:
423:
394:
229:
218:
119:CO dehydrogenase
61:
1202:
1201:
1197:
1196:
1195:
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1192:
1191:
1177:
1176:
1148:(1–3): 209–21.
1139:
1098:
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1083:Further reading
1080:
1079:
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978:
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876:
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714:Current Biology
707:
706:
702:
671:(19): 5377–87.
658:
657:
653:
607:
606:
602:
560:
556:
555:
551:
539:
535:
505:
504:
497:
492:
469:Carbon fixation
465:
426:
397:
368:
364:
361:
354:
351:and relied on H
350:
316:
308:carbon fixation
301:
286:observed using
281:
251:
245:
240:
228:
224:
221:electron donors
217:
213:
207:
159:
155:
148:. For example,
136:
108:
91:carbon monoxide
73:
60:
56:
17:
12:
11:
5:
1200:
1198:
1190:
1189:
1179:
1178:
1175:
1174:
1137:
1096:
1092:
1084:
1081:
1078:
1077:
1020:
971:
928:
893:(4): 534–542.
866:
816:
802:
775:(7): 358–363.
755:
700:
651:
600:
573:(4): 374–380.
558:
549:
533:
494:
493:
491:
488:
487:
486:
484:Methanogenesis
481:
476:
471:
464:
461:
460:
459:
424:
395:
366:
360:
357:
352:
348:
315:
312:
299:
296:reducing agent
279:
265:metal sulfides
247:Main article:
244:
241:
239:
236:
205:
200:methanogenesis
157:
153:
134:
106:
80:building block
71:
68:carbon dioxide
64:electron donor
23:The reductive
15:
13:
10:
9:
6:
4:
3:
2:
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1117:
1112:
1109:(2): 156–63.
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1055:
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417:
413:
409:
406:(1): 415–50.
405:
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380:
377:(1): 515–38.
376:
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356:
346:
342:
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321:
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293:
292:zerovalent Fe
289:
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125:. The former
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69:
65:
54:
50:
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34:
26:
21:
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988:
984:
974:
941:
937:
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886:
826:
822:
772:
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744:cite journal
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603:
570:
566:
562:
552:
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511:
507:
436:
432:
403:
399:
374:
370:
341:phylogenomic
317:
252:
204:to reduce CO
198:
181:methanogenic
174:
139:
103:methyl group
99:formyl group
88:
84:biosynthesis
32:
30:
439:(1): 1–25.
288:native iron
190:. In these
188:methanogens
177:Wolfe Cycle
95:formic acid
1040:(1): 413.
490:References
310:network".
111:coenzyme A
45:acetyl-CoA
25:acetyl-CoA
1054:2399-3642
923:211729738
907:2397-334X
843:2397-334X
789:0968-0004
587:0302-8933
508:Chem. Rev
304:TCA cycle
276:prebiotic
238:Evolution
192:anaerobic
142:anaerobic
133:of the CO
131:reduction
127:catalyzes
93:(CO) and
78:and as a
41:reductive
1181:Category
1133:45967404
1072:33772086
1015:32316034
958:27562259
915:32123322
861:29686234
797:15236743
736:29990451
695:22865842
646:22955879
528:16895330
463:See also
455:19575555
337:evidence
284:pyruvate
272:catalyze
258:alkaline
255:deep sea
234:(HCOO).
74:) as an
62:) as an
53:hydrogen
37:bacteria
1170:7473300
1162:7747932
1125:1900793
1103:FASEB J
1063:7997952
1006:7403611
966:2997255
852:5969571
686:3457241
637:3458314
595:2158253
420:3096193
391:4899080
333:protein
320:genomes
294:) as a
232:formate
219:) with
210:methane
202:pathway
195:archaea
186:called
184:archaea
166:sulfide
162:sulfate
146:acetate
115:enzymes
49:pathway
27:pathway
1168:
1160:
1131:
1123:
1070:
1060:
1052:
1013:
1003:
964:
956:
921:
913:
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859:
849:
841:
795:
787:
734:
693:
683:
644:
634:
593:
585:
526:
453:
418:
389:
263:where
230:) and
66:, and
1166:S2CID
1129:S2CID
1095:and H
962:S2CID
919:S2CID
883:(PDF)
591:S2CID
290:(Fe,
208:into
156:and H
140:Some
1158:PMID
1121:PMID
1068:PMID
1050:ISSN
1011:PMID
954:PMID
911:PMID
903:ISSN
857:PMID
839:ISSN
793:PMID
785:ISSN
750:link
732:PMID
691:PMID
642:PMID
583:ISSN
524:PMID
451:PMID
416:PMID
387:PMID
339:and
274:the
267:and
129:the
121:and
105:(−CH
82:for
31:The
1150:doi
1111:doi
1058:PMC
1042:doi
1001:PMC
993:doi
946:doi
895:doi
847:PMC
831:doi
777:doi
722:doi
681:PMC
673:doi
669:194
632:PMC
622:doi
618:109
575:doi
571:150
565:".
561:by
542:doi
516:doi
512:106
441:doi
408:doi
379:doi
164:to
70:(CO
1183::
1164:.
1156:.
1146:66
1144:.
1127:.
1119:.
1105:.
1101:.
1066:.
1056:.
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712:.
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498:^
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435:.
431:.
414:.
404:40
402:.
385:.
375:23
373:.
355:.
214:CH
86:.
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1135:.
1113::
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1038:4
1017:.
995::
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367:2
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349:2
300:2
280:2
227:2
225:H
216:4
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206:2
158:2
154:2
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107:3
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57:H
55:(
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