256:
104:
35:
20:
195:
477:
are commonly used. Age determination of fish and shellfish is a fundamental step in generating basic biological data such as growth curves, and is needed for many stock assessment methods. Several studies have indicated that quantifying the amount of lipofuscin present in the eye-stalks of various
869:
Elleder, M; Drahota, Z; Lisá, V; Mares, V; Mandys, V; Müller, J; Palmer, DN (1995). "Tissue culture loading test with storage granules from animal models of neuronal ceroid-lipofuscinosis (Batten disease): testing their lysosomal degradability by normal and Batten cells".
1018:
Joakim
Allaire; François Maltais; Pierre LeBlanc; Pierre-Michel Simard; François Whittom; Jean-François Doyon; Clermont Simard; Jean Jobin (2002). "Lipofuscin accumulation in the vastus lateralis muscle in patients with chronic obstructive pulmonary disease".
478:
crustaceans can give an index of their age. This method has not yet been widely applied in fisheries management mainly due to problems in relating lipofuscin levels in wild-caught animals with accumulation curves derived from aquarium-reared animals.
179:); after a period of three months, the levels of the lipofuscin-like material return to normal, indicating the action of a significant disposal mechanism. However, this result is controversial, as it is questionable if the
444:
Soraprazan (remofuscin) has been found to remove lipofuscin from retinal pigment epithelial cells in animals. This opens up a new therapy option for the treatment of dry age-related macular degeneration and
171:
The accumulation of lipofuscin-like material may be the result of an imbalance between formation and disposal mechanisms. Such accumulation can be induced in rats by administering a
1131:
Paula-Barbosa, M.; et al. (1991). "The effects of
Piracetam on lipofuscin of the rat cerebellar and hippocampa; neurons after long-term alcohol treatment and withdrawal".
429:
predominantly heats and kills lipofuscin-rich cells, leaving untouched healthy cells to multiply and fill in the gaps. The technique is also used as a skin treatment to remove
222:
knockout mouse has delayed dark adaptation but normal final rod threshold relative to controls. Bleaching the retina with strong light leads to formation of toxic cationic
247:. From this experiment, it was concluded that ABCR has a significant role in preventing formation of A2E in extracellular photoreceptor surfaces during bleach recovery.
812:
826:
Terman, A; Brunk, UT (1998). "Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis".
437:, and in general make skin appear younger. This ability to selectively target lipofuscin has opened up research opportunities in the field of
524:
335:
1597:
907:"Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice"
1166:
Roy, D; Pathak, DN; Singh, R (1983). "Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain".
1645:
473:. Since these animals lack bony parts, they cannot be aged in the same way as bony fish, in which annual increments in the ear-bones or
1956:
1613:
575:
1924:
244:
1282:"Effect of lifetime, administration of dimethylaminoethanol on longevity, aging changes, and cryptogenic neoplasms in C3H mice"
492:
293:
1465:
769:
Terman, A, Brunk, UT (1998). "On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes".
312:
164:. Lipofuscin is also accepted as consisting of oxidized proteins (30–70%) as well as lipids (20–50%). It is a type of
1390:
Julien, S; Schraermeyer, U (Oct 2012). "Lipofuscin can be removed from the retinal pigment epithelium of monkeys".
289:
255:
1064:
Kakimoto, Yu; Okada, Chisa; Kawabe, Noboru; Sasaki, Ayumi; Tsukamoto, Hideo; Nagao, Ryoko; Osawa, Motoki (2019).
281:
103:
118:
1559:
20. Young B, Lowe JS, Stevens A, Heath JW. Wheater's
Functional Histology: A Text and Atlas. 6th ed. Elsevier
34:
1433:
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1638:
1512:
361:
339:
308:
304:
133:
60:
557:
Young B, Lowe JS, Stevens A, Heath JW. Wheater's
Functional Histology: A Text and Atlas. 6th ed. Elsevier
353:
lipofuscin accumulation more directly reflects chronological ageing rather than human cardiac pathology.
2057:
1819:
1787:
806:
1502:
Kerry E. Maxwell; Thomas R. Matthews; Matt R. J. Sheehy; Rodney D. Bertelsen; Charles D. Derby (2007).
1989:
1984:
1941:
1891:
1782:
1761:
1077:
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183:-induced material is true lipofuscin. There exists evidence that "true lipofuscin" is not degradable
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1946:
1914:
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1005:
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23:
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Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment.
1191:
1046:
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851:
794:
635:
394:
1006:
Harvard
Medical signs agreement with Merck to develop potential therapy for macular degeneration
144:. Aside from a large lipid content, lipofuscin is known to contain sugars and metals, including
2011:
1586:
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1407:
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Double, KL; Dedov, VN; Fedorow, H; Kettle, E; Halliday, GM; Garner, B; Brunk, UT (June 2008).
520:
446:
316:
274:
145:
71:
digestion. It is considered to be one of the aging or "wear-and-tear" pigments, found in the
1931:
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422:
1999:
1979:
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389:
1403:
678:"Reversible accumulation of lipofuscin-like inclusions in the retinal pigment epithelium"
1081:
622:
597:
382:
appears to significantly reduce accumulation of lipofuscin in the brain tissue of rats.
2021:
2016:
1936:
1335:
Shen, Li-Rong; Parnell, Laurence D.; Ordovas, Jose M.; Lai, Chao-Qiang (January 2013).
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designation for the treatment of
Stargardt disease by the European Medicines Agency.
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19:
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1614:
Unfocused Pulsed Lasers
Selectively Destroy Lipofuscin, AcceleratingFuture.com
613:
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598:"The comparative biology of neuromelanin and lipofuscin in the human brain"
449:, for which there is currently no treatment. The drug has now been granted
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905:
Weng J, Mata NL, Azarian SM, Tzekov RT, Birch DG, Travis GH (July 1999).
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331:
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Lipofuscin accumulation in the eye, is a major risk factor implicated in
172:
141:
92:
68:
1533:
342:. Accumulation of lipofuscin in the colon is the cause of the condition
1909:
1874:
1854:
1731:
1668:
1488:
1066:"Myocardial lipofuscin accumulation in ageing and sudden cardiac death"
474:
466:
324:
84:
57:
1352:
1034:
956:"Retinopathy in mice induced by disrupted all-trans-retinal clearance"
1525:
157:
114:
76:
519:(32nd ed.). Philadelphia, PA: Saunders/Elsevier. p. 1062.
1479:
1456:
461:
Lipofuscin quantification is used for age determination in various
426:
328:
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193:
111:
102:
88:
80:
72:
64:
33:
18:
1280:
Stenbäck, Frej; Weisburger, J. H.; Williams, G. M. (1988-02-01).
161:
153:
1627:
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Also, pathological accumulation of lipofuscin is implicated in
194:
1623:
1213:
954:
Maeda A, Maeda T, Golczak M, Palczewski K (September 2008).
1609:
Destroying
Lipofuscin and Destroying Cancer, FightAging.org
1455:
Ingebrigt Uglem, Mark
Belchier & Terje Svåsand (2005).
1231:"Effect of ginkgo biloba extract on livers in aged rats"
136:
and may be symptomatic of membrane damage, or damage to
372:
appear to reduce or halt the production of lipofuscin.
41:
showing a cluster of lipofuscin particles (arrow) in a
1605: – Histology Learning System at Boston University
277:, an inherited juvenile form of macular degeneration.
30:
showing stained lipofuscin granules in blue and yellow
1965:
1890:
1661:
1461:L.) by histological quantification of lipofuscin"
1229:Huang, SZ; Luo, YJ; Wang, L; Cai, KY (Jan 2005).
168:and is specifically arranged around the nucleus.
682:Investigative Ophthalmology & Visual Science
49:stain; scale bar = 10 microns (0.01 millimeters)
510:
508:
284:, abnormal accumulation of lipofuscin known as
1133:Alcoholism: Clinical and Experimental Research
744:Investigative Ophthalmology and Visual Science
713:Investigative Ophthalmology and Visual Science
16:Lipid-containing residue associated with aging
1639:
8:
811:: CS1 maint: multiple names: authors list (
262:of heart muscle showing lipofuscin pigment,
128:Lipofuscin appears to be the product of the
1646:
1632:
1624:
1508:, the Caribbean spiny lobster, in Florida"
110:showing lipofuscin, in brown/yellow, in a
1478:
1457:"Age determination of European lobsters (
1256:
1246:
1107:
1089:
981:
971:
922:
738:Davies, Sallyanne; Ellis, Steven (1999).
621:
584:Stanislaus Journal of Biochemical Reviews
567:
565:
563:
1569:Terman A, Brunk U (2004). "Lipofuscin".
1504:"Neurolipofuscin is a measure of age in
517:Dorland's illustrated medical dictionary
504:
191:over longer time periods is not clear.
56:is the name given to fine yellow-brown
804:
709:"Is Lipofuscin Eliminated from Cells?"
707:Terman, Alexei; Brunk, Ulf T. (1999).
336:chronic obstructive pulmonary disease
7:
1404:10.1016/j.neurobiolaging.2011.12.009
1286:Mechanisms of Ageing and Development
676:Katz, ML; Rice, LM; Gao, CL (1999).
602:Cellular and Molecular Life Sciences
960:The Journal of Biological Chemistry
1957:Fluorescence in situ hybridization
1563:External links for general reviews
1145:10.1111/j.1530-0277.1991.tb00610.x
541:"Medical Definition of LIPOFUSCIN"
14:
1925:Oral and maxillofacial pathology
245:age-related macular degeneration
515:Alberts, Daniel Albert (2012).
493:Advanced glycation end-products
421:can be treated using selective
288:is associated with a family of
296:, the most common of these is
294:neuronal ceroid lipofuscinoses
273:, a degenerative disease, and
1:
1466:Journal of Crustacean Biology
924:10.1016/S0092-8674(00)80602-9
840:10.1016/s0047-6374(98)00073-6
783:10.1016/S0047-6374(97)00129-2
313:amyotrophic lateral sclerosis
1598:Histology at neuro.wustl.edu
1583:10.1016/j.biocel.2003.08.009
1298:10.1016/0047-6374(88)90068-1
1180:10.1016/0531-5565(83)90031-1
243:), which causes dry and wet
385:Other possible treatments:
290:neurodegenerative disorders
2079:
1091:10.1038/s41598-019-40250-0
1603:Histology image: 20301loa
1219:1989 Sep-Oct;9(2):147-53.
614:10.1007/s00018-008-7581-9
425:where a pulsed unfocused
282:peripheral nervous system
119:ground glass hepatocytes
67:-containing residues of
2032:Microbiological culture
1662:Principles of pathology
1571:Int J Biochem Cell Biol
1513:The Biological Bulletin
884:10.1002/ajmg.1320570220
545:www.merriam-webster.com
214:, a lipofuscin example)
134:unsaturated fatty acids
1248:10.3748/wjg.v11.i1.132
1217:Arch Gerontol Geriatr.
1208:Amenta F, Ferrante F,
973:10.1074/jbc.M804505200
340:centronuclear myopathy
266:
215:
125:
99:Formation and turnover
50:
31:
1995:Diagnostic immunology
1820:Programmed cell death
1788:Liquefactive necrosis
1235:World J Gastroenterol
740:"Lipofuscin Turnover"
258:
235:-retinyl-ethanolamine
206:-retinyl-ethanolamine
197:
187:; whether this holds
106:
37:
22:
1990:Medical microbiology
1985:Transfusion medicine
1942:Immunohistochemistry
1892:Anatomical pathology
1783:Coagulative necrosis
1337:"Curcumin and aging"
419:macular degeneration
407:Dimethylethanolamine
271:macular degeneration
251:Relation to diseases
1947:Electron microscopy
1915:Molecular pathology
1793:Gangrenous necrosis
1725:Cellular adaptation
1436:. 17 September 2018
1082:2019NatSR...9.3304K
658:The Free Dictionary
439:anti-aging medicine
362:Calorie restriction
349:On the other hand,
309:Parkinson's disease
305:Alzheimer's disease
1975:Clinical chemistry
1967:Clinical pathology
1952:Immunofluorescence
1920:Forensic pathology
1900:Surgical pathology
1808:Fibrinoid necrosis
1070:Scientific Reports
578:2007-07-15 at the
395:Acetyl-L-carnitine
357:Possible therapies
317:lysosomal diseases
267:
226:-pyridinium salt,
216:
126:
51:
32:
2045:
2044:
2012:Mass spectrometry
1353:10.1002/biof.1086
1035:10.1002/mus.10039
719:(10): 2463–2464.
526:978-1-4160-6257-8
447:Stargardt disease
275:Stargardt disease
2070:
1932:Gross processing
1798:Caseous necrosis
1648:
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1022:Muscle and Nerve
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966:(39): 26684–93.
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750:(8): 1887–1888.
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571:Chris Gaugler, "
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423:photothermolysis
368:, and increased
83:muscle, retina,
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2000:Immunopathology
1980:Hematopathology
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1506:Panulirus argus
1501:
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1392:Neurobiol Aging
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771:Mech Ageing Dev
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608:(11): 1669–82.
595:
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580:Wayback Machine
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1480:10.1651/c-2448
1447:
1434:"EU/3/13/1208"
1425:
1398:(10): 2390–7.
1382:
1347:(1): 133–140.
1327:
1292:(2): 129–138.
1272:
1221:
1201:
1158:
1139:(5): 834–838.
1123:
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1029:(3): 383–389.
1010:
1008:", 23-May-2006
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897:
878:(2): 213–221.
872:Am J Med Genet
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471:spiny lobsters
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377:nootropic drug
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344:melanosis coli
323:, denervation
298:Batten disease
286:lipofuscinosis
252:
249:
231:-retinylidene-
202:-retinylidene-
100:
97:
47:toluidine blue
45:of the brain;
24:Confocal image
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1849:Accumulations
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1577:(8): 1400–4.
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1174:(3): 185–97.
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401:Ginkgo biloba
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264:H&E stain
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123:H&E stain
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36:
29:
25:
21:
2058:Biomolecules
2007:Enzyme assay
1869:
1853:
1848:
1837:Karyorrhexis
1813:Myocytolysis
1803:Fat necrosis
1708:Inflammation
1696:Hemodynamics
1689:Pathogenesis
1574:
1570:
1558:
1520:(1): 55–66.
1517:
1511:
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1497:
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1470:
1464:
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1438:. Retrieved
1428:
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1238:
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1168:Exp Gerontol
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807:cite journal
774:
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685:
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671:
661:, retrieved
657:
654:"lipochrome"
648:
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188:
184:
170:
138:mitochondria
127:
63:composed of
53:
52:
28:motor neuron
26:of a spinal
1861:Hemosiderin
1742:Hyperplasia
1737:Hypertrophy
1713:Cell damage
1076:(1): 3304.
463:crustaceans
451:orphan drug
370:glutathione
175:inhibitor (
91:cells, and
2063:Senescence
2052:Categories
2027:Blood bank
1870:Lipofuscin
1866:Lipochrome
1842:Karyolysis
1771:Cell death
1752:Metaplasia
1619:Lipofuscin
1341:BioFactors
663:2021-02-18
573:Lipofuscin
500:References
457:Other uses
435:liverspots
351:myocardial
321:acromegaly
315:, certain
260:Micrograph
166:lipochrome
108:Micrograph
54:Lipofuscin
43:nerve cell
39:Micrograph
1882:Steatosis
1825:Apoptosis
1762:Glandular
1747:Dysplasia
1679:Neoplasia
1674:Infection
1655:Pathology
1361:1872-8081
1306:0047-6374
1100:2045-2322
380:piracetam
366:vitamin E
181:leupeptin
177:leupeptin
150:aluminium
142:lysosomes
130:oxidation
69:lysosomal
2037:Serology
1832:Pyknosis
1778:Necrosis
1757:Squamous
1701:Ischemia
1591:15147719
1542:17679720
1534:25066618
1420:22829613
1412:22244091
1377:39360837
1369:23325575
1322:45595812
1267:15609412
1196:29129359
1118:30824797
1051:22309073
1043:11870715
992:18658157
941:18605680
933:10412977
856:44822239
799:34448638
756:10393067
725:10476822
632:18278576
623:11131928
586:May 1997
576:Archived
482:See also
475:otoliths
467:lobsters
465:such as
412:Curcumin
332:myopathy
220:ABCR -/-
185:in vitro
173:protease
95:cells.
93:ganglion
85:adrenals
61:granules
1910:Autopsy
1875:Melanin
1855:pigment
1732:Atrophy
1669:Disease
1550:8522101
1489:1549930
1314:3361965
1258:4205372
1188:6416880
1153:1755517
1109:6397159
1078:Bibcode
983:2546559
892:7668332
848:9818731
791:9541135
694:9888441
640:6833509
431:tattoos
325:atrophy
280:In the
189:in vivo
146:mercury
58:pigment
1589:
1548:
1540:
1532:
1487:
1440:1 June
1418:
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1210:et al.
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630:
620:
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495:(AGEs)
338:, and
158:copper
115:biopsy
77:kidney
1684:Cause
1546:S2CID
1530:JSTOR
1485:JSTOR
1416:S2CID
1373:S2CID
1318:S2CID
1192:S2CID
1047:S2CID
937:S2CID
852:S2CID
795:S2CID
636:S2CID
427:laser
329:lipid
117:with
112:liver
89:nerve
81:heart
73:liver
65:lipid
1587:PMID
1538:PMID
1442:2021
1408:PMID
1365:PMID
1357:ISSN
1310:PMID
1302:ISSN
1263:PMID
1184:PMID
1149:PMID
1114:PMID
1096:ISSN
1039:PMID
988:PMID
929:PMID
911:Cell
888:PMID
844:PMID
813:link
787:PMID
752:PMID
721:PMID
690:PMID
628:PMID
521:ISBN
469:and
417:Wet
375:The
218:The
162:zinc
160:and
154:iron
140:and
1579:doi
1522:doi
1518:213
1475:doi
1400:doi
1349:doi
1294:doi
1253:PMC
1243:doi
1176:doi
1141:doi
1104:PMC
1086:doi
1031:doi
978:PMC
968:doi
964:283
919:doi
880:doi
836:doi
832:104
779:doi
775:100
618:PMC
610:doi
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240:A2E
224:bis
211:A2E
132:of
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