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Ichthyotoxin

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104:, an angiogenic inhibitor and alkaloid toxin derived from fire ant venom, euglonophycin has been studied for potential application in natural products and drug development for cancer therapy. Based on experimental studies, anti-cancer activity by euglonophycin was demonstrated in leukemia, neuroblastoma, and colorectal cancer cell lines. Specifically, in colorectal cancer cells, euglenophycin exposure exhibited cytotoxic, anti-proliferative, anti-migratory, and anti-inflammatory activity.  It was determined that autophagic regulation and G1 cell cycle arrest contributes to euglenophycin's ability to inhibit colorectal cancer cell proliferation, prevent metastasis, and suppress tumour inflammation.   49:. Many toxin-producing algal species can be found both in marine and fresh water environments when the algae are in bloom. Ichthyotoxic poisoning in humans can cause symptoms ranging in severity dependent on how much toxin was consumed. The symptoms of an ichthyotoxin poisoning from fish venoms can include headache, vomiting, diarrhea, dizziness, and drop in blood pressure. 416: 218:
Zimba PV, Moeller PD, Beauchesne K, Lane HE, Triemer RE (January 2010). "Identification of euglenophycin--a toxin found in certain euglenoids".
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Ostrand KG, Thies ML, Hall DD, Carpenter M (1996). "Gar ichthyotoxin: Its effect on natural predators and the toxin's evolutionary function".
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are compounds which are either toxic to fish, or are toxins produced by fish. The former include the algae-produced
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Wahome PG, Beauchesne KR, Pedone AC, Cavanagh J, Melander C, Zimba P, Moeller PD (December 2014).
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Cabang AB, De Mukhopadhyay K, Meyers S, Morris J, Zimba PV, Wargovich MJ (November 2017).
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and eggs of several other fish species contain toxins. Toxin-producing algae include
58: 34: 364:"Therapeutic effects of the euglenoid ichthyotoxin, euglenophycin, in colon cancer" 42: 231: 118: 379: 274: 101: 38: 113: 100:, displays anticancer activity. By sharing a similar chemical structure to 17: 397: 343: 292: 239: 415: 308:"Augmenting anti-cancer natural products with a small molecule adjuvant" 253:
Kulczycka A, Łukomska-Kowalczyk M, Zakryś B, Milanowski R (2018-06-01).
204: 324: 46: 41:, which can cause large-scale fish deaths. The latter includes 168:
Dangerous fishes of the Eastern and Southern Arabian Peninsula
68: 64: 121:, poisons derived from plants used for hunting fish 255:"PCR identification of toxic euglenid species 150:"Ichthyotoxic algae and their effects on fish" 8: 387: 333: 323: 282: 94:, a euglenoid ichthyotoxin derived from 137: 357: 355: 353: 7: 143: 141: 25: 414: 1: 232:10.1016/j.toxicon.2009.07.004 263:Journal of Applied Phycology 193:The Southwestern Naturalist 453: 127:, fish which produce venom 56: 380:10.18632/oncotarget.22238 275:10.1007/s10811-017-1376-z 90:It was discovered that 374:(61): 104347–104358. 423:at Wikimedia Commons 81:Anti-cancer research 148:Andersen N (2012). 325:10.3390/md13010065 170:. Cham: Springer. 419:Media related to 257:Euglena sanguinea 166:Jawad LA (2018). 97:Euglena sanguinea 74:Prymnesium parvum 16:(Redirected from 444: 418: 402: 401: 391: 359: 348: 347: 337: 327: 303: 297: 296: 286: 269:(3): 1759–1763. 250: 244: 243: 215: 209: 208: 188: 182: 181: 163: 157: 156: 154: 145: 21: 452: 451: 447: 446: 445: 443: 442: 441: 427: 426: 411: 406: 405: 361: 360: 351: 305: 304: 300: 252: 251: 247: 217: 216: 212: 190: 189: 185: 178: 165: 164: 160: 152: 147: 146: 139: 134: 110: 88: 83: 61: 55: 28: 27:Class of toxins 23: 22: 15: 12: 11: 5: 450: 448: 440: 439: 429: 428: 425: 424: 410: 409:External links 407: 404: 403: 349: 298: 245: 210: 199:(4): 375–377. 183: 176: 158: 136: 135: 133: 130: 129: 128: 122: 116: 109: 106: 87: 84: 82: 79: 54: 51: 45:, produced by 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 449: 438: 437:Ichthyotoxins 435: 434: 432: 422: 421:Ichthyotoxins 417: 413: 412: 408: 399: 395: 390: 385: 381: 377: 373: 369: 365: 358: 356: 354: 350: 345: 341: 336: 331: 326: 321: 317: 313: 309: 302: 299: 294: 290: 285: 280: 276: 272: 268: 264: 260: 258: 249: 246: 241: 237: 233: 229: 225: 221: 214: 211: 206: 202: 198: 194: 187: 184: 179: 177:9783319579269 173: 169: 162: 159: 151: 144: 142: 138: 131: 126: 125:Venomous fish 123: 120: 117: 115: 112: 111: 107: 105: 103: 99: 98: 93: 92:euglonophycin 86:Euglonophycin 85: 80: 78: 76: 75: 70: 66: 60: 59:Venomous fish 52: 50: 48: 44: 40: 36: 35:euglenophycin 32: 31:Ichthyotoxins 19: 371: 367: 318:(1): 65–75. 315: 312:Marine Drugs 311: 301: 266: 262: 256: 248: 226:(1): 100–4. 223: 219: 213: 196: 192: 186: 167: 161: 95: 89: 72: 63:The eggs of 62: 43:ostracitoxin 30: 29: 18:Ichthyotoxic 119:Fish toxins 368:Oncotarget 132:References 102:solenopsin 57:See also: 39:prymnesins 114:Piscicide 431:Category 398:29262645 344:25548974 293:29899599 240:19615398 205:30055193 108:See also 67:and the 53:Examples 389:5732811 335:4306925 284:5982438 220:Toxicon 47:boxfish 396:  386:  342:  332:  291:  281:  238:  203:  174:  201:JSTOR 153:(PDF) 394:PMID 340:PMID 289:PMID 236:PMID 172:ISBN 77:. 37:and 384:PMC 376:doi 330:PMC 320:doi 279:PMC 271:doi 228:doi 69:roe 65:gar 433:: 392:. 382:. 370:. 366:. 352:^ 338:. 328:. 316:13 314:. 310:. 287:. 277:. 267:30 265:. 261:. 234:. 224:55 222:. 197:41 195:. 140:^ 400:. 378:: 372:8 346:. 322:: 295:. 273:: 259:" 242:. 230:: 207:. 180:. 155:. 20:)

Index

Ichthyotoxic
euglenophycin
prymnesins
ostracitoxin
boxfish
Venomous fish
gar
roe
Prymnesium parvum
euglonophycin
Euglena sanguinea
solenopsin
Piscicide
Fish toxins
Venomous fish


"Ichthyotoxic algae and their effects on fish"
ISBN
9783319579269
JSTOR
30055193
doi
10.1016/j.toxicon.2009.07.004
PMID
19615398
"PCR identification of toxic euglenid species Euglena sanguinea"
doi
10.1007/s10811-017-1376-z
PMC

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