302:
344:
InChI=1S/C67H122N12O13/c1-26-48-63(88)73(19)46(17)62(87)74(20)50(34-38(4)5)59(84)72-53(41(10)11)66(91)75(21)49(33-37(2)3)58(83)69-44(15)57(82)70-45(16)61(86)76(22)51(35-39(6)7)64(89)77(23)52(36-40(8)9)65(90)78(24)54(42(12)13)67(92)79(25)55(60(85)71-48)56(81)43(14)31-29-27-28-30-32-68-47(18)80/h37-46,48-56,81H,26-36H2,1-25H3,(H,68,80)(H,69,83)(H,70,82)(H,71,85)(H,72,84)/t43-,44+,45-,46-,48+,49+,50+,51+,52+,53+,54+,55+,56-/m1/s1
83:
25:
499:
Remenchik, Ellen; Mayo, Patrick R.; Hobbs, Todd M.; Greytok, Jill A.; Foster, Erin P.; Zhao, Caroline; Ure, Daren; Trepanier, Daniel J.; Foster, Robert T. (March 2023). "Effect of a High-Fat Meal on Single-Dose
Rencofilstat (CRV431) Oral Bioavailability in Healthy Human Subjects".
543:
Ure, Daren; Leslie, Jack; Haddon, Lacey; Fu, Claude; Mann, Jelena; Mann, Derek (4 April 2023). "Abstract 4125: Rencofilstat exerts a dominant role in synergistic anti-PD1-combination effects in a fatty liver model of hepatocellular carcinoma".
585:
399:
Harrison, Stephen A.; Mayo, Patrick R.; Hobbs, Todd M.; Canizares, Carlos; Foster, Erin P.; Zhao, Caroline; Ure, Daren R.; Trepanier, Daniel J.; Greytok, Jill A.; Foster, Robert T. (December 2022).
324:
CC1C(=O)N((C(=O)N((C(=O)N(C(=O)N((C(=O)N(C(=O)N(C(=O)N((C(=O)N((C(=O)N((C(=O)N((C(=O)N1)((C)CCCCCCNC(=O)C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C
316:
590:
336:
450:"The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of Its Antiviral Activity"
111:
375:
196:
401:"Rencofilstat, a cyclophilin inhibitor: A phase 2a, multicenter, single-blind, placebo-controlled study in F2/F3 NASH"
595:
379:
225:
448:
Stauffer, Winston; Bobardt, Michael; Ure, Daren; Foster, Robert; Gallay, Philippe (17 October 2023).
131:
561:
525:
517:
481:
430:
185:
140:
553:
509:
471:
461:
420:
412:
241:
35:
205:
476:
449:
425:
400:
371:
165:
579:
565:
529:
54:
557:
367:
274:
176:
74:
44:
521:
485:
434:
24:
82:
151:
513:
466:
416:
216:
586:
Experimental drugs developed for non-alcoholic fatty liver disease
301:
292:
18:
49:
39:
290:
273:
240:
235:
215:
195:
175:
150:
130:
102:
94:
89:
164:
139:
8:
73:
184:
81:
502:Clinical Pharmacology in Drug Development
475:
465:
424:
204:
391:
341:
321:
116:
72:
224:
7:
155:
122:--8-hydroxy-7-methyloctyl]acetamide
14:
258:
252:
23:
349:Key:KBARHGHBFILILC-NGIJKBHDSA-N
264:
246:
1:
558:10.1158/1538-7445.AM2023-4125
376:nonalcoholic steatohepatitis
612:
236:Chemical and physical data
591:Experimental cancer drugs
405:Hepatology Communications
332:
312:
107:
80:
380:hepatocellular carcinoma
370:inhibitor and analog of
38:, as no other articles
552:(7_Supplement): 4125.
77:
57:for suggestions.
47:to this page from
514:10.1002/cpdd.1179
467:10.3390/v15102099
417:10.1002/hep4.2100
411:(12): 3379–3392.
357:
356:
303:Interactive image
71:
70:
16:Chemical compound
603:
570:
569:
540:
534:
533:
496:
490:
489:
479:
469:
445:
439:
438:
428:
396:
305:
285:
283:
266:
260:
254:
248:
228:
208:
188:
168:
158:
157:
143:
85:
78:
76:
66:
63:
52:
50:related articles
27:
19:
611:
610:
606:
605:
604:
602:
601:
600:
596:Cyclic peptides
576:
575:
574:
573:
546:Cancer Research
542:
541:
537:
498:
497:
493:
447:
446:
442:
398:
397:
393:
388:
353:
350:
345:
340:
339:
328:
325:
320:
319:
308:
281:
279:
269:
263:
257:
251:
231:
211:
191:
171:
154:
146:
126:
123:
115:
114:
67:
61:
58:
48:
45:introduce links
28:
17:
12:
11:
5:
609:
607:
599:
598:
593:
588:
578:
577:
572:
571:
535:
508:(3): 287–293.
491:
440:
390:
389:
387:
384:
374:developed for
372:cyclosporine A
355:
354:
352:
351:
348:
346:
343:
335:
334:
333:
330:
329:
327:
326:
323:
315:
314:
313:
310:
309:
307:
306:
298:
296:
288:
287:
277:
271:
270:
267:
261:
255:
249:
244:
238:
237:
233:
232:
230:
229:
221:
219:
213:
212:
210:
209:
201:
199:
193:
192:
190:
189:
181:
179:
173:
172:
170:
169:
161:
159:
148:
147:
145:
144:
136:
134:
128:
127:
125:
124:
118:
110:
109:
108:
105:
104:
100:
99:
96:
92:
91:
87:
86:
69:
68:
55:Find link tool
31:
29:
22:
15:
13:
10:
9:
6:
4:
3:
2:
608:
597:
594:
592:
589:
587:
584:
583:
581:
567:
563:
559:
555:
551:
547:
539:
536:
531:
527:
523:
519:
515:
511:
507:
503:
495:
492:
487:
483:
478:
473:
468:
463:
459:
455:
451:
444:
441:
436:
432:
427:
422:
418:
414:
410:
406:
402:
395:
392:
385:
383:
381:
377:
373:
369:
365:
361:
347:
342:
338:
331:
322:
318:
311:
304:
300:
299:
297:
294:
289:
278:
276:
272:
245:
243:
239:
234:
227:
226:ChEMBL4297487
223:
222:
220:
218:
214:
207:
203:
202:
200:
198:
194:
187:
183:
182:
180:
178:
174:
167:
163:
162:
160:
153:
149:
142:
138:
137:
135:
133:
129:
121:
117:
113:
106:
101:
97:
93:
90:Clinical data
88:
84:
79:
65:
62:December 2023
56:
51:
46:
42:
41:
37:
32:This article
30:
26:
21:
20:
549:
545:
538:
505:
501:
494:
460:(10): 2099.
457:
453:
443:
408:
404:
394:
363:
360:Rencofilstat
359:
358:
141:1383420-08-3
119:
75:Rencofilstat
59:
33:
368:cyclophilin
366:) is a pan-
286: g·mol
103:Identifiers
95:Other names
580:Categories
386:References
291:3D model (
275:Molar mass
206:M3H4D91AY5
177:ChemSpider
132:CAS Number
112:IUPAC name
53:; try the
40:link to it
566:258002007
530:252915396
166:134812041
43:. Please
522:36251165
486:37896876
477:10612079
435:36271849
186:81368207
454:Viruses
426:9701462
242:Formula
152:PubChem
564:
528:
520:
484:
474:
433:
423:
364:CRV431
317:SMILES
217:ChEMBL
98:CRV431
36:orphan
34:is an
562:S2CID
526:S2CID
337:InChI
293:JSmol
518:PMID
482:PMID
431:PMID
378:and
284:.784
197:UNII
554:doi
510:doi
472:PMC
462:doi
421:PMC
413:doi
282:303
256:122
156:CID
582::
560:.
550:83
548:.
524:.
516:.
506:12
504:.
480:.
470:.
458:15
456:.
452:.
429:.
419:.
407:.
403:.
382:.
268:13
262:12
250:67
568:.
556::
532:.
512::
488:.
464::
437:.
415::
409:6
362:(
295:)
280:1
265:O
259:N
253:H
247:C
120:N
64:)
60:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
