498:
50:
529:. However, normal ranges for mast cell counts in the gastrointestinal tract mucosa are not well established in the literature, and depend upon the exact location (e.g. right versus left colon), gender, and patient populations (such as asymptomatic patients versus patients with chronic diarrhea of unknown etiology). Quantitative mast cell stains may yield little diagnostic information, and further research studies are warranted to determine whether "mastocytic enterocolitis" truly represents a distinct entity.
137:
148:, the substances that are released can cause a number of symptoms that can vary over time and can range in intensity from mild to severe. Because mast cells play a role in allergic reactions, the symptoms of mastocytosis often are similar to the symptoms of an allergic reaction. They may include, but are not limited to
380:
In case of suspicion of systemic disease the level of serum tryptase in the blood can be of help. If the base level of s-tryptase is elevated, this implies that the mastocytosis can be systemic. In cases of suspicion of SM help can also be drawn from analysis of mutation in KIT(D816V) in peripheral
770:
Some of the most important research advances for this rare disorder include improved diagnosis of mast cell disease and identification of growth factors and genetic mechanisms responsible for increased mast cell production. Researchers are currently evaluating approaches to improve ways to treat
887:
Hermine, Olivier; Lortholary, Olivier; Leventhal, Phillip S.; Catteau, Adeline; Soppelsa, Frédérique; Baude, Cedric; Cohen-Akenine, Annick; Palmérini, Fabienne; Hanssens, Katia; Yang, Ying; Sobol, Hagay; Fraytag, Sylvie; Ghez, David; Suarez, Felipe; Barete, Stéphane; Casassus, Philippe; Sans,
473:
Generalized eruption of cutaneous mastocytosis (adult type) is the most common pattern of mastocytosis presenting to the dermatologist, with the most common lesions being macules, papules, or nodules that are disseminated over most of the body but especially on the upper arms, legs, and
512:
Systemic mastocytosis involves the bone marrow in the majority of cases and in some cases other internal organs, usually in addition to involving the skin. Mast cells collect in various tissues and can affect organs where mast cells do not normally inhabit such as the
1355:
Noack, F.; Escribano, L.; Sotlar, K.; Nunez, R.; Schuetze, K.; Valent, P.; Horny, H.-P. (July 2009). "Evolution of
Urticaria Pigmentosa into Indolent Systemic Mastocytosis: Abnormal Immunophenotype of Mast Cells without Evidence of c-kit Mutation ASP-816-VAL".
1713:
Broesby-Olsen, Sigurd; Farkas, Dóra Körmendiné; Vestergaard, Hanne; Hermann, Anne
Pernille; Møller, Michael Boe; Mortz, Charlotte Gotthard; Kristensen, Thomas Kielsgaard; Bindslev-Jensen, Carsten; Sørensen, Henrik Toft; Frederiksen, Henrik (November 2016).
1461:
Sethi, Aisha; Jain, Dhanpat; Roland, Bani
Chander; Kinzel, Jason; Gibson, Joanna; Schrader, Ronald; Hanson, Joshua Anspach (2015-02-01). "Performing Colonic Mast Cell Counts in Patients With Chronic Diarrhea of Unknown Etiology Has Limited Diagnostic Use".
774:
Scientists also are focusing on identifying disease-associated mutations (changes in genes). NIH scientists have identified some mutations, which may help researchers understand the causes of mastocytosis, improve diagnosis, and develop better treatments.
2652:
3762:
3743:
3728:
3382:
950:
Moura, Daniela Silva; Sultan, Serge; Georgin-Lavialle, Sophie; Pillet, Nathalie; Montestruc, François; Gineste, Paul; Barete, Stéphane; Damaj, Gandhi; Moussy, Alain; Lortholary, Olivier; Hermine, Olivier; Hashimoto, Kenji (21 October 2011).
739:
Patients with indolent systemic mastocytosis have a normal life expectancy. The prognosis for patients with advanced systemic mastocytosis differs depending on type of disease with MCL being the most serious form with short survival.
752:"; orphan diseases affect 200,000 or fewer people in the United States. Mastocytosis, however, often may be misdiagnosed, as it typically occurs secondary to another condition, and thus may occur more frequently than assumed.
3457:
2645:
429:
Monoclonal mast cell activation, defined by the World Health
Organization definitions 2010, also has increased mast cells but insufficient to be systemic mastocytosis (in World Health Organization Definitions)
470:(TMEP) is a much rarer form of cutaneous mastocytosis that affects adults. MPCM and TMEP can be a part of indolent systemic mastocytosis. This should be considered if patients develop any systemic symptoms
2638:
2517:
280:
There are few qualitative studies about the effects of mastocytosis on daily life. However, a Danish study from 2018 describes the multidimensional impact of the disease on everyday life.
1217:
Arber, Daniel A.; Orazi, Attilio; Hasserjian, Robert; Thiele, JĂĽrgen; Borowitz, Michael J.; Le Beau, Michelle M.; Bloomfield, Clara D.; Cazzola, Mario; Vardiman, James W. (19 May 2016).
3605:
3473:
2877:
644:
are an important and often overlooked tool in the treatment of mastocytosis. Depression and other neurological symptoms have been noted in mastocytosis. Some antidepressants, such as
299:, the linings of the stomach and intestine, and other sites. They play an important role in the immune defence against bacteria and parasites. By releasing chemical "alarms" such as
3781:
2906:
2872:
760:
1997:
612:
help reduce production of gastric acid, which is often increased in patients with mastocytosis. Excess gastric acid can harm the stomach, esophagus, and small intestine.
1572:
Rogers, M P; Bloomingdale, K; Murawski, B J; Soter, N A; Reich, P; Austen, K F (July 1986). "Mixed organic brain syndrome as a manifestation of systemic mastocytosis".
2813:
2438:
2148:
3313:
660:
In cases of advanced systemic mastocytosis or rare cases with indolent systemic mastocytosis with very troublesome symptoms, cytoreductive therapy can be indicated.
2808:
1716:"Risk of solid cancer, cardiovascular disease, anaphylaxis, osteoporosis and fractures in patients with systemic mastocytosis: A nationwide population-based study"
2101:
2002:
3309:
3615:
1926:
2297:
3260:
3121:
2901:
2896:
2886:
2007:
497:
3640:
3377:
2925:
466:
3600:
3195:
2920:
2852:
3898:
3849:
3665:
3255:
3250:
1764:
361:
receptor (mutation KIT(D816V)), leading to constitutive signalling through the receptor is found in >90% of patients with systemic mastocytosis.
2891:
2857:
2418:
789:
was first described in 1869. The first report of a primary mast cell disorder is attributed to Unna, who in 1887 reported that skin lesions of
373:(cutaneous mastocytosis, see above) can often be done by seeing the characteristic lesions that are dark brown and fixed. A small skin sample (
618:
constricts blood vessels and opens airways to maintain adequate circulation and ventilation when excessive mast cell degranulation has caused
2867:
2726:
2074:
3387:
2972:
2583:
716:
3789:
2862:
2433:
3680:
3625:
3152:
2982:
2915:
1407:
3169:
3903:
3265:
2158:
1919:
489:
Cutaneous mastocytosis in children usually presents in the first year after birth and in most cases vanishes during adolescence.
3670:
2759:
778:
In Europe the
European Competence Network on Mastocytosis (ECNM) coordinates studies, registries and education on mastocytosis.
3690:
3620:
3590:
3467:
3240:
2945:
2818:
2803:
2423:
2334:
2163:
2992:
3304:
3215:
2507:
1062:
314:, mast cells may play a part in wound healing. For example, the typical itching felt around a healing scab may be caused by
330:
or no mast cells has been found, which indicates to some scientists we may not be able to survive with too few mast cells.
3630:
3583:
3210:
3133:
2847:
2793:
2275:
2136:
2034:
764:
432:
2630:
3038:
2730:
2615:
2550:
2086:
2012:
525:, and organs which have normal populations but where numbers are increased. In the bowel, it may manifest as mastocytic
1320:
Ellis DL (1996). "Treatment of telangiectasia macularis eruptiva perstans with the 585-nm flashlamp-pumped dye laser".
748:
The true incidence and prevalence of mastocytosis is unknown, but mastocytosis generally has been considered to be an "
3655:
3372:
3032:
2600:
2381:
2317:
2265:
2253:
2024:
1992:
1912:
637:
Drugs to prevent/treat osteoporosis include
Calcium-Vitamine D, bisphosphonates and in rare cases inhibitors of RANK-L
435:– has normal number of mast cells, but all the symptoms and in some cases the genetic markers of systemic mastocytosis
3116:
3023:
674:(CdA). Chemotherapy which is given as subcutaneous injections. Side effects include immunodeficiency and infections.
384:
To set the diagnosis of systemic mastocytosis, certain criteria must be met. Either one major + one minor criterion
3245:
2512:
2279:
677:
3449:
2997:
862:
719:
has been used in rare cases with aggressive systemic mastocytosis in patients deemed to be fit for the procedure.
3015:
2740:
2327:
2218:
3200:
101:
affecting both children and adults caused by the accumulation of functionally defective mast cells (also called
3800:
3290:
3278:
3236:
3222:
3190:
3186:
3094:
3089:
3084:
3080:
3072:
3043:
2403:
2369:
2069:
1939:
166:
888:
Beatrice; Arock, Michel; Kinet, Jean Pierre; Dubreuil, Patrice; Moussy, Alain; Soyer, H. Peter (28 May 2008).
481:
may be thickened and infiltrated with mast cells to produce a peculiar orange color, giving rise to the term
3568:
2987:
2950:
2798:
2096:
1167:"Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future"
346:
49:
3174:
3001:
2977:
1219:"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia"
606:
is available in Canada and Europe and more recently in the U.S. It is also available as eyedrops (Zaditor).
3908:
3876:
3685:
3650:
3573:
3367:
3355:
3205:
3048:
2573:
2359:
2243:
2208:
2126:
2059:
1982:
1765:
To quell unpredictable allergic reactions, an experimental drug takes aim at a genetic cause, not symptoms
460:
The most common cutaneous mastocytosis is maculopapular cutaneous mastocytosis, previously named papular
3550:
3461:
2837:
2686:
2610:
609:
334:
260:
1420:
Ramsay, David B.; Stephen, Sindu; Borum, Marie; Voltaggio, Lysandra; Doman, David B. (December 2010).
793:
contained numerous mast cells. Systemic mastocytosis was first reported by French scientists in 1936.
3540:
3442:
2960:
2532:
2522:
2428:
1505:
964:
901:
595:
501:
478:
256:
157:
652:, are themselves potent antihistamines and can help relieve physical as well as cognitive symptoms.
634:
can be used topically, inhaled, or systemically to reduce inflammation associated with mastocytosis.
3766:
3348:
3227:
2777:
2735:
2718:
2708:
2691:
2661:
566:
There is no cure for mastocytosis, but there are a number of medicines to help treat the symptoms:
210:
74:
686:. TKI acting on many different tyrosine kinases, approved by FDA and EMA for advanced mastocytosis
357:
appears to be important for the proliferation of mast cells. Mutations of the gene coding for the
3610:
3126:
2823:
2769:
2749:
2700:
2477:
1745:
1597:
1381:
1147:
1090:
1061:
Jensen, Britt; Broesby-Olsen, Sigurd; Bindslev-Jensen, Carsten; Nielsen, Dorthe S. (April 2019).
953:"Depression in Patients with Mastocytosis: Prevalence, Features and Effects of Masitinib Therapy"
548:
221:
3865:
1620:"Systemic mastocytosis in adults: 2017 update on diagnosis, risk stratification and management"
763:
scientists have been studying and treating patients with mastocytosis for several years at the
3811:
3635:
3595:
3517:
3392:
3336:
3270:
2935:
2527:
2482:
2391:
1893:
1836:
1809:
1737:
1695:
1641:
1589:
1554:
1487:
1479:
1443:
1403:
1373:
1337:
1289:
1240:
1196:
1139:
1082:
1043:
992:
929:
844:
439:
292:
69:
3737:
3522:
3157:
2968:
2940:
1885:
1799:
1791:
1727:
1685:
1675:
1631:
1581:
1544:
1536:
1471:
1433:
1365:
1329:
1279:
1271:
1230:
1186:
1178:
1131:
1121:
1074:
1033:
1023:
982:
972:
919:
909:
834:
668:. Given as subcutaneous injections. Side effects include fatigue and influenza-like symptoms
599:
175:
1904:
318:
released by mast cells. Researchers also think mast cells may have a role in the growth of
3545:
3063:
2588:
602:
is the only medicine specifically approved by the FDA for the treatment of mastocytosis.
1876:
Gruchalla, Rebecca S. (June 1995). "Mastocytosis: Developments During the Past Decade".
1165:
Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, et al. (March 2017).
968:
905:
3771:
3660:
3645:
3578:
3360:
3331:
3181:
3145:
3099:
3058:
2754:
2677:
1804:
1779:
1690:
1663:
1549:
1524:
1438:
1421:
1307:
1284:
1259:
1191:
1166:
1038:
1011:
987:
952:
924:
889:
641:
631:
628:
and other beta-2 agonists open airways that can constrict in the presence of histamine.
240:
181:
3854:
3775:
710:
in trials; currently being tested but showing promise in reduction of tryptase levels.
17:
3892:
3507:
3427:
3011:
2183:
2115:
1889:
1585:
1333:
1126:
1109:
575:
556:
526:
304:
270:
264:
145:
1749:
1601:
1385:
1151:
1094:
397:
Dense infiltrates of >15 mast cells in the bone marrow or an extracutaneous organ
112:
People affected by mastocytosis are susceptible to a variety of symptoms, including
3840:
3512:
3502:
3419:
2669:
749:
323:
319:
236:
98:
1182:
890:"Case-Control Cohort Study of Patients' Perceptions of Disability in Mastocytosis"
61:
3805:
1854:
SĂ©zary A, Levy-Coblentz G, Chauvillon P (1936). "Dermographisme et mastocytose".
1833:
Contributions to the anatomy and pathogenesis of urticaria simplex and pigmentosa
1540:
1235:
1218:
1110:"Recent advances in the understanding of mastocytosis: the role of KIT mutations"
977:
914:
310:
Mast cells seem to have other roles as well. Because they gather together around
3675:
3383:
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome
3284:
3163:
3139:
2467:
1953:
1369:
802:
728:
707:
701:
683:
649:
619:
589:
217:
206:
121:
3843:
1275:
1063:"Everyday life and mastocytosis from a patient perspective-a qualitative study"
136:
3816:
3756:
3752:
3433:
3028:
2665:
1475:
671:
665:
625:
615:
592:
antagonists block receptors targeted by leukotrienes released from mast cells.
522:
505:
82:
57:
1840:
1483:
3835:
3695:
1971:
1780:"Reports of Medical and Surgical Practice in the Hospitals of Great Britain"
695:
603:
508:
highlights mast cells (darkly stained) in the mucosa of the small intestine.
315:
300:
288:
226:
125:
94:
1813:
1741:
1699:
1645:
1558:
1491:
1447:
1377:
1293:
1244:
1200:
1143:
1086:
1047:
996:
933:
848:
477:
Diffuse cutaneous mastocytosis has diffuse involvement in which the entire
1897:
1829:
Beiträge zur
Anatomie und Pathogenese der Urticaria simplex und Pigmentosa
1795:
1593:
1341:
3871:
3413:
3298:
3110:
2456:
2197:
2048:
1680:
689:
195:
190:
78:
1028:
2306:
2232:
1935:
1135:
1078:
866:
645:
230:
3720:
1732:
1715:
1636:
1619:
839:
822:
578:
block receptors targeted by histamine released from mast cells. Both H
3747:
3732:
3458:
Template:Congenital malformations and deformations of skin appendages
3342:
2413:
1962:
1947:
1856:
Bulletin de la Société Française de
Dermatologie et de Syphiligraphie
731:
can relieve skin symptoms, but may increase the risk of skin cancer.
542:
Systemic mastocytosis with associated hematological neoplasm (SM-AHN)
518:
374:
186:
3532:
2348:
536:
Indolent systemic mastocytosis (ISM). The most common SM (>90%)
514:
496:
342:
311:
135:
117:
3860:
3794:
598:
help prevent mast cells from releasing their chemical contents.
296:
162:
113:
106:
3191:
Focal palmoplantar keratoderma with oral mucosal hyperkeratosis
2634:
1908:
1525:"Mastocytosis: update on pharmacotherapy and future directions"
407:
Aberrant phenotype on the mast cells (pos. for CD2 and/or CD25)
1523:
Cardet, Juan Carlos; Akin, Cem; Lee, Min Jung (October 2013).
692:. Can have effect in rare cases without mutation in KIT(D816V)
1664:"Novel approaches to treating advanced systemic mastocytosis"
1470:(2). Archives of Pathology and Laboratory Medicine: 225–232.
464:(UP), more common in children, although also seen in adults.
273:(due to inactivation of pancreatic enzymes by increased acid)
2518:
Adult type of generalized eruption of cutaneous mastocytosis
178:, a reaction to stroking or scratching of urticaria lesions.
1108:
Orfao A, Garcia-Montero AC, Sanchez L, Escribano L (2007).
1010:
Lee, JK; Whittaker, SJ; Enns, RA; Zetler, P (Dec 7, 2008).
1012:"Gastrointestinal manifestations of systemic mastocytosis"
438:
Another known but rare mast cell proliferation disease is
555:
Further information on the investigational new drug:
3606:
Congenital hypertrophy of the lateral fold of the hallux
1662:
Gilreath, JA; Tchertanov, L; Deininger, MW (July 2019).
3474:
Template:DNA replication and repair-deficiency disorder
128:
and other pro-inflammatory substances from mast cells.
1398:
James, William; Berger, Timothy; Elston, Dirk (2005).
761:
National
Institute of Allergy and Infectious Diseases
3710:
1260:"Mast cell activation: proposed diagnostic criteria"
3826:
3714:
3561:
3531:
3495:
3486:
3405:
3324:
3071:
3057:
3010:
2959:
2836:
2786:
2768:
2717:
2699:
2685:
2676:
2597:
2570:
2563:
2541:
2496:
2464:
2455:
2400:
2378:
2356:
2347:
2314:
2305:
2296:
2262:
2240:
2231:
2205:
2196:
2176:
2145:
2123:
2114:
2083:
2056:
2047:
2021:
1979:
1970:
1961:
1946:
1400:
68:
37:
32:
235:Decreased bone density or increased bone density (
3090:Diffuse nonepidermolytic palmoplantar keratoderma
2814:Nonbullous congenital ichthyosiform erythroderma
2439:Refractory cytopenia with multilineage dysplasia
1668:Clinical Pharmacology: Advances and Applications
1306:National Organization for Rare Disorders (NORD)
3279:Palmoplantar keratoderma and spastic paraplegia
1657:
1655:
1613:
1611:
1464:Archives of Pathology & Laboratory Medicine
532:There are five types of systemic mastocytosis:
3085:Diffuse epidermolytic palmoplantar keratoderma
2102:Accelerated phase chronic myelogenous leukemia
1264:The Journal of Allergy and Clinical Immunology
1212:
1210:
945:
943:
586:blockers may be helpful, often in combination.
451:Mastocytosis can occur in a variety of forms:
410:Aberrant mast cell morphology (spindle-shaped)
303:, mast cells attract other key players of the
3616:Congenital malformations of the dermatoglyphs
2646:
1920:
865:. Mastocytosis Society Canada. Archived from
8:
1878:The American Journal of the Medical Sciences
1835:] (in German). Verlag von Leopold Voss.
307:to areas of the body where they are needed.
3711:
3641:Melanotic neuroectodermal tumor of infancy
3492:
3378:Keratosis follicularis spinulosa decalvans
3068:
2809:Ichthyosis–sclerosing cholangitis syndrome
2696:
2682:
2653:
2639:
2631:
2567:
2461:
2353:
2311:
2302:
2237:
2202:
2120:
2053:
1976:
1967:
1958:
1927:
1913:
1905:
698:. Is being tested in trials. Not approved.
467:Telangiectasia macularis eruptiva perstans
425:Other types of mast cell disease include:
388:three minor criteria has to be fulfilled:
255:Increased stomach acid production causing
48:
29:
3601:Congenital cartilaginous rest of the neck
3196:Focal palmoplantar and gingival keratosis
1803:
1731:
1689:
1679:
1635:
1548:
1437:
1283:
1234:
1190:
1125:
1037:
1027:
986:
976:
923:
913:
838:
3666:Rapidly involuting congenital hemangioma
3256:Keratosis punctata of the palmar creases
3251:Keratosis punctata palmaris et plantaris
3122:Clouston's hidrotic ectodermal dysplasia
1422:"Mast Cells in Gastrointestinal Disease"
863:"Mastocytosis & mast cell disorders"
2419:Refractory anemia with excess of blasts
813:
539:Smouldering systemic mastocytosis (SSM)
1258:Akin C, Valent P, Metcalfe DD (2010).
545:Aggressive systemic mastocytosis (ASM)
2727:Congenital ichthyosiform erythroderma
821:Horny HP, Sotlar K, Valent P (2007).
381:blood using sensitive PCR-technology
7:
3388:Keratosis pilaris atrophicans faciei
2973:Dermatopathia pigmentosa reticularis
2584:Acute panmyelosis with myelofibrosis
1618:Pardanani, Animesh (November 2016).
717:Allogeneic stem cell transplantation
263:and direct histamine stimulation on
2434:Paroxysmal nocturnal hemoglobinuria
3681:Superficial lymphatic malformation
3626:Congenital smooth muscle hamartoma
3095:Palmoplantar keratoderma of Sybert
2664:malformations and deformations of
1506:"Mastocytosis - Treatment Options"
377:) may help confirm the diagnosis.
25:
3153:Scleroatrophic syndrome of Huriez
2983:Hypohidrotic ectodermal dysplasia
1529:Expert Opinion on Pharmacotherapy
1426:Gastroenterology & Hepatology
1016:World Journal of Gastroenterology
413:Finding of mutation in KIT(D816V)
3266:Porokeratosis plantaris discreta
3223:Striate palmoplantar keratoderma
2159:Juvenile myelomonocytic leukemia
1890:10.1097/00000441-199506000-00007
1827:Unna, Paul Gerson; Unna (1887).
1586:10.1097/00006842-198607000-00006
1127:10.1111/j.1365-2141.2007.06619.x
823:"Mastocytosis: state of the art"
3899:Dermal and subcutaneous growths
3691:Verrucous vascular malformation
3621:Congenital preauricular fistula
3591:Accessory nail of the fifth toe
3468:Template:Pigmentation disorders
3261:Schöpf–Schulz–Passarge syndrome
3241:Acrokeratoelastoidosis of Costa
2946:Laryngoonychocutaneous syndrome
2819:Ichthyosis linearis circumflexa
2804:Ichthyosis prematurity syndrome
2424:Chromosome 5q deletion syndrome
2335:Acute megakaryoblastic leukemia
2164:Chronic myelomonocytic leukemia
2075:Myeloid dendritic cell leukemia
213:from allergic or immune causes)
75:Clinical Immunology and Allergy
3305:Erythrokeratodermia variabilis
3216:Pachyonychia congenita type II
2508:Diffuse cutaneous mastocytosis
1720:American Journal of Hematology
1624:American Journal of Hematology
60:of mastocytosis. Skin biopsy.
1:
3631:Cystic lymphatic malformation
3584:Cavernous venous malformation
3211:Pachyonychia congenita type I
3134:Corneodermatoosseous syndrome
2794:Ichthyosis bullosa of Siemens
2276:Chronic eosinophilic leukemia
2035:Chronic neutrophilic leukemia
1183:10.1158/0008-5472.CAN-16-2234
765:National Institutes of Health
433:Mast cell activation syndrome
3039:Popliteal pterygium syndrome
2731:Epidermolytic hyperkeratosis
2616:Biphenotypic acute leukaemia
2551:Xanthelasmoidal mastocytosis
1778:Nettleship E, Tay W (1869).
1541:10.1517/14656566.2013.824424
1334:10.1016/1076-0512(95)00388-6
1236:10.1182/blood-2016-03-643544
978:10.1371/journal.pone.0026375
915:10.1371/journal.pone.0002266
416:S-tryptase >20 ng/ml
203:Ear/nose/throat inflammation
3671:Rosenthal–Kloepfer syndrome
3656:Omphalomesenteric duct cyst
3373:Keratolytic winter erythema
3033:Gerodermia osteodysplastica
1993:Acute myeloblastic leukemia
1370:10.1080/1042819021000037967
1067:Journal of Clinical Nursing
455:Cutaneous mastocytosis (CM)
124:, caused by the release of
42:Clonal bone marrow disorder
3925:
3246:Focal acral hyperkeratosis
2993:Ellis–van Creveld syndrome
2513:Erythrodermic mastocytosis
2280:Hypereosinophilic syndrome
1276:10.1016/j.jaci.2010.08.035
678:Tyrosine kinase inhibitors
554:
493:Systemic mastocytosis (SM)
353:). In laboratory studies,
259:(increased stimulation of
3170:Papillon–Lefèvre syndrome
2741:Harlequin-type ichthyosis
2328:Essential thrombocythemia
1476:10.5858/arpa.2013-0594-oa
56:
47:
3044:Pseudoxanthoma elasticum
2760:Sjögren–Larsson syndrome
1940:hematological malignancy
1402:. (10th ed.). Saunders.
421:Other mast cell diseases
144:When mast cells undergo
109:+ mast cell precursors.
3904:Immune system disorders
3569:Aplasia cutis congenita
2988:Focal dermal hypoplasia
2951:Skin fragility syndrome
2799:Ichthyosis follicularis
2097:Philadelphia chromosome
1358:Leukemia & Lymphoma
767:(NIH) Clinical Center.
218:very low blood pressure
3686:Thyroglossal duct cyst
3651:Nasolacrimal duct cyst
3574:Amniotic band syndrome
3368:Dyskeratosis congenita
3356:Dyskeratosis congenita
3206:Pachyonychia congenita
3117:Bart–Pumphrey syndrome
3049:Van der Woude syndrome
3024:Ehlers–Danlos syndrome
1768:, Stat, March 16, 2020
1574:Psychosomatic Medicine
610:Proton-pump inhibitors
509:
349:for stem cell factor (
220:(including shock) and
141:
18:Mastocytosis, systemic
3551:Nevus flammeus nuchae
3462:Template:Phakomatoses
3434:Hereditary lymphedema
2998:Rapp–Hodgkin syndrome
2687:Congenital ichthyosis
2611:Primary myelofibrosis
2543:Systemic mastocytosis
2488:Systemic mastocytosis
1796:10.1136/bmj.2.455.323
656:Cytoreductive therapy
596:Mast cell stabilizers
570:Anti-mediator therapy
500:
335:cell surface receptor
333:Mast cells express a
305:immune defense system
261:enterochromaffin cell
200:Olfactive intolerance
139:
3541:Capillary hemangioma
3443:Urticaria pigmentosa
3201:Howel–Evans syndrome
2961:Ectodermal dysplasia
2902:Generalized atrophic
2533:Solitary mastocytoma
2523:Urticaria pigmentosa
2429:Sideroblastic anemia
1681:10.2147/CPAA.S206615
791:urticaria pigmentosa
787:Urticaria pigmentosa
502:Immunohistochemistry
462:urticaria pigmentosa
371:urticaria pigmentosa
182:Abdominal discomfort
158:urticaria pigmentosa
3228:Tyrosinemia type II
2778:X-linked ichthyosis
2736:Lamellar ichthyosis
2709:Ichthyosis vulgaris
2692:erythrokeratodermia
1029:10.3748/wjg.14.7005
969:2011PLoSO...626375M
906:2008PLoSO...3.2266H
3827:External resources
3611:Congenital lip pit
3175:Haim–Munk syndrome
3127:Vohwinkel syndrome
3002:Hay–Wells syndrome
2978:Hay–Wells syndrome
2824:Ichthyosis hystrix
2750:Netherton syndrome
2478:Mast cell leukemia
2370:Erythroleukemia/M6
2254:Acute eosinophilic
1079:10.1111/jocn.14676
1073:(7–8): 1114–1124.
549:Mast cell leukemia
510:
276:Hepatosplenomegaly
142:
132:Signs and symptoms
122:anaphylactic shock
3886:
3885:
3708:
3707:
3704:
3703:
3636:Median raphe cyst
3596:Bronchogenic cyst
3518:PHACE association
3482:
3481:
3401:
3400:
3393:Keratosis pilaris
3337:Keratosis pilaris
3291:Carvajal syndrome
3271:Spiny keratoderma
2936:Costello syndrome
2832:
2831:
2628:
2627:
2624:
2623:
2559:
2558:
2528:Mast cell sarcoma
2483:Mast cell sarcoma
2451:
2450:
2447:
2446:
2414:Refractory anemia
2392:Polycythemia vera
2343:
2342:
2292:
2291:
2288:
2287:
2227:
2226:
2192:
2191:
2172:
2171:
2110:
2109:
2043:
2042:
1733:10.1002/ajh.24490
1726:(11): 1069–1075.
1637:10.1002/ajh.24553
1630:(11): 1146–1159.
1535:(15): 2033–2045.
1229:(20): 2391–2405.
840:10.1159/000101711
729:ultraviolet light
440:mast cell sarcoma
293:connective tissue
252:Ocular discomfort
88:
87:
27:Medical condition
16:(Redirected from
3916:
3712:
3523:Sinus pericranii
3493:
3349:Darier's disease
3158:Olmsted syndrome
3069:
2969:Naegeli syndrome
2941:Kindler syndrome
2697:
2683:
2655:
2648:
2641:
2632:
2604:
2577:
2568:
2564:Multiple/unknown
2544:
2501:
2471:
2462:
2407:
2385:
2363:
2354:
2321:
2312:
2303:
2269:
2247:
2238:
2219:Acute basophilic
2212:
2203:
2152:
2130:
2121:
2090:
2063:
2054:
2028:
1986:
1977:
1968:
1959:
1929:
1922:
1915:
1906:
1901:
1864:
1863:
1851:
1845:
1844:
1824:
1818:
1817:
1807:
1775:
1769:
1760:
1754:
1753:
1735:
1710:
1704:
1703:
1693:
1683:
1659:
1650:
1649:
1639:
1615:
1606:
1605:
1569:
1563:
1562:
1552:
1520:
1514:
1513:
1502:
1496:
1495:
1458:
1452:
1451:
1441:
1417:
1411:
1396:
1390:
1389:
1352:
1346:
1345:
1317:
1311:
1304:
1298:
1297:
1287:
1255:
1249:
1248:
1238:
1214:
1205:
1204:
1194:
1177:(6): 1261–1270.
1162:
1156:
1155:
1129:
1105:
1099:
1098:
1058:
1052:
1051:
1041:
1031:
1007:
1001:
1000:
990:
980:
947:
938:
937:
927:
917:
884:
878:
877:
875:
874:
859:
853:
852:
842:
818:
600:Cromoglicic acid
345:), which is the
295:, including the
52:
30:
21:
3924:
3923:
3919:
3918:
3917:
3915:
3914:
3913:
3889:
3888:
3887:
3882:
3881:
3822:
3821:
3723:
3709:
3700:
3562:Other/ungrouped
3557:
3546:Port-wine stain
3527:
3488:
3478:
3397:
3320:
3062:
3053:
3006:
2955:
2840:
2828:
2782:
2764:
2713:
2690:
2672:
2659:
2629:
2620:
2598:
2593:
2589:Myeloid sarcoma
2571:
2555:
2542:
2537:
2497:
2492:
2465:
2443:
2401:
2396:
2379:
2374:
2357:
2339:
2315:
2284:
2263:
2258:
2241:
2223:
2206:
2188:
2168:
2146:
2141:
2124:
2106:
2084:
2079:
2057:
2039:
2022:
2017:
1980:
1951:
1942:
1933:
1875:
1872:
1870:Further reading
1867:
1853:
1852:
1848:
1826:
1825:
1821:
1777:
1776:
1772:
1762:Garde, Damian,
1761:
1757:
1712:
1711:
1707:
1661:
1660:
1653:
1617:
1616:
1609:
1571:
1570:
1566:
1522:
1521:
1517:
1512:. 25 June 2012.
1504:
1503:
1499:
1460:
1459:
1455:
1432:(12): 772–777.
1419:
1418:
1414:
1397:
1393:
1354:
1353:
1349:
1319:
1318:
1314:
1305:
1301:
1270:(6): 1099–104.
1257:
1256:
1252:
1216:
1215:
1208:
1171:Cancer Research
1164:
1163:
1159:
1114:Br. J. Haematol
1107:
1106:
1102:
1060:
1059:
1055:
1009:
1008:
1004:
949:
948:
941:
886:
885:
881:
872:
870:
861:
860:
856:
820:
819:
815:
811:
799:
784:
758:
746:
737:
727:Treatment with
725:
658:
642:Antidepressants
632:Corticosteroids
585:
581:
572:
564:
559:
495:
457:
449:
423:
404:
394:
392:Major criterion
367:
326:). No one with
291:are located in
286:
284:Pathophysiology
176:"Darier's Sign"
167:dermatographic
134:
28:
23:
22:
15:
12:
11:
5:
3922:
3920:
3912:
3911:
3906:
3901:
3891:
3890:
3884:
3883:
3880:
3879:
3868:
3857:
3846:
3831:
3830:
3828:
3824:
3823:
3820:
3819:
3808:
3797:
3786:
3778:
3759:
3740:
3724:
3719:
3718:
3716:
3715:Classification
3706:
3705:
3702:
3701:
3699:
3698:
3693:
3688:
3683:
3678:
3673:
3668:
3663:
3661:Poland anomaly
3658:
3653:
3648:
3646:Mongolian spot
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3587:
3586:
3581:
3579:Branchial cyst
3576:
3571:
3565:
3563:
3559:
3558:
3556:
3555:
3554:
3553:
3543:
3537:
3535:
3529:
3528:
3526:
3525:
3520:
3515:
3510:
3505:
3499:
3497:
3490:
3484:
3483:
3480:
3479:
3453:
3452:
3447:
3446:
3445:
3436:
3424:
3423:
3422:
3409:
3407:
3403:
3402:
3399:
3398:
3396:
3395:
3390:
3385:
3380:
3375:
3370:
3364:
3363:
3361:Lelis syndrome
3358:
3353:
3352:
3351:
3339:
3334:
3332:Meleda disease
3328:
3326:
3322:
3321:
3319:
3318:
3317:
3316:
3307:
3295:
3294:
3293:
3281:
3274:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3233:
3232:
3231:
3230:
3225:
3220:
3219:
3218:
3213:
3203:
3198:
3193:
3184:
3182:Camisa disease
3179:
3178:
3177:
3172:
3160:
3155:
3150:
3149:
3148:
3146:Naxos syndrome
3136:
3131:
3130:
3129:
3124:
3119:
3103:
3102:
3100:Meleda disease
3097:
3092:
3087:
3077:
3075:
3066:
3059:Hyperkeratosis
3055:
3054:
3052:
3051:
3046:
3041:
3036:
3026:
3020:
3018:
3008:
3007:
3005:
3004:
2995:
2990:
2985:
2980:
2975:
2965:
2963:
2957:
2956:
2954:
2953:
2948:
2943:
2938:
2931:
2930:
2929:
2928:
2923:
2912:
2911:
2910:
2909:
2904:
2899:
2894:
2883:
2882:
2881:
2880:
2875:
2870:
2865:
2860:
2855:
2844:
2842:
2834:
2833:
2830:
2829:
2827:
2826:
2821:
2816:
2811:
2806:
2801:
2796:
2790:
2788:
2784:
2783:
2781:
2780:
2774:
2772:
2766:
2765:
2763:
2762:
2757:
2755:CHIME syndrome
2752:
2746:
2745:
2744:
2743:
2733:
2723:
2721:
2715:
2714:
2712:
2711:
2705:
2703:
2694:
2680:
2678:Genodermatosis
2674:
2673:
2660:
2658:
2657:
2650:
2643:
2635:
2626:
2625:
2622:
2621:
2619:
2618:
2613:
2607:
2605:
2595:
2594:
2592:
2591:
2586:
2580:
2578:
2565:
2561:
2560:
2557:
2556:
2554:
2553:
2547:
2545:
2539:
2538:
2536:
2535:
2530:
2525:
2520:
2515:
2510:
2504:
2502:
2494:
2493:
2491:
2490:
2485:
2480:
2474:
2472:
2459:
2453:
2452:
2449:
2448:
2445:
2444:
2442:
2441:
2436:
2431:
2426:
2421:
2416:
2410:
2408:
2398:
2397:
2395:
2394:
2388:
2386:
2376:
2375:
2373:
2372:
2366:
2364:
2351:
2345:
2344:
2341:
2340:
2338:
2337:
2331:
2330:
2324:
2322:
2309:
2300:
2294:
2293:
2290:
2289:
2286:
2285:
2283:
2282:
2272:
2270:
2260:
2259:
2257:
2256:
2250:
2248:
2235:
2229:
2228:
2225:
2224:
2222:
2221:
2215:
2213:
2200:
2194:
2193:
2190:
2189:
2187:
2186:
2180:
2178:
2174:
2173:
2170:
2169:
2167:
2166:
2161:
2155:
2153:
2143:
2142:
2140:
2139:
2133:
2131:
2118:
2112:
2111:
2108:
2107:
2105:
2104:
2099:
2093:
2091:
2081:
2080:
2078:
2077:
2072:
2066:
2064:
2051:
2045:
2044:
2041:
2040:
2038:
2037:
2031:
2029:
2019:
2018:
2016:
2015:
2010:
2005:
2000:
1995:
1989:
1987:
1974:
1965:
1956:
1944:
1943:
1934:
1932:
1931:
1924:
1917:
1909:
1903:
1902:
1884:(6): 328–338.
1871:
1868:
1866:
1865:
1846:
1819:
1790:(455): 323–4.
1770:
1755:
1705:
1651:
1607:
1580:(6): 437–447.
1564:
1515:
1497:
1453:
1412:
1391:
1364:(2): 313–319.
1347:
1312:
1308:"Mastocytosis"
1299:
1250:
1206:
1157:
1100:
1053:
1022:(45): 7005–8.
1002:
963:(10): e26375.
939:
879:
854:
812:
810:
807:
806:
805:
798:
795:
783:
780:
771:mastocytosis.
757:
754:
750:orphan disease
745:
742:
736:
733:
724:
721:
714:
713:
712:
711:
705:
704:- 60% respond.
699:
693:
687:
675:
669:
657:
654:
639:
638:
635:
629:
623:
613:
607:
593:
587:
583:
579:
576:Antihistamines
571:
568:
563:
560:
553:
552:
546:
543:
540:
537:
494:
491:
487:
486:
475:
471:
456:
453:
448:
447:Classification
445:
444:
443:
436:
430:
422:
419:
418:
417:
414:
411:
408:
403:
402:Minor criteria
400:
399:
398:
393:
390:
366:
363:
285:
282:
278:
277:
274:
268:
253:
250:
247:
244:
241:osteosclerosis
233:
224:
214:
204:
201:
198:
193:
184:
179:
173:
172:(skin writing)
155:Skin lesions (
153:
133:
130:
97:disease, is a
86:
85:
72:
66:
65:
54:
53:
45:
44:
39:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3921:
3910:
3909:Rare diseases
3907:
3905:
3902:
3900:
3897:
3896:
3894:
3878:
3874:
3873:
3869:
3867:
3863:
3862:
3858:
3856:
3852:
3851:
3847:
3845:
3842:
3838:
3837:
3833:
3832:
3829:
3825:
3818:
3814:
3813:
3809:
3807:
3803:
3802:
3798:
3796:
3792:
3791:
3787:
3784:
3783:
3779:
3777:
3773:
3769:
3768:
3764:
3760:
3758:
3754:
3750:
3749:
3745:
3741:
3739:
3735:
3734:
3730:
3726:
3725:
3722:
3717:
3713:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3588:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3566:
3564:
3560:
3552:
3549:
3548:
3547:
3544:
3542:
3539:
3538:
3536:
3534:
3530:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3508:Encephalocele
3506:
3504:
3501:
3500:
3498:
3494:
3491:
3487:Developmental
3485:
3477:
3476:
3475:
3470:
3469:
3464:
3463:
3459:
3451:
3450:Hailey–Hailey
3448:
3444:
3440:
3437:
3435:
3432:
3431:
3430:
3429:
3428:immune system
3425:
3421:
3418:
3417:
3416:
3415:
3411:
3410:
3408:
3404:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3365:
3362:
3359:
3357:
3354:
3350:
3347:
3346:
3345:
3344:
3340:
3338:
3335:
3333:
3330:
3329:
3327:
3323:
3315:
3311:
3308:
3306:
3303:
3302:
3301:
3300:
3296:
3292:
3289:
3288:
3287:
3286:
3282:
3280:
3276:
3275:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3238:
3235:
3234:
3229:
3226:
3224:
3221:
3217:
3214:
3212:
3209:
3208:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3188:
3185:
3183:
3180:
3176:
3173:
3171:
3168:
3167:
3166:
3165:
3161:
3159:
3156:
3154:
3151:
3147:
3144:
3143:
3142:
3141:
3137:
3135:
3132:
3128:
3125:
3123:
3120:
3118:
3115:
3114:
3113:
3112:
3108:
3107:
3105:
3104:
3101:
3098:
3096:
3093:
3091:
3088:
3086:
3082:
3079:
3078:
3076:
3074:
3070:
3067:
3065:
3064:keratinopathy
3060:
3056:
3050:
3047:
3045:
3042:
3040:
3037:
3034:
3030:
3027:
3025:
3022:
3021:
3019:
3017:
3013:
3009:
3003:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2970:
2967:
2966:
2964:
2962:
2958:
2952:
2949:
2947:
2944:
2942:
2939:
2937:
2933:
2932:
2927:
2924:
2922:
2919:
2918:
2917:
2914:
2913:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2889:
2888:
2885:
2884:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2850:
2849:
2846:
2845:
2843:
2839:
2835:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2791:
2789:
2785:
2779:
2776:
2775:
2773:
2771:
2767:
2761:
2758:
2756:
2753:
2751:
2748:
2747:
2742:
2739:
2738:
2737:
2734:
2732:
2728:
2725:
2724:
2722:
2720:
2716:
2710:
2707:
2706:
2704:
2702:
2698:
2695:
2693:
2688:
2684:
2681:
2679:
2675:
2671:
2667:
2663:
2656:
2651:
2649:
2644:
2642:
2637:
2636:
2633:
2617:
2614:
2612:
2609:
2608:
2606:
2603:
2602:
2596:
2590:
2587:
2585:
2582:
2581:
2579:
2576:
2575:
2569:
2566:
2562:
2552:
2549:
2548:
2546:
2540:
2534:
2531:
2529:
2526:
2524:
2521:
2519:
2516:
2514:
2511:
2509:
2506:
2505:
2503:
2500:
2495:
2489:
2486:
2484:
2481:
2479:
2476:
2475:
2473:
2470:
2469:
2463:
2460:
2458:
2454:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2411:
2409:
2406:
2405:
2399:
2393:
2390:
2389:
2387:
2384:
2383:
2377:
2371:
2368:
2367:
2365:
2362:
2361:
2355:
2352:
2350:
2346:
2336:
2333:
2332:
2329:
2326:
2325:
2323:
2320:
2319:
2313:
2310:
2308:
2304:
2301:
2299:
2295:
2281:
2277:
2274:
2273:
2271:
2268:
2267:
2261:
2255:
2252:
2251:
2249:
2246:
2245:
2239:
2236:
2234:
2230:
2220:
2217:
2216:
2214:
2211:
2210:
2204:
2201:
2199:
2195:
2185:
2184:Histiocytosis
2182:
2181:
2179:
2175:
2165:
2162:
2160:
2157:
2156:
2154:
2151:
2150:
2144:
2138:
2135:
2134:
2132:
2129:
2128:
2122:
2119:
2117:
2116:Myelomonocyte
2113:
2103:
2100:
2098:
2095:
2094:
2092:
2089:
2088:
2082:
2076:
2073:
2071:
2068:
2067:
2065:
2062:
2061:
2055:
2052:
2050:
2046:
2036:
2033:
2032:
2030:
2027:
2026:
2020:
2014:
2011:
2009:
2006:
2004:
2001:
1999:
1996:
1994:
1991:
1990:
1988:
1985:
1984:
1978:
1975:
1973:
1969:
1966:
1964:
1960:
1957:
1955:
1949:
1945:
1941:
1937:
1930:
1925:
1923:
1918:
1916:
1911:
1910:
1907:
1899:
1895:
1891:
1887:
1883:
1879:
1874:
1873:
1869:
1861:
1857:
1850:
1847:
1842:
1838:
1834:
1830:
1823:
1820:
1815:
1811:
1806:
1801:
1797:
1793:
1789:
1785:
1781:
1774:
1771:
1767:
1766:
1759:
1756:
1751:
1747:
1743:
1739:
1734:
1729:
1725:
1721:
1717:
1709:
1706:
1701:
1697:
1692:
1687:
1682:
1677:
1673:
1669:
1665:
1658:
1656:
1652:
1647:
1643:
1638:
1633:
1629:
1625:
1621:
1614:
1612:
1608:
1603:
1599:
1595:
1591:
1587:
1583:
1579:
1575:
1568:
1565:
1560:
1556:
1551:
1546:
1542:
1538:
1534:
1530:
1526:
1519:
1516:
1511:
1507:
1501:
1498:
1493:
1489:
1485:
1481:
1477:
1473:
1469:
1465:
1457:
1454:
1449:
1445:
1440:
1435:
1431:
1427:
1423:
1416:
1413:
1409:
1408:0-7216-2921-0
1405:
1401:
1395:
1392:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1351:
1348:
1343:
1339:
1335:
1331:
1327:
1323:
1322:Dermatol Surg
1316:
1313:
1309:
1303:
1300:
1295:
1291:
1286:
1281:
1277:
1273:
1269:
1265:
1261:
1254:
1251:
1246:
1242:
1237:
1232:
1228:
1224:
1220:
1213:
1211:
1207:
1202:
1198:
1193:
1188:
1184:
1180:
1176:
1172:
1168:
1161:
1158:
1153:
1149:
1145:
1141:
1137:
1133:
1128:
1123:
1119:
1115:
1111:
1104:
1101:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1057:
1054:
1049:
1045:
1040:
1035:
1030:
1025:
1021:
1017:
1013:
1006:
1003:
998:
994:
989:
984:
979:
974:
970:
966:
962:
958:
954:
946:
944:
940:
935:
931:
926:
921:
916:
911:
907:
903:
899:
895:
891:
883:
880:
869:on 2013-12-28
868:
864:
858:
855:
850:
846:
841:
836:
833:(2): 121–32.
832:
828:
824:
817:
814:
808:
804:
801:
800:
796:
794:
792:
788:
781:
779:
776:
772:
768:
766:
762:
755:
753:
751:
743:
741:
734:
732:
730:
722:
720:
718:
709:
706:
703:
700:
697:
694:
691:
688:
685:
682:
681:
679:
676:
673:
670:
667:
663:
662:
661:
655:
653:
651:
647:
643:
636:
633:
630:
627:
624:
621:
617:
614:
611:
608:
605:
601:
597:
594:
591:
588:
577:
574:
573:
569:
567:
561:
558:
557:Bezuclastinib
550:
547:
544:
541:
538:
535:
534:
533:
530:
528:
527:enterocolitis
524:
520:
516:
507:
503:
499:
492:
490:
484:
480:
476:
472:
469:
468:
463:
459:
458:
454:
452:
446:
441:
437:
434:
431:
428:
427:
426:
420:
415:
412:
409:
406:
405:
401:
396:
395:
391:
389:
387:
382:
378:
376:
372:
369:Diagnosis of
364:
362:
360:
356:
352:
348:
344:
340:
336:
331:
329:
325:
321:
320:blood vessels
317:
313:
308:
306:
302:
298:
294:
290:
283:
281:
275:
272:
271:Malabsorption
269:
266:
265:parietal cell
262:
258:
257:peptic ulcers
254:
251:
248:
245:
242:
238:
234:
232:
228:
225:
223:
219:
215:
212:
208:
205:
202:
199:
197:
194:
192:
188:
185:
183:
180:
177:
174:
171:
170:
164:
160:
159:
154:
151:
150:
149:
147:
146:degranulation
138:
131:
129:
127:
123:
119:
115:
110:
108:
104:
100:
99:rare disorder
96:
92:
84:
80:
76:
73:
71:
67:
63:
62:H&E stain
59:
55:
51:
46:
43:
40:
36:
31:
19:
3870:
3866:mastocytosis
3859:
3855:mastocytosis
3848:
3834:
3810:
3799:
3788:
3780:
3761:
3742:
3727:
3513:Nasal glioma
3503:Dermoid cyst
3472:
3466:
3455:
3454:
3439:Mastocytosis
3438:
3426:
3420:EEM syndrome
3412:
3341:
3297:
3283:
3162:
3138:
3109:
2670:skin disease
2599:
2572:
2499:Mastocytosis
2498:
2487:
2466:
2402:
2380:
2358:
2316:
2264:
2242:
2207:
2147:
2125:
2085:
2058:
2023:
1981:
1954:granulocytes
1881:
1877:
1859:
1855:
1849:
1832:
1828:
1822:
1787:
1783:
1773:
1763:
1758:
1723:
1719:
1708:
1671:
1667:
1627:
1623:
1577:
1573:
1567:
1532:
1528:
1518:
1509:
1500:
1467:
1463:
1456:
1429:
1425:
1415:
1399:
1394:
1361:
1357:
1350:
1325:
1321:
1315:
1302:
1267:
1263:
1253:
1226:
1222:
1174:
1170:
1160:
1120:(1): 12–30.
1117:
1113:
1103:
1070:
1066:
1056:
1019:
1015:
1005:
960:
956:
900:(5): e2266.
897:
893:
882:
871:. Retrieved
867:the original
857:
830:
827:Pathobiology
826:
816:
790:
786:
785:
777:
773:
769:
759:
747:
744:Epidemiology
738:
726:
715:
659:
640:
565:
531:
511:
488:
483:homme orange
482:
465:
461:
450:
424:
385:
383:
379:
370:
368:
358:
354:
350:
338:
332:
327:
324:angiogenesis
309:
287:
279:
237:osteoporosis
216:Episodes of
168:
156:
143:
140:Mastocytosis
111:
102:
93:, a type of
91:Mastocytosis
90:
89:
41:
33:Mastocytosis
3676:Skin dimple
3285:desmoplakin
3277:ungrouped:
3164:Cathepsin C
3140:plakoglobin
2841:and related
2468:Mastocytoma
1328:(1): 33–7.
1136:10261/62846
803:Mastocytoma
708:Avapritinib
702:Midostaurin
684:Midostaurin
650:mirtazapine
620:anaphylaxis
616:Epinephrine
590:Leukotriene
523:lymph nodes
231:muscle pain
207:Anaphylaxis
38:Other names
3893:Categories
3812:DiseasesDB
3106:syndromic
3029:Cutis laxa
3016:Connective
2666:integument
2662:Congenital
1952:and other
1510:Cancer.Net
873:2017-11-02
809:References
672:Cladribine
666:interferon
626:Salbutamol
479:integument
289:Mast cells
249:Depression
103:mastocytes
83:hematology
58:Micrograph
3836:eMedicine
3696:Birthmark
3489:anomalies
3456:see also
2934:related:
2787:Ungrouped
1972:Myelocyte
1938:-related
1862:: 359–61.
1841:840287852
1674:: 77–92.
1484:1543-2165
735:Prognosis
696:Masitinib
604:Ketotifen
562:Treatment
365:Diagnosis
316:histamine
301:histamine
222:faintness
169:urticaria
126:histamine
95:mast cell
70:Specialty
3872:Orphanet
3844:med/1401
3841:derm/258
3785:: 9741/3
3414:cadherin
3299:connexin
3237:punctate
3111:connexin
2457:CFU-Mast
2198:CFU-Baso
2049:Monocyte
1814:20745623
1784:Br Med J
1750:24088671
1742:27428296
1700:31372066
1646:27762455
1602:37335288
1559:24044484
1492:25611105
1448:21301631
1386:30459720
1378:12688351
1294:21035176
1245:27069254
1201:28254862
1152:12120327
1144:17555444
1095:52298220
1087:30230078
1048:19058339
997:22031830
957:PLOS ONE
934:18509466
894:PLOS ONE
849:17587883
797:See also
756:Research
690:Imatinib
347:receptor
246:Headache
196:Diarrhea
191:vomiting
79:Oncology
3806:D008415
3496:Midline
3081:diffuse
3012:Elastic
2307:CFU-Meg
2233:CFU-Eos
2070:AMoL/M5
1936:Myeloid
1898:7771504
1805:2260962
1691:6630092
1594:3749421
1550:4362676
1439:3033552
1342:8556255
1285:3753019
1192:5354959
1039:2773867
988:3198767
965:Bibcode
925:2386235
902:Bibcode
782:History
646:doxepin
328:too few
163:itching
152:Fatigue
114:itching
3795:154800
3772:757.33
3343:ATP2A2
2907:JEB-PA
2878:EBS-MP
2873:EBS-MD
2868:EBS-OG
2863:EBS-DM
2858:EBS-WC
2013:APL/M3
1963:CFU-GM
1948:CFU-GM
1896:
1839:
1812:
1802:
1748:
1740:
1698:
1688:
1644:
1600:
1592:
1557:
1547:
1490:
1482:
1446:
1436:
1406:
1384:
1376:
1340:
1310:, 2017
1292:
1282:
1243:
1199:
1189:
1150:
1142:
1093:
1085:
1046:
1036:
995:
985:
932:
922:
847:
680:(TKI)
519:spleen
375:biopsy
312:wounds
187:Nausea
165:, and
120:, and
105:) and
3877:98292
3782:ICD-O
3776:202.6
3757:C96.2
3753:Q82.2
3533:Nevus
3406:Other
3325:Other
3187:focal
2897:Mitis
2892:JEB-H
2853:EBS-K
2349:CFU-E
2177:Other
2149:MD-MP
1831:[
1746:S2CID
1598:S2CID
1382:S2CID
1223:Blood
1148:S2CID
1091:S2CID
723:Other
582:and H
551:(MCL)
515:liver
506:c-KIT
474:trunk
359:c-kit
343:CD117
339:c-kit
211:shock
118:hives
3861:GARD
3850:NORD
3817:7864
3801:MeSH
3790:OMIM
3767:9-CM
3738:2A21
2926:RDEB
2921:DDEB
1894:PMID
1837:OCLC
1810:PMID
1738:PMID
1696:PMID
1642:PMID
1590:PMID
1555:PMID
1488:PMID
1480:ISSN
1444:PMID
1404:ISBN
1374:PMID
1338:PMID
1290:PMID
1241:PMID
1197:PMID
1140:PMID
1083:PMID
1044:PMID
993:PMID
930:PMID
845:PMID
648:and
521:and
504:for
297:skin
227:Bone
189:and
107:CD34
3763:ICD
3744:ICD
3729:ICD
3314:KID
3310:HID
3073:PPK
2916:DEB
2887:JEB
2848:EBS
2574:AML
2360:AML
2298:MEP
2244:AML
2209:AML
2127:AML
2087:CML
2060:AML
1983:AML
1886:doi
1882:309
1800:PMC
1792:doi
1728:doi
1686:PMC
1676:doi
1632:doi
1582:doi
1545:PMC
1537:doi
1472:doi
1468:139
1434:PMC
1366:doi
1330:doi
1280:PMC
1272:doi
1268:126
1231:doi
1227:127
1187:PMC
1179:doi
1132:hdl
1122:doi
1118:138
1075:doi
1034:PMC
1024:doi
983:PMC
973:doi
920:PMC
910:doi
835:doi
355:scf
351:scf
239:or
229:or
161:),
3895::
3875::
3864::
3853::
3839::
3815::
3804::
3793::
3774:,
3770::
3755:,
3751::
3748:10
3736::
3733:11
3471:,
3465:,
3460:,
3239::
3189::
3083::
2838:EB
2770:XR
2729::
2719:AR
2701:AD
2668:/
2601:MP
2404:MD
2382:MP
2318:MP
2266:MP
2137:M4
2025:MP
2008:M2
2003:M1
1998:M0
1892:.
1880:.
1860:43
1858:.
1808:.
1798:.
1786:.
1782:.
1744:.
1736:.
1724:91
1722:.
1718:.
1694:.
1684:.
1672:11
1670:.
1666:.
1654:^
1640:.
1628:91
1626:.
1622:.
1610:^
1596:.
1588:.
1578:48
1576:.
1553:.
1543:.
1533:14
1531:.
1527:.
1508:.
1486:.
1478:.
1466:.
1442:.
1428:.
1424:.
1380:.
1372:.
1362:44
1360:.
1336:.
1326:22
1324:.
1288:.
1278:.
1266:.
1262:.
1239:.
1225:.
1221:.
1209:^
1195:.
1185:.
1175:77
1173:.
1169:.
1146:.
1138:.
1130:.
1116:.
1112:.
1089:.
1081:.
1071:28
1069:.
1065:.
1042:.
1032:.
1020:14
1018:.
1014:.
991:.
981:.
971:.
959:.
955:.
942:^
928:.
918:.
908:.
896:.
892:.
843:.
831:74
829:.
825:.
664:É‘-
517:,
386:or
337:,
116:,
81:,
77:,
3765:-
3746:-
3731:-
3721:D
3441:/
3312:/
3061:/
3035:)
3031:(
3014:/
3000:/
2971:/
2689:/
2654:e
2647:t
2640:v
2278:/
1950:/
1928:e
1921:t
1914:v
1900:.
1888::
1843:.
1816:.
1794::
1788:2
1752:.
1730::
1702:.
1678::
1648:.
1634::
1604:.
1584::
1561:.
1539::
1494:.
1474::
1450:.
1430:6
1410:.
1388:.
1368::
1344:.
1332::
1296:.
1274::
1247:.
1233::
1203:.
1181::
1154:.
1134::
1124::
1097:.
1077::
1050:.
1026::
999:.
975::
967::
961:6
936:.
912::
904::
898:3
876:.
851:.
837::
622:.
584:2
580:1
485:.
442:.
341:(
322:(
267:)
243:)
209:(
64:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
