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85:-based mitotoxins. Because of the high affinity and specificity of mitotoxin binding, they present the possibility of creating precise therapeutic agents. A major one of these possibilities is the potential usage of growth factor-based mitotoxins as
42:. Mitotoxins are responsible for mediating cell death by interfering with protein or DNA synthesis. Some mechanisms by which mitotoxins can interfere with DNA or protein synthesis include the inactivation of
50:. These toxins have a very high affinity and level of specificity for the receptors that they bind to. Mitotoxins bind to receptors on cell surfaces and are then internalized into cells via
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There are different classes of mitotoxins, each acting on a different type of cell or system. The mitotoxin classes that have been identified thus far include:
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Souders, Christopher L.; Wei, Chi; Schmidt, Jordan T.; Da Fonte, Dillon F.; Xing, Lei; Trudeau, Vance L.; Martyniuk, Christopher J. (May 2021).
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168:"The basic fibroblast growth factor-saporin mitotoxin acts through the basic fibroblast growth factor receptor"
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325:"Anti-B16-F10 melanoma activity of a basic fibroblast growth factor-saporin mitotoxin"
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Lappi, Douglas A.; Maher, Pamela A.; Martineau, Darlene; Baird, Andrew (April 1991).
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Comparative
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121:"Mitotoxins: Growth factor-targeted cytotoxic molecules"
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89:agents that can modulate the growth of
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278:"Chimeric toxins in cancer treatment"
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276:Kreitman, Robert J (February 2000).
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411:. You can help Knowledge (XXG) by
125:Progress in Growth Factor Research
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79:insulin-like growth factor
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83:fibroblast growth factor
16:Not to be confused with
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71:epidermal growth factor
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233:: 108995.
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18:maitotoxin
302:1361-9195
263:231918972
247:1532-0456
192:0021-9541
145:0955-2235
91:melanomas
44:ribosomes
29:cytotoxic
25:mitotoxin
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77:-based,
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