17:
160:
proteins. By 10–14 days of exposure to retinoic acid, NTERA-2 cells begin to take on the morphological characteristics of neurons, such as rounded cell bodies and
404:"The human NTERA2 neural cell line generates neurons on growth under neural stem cell conditions and exhibits characteristics of radial glial cells"
230:"Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins"
334:"Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro"
25:
113:
284:"NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell"
188:
differentiation of neuronal precursor cells. They have also been proposed as an in vitro test system for developmental
565:
560:
145:
133:
365:"Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro"
402:
Marchal-Victorion S, Deleyrolle L, De Weille J, Saunier M, Dromard C, Sandillon F, et al. (2003).
501:
48:
181:
56:
525:
431:
311:
70:
NTERA-2 cells exhibit biochemical and developmental properties similar to the cells of the early
517:
470:
423:
384:
345:
303:
261:
509:
462:
451:"NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells"
415:
376:
295:
251:
241:
161:
101:
165:
117:
490:"Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity"
332:
Andrews PW, Damjanov I, Simon D, Banting GS, Carlin C, Dracopoli NC, et al. (1984).
505:
449:
Schwartz CM, Spivak CE, Baker SC, McDaniel TK, Loring JF, Nguyen C, et al. (2005).
16:
256:
246:
229:
109:
419:
554:
380:
189:
157:
153:
137:
21:
20:
NTERA-2 cells before (left) and after (right) differentiation induced by exposure to
529:
435:
315:
185:
79:
75:
52:
513:
201:
169:
91:
466:
209:
83:
59:
521:
489:
474:
450:
427:
403:
388:
364:
349:
333:
307:
299:
283:
265:
212:
onto a mouse, and from this cells were cloned into the NTERA-2 cell line.
121:
105:
87:
545:
204:
from a 22-year-old male patient with primary embryonal carcinoma of the
94:
205:
141:
97:
71:
149:
140:
and lose expression of SSEA-3. Differentiation produces
74:, and can be used to study the early stages of human
200:NTERA-2 cells were originally isolated from a lung
164:. NTERA-2 cells can also produce a small number of
28:, a neural precursor marker, after differentiation.
24:. The bottom panels show NTERA-2 cells expressing
168:-type cells, but they cannot differentiate into
327:
325:
277:
275:
8:
120:. NTERA-2 cells also accumulate cytoplasmic
488:Stern M, Gierse A, Tan S, Bicker G (2014).
255:
245:
15:
220:
184:, NTERA-2 cells are used to study the
148:, and these cells form interconnected
180:Because of their similarity to human
108:, which are found in neuroepithelial
7:
247:10.1523/jneurosci.06-02-00514.1986
14:
114:microtubule-associated proteins
1:
546:Cellosaurus entry for NTERA-2
420:10.1016/s1044-7431(03)00161-1
381:10.1016/0012-1606(84)90316-6
282:Pleasure SJ, Lee VM (1993).
90:, and the expression of the
228:Lee VM, Andrews PW (1986).
78:. The cells exhibit a high
582:
514:10.1007/s00204-013-1098-1
146:asymmetric cell division
467:10.1089/scd.2005.14.517
29:
300:10.1002/jnr.490350603
152:networks and express
19:
182:embryonic stem cells
100:. They also express
506:2014ArTox..88..127S
363:Andrews PW (1984).
116:expressed in human
57:embryonal carcinoma
566:Stem cell research
30:
408:Mol Cell Neurosci
86:ratio, prominent
47:) cell line is a
36:(also designated
573:
561:Human cell lines
534:
533:
485:
479:
478:
446:
440:
439:
399:
393:
392:
360:
354:
353:
329:
320:
319:
279:
270:
269:
259:
249:
225:
208:. The tumor was
136:when exposed to
581:
580:
576:
575:
574:
572:
571:
570:
551:
550:
542:
537:
487:
486:
482:
448:
447:
443:
401:
400:
396:
362:
361:
357:
331:
330:
323:
281:
280:
273:
227:
226:
222:
218:
198:
178:
166:oligodendrocyte
130:
128:Differentiation
118:neuroepithelium
110:precursor cells
68:
66:Characteristics
12:
11:
5:
579:
577:
569:
568:
563:
553:
552:
549:
548:
541:
540:External links
538:
536:
535:
480:
455:Stem Cells Dev
441:
414:(1): 198–213.
394:
355:
321:
294:(6): 585–602.
288:J Neurosci Res
271:
219:
217:
214:
197:
194:
177:
174:
156:receptors and
132:NTERA-2 cells
129:
126:
67:
64:
13:
10:
9:
6:
4:
3:
2:
578:
567:
564:
562:
559:
558:
556:
547:
544:
543:
539:
531:
527:
523:
519:
515:
511:
507:
503:
500:(1): 127–36.
499:
495:
491:
484:
481:
476:
472:
468:
464:
461:(5): 517–34.
460:
456:
452:
445:
442:
437:
433:
429:
425:
421:
417:
413:
409:
405:
398:
395:
390:
386:
382:
378:
375:(2): 285–93.
374:
370:
366:
359:
356:
351:
347:
344:(2): 147–62.
343:
339:
335:
328:
326:
322:
317:
313:
309:
305:
301:
297:
293:
289:
285:
278:
276:
272:
267:
263:
258:
253:
248:
243:
240:(2): 514–21.
239:
235:
231:
224:
221:
215:
213:
211:
207:
203:
195:
193:
191:
190:neurotoxicity
187:
183:
175:
173:
171:
167:
163:
159:
158:neurofilament
155:
154:tetanus toxin
151:
147:
143:
139:
138:retinoic acid
135:
134:differentiate
127:
125:
123:
119:
115:
112:, as well as
111:
107:
103:
99:
96:
93:
89:
85:
81:
77:
73:
65:
63:
61:
58:
54:
50:
46:
42:
39:
35:
27:
23:
22:retinoic acid
18:
497:
494:Arch Toxicol
493:
483:
458:
454:
444:
411:
407:
397:
372:
368:
358:
341:
337:
291:
287:
237:
233:
223:
199:
186:dopaminergic
179:
131:
76:neurogenesis
69:
44:
40:
37:
33:
31:
210:xenografted
84:cytoplasmic
53:pluripotent
555:Categories
338:Lab Invest
234:J Neurosci
216:References
202:metastasis
170:astrocytes
92:glycolipid
38:NTERA2/D1,
162:processes
60:cell line
51:derived,
530:11009212
522:23917397
475:16305337
436:19602356
428:14550780
369:Dev Biol
316:33458224
176:Research
122:glycogen
106:vimentin
88:nucleoli
49:clonally
502:Bibcode
389:6144603
350:6694356
308:8411264
266:2419526
257:6568536
196:History
142:neurons
95:antigen
34:NTERA-2
528:
520:
473:
434:
426:
387:
348:
314:
306:
264:
254:
206:testis
102:nestin
98:SSEA-3
80:nucleo
72:embryo
55:human
41:NTERA2
526:S2CID
432:S2CID
312:S2CID
43:, or
518:PMID
471:PMID
424:PMID
385:PMID
346:PMID
304:PMID
262:PMID
150:axon
144:via
104:and
32:The
26:GFAP
510:doi
463:doi
416:doi
377:doi
373:103
296:doi
252:PMC
242:doi
45:NT2
557::
524:.
516:.
508:.
498:88
496:.
492:.
469:.
459:14
457:.
453:.
430:.
422:.
412:24
410:.
406:.
383:.
371:.
367:.
342:50
340:.
336:.
324:^
310:.
302:.
292:35
290:.
286:.
274:^
260:.
250:.
236:.
232:.
192:.
172:.
124:.
62:.
532:.
512::
504::
477:.
465::
438:.
418::
391:.
379::
352:.
318:.
298::
268:.
244::
238:6
82:-
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
