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for products marketed to contain an adaptogen. As an example in 2020, the FDA issued a warning letter to a manufacturer of mushroom supplements purported to contain adaptogens having diverse antidisease effects, stating that such products "are not generally recognized as safe and effective for the
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above referenced uses and, therefore, these products are "new drugs" under section 201(p) of the FD&C Act . New drugs may not be legally introduced or delivered for introduction into interstate commerce without prior approval from the FDA."
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purported to diminish stress and support overall wellbeing when consumed. However, the definition of an adaptogen is vague and without adequate scientific evidence, making it impossible to determine what exactly makes a substance an adaptogen.
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319:"Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs"
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421:"Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity"
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Nikolai
Lazarev to describe substances that may increase resistance to stress. The term "adaptogenesis" was later applied in the
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or clinical settings, and is not approved for marketing in the
European Union or United States. From 2020 to 2023, the US
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Brekhman II, Dardymov IV (1969). "New
Substances of Plant Origin which Increase Nonspecific Resistance".
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Compounds studied for putative adaptogenic properties are often derived from the following plants:
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255:"Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature"
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397:. Division of Human and Animal Food Operations East, US Food and Drug Administration
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109:. Most of the studies conducted on adaptogens were performed in the Soviet Union,
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479:. European Medicines Agency, Committee on Herbal Medicinal Products. 8 May 2008
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before the 1980s. As of 2020, the term was not accepted in pharmacological,
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to describe remedies thought to increase the resistance of organisms to
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Tinsley GM, Jagim AR, Potter GDM, Garner D, Galpin AJ (August 2023).
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Siwek M, Woroń J, Wrzosek A, Gupało J, Chrobak AA (2023).
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The term "adaptogen" refers to non-toxic plants or their
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The concept of an adaptogenic effect is not accepted in
97:The term "adaptogens" was coined in 1947 by Soviet
374:. US Food and Drug Administration. 3 November 2023
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474:"Reflection Paper on the Adaptogenic Concept"
395:"FDA warning letter to Mushroom Revival, Inc"
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372:"Warning letters (search term: adaptogen)"
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30:for the purported stabilization of
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16:Substance used in herbal medicine
419:Panossian A, Wikman G (2010).
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206:Annual Review of Pharmacology
259:British Journal of Nutrition
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84:making illegal, unapproved
34:processes and promotion of
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336:10.3389/fphar.2023.1271776
139:Eleutherococcus senticosus
56:Concept and non-acceptance
323:Frontiers in Pharmacology
272:10.1017/S0007114523001988
51:root, cited as adaptogen.
242:. Dictionary.com. 2012.
160:Rhaponticum cartamoides
26:substances are used in
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174:Schisandra chinensis
80:to manufacturers of
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329:: 1271776.
240:"Adaptogen"
212:: 419–430.
36:homeostasis
24:adaptogenic
499:Categories
483:26 October
401:5 November
378:5 November
188:References
20:Adaptogens
505:Herbalism
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