Knowledge (XXG)

Antiandrogens in the environment

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Reinforcing the evidence suggesting that there is a relationship between chemicals and GM, it is worthwhile mentioning the epidemic onset observed among Haitian refugees in 1981 about four months after arrival in United States detention centers.22 After analyzing all identifiable environmental
902: 210:, have been found to mimic androgen antagonist activity. Antiandrogenic endocrine disruption has been shown in aquatic species, but the mechanism is unknown. Researchers believe parabens have the ability to bind to human androgen receptors but it still remains unclear. 199:(DEHP) and di-n-pentyl phthalate (DPP) were combined, reductions in both testosterone synthesis and gene expression of steroidogenic pathway proteins were seen. The results in male rats were undescended testes and abnormal development of reproductive tissues. 92:(p.p’-DDE) have shown irregular reproductive development due to their function as androgen receptor antagonists that inhibit androgen-activated gene expression. Even with low doses of antiandrogenic pesticides, developmental effects such as reduced 60:
Exposure to pesticides with antiandrogen properties has been found to negatively affect laboratory animals. Androgens are important in fetal development as well as in pubertal development. Exposure during critical periods of development can cause
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Phthalates are mainly found as softeners in plastics, but also perfumes, nail varnish and other cosmetics. Fetuses that are exposed to a mixture of phthalates in utero may show signs of disrupted reproductive development. When
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exposures, it was then found that phenothrin, a multi-insecticide contained in sprays that they had used was the causative agent.23 It is now widely known that phenothrin has antiandrogenic activity.
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antifungal agent effective against a variety of fungal infections. Although ketoconazole is a relatively weak antiandrogen, high doses side-effects lead to reduced levels of androgens from both the
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Animal studies show that deformities result in offspring exposed to antiandrogens. Male mice can display malformations that resemble the reproductive organs of females as in the case of exposure to
1834: 52:, that antagonistically affect androgen receptors and androgen production can negatively affect animals that come in contact with the compounds as well as their future generations. 750: 48:
Exposure to antiandrogens can occur unintentionally due to natural or anthropogenic compounds in the environment. Environmental compounds affecting the endocrine system, termed
41:. Certain plant species have also been found to produce antiandrogens. In animal studies, environmental antiandrogens can harm reproductive organ development in fetuses exposed 4119: 123:, and presence of a vaginal pouch. Male mice exposed before puberty to vinclozolin experienced delayed pubertal development visualized by delayed onset of androgen-dependent 2266: 206:
and/or antimicrobial agents and commonly found in food, soap, detergent, toothpaste, disinfectant, cosmetic and pharmaceutical products. Paraben esters, such as
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Schleich S, Papaioannou M, Baniahmad A, Matusch R (July 2006). "Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity".
350:"Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity" 107:
or procymidone. Exposure to vinclozolin or procymidone in utero feminized male offspring, as seen in abnormalities of anogenital distance, small or absent
1827: 1796: 508:"Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks" 4081: 743: 612:"NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth" 4112: 4086: 2566: 4076: 3028: 1820: 1786: 1753: 171:
Industrial chemicals with antiandrogenic effects are ubiquitous in the environment. Consumer products such as toys and cosmetics may contain
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Gray LE, Ostby J, Furr J, Wolf CJ, Lambright C, Parks L, Veeramachaneni DN, Wilson V, Price M, Hotchkiss A, Orlando E, Guillette L (2001).
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Papaioannou M, Schleich S, Roell D, Schubert U, Tanner T, Claessens F, Matusch R, Baniahmad A (December 2010).
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native to southern Europe, India, and parts of Asia has shown antiandrogen activity in male rats.
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Zamansoltani F, Nassiri-Asl M, Sarookhani MR, Jahani-Hashemi H, Zangivand AA (August 2009).
666: 623: 582: 519: 471: 453: 412: 369: 361: 313: 302:"Effects of environmental antiandrogens on reproductive development in experimental animals" 159:
that also possesses antiandrogen activity and has been associated with a small epidemic of
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Barros, Alfredo Carlos Simões Dornellas de; Sampaio, Marcelo de Castro Moura (2012).
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Le, H. T.; Schaldach, C. M.; Firestone, G. L.; Bjeldanes, L. F. (6 June 2003).
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Trenbolone hexahydrobenzylcarbonate (trenbolone cyclohexylmethylcarbonate)
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found in cruciferous vegetables, which are members of the cabbage family.
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in males while exposure after birth and before puberty can delay
3980: 3293: 4101: 1816: 732: 3663: 694:"Antiandrogenic activities of Glycyrrhiza glabra in male rats" 85: 3070:
Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4)
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Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione)
442:"Gynecomastia: physiopathology, evaluation and treatment" 2754:
17α-Alkylated 5α-dihydro-19-nortestosterone derivatives:
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7α-Methyl-19-norandrostenedione (MENT dione, trestione)
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5α-Dihydro-17α-ethynyl-19-nortestosterone derivatives:
399:"Organophosphate antagonism of the androgen receptor" 348:
Rider CV, Furr JR, Wilson VS, Gray LE Jr (Apr 2010).
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Androstanolone (stanolone, dihydrotestosterone, DHT)
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Normethandrone (methylestrenolone, normethisterone)
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Normethandrone (methylestrenolone, normethisterone)
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Drostanolone propionate (dromostanolone propionate)
790: 777: 770: 248:, the Subsaharan red stinkwood tree, is a specific 228:Antiandrogens can also occur naturally in plants. 2597:17α-Alkylated 5α-dihydrotestosterone derivatives: 1047:Metandienone (methandienone, methandrostenolone) 2816:5α-Dihydro-17α-ethynyltestosterone derivatives: 2267:11β-Methyl-19-nortestosterone dodecylcarbonate 1099:17α-Alkylated dihydrotestosterone derivatives: 4113: 3034:Tooltip Selective androgen receptor modulator 2679:17α-Alkylated 19-nortestosterone derivatives: 1828: 1139:17α-Alkylated 19-nortestosterone derivatives: 744: 252:and has been used as alternative medicine in 231:The best known plant-derived antiandrogen is 8: 3085:Enobosarm (ostarine, MK-2866, GTx-024, S-22) 958:Metenolone enanthate (methenolone enanthate) 2836:17α-Ethynyl-19-nortestosterone derivatives: 1282: 4120: 4106: 4098: 3946: 2558:Methylclostebol (chloromethyltestosterone) 2453:5α-Dihydro-19-nortestosterone derivatives: 1864: 1835: 1821: 1813: 1478: 1315: 787: 751: 737: 729: 2779:17α-Vinyl-19-nortestosterone derivatives: 2395:Oxabolone cipionate (oxabolone cypionate) 2011:DHEA (androstenolone, prasterone; 5-DHEA) 1855: 1320: 1002:Oxabolone cipionate (oxabolone cypionate) 846:Prasterone (dehydroepiandrosterone, DHEA) 792: 709: 586: 523: 475: 457: 416: 373: 317: 2486:Chlorodehydromethylandrostenediol (CDMA) 953:Metenolone acetate (methenolone acetate) 501: 499: 4087:List of androgens and anabolic steroids 2473:17α-Alkylated testosterone derivatives: 1019:17α-Alkylated testosterone derivatives: 343: 341: 339: 337: 273: 2491:Chlorodehydromethyltestosterone (CDMT) 2247:Testifenon (testiphenon, testiphenone) 1032:Chlorodehydromethyltestosterone (CDMT) 295: 293: 291: 289: 287: 285: 283: 281: 279: 277: 220:are both antiandrogens and estrogens. 2772:Norvinisterone (vinylnortestosterone) 2306:Bolmantalate (nandrolone adamantoate) 2301:Bolandione (19-nor-4-androstenedione) 2016:DHEA enanthate (prasterone enanthate) 1172:Norvinisterone (vinylnortestosterone) 851:Prasterone enanthate (DHEA enanthate) 163:via isolated environmental exposure. 25:have become a topic of concern. Many 7: 4375:List of environmental health hazards 4042:Tooltip Sex hormone-binding globulin 2789:17α-Ethynyltestosterone derivatives: 2068:Polytestosterone phloretin phosphate 1296:Tooltip human chorionic gonadotropin 1179:17α-Ethynyltestosterone derivatives: 179:, which disrupt androgen synthesis. 2712:Methylhydroxynandrolone (MOHN, MHN) 2417:Trenbolone hexahydrobenzylcarbonate 2077:5α-Dihydrotestosterone derivatives: 1945:Androstenedione (4-androstenedione) 1802:List of androgens/anabolic steroids 782:Tooltip anabolic–androgenic steroid 37:, exhibit antiandrogen activity in 4260:Miscellaneous additives incl. PHCs 2769:17α-Vinyltestosterone derivatives: 2531:Methandriol (methylandrostenediol) 1731:Androvax (androstenedione albumin) 1169:17α-Vinyltestosterone derivatives: 1052:Methandriol (methylandrostenediol) 354:International Journal of Andrology 14: 2809:Ethisterone (ethynyltestosterone) 2526:Metandienone (methandrostenolone) 2356:Methoxydienone (methoxygonadiene) 1967:Boldione (1,4-androstadienedione) 1918:Androstenediol (5-androstenediol) 1883:4-Dehydroepiandrosterone (4-DHEA) 1797:Progestogens and antiprogestogens 1196:ethisterone (ethynyltestosterone) 856:Prasterone sulfate (DHEA sulfate) 506:Darbre PD, Harvey PW (Jul 2008). 242:(NBBS) isolated from the bark of 4082:Progesterone receptor modulators 2573:Methyltestosterone 3-hexyl ether 2536:Methandriol bisenanthoyl acetate 2496:Chloromethylandrostenediol (CMA) 2331:Dimethandrolone dodecylcarbonate 2090:1-Androsterone (1-andro, 1-DHEA) 1077:Methyltestosterone 3-hexyl ether 1057:Methandriol bisenanthoyl acetate 915:Dihydrotestosterone derivatives: 711:10.1111/j.1365-2605.2008.00944.x 366:10.1111/j.1365-2605.2009.01049.x 90:dichlorodiphenyldichloroethylene 2254:19-Nortestosterone derivatives: 970:19-Nortestosterone derivatives: 459:10.1590/S1516-31802012000300009 3269:15β-Hydroxycyproterone acetate 3160:OPK-88004 (LY-2452473, TT-701) 1736:Ovandrotone albumin (Fecundin) 1208:norethisterone (norethindrone) 1: 4067:Receptor/signaling modulators 2824:17α-Ethynyl-3β-androstanediol 2819:17α-Ethynyl-3α-androstanediol 2262:11β-Methyl-19-nortestosterone 512:Journal of Applied Toxicology 4406:Toxic Substances Control Act 4365:Persistent organic pollutant 4077:Estrogen receptor modulators 3524:Trimethyltrienolone (R-2956) 2896:Lynestrenol phenylpropionate 2284:19-Nordehydroepiandrosterone 1787:Androgen receptor modulators 1699:hydroxyprogesterone caproate 1162:Propetandrol (propethandrol) 1092:Tiomesterone (thiomesterone) 254:benign prostatic hyperplasia 45:as well as their offspring. 4360:Great Pacific garbage patch 4072:Androgens and antiandrogens 3843:Ralaniten acetate (EPI-506) 3259:7α-Thiomethylspironolactone 2974:Medroxyprogesterone acetate 2336:Dimethandrolone undecanoate 2147:Dihydromethylandrostenediol 1938:Androstenediol dipropionate 1792:Estrogens and antiestrogens 1728:Androstenedione immunogens: 1707:medroxyprogesterone acetate 1287:Tooltip luteinizing hormone 1232:Medroxyprogesterone acetate 986:nandrolone phenylpropionate 891:testosterone ester mixtures 811:Androstenediol dipropionate 547:Yang, Sarah (12 May 2003). 197:Bis(2-ethylhexyl) phthalate 56:Pesticides and insecticides 4448: 4401:Japan Toxic Substances Law 4196:Miscellaneous plasticizers 2162:Dihydrotestosterone esters 2115:11-Ketodihydrotestosterone 1928:Androstenediol 17β-acetate 1908:11β-Hydroxyandrostenedione 1893:4,17α-Dimethyltestosterone 1657:ethinylestradiol sulfonate 119:, retained nipples, cleft 63:reproductive malformations 4396:European REACH regulation 4391:California Proposition 65 4134:polyhalogenated compounds 4059: 2966:Progesterone derivatives: 2757:5α-Dihydronorethandrolone 2326:Dimethandrolone buciclate 2156:androstanolone, stanolone 2152:Dihydrotestosterone (DHT) 2110:7β-Hydroxyepiandrosterone 1999:Cloxotestosterone acetate 1923:Androstenediol 3β-acetate 1875:Testosterone derivatives: 1860:Tooltip Androgen receptor 1748: 1325:Tooltip Androgen receptor 1229:Progesterone derivatives: 841:Cloxotestosterone acetate 808:Testosterone derivatives: 797:Tooltip Androgen receptor 628:10.1007/s10637-009-9304-y 446:Sao Paulo Medical Journal 306:Human Reproduction Update 240:N-butylbenzenesulfonamide 3772:-Butylbenzenesulfonamide 2959:5α-Dihydronorethisterone 2954:5α-Dihydrolevonorgestrel 2916:norethisterone enanthate 2885:levonorgestrel butanoate 2762:5α-Dihydronormethandrone 2615:Mebolazine (dimethazine) 2605:Desoxymethyltestosterone 2546:Methandriol dipropionate 2343:LS-1727 (nandrolone 17β- 2279:19-Nor-5-androstenedione 2137:Dihydroethyltestosterone 1933:Androstenediol diacetate 1112:Mebolazine (dimethazine) 1062:Methandriol dipropionate 887:testosterone undecanoate 137:derivative is used as a 100:were seen in male rats. 3903:Topilutamide (fluridil) 3264:11α-Hydroxyprogesterone 2274:19-Nor-5-androstenediol 2174:Drostanolone propionate 1462:Topilutamide (fluridil) 883:testosterone propionate 4287:Perfluorooctanoic acid 3788:-Desmethylenzalutamide 3494:SC-5233 (spirolactone) 2912:norethisterone acetate 2551:Methandriol propionate 2422:Trenbolone undecanoate 2294:Bolandiol dipropionate 2142:Dihydrofluoxymesterone 2105:5α-Androst-2-en-17-one 1960:Boldenone undecylenate 1067:Methandriol propionate 973:Bolandiol dipropionate 879:testosterone enanthate 875:testosterone cypionate 816:Boldenone undecylenate 588:10.1074/jbc.M300588200 404:Toxicological Sciences 397:Curtis LR (Mar 2001). 319:10.1093/humupd/7.3.248 193:benzyl butyl phthalate 3780:-Desmethylapalutamide 3309:Chlormadinone acetate 3254:7α-Thiospironolactone 3125:LGD-2941 (LGD-122941) 3115:LG121071 (LGD-121071) 2989:3-Keto-5α-abiraterone 2969:6α-Methylprogesterone 2908:Norethisterone esters 2881:Levonorgestrel esters 2797:Ethinylandrostenediol 2647:Methyl-1-testosterone 2567:+esterified estrogens 2541:Methandriol diacetate 2206:Mesterolone cipionate 1888:4-Hydroxytestosterone 1691:chlormadinone acetate 1352:Chlormadinone acetate 923:Androstanolone esters 671:10.1055/s-2006-946638 418:10.1093/toxsci/60.1.1 233:3,3'-diindolylmethane 202:Parabens are used as 4432:Endocrine disruptors 3469:Potassium canrenoate 2937:Quingestanol acetate 2747:Tetrahydrogestrinone 2635:Metenolone enanthate 2461:5α-Dihydrotrestolone 2456:5α-Dihydronandrolone 2444:Trestolone enanthate 2412:Trenbolone enanthate 2378:Norclostebol acetate 1987:Clostebol propionate 1703:gestonorone caproate 1511:Saw palmetto extract 1402:Potassium canrenoate 997:Norclostebol acetate 982:nandrolone decanoate 836:Clostebol propionate 189:diisobutyl phthalate 185:di-n-butyl phthalate 167:Industrial chemicals 109:sex accessory glands 72:Animal studies with 50:endocrine disruptors 27:industrial chemicals 4317:Endocrine disruptor 3992:Dihydrotestosterone 3987:Dehydroandrosterone 3838:Ralaniten (EPI-002) 3719:Inocoterone acetate 3444:Nomegestrol acetate 3344:Delmadinone acetate 3334:Cyproterone acetate 3279:Abiraterone acetate 3249:7α-Thioprogesterone 2859:Etynodiol diacetate 2063:Testosterone esters 2006:Dehydroandrosterone 1903:11-Ketotestosterone 1695:cyproterone acetate 1603:prolactin releasers 1545:Cyproterone acetate 1527:Abiraterone acetate 1387:Nomegestrol acetate 1362:Delmadinone acetate 1357:Cyproterone acetate 1339:Abiraterone acetate 871:Testosterone esters 250:androgen antagonist 94:anogenital distance 4332:Polymer fume fever 2829:Dihydroethisterone 2692:Dimethyltrienolone 2652:Methylepitiostanol 2630:Metenolone acetate 2563:Methyltestosterone 2466:19-Norandrosterone 2439:Trestolone acetate 2407:Trenbolone acetate 2351:-nitrosocarbamate) 2240:Stenbolone acetate 2130:Bolazine capronate 1982:Clostebol caproate 1775:Never to phase III 1641:diethylstilbestrol 1268:GnRH (gonadorelin) 1072:Methyltestosterone 1007:Trenbolone acetate 963:Stenbolone acetate 928:Bolazine capronate 831:Clostebol caproate 262:Glycyrrhiza glabra 117:undescended testes 39:animal experiments 4414: 4413: 4348:Plastic pollution 4128:Health issues of 4095: 4094: 4055: 4054: 4025: 4018: 4011: 4004: 3936: 3935: 3459:Osaterone acetate 3419:Megestrol acetate 3284:Allyltestosterone 3060:Acetothiolutamide 2979:Megestrol acetate 2782:Vinyltestosterone 2687:Dimethyldienolone 2506:Ethyltestosterone 2434:Trestolone (MENT) 2366:Nandrolone esters 2347:-(2-chloroethyl)- 2223:Nisterime acetate 2100:3α-Androstanediol 2085:1-Androstenedione 1994:Cloxotestosterone 1977:Clostebol acetate 1898:5-Androstenedione 1844:Androgen receptor 1810: 1809: 1744: 1743: 1711:megestrol acetate 1584:Antigonadotropins 1578: 1577: 1535:Aminoglutethimide 1392:Osaterone acetate 1382:Megestrol acetate 1305: 1304: 978:Nandrolone esters 826:Clostebol acetate 96:and induction of 4439: 4353:Rubber pollution 4203:Organophosphates 4122: 4115: 4108: 4099: 4043: 4039: 4023: 4016: 4009: 4002: 3947: 3729:Ketodarolutamide 3709:Hydroxyflutamide 3666:(via metabolite 3035: 3031: 2986:Others/unsorted: 2657:Methylstenbolone 2521:Hydroxystenozole 2080:1-Androstenediol 1878:4-Androstenediol 1865: 1861: 1857: 1837: 1830: 1823: 1814: 1677:GnRH antagonists 1653:ethinylestradiol 1649:estradiol esters 1479: 1326: 1322: 1316: 1297: 1293: 1288: 1284: 1242:Progonadotropins 907:Testoviron Depot 798: 794: 788: 783: 779: 753: 746: 739: 730: 724: 723: 713: 689: 683: 682: 654: 648: 647: 616:Invest New Drugs 607: 601: 600: 590: 581:(23): 21136–45. 566: 560: 559: 557: 555: 544: 538: 537: 527: 525:10.1002/jat.1358 503: 494: 493: 479: 461: 437: 431: 430: 420: 394: 388: 387: 377: 345: 332: 331: 321: 297: 4447: 4446: 4442: 4441: 4440: 4438: 4437: 4436: 4417: 4416: 4415: 4410: 4379: 4336: 4293: 4255: 4222: 4191: 4137: 4126: 4096: 4091: 4051: 4041: 3932: 3654:Cyanonilutamide 3583:Bavdegalutamide 3394:Epitestosterone 3234: 3065:Acetoxolutamide 3033: 3023: 2732:Norethandrolone 2707:Methyldienolone 2511:Fluoxymesterone 2321:Dimethandrolone 2181:Epiandrosterone 1859: 1849: 1841: 1811: 1806: 1780: 1765:Clinical trials 1740: 1716: 1595: 1574: 1515: 1473: 1472:Steroidogenesis 1466: 1324: 1301: 1295: 1286: 1236: 1152:Norethandrolone 1037:Fluoxymesterone 796: 781: 774: 766: 757: 727: 691: 690: 686: 656: 655: 651: 609: 608: 604: 568: 567: 563: 553: 551: 546: 545: 541: 505: 504: 497: 439: 438: 434: 396: 395: 391: 347: 346: 335: 299: 298: 275: 271: 245:Prunus africana 226: 169: 58: 12: 11: 5: 4445: 4443: 4435: 4434: 4429: 4419: 4418: 4412: 4411: 4409: 4408: 4403: 4398: 4393: 4387: 4385: 4381: 4380: 4378: 4377: 4372: 4367: 4362: 4357: 4356: 4355: 4344: 4342: 4338: 4337: 4335: 4334: 4329: 4324: 4319: 4314: 4309: 4303: 4301: 4295: 4294: 4292: 4291: 4290: 4289: 4279: 4274: 4269: 4263: 4261: 4257: 4256: 4254: 4253: 4246:Vinyl chloride 4243: 4240:Polycarbonates 4232: 4230: 4224: 4223: 4221: 4220: 4214: 4205: 4199: 4197: 4193: 4192: 4190: 4189: 4184: 4179: 4173: 4168: 4162: 4157: 4151: 4149: 4139: 4138: 4127: 4125: 4124: 4117: 4110: 4102: 4093: 4092: 4090: 4089: 4084: 4079: 4074: 4069: 4064: 4060: 4057: 4056: 4053: 4052: 4050: 4049: 4044: 4034: 4029: 4005:-α-Amino acids 3999: 3994: 3989: 3984: 3953: 3951: 3944: 3938: 3937: 3934: 3933: 3931: 3930: 3925: 3920: 3915: 3910: 3905: 3900: 3895: 3890: 3885: 3880: 3875: 3870: 3865: 3860: 3855: 3850: 3845: 3840: 3835: 3830: 3825: 3820: 3815: 3810: 3805: 3800: 3795: 3790: 3782: 3774: 3766: 3761: 3756: 3751: 3746: 3741: 3736: 3731: 3726: 3721: 3716: 3711: 3706: 3701: 3696: 3691: 3686: 3681: 3676: 3671: 3661: 3656: 3651: 3646: 3641: 3636: 3631: 3626: 3621: 3595: 3590: 3585: 3580: 3575: 3570: 3565: 3560: 3555: 3550: 3545: 3532: 3531: 3526: 3521: 3516: 3511: 3506: 3501: 3499:Spironolactone 3496: 3491: 3486: 3481: 3476: 3471: 3466: 3461: 3456: 3451: 3446: 3441: 3436: 3431: 3426: 3421: 3416: 3411: 3406: 3401: 3396: 3391: 3386: 3381: 3376: 3371: 3366: 3361: 3356: 3351: 3346: 3341: 3336: 3331: 3326: 3324:Cyproheptadine 3321: 3316: 3311: 3306: 3301: 3299:Canrenoic acid 3296: 3291: 3286: 3281: 3276: 3271: 3266: 3261: 3256: 3251: 3242: 3240: 3236: 3235: 3233: 3232: 3227: 3222: 3217: 3208: 3207: 3202: 3197: 3192: 3187: 3182: 3177: 3172: 3167: 3162: 3157: 3152: 3147: 3142: 3137: 3132: 3127: 3122: 3117: 3112: 3107: 3102: 3097: 3092: 3087: 3082: 3077: 3072: 3067: 3062: 3057: 3052: 3047: 3038: 3036: 3025: 3024: 3022: 3021: 3016: 3011: 3006: 3001: 2996: 2991: 2982: 2981: 2976: 2971: 2962: 2961: 2956: 2947: 2946: 2941: 2940: 2939: 2929: 2927:Norgestrienone 2924: 2919: 2905: 2903:Norethisterone 2900: 2899: 2898: 2888: 2878: 2876:Levonorgestrel 2873: 2868: 2863: 2862: 2861: 2851: 2846: 2841: 2832: 2831: 2826: 2821: 2812: 2811: 2806: 2805: 2804: 2794: 2785: 2784: 2775: 2774: 2765: 2764: 2759: 2750: 2749: 2744: 2739: 2734: 2729: 2724: 2719: 2714: 2709: 2704: 2699: 2697:Ethyldienolone 2694: 2689: 2684: 2675: 2674: 2669: 2664: 2659: 2654: 2649: 2644: 2639: 2638: 2637: 2632: 2622: 2617: 2612: 2607: 2602: 2600:Androisoxazole 2593: 2592: 2587: 2582: 2577: 2576: 2575: 2560: 2555: 2554: 2553: 2548: 2543: 2538: 2528: 2523: 2518: 2513: 2508: 2503: 2498: 2493: 2488: 2483: 2478: 2469: 2468: 2463: 2458: 2449: 2448: 2447: 2446: 2441: 2431: 2426: 2425: 2424: 2419: 2414: 2409: 2399: 2398: 2397: 2387: 2382: 2381: 2380: 2370: 2369: 2368: 2358: 2353: 2340: 2339: 2338: 2333: 2328: 2318: 2313: 2308: 2303: 2298: 2297: 2296: 2286: 2281: 2276: 2271: 2270: 2269: 2259: 2250: 2249: 2244: 2243: 2242: 2232: 2227: 2226: 2225: 2215: 2213:Methyldiazinol 2210: 2209: 2208: 2198: 2193: 2188: 2183: 2178: 2177: 2176: 2166: 2165: 2164: 2149: 2144: 2139: 2134: 2133: 2132: 2122: 2117: 2112: 2107: 2102: 2097: 2095:1-Testosterone 2092: 2087: 2082: 2073: 2072: 2071: 2070: 2065: 2050: 2045: 2040: 2035: 2030: 2025: 2024: 2023: 2018: 2008: 2003: 2002: 2001: 1991: 1990: 1989: 1984: 1979: 1969: 1964: 1963: 1962: 1952: 1947: 1942: 1941: 1940: 1935: 1930: 1925: 1915: 1910: 1905: 1900: 1895: 1890: 1885: 1880: 1871: 1869: 1862: 1851: 1850: 1842: 1840: 1839: 1832: 1825: 1817: 1808: 1807: 1805: 1804: 1799: 1794: 1789: 1784: 1779: 1778: 1777: 1776: 1773: 1762: 1756: 1750: 1749: 1746: 1745: 1742: 1741: 1739: 1738: 1733: 1724: 1722: 1718: 1717: 1715: 1714: 1684: 1674: 1664: 1661:paroxypropione 1630: 1623:chlorpromazine 1611:metoclopramide 1593: 1588: 1586: 1580: 1579: 1576: 1575: 1573: 1572: 1570:Spironolactone 1567: 1562: 1557: 1552: 1547: 1542: 1537: 1532: 1523: 1521: 1517: 1516: 1514: 1513: 1508: 1503: 1498: 1493: 1487: 1485: 1476: 1468: 1467: 1465: 1464: 1459: 1454: 1449: 1444: 1439: 1434: 1429: 1424: 1419: 1410: 1409: 1407:Spironolactone 1404: 1399: 1394: 1389: 1384: 1379: 1374: 1369: 1364: 1359: 1354: 1349: 1344: 1332: 1330: 1313: 1307: 1306: 1303: 1302: 1300: 1299: 1275: 1261: 1246: 1244: 1238: 1237: 1235: 1234: 1225: 1224: 1219: 1216:norgestrienone 1200:levonorgestrel 1189: 1184: 1175: 1174: 1165: 1164: 1159: 1154: 1149: 1144: 1135: 1134: 1129: 1124: 1119: 1114: 1109: 1104: 1102:Androisoxazole 1095: 1094: 1089: 1084: 1079: 1074: 1069: 1064: 1059: 1054: 1049: 1044: 1039: 1034: 1029: 1024: 1015: 1014: 1009: 1004: 999: 994: 989: 975: 966: 965: 960: 955: 950: 945: 940: 935: 930: 925: 920: 911: 910: 868: 863: 858: 853: 848: 843: 838: 833: 828: 823: 818: 813: 804: 802: 785: 768: 767: 758: 756: 755: 748: 741: 733: 726: 725: 698:Int. J. Androl 684: 649: 602: 561: 539: 495: 452:(3): 187–197. 432: 389: 333: 272: 270: 267: 225: 224:Phytochemicals 222: 168: 165: 147:adrenal glands 139:broad-spectrum 57: 54: 13: 10: 9: 6: 4: 3: 2: 4444: 4433: 4430: 4428: 4427:Antiandrogens 4425: 4424: 4422: 4407: 4404: 4402: 4399: 4397: 4394: 4392: 4389: 4388: 4386: 4382: 4376: 4373: 4371: 4368: 4366: 4363: 4361: 4358: 4354: 4351: 4350: 4349: 4346: 4345: 4343: 4339: 4333: 4330: 4328: 4325: 4323: 4320: 4318: 4315: 4313: 4310: 4308: 4305: 4304: 4302: 4300: 4299:Health issues 4296: 4288: 4285: 4284: 4283: 4280: 4278: 4275: 4273: 4270: 4268: 4265: 4264: 4262: 4258: 4251: 4247: 4244: 4241: 4237: 4234: 4233: 4231: 4229: 4225: 4218: 4215: 4213: 4209: 4206: 4204: 4201: 4200: 4198: 4194: 4188: 4185: 4183: 4180: 4177: 4174: 4172: 4169: 4166: 4163: 4161: 4158: 4156: 4153: 4152: 4150: 4148: 4144: 4140: 4135: 4131: 4123: 4118: 4116: 4111: 4109: 4104: 4103: 4100: 4088: 4085: 4083: 4080: 4078: 4075: 4073: 4070: 4068: 4065: 4062: 4061: 4058: 4048: 4045: 4040: 4035: 4033: 4030: 4027: 4020: 4013: 4006: 4000: 3998: 3995: 3993: 3990: 3988: 3985: 3982: 3978: 3974: 3970: 3966: 3962: 3958: 3955: 3954: 3952: 3948: 3945: 3943: 3939: 3929: 3926: 3924: 3921: 3919: 3916: 3914: 3911: 3909: 3908:Valproic acid 3906: 3904: 3901: 3899: 3896: 3894: 3891: 3889: 3886: 3884: 3881: 3879: 3876: 3874: 3871: 3869: 3866: 3864: 3861: 3859: 3856: 3854: 3853:Rezvilutamide 3851: 3849: 3846: 3844: 3841: 3839: 3836: 3834: 3831: 3829: 3828:Proxalutamide 3826: 3824: 3821: 3819: 3816: 3814: 3811: 3809: 3806: 3804: 3801: 3799: 3796: 3794: 3791: 3789: 3787: 3783: 3781: 3779: 3775: 3773: 3771: 3767: 3765: 3762: 3760: 3757: 3755: 3752: 3750: 3747: 3745: 3742: 3740: 3737: 3735: 3732: 3730: 3727: 3725: 3722: 3720: 3717: 3715: 3712: 3710: 3707: 3705: 3702: 3700: 3697: 3695: 3692: 3690: 3687: 3685: 3682: 3680: 3677: 3675: 3672: 3669: 3665: 3662: 3660: 3657: 3655: 3652: 3650: 3647: 3645: 3642: 3640: 3637: 3635: 3632: 3630: 3627: 3625: 3622: 3619: 3615: 3611: 3607: 3603: 3599: 3596: 3594: 3591: 3589: 3586: 3584: 3581: 3579: 3576: 3574: 3571: 3569: 3566: 3564: 3561: 3559: 3556: 3554: 3551: 3549: 3546: 3544: 3543:-Bicalutamide 3542: 3537: 3536:Nonsteroidal: 3534: 3533: 3530: 3527: 3525: 3522: 3520: 3517: 3515: 3512: 3510: 3507: 3505: 3502: 3500: 3497: 3495: 3492: 3490: 3487: 3485: 3482: 3480: 3477: 3475: 3472: 3470: 3467: 3465: 3462: 3460: 3457: 3455: 3452: 3450: 3447: 3445: 3442: 3440: 3437: 3435: 3432: 3430: 3427: 3425: 3422: 3420: 3417: 3415: 3412: 3410: 3407: 3405: 3404:Guggulsterone 3402: 3400: 3397: 3395: 3392: 3390: 3387: 3385: 3382: 3380: 3377: 3375: 3372: 3370: 3367: 3365: 3362: 3360: 3357: 3355: 3352: 3350: 3347: 3345: 3342: 3340: 3337: 3335: 3332: 3330: 3327: 3325: 3322: 3320: 3317: 3315: 3312: 3310: 3307: 3305: 3302: 3300: 3297: 3295: 3292: 3290: 3287: 3285: 3282: 3280: 3277: 3275: 3272: 3270: 3267: 3265: 3262: 3260: 3257: 3255: 3252: 3250: 3247: 3244: 3243: 3241: 3237: 3231: 3228: 3226: 3223: 3221: 3218: 3216: 3213: 3210: 3209: 3206: 3203: 3201: 3198: 3196: 3193: 3191: 3188: 3186: 3183: 3181: 3178: 3176: 3173: 3171: 3168: 3166: 3163: 3161: 3158: 3156: 3153: 3151: 3148: 3146: 3143: 3141: 3138: 3136: 3133: 3131: 3128: 3126: 3123: 3121: 3118: 3116: 3113: 3111: 3108: 3106: 3103: 3101: 3098: 3096: 3093: 3091: 3088: 3086: 3083: 3081: 3078: 3076: 3073: 3071: 3068: 3066: 3063: 3061: 3058: 3056: 3053: 3051: 3048: 3046: 3043: 3042:Nonsteroidal: 3040: 3039: 3037: 3032: 3026: 3020: 3017: 3015: 3012: 3010: 3007: 3005: 3002: 3000: 2997: 2995: 2994:5α-Androstane 2992: 2990: 2987: 2984: 2983: 2980: 2977: 2975: 2972: 2970: 2967: 2964: 2963: 2960: 2957: 2955: 2952: 2949: 2948: 2945: 2942: 2938: 2935: 2934: 2933: 2930: 2928: 2925: 2923: 2920: 2917: 2913: 2909: 2906: 2904: 2901: 2897: 2894: 2893: 2892: 2889: 2886: 2882: 2879: 2877: 2874: 2872: 2869: 2867: 2864: 2860: 2857: 2856: 2855: 2852: 2850: 2847: 2845: 2842: 2840: 2837: 2834: 2833: 2830: 2827: 2825: 2822: 2820: 2817: 2814: 2813: 2810: 2807: 2803: 2802:Ethandrostate 2800: 2799: 2798: 2795: 2793: 2790: 2787: 2786: 2783: 2780: 2777: 2776: 2773: 2770: 2767: 2766: 2763: 2760: 2758: 2755: 2752: 2751: 2748: 2745: 2743: 2740: 2738: 2735: 2733: 2730: 2728: 2725: 2723: 2720: 2718: 2715: 2713: 2710: 2708: 2705: 2703: 2702:Ethylestrenol 2700: 2698: 2695: 2693: 2690: 2688: 2685: 2683: 2680: 2677: 2676: 2673: 2670: 2668: 2665: 2663: 2660: 2658: 2655: 2653: 2650: 2648: 2645: 2643: 2640: 2636: 2633: 2631: 2628: 2627: 2626: 2623: 2621: 2618: 2616: 2613: 2611: 2608: 2606: 2603: 2601: 2598: 2595: 2594: 2591: 2588: 2586: 2583: 2581: 2578: 2574: 2571: 2570: 2568: 2564: 2561: 2559: 2556: 2552: 2549: 2547: 2544: 2542: 2539: 2537: 2534: 2533: 2532: 2529: 2527: 2524: 2522: 2519: 2517: 2514: 2512: 2509: 2507: 2504: 2502: 2499: 2497: 2494: 2492: 2489: 2487: 2484: 2482: 2479: 2477: 2474: 2471: 2470: 2467: 2464: 2462: 2459: 2457: 2454: 2451: 2450: 2445: 2442: 2440: 2437: 2436: 2435: 2432: 2430: 2427: 2423: 2420: 2418: 2415: 2413: 2410: 2408: 2405: 2404: 2403: 2400: 2396: 2393: 2392: 2391: 2388: 2386: 2383: 2379: 2376: 2375: 2374: 2371: 2367: 2364: 2363: 2362: 2359: 2357: 2354: 2352: 2350: 2346: 2341: 2337: 2334: 2332: 2329: 2327: 2324: 2323: 2322: 2319: 2317: 2314: 2312: 2309: 2307: 2304: 2302: 2299: 2295: 2292: 2291: 2290: 2287: 2285: 2282: 2280: 2277: 2275: 2272: 2268: 2265: 2264: 2263: 2260: 2258: 2255: 2252: 2251: 2248: 2245: 2241: 2238: 2237: 2236: 2233: 2231: 2228: 2224: 2221: 2220: 2219: 2216: 2214: 2211: 2207: 2204: 2203: 2202: 2199: 2197: 2194: 2192: 2189: 2187: 2184: 2182: 2179: 2175: 2172: 2171: 2170: 2167: 2163: 2160: 2159: 2157: 2153: 2150: 2148: 2145: 2143: 2140: 2138: 2135: 2131: 2128: 2127: 2126: 2123: 2121: 2118: 2116: 2113: 2111: 2108: 2106: 2103: 2101: 2098: 2096: 2093: 2091: 2088: 2086: 2083: 2081: 2078: 2075: 2074: 2069: 2066: 2064: 2061: 2060: 2058: 2054: 2051: 2049: 2046: 2044: 2041: 2039: 2036: 2034: 2031: 2029: 2026: 2022: 2019: 2017: 2014: 2013: 2012: 2009: 2007: 2004: 2000: 1997: 1996: 1995: 1992: 1988: 1985: 1983: 1980: 1978: 1975: 1974: 1973: 1970: 1968: 1965: 1961: 1958: 1957: 1956: 1953: 1951: 1948: 1946: 1943: 1939: 1936: 1934: 1931: 1929: 1926: 1924: 1921: 1920: 1919: 1916: 1914: 1911: 1909: 1906: 1904: 1901: 1899: 1896: 1894: 1891: 1889: 1886: 1884: 1881: 1879: 1876: 1873: 1872: 1870: 1866: 1863: 1858: 1852: 1848: 1845: 1838: 1833: 1831: 1826: 1824: 1819: 1818: 1815: 1803: 1800: 1798: 1795: 1793: 1790: 1788: 1785: 1782: 1781: 1774: 1772: 1769: 1768: 1766: 1763: 1760: 1757: 1755: 1752: 1751: 1747: 1737: 1734: 1732: 1729: 1726: 1725: 1723: 1719: 1712: 1708: 1704: 1700: 1696: 1692: 1688: 1685: 1682: 1678: 1675: 1672: 1668: 1667:GnRH agonists 1665: 1662: 1658: 1654: 1650: 1646: 1642: 1638: 1634: 1631: 1628: 1624: 1620: 1616: 1612: 1608: 1604: 1600: 1597: 1590: 1589: 1587: 1585: 1581: 1571: 1568: 1566: 1563: 1561: 1558: 1556: 1553: 1551: 1548: 1546: 1543: 1541: 1538: 1536: 1533: 1531: 1528: 1525: 1524: 1522: 1518: 1512: 1509: 1507: 1504: 1502: 1499: 1497: 1494: 1492: 1489: 1488: 1486: 1484: 1480: 1477: 1475: 1469: 1463: 1460: 1458: 1455: 1453: 1450: 1448: 1445: 1443: 1440: 1438: 1435: 1433: 1430: 1428: 1425: 1423: 1420: 1418: 1415: 1414:Nonsteroidal: 1412: 1411: 1408: 1405: 1403: 1400: 1398: 1395: 1393: 1390: 1388: 1385: 1383: 1380: 1378: 1375: 1373: 1370: 1368: 1365: 1363: 1360: 1358: 1355: 1353: 1350: 1348: 1345: 1343: 1340: 1337: 1334: 1333: 1331: 1329: 1323: 1317: 1314: 1312: 1311:Antiandrogens 1308: 1294: 1285: 1279: 1278:Gonadotropins 1276: 1273: 1269: 1265: 1264:GnRH agonists 1262: 1259: 1255: 1251: 1250:Antiestrogens 1248: 1247: 1245: 1243: 1239: 1233: 1230: 1227: 1226: 1223: 1220: 1217: 1213: 1209: 1205: 1201: 1197: 1193: 1190: 1188: 1185: 1183: 1180: 1177: 1176: 1173: 1170: 1167: 1166: 1163: 1160: 1158: 1155: 1153: 1150: 1148: 1145: 1143: 1142:Ethylestrenol 1140: 1137: 1136: 1133: 1130: 1128: 1125: 1123: 1120: 1118: 1115: 1113: 1110: 1108: 1105: 1103: 1100: 1097: 1096: 1093: 1090: 1088: 1085: 1083: 1080: 1078: 1075: 1073: 1070: 1068: 1065: 1063: 1060: 1058: 1055: 1053: 1050: 1048: 1045: 1043: 1040: 1038: 1035: 1033: 1030: 1028: 1025: 1023: 1020: 1017: 1016: 1013: 1010: 1008: 1005: 1003: 1000: 998: 995: 993: 990: 987: 983: 979: 976: 974: 971: 968: 967: 964: 961: 959: 956: 954: 951: 949: 946: 944: 941: 939: 936: 934: 931: 929: 926: 924: 921: 919: 916: 913: 912: 908: 904: 900: 896: 892: 888: 884: 880: 876: 872: 869: 867: 864: 862: 859: 857: 854: 852: 849: 847: 844: 842: 839: 837: 834: 832: 829: 827: 824: 822: 819: 817: 814: 812: 809: 806: 805: 803: 801: 795: 789: 786: 780: 773: 769: 765: 764:antiandrogens 761: 754: 749: 747: 742: 740: 735: 734: 731: 721: 717: 712: 707: 704:(4): 417–22. 703: 699: 695: 688: 685: 680: 676: 672: 668: 665:(9): 807–13. 664: 660: 653: 650: 645: 641: 637: 633: 629: 625: 622:(6): 729–43. 621: 617: 613: 606: 603: 598: 594: 589: 584: 580: 576: 572: 565: 562: 550: 543: 540: 535: 531: 526: 521: 518:(5): 561–78. 517: 513: 509: 502: 500: 496: 492: 487: 483: 478: 473: 469: 465: 460: 455: 451: 447: 443: 436: 433: 428: 424: 419: 414: 410: 406: 405: 400: 393: 390: 385: 381: 376: 371: 367: 363: 360:(2): 443–62. 359: 355: 351: 344: 342: 340: 338: 334: 329: 325: 320: 315: 312:(3): 248–64. 311: 307: 303: 296: 294: 292: 290: 288: 286: 284: 282: 280: 278: 274: 268: 266: 264: 263: 259:Licorice, or 257: 255: 251: 247: 246: 241: 238:The compound 236: 234: 229: 223: 221: 219: 215: 211: 209: 205: 204:preservatives 200: 198: 194: 190: 186: 180: 178: 174: 166: 164: 162: 158: 154: 150: 148: 144: 140: 136: 132: 128: 126: 122: 118: 114: 110: 106: 101: 99: 95: 91: 87: 83: 79: 75: 70: 68: 64: 55: 53: 51: 46: 44: 40: 36: 32: 28: 24: 23: 19: 18:Antiandrogens 4143:Plasticizers 4047:Testosterone 3833:Pyrilutamide 3785: 3777: 3769: 3734:Lavender oil 3724:Ketoconazole 3689:Enzalutamide 3659:Darolutamide 3593:Bicalutamide 3568:Atraric acid 3540: 3535: 3519:Trimegestone 3474:Promegestone 3439:Mifepristone 3414:Medrogestone 3359:Drospirenone 3314:Clascoterone 3245: 3211: 3155:JNJ-37654032 3150:JNJ-28330835 3145:JNJ-26146900 3041: 2985: 2965: 2950: 2932:Quingestanol 2849:Etonogestrel 2835: 2815: 2788: 2778: 2768: 2753: 2737:Propetandrol 2678: 2667:Oxymetholone 2642:Methasterone 2596: 2590:Tiomesterone 2580:Oxymesterone 2472: 2452: 2373:Norclostebol 2348: 2344: 2253: 2191:Mepitiostane 2186:Epitiostanol 2169:Drostanolone 2120:Androsterone 2076: 2057:+dutasteride 2053:Testosterone 2021:DHEA sulfate 1874: 1727: 1687:Progestogens 1555:Ketoconazole 1483:5α-Reductase 1447:Ketoconazole 1437:Enzalutamide 1432:Darolutamide 1422:Bicalutamide 1413: 1377:Medrogestone 1372:Drospirenone 1335: 1228: 1178: 1168: 1138: 1127:Oxymetholone 1098: 1082:Oxymesterone 1018: 992:Norclostebol 969: 943:Mepitiostane 938:Epitiostanol 914: 866:Testosterone 807: 701: 697: 687: 662: 658: 652: 619: 615: 605: 578: 574: 564: 552:. Retrieved 542: 515: 511: 489: 449: 445: 435: 408: 402: 392: 357: 353: 309: 305: 260: 258: 243: 237: 230: 227: 212: 208:butylparaben 201: 181: 170: 161:gynecomastia 151: 131:Ketoconazole 129: 127:separation. 102: 71: 59: 47: 29:, including 16: 15: 4384:Regulations 4236:Bisphenol A 4032:Osteocalcin 3913:Vinclozolin 3898:Thalidomide 3893:Seviteronel 3823:Procymidone 3759:Masofaniten 3714:Inocoterone 3618:bisphenol S 3614:bisphenol F 3610:bisphenol A 3588:BAY-1024767 3563:Apalutamide 3509:Spiroxasone 3504:Spirorenone 3484:Rosterolone 3424:Mespirenone 3369:Edogestrone 3339:Delanterone 3329:Cyproterone 3319:Clometerone 3289:Benorterone 3274:Abiraterone 3239:Antagonists 3170:PF-06260414 3075:BMS-564,929 2999:Alternariol 2891:Lynestrenol 2844:Desogestrel 2727:Norboletone 2717:Metribolone 2662:Oxandrolone 2620:Mestanolone 2585:Penmesterol 2516:Formebolone 2481:Calusterone 2476:Bolasterone 2230:Prostanozol 2201:Mesterolone 1761:from market 1671:leuprorelin 1619:haloperidol 1615:risperidone 1607:domperidone 1599:antagonists 1565:Seviteronel 1506:Finasteride 1501:Epristeride 1496:Dutasteride 1491:Alfatradiol 1457:Seviteronel 1417:Apalutamide 1328:antagonists 1272:leuprorelin 1212:lynestrenol 1122:Oxandrolone 1117:Mestanolone 1087:Penmesterol 1042:Formebolone 1027:Calusterone 1022:Bolasterone 948:Mesterolone 895:Deposterona 575:J Biol Chem 218:bisphenol A 157:insecticide 113:hypospadias 105:vinclozolin 88:metabolite 78:procymidone 74:vinclozolin 22:environment 4421:Categories 4312:Carcinogen 4277:Organotins 4147:Phthalates 4026:-ornithine 3969:gadolinium 3818:Prochloraz 3813:Phenothrin 3793:Nilutamide 3764:Methiocarb 3684:Endosulfan 3649:Cioteronel 3644:Cimetidine 3634:BMS-641988 3629:BMS-570511 3624:BMS-501949 3598:Bisphenols 3553:Antarlides 3529:Zanoterone 3464:Oxendolone 3409:Ludaterone 3399:Galeterone 3349:Dicirenone 3246:Steroidal: 3212:Steroidal: 3205:Vosilasarm 3100:GSK2881078 3055:AC-262,536 3014:Trilostane 2922:Norgestrel 2871:Gestrinone 2839:Δ-Tibolone 2722:Mibolerone 2672:Stanozolol 2625:Metenolone 2402:Trenbolone 2361:Nandrolone 2311:Dienedione 2235:Stenbolone 2196:Mesabolone 2048:Silandrone 2043:Quinbolone 2038:Plomestane 2033:Formestane 2028:Exemestane 1950:Atamestane 1847:modulators 1681:cetrorelix 1637:bifluranol 1560:Nilutamide 1540:Bifluranol 1530:+niraparib 1474:inhibitors 1452:Nilutamide 1427:Cimetidine 1397:Oxendolone 1342:+niraparib 1336:Steroidal: 1204:norgestrel 1192:Progestins 1187:Gestrinone 1147:Mibolerone 1132:Stanozolol 861:Quinbolone 659:Planta Med 411:(1): 1–2. 269:References 214:Bisphenols 173:phthalates 153:Phenothrin 84:, and the 35:pesticides 31:phthalates 4341:Pollution 4307:Teratogen 4238:(BPA, in 4012:-arginine 3997:Estradiol 3977:strontium 3973:magnesium 3961:aluminium 3928:YM-175735 3863:Ro 5-2537 3858:Ro 2-7239 3808:PF-998425 3803:Pentomone 3744:LG-120907 3704:Flutamide 3699:Fenarimol 3639:CH5137291 3578:Bakuchiol 3514:Topterone 3479:Prorenone 3454:Osaterone 3449:Nordinone 3434:Mexrenone 3354:Dienogest 3304:Canrenone 3225:TFM-4AS-1 3165:ORM-11984 3105:GSK-4336A 3095:GLPG-0492 3019:ZM-182345 2866:Gestodene 2854:Etynodiol 2610:Furazabol 2501:Enestebol 2429:Trendione 2390:Oxabolone 2316:Dienolone 2289:Bolandiol 2218:Nisterime 1972:Clostebol 1955:Boldenone 1771:Phase III 1759:Withdrawn 1645:estradiol 1633:Estrogens 1627:sulpiride 1605:) (e.g., 1550:Flutamide 1442:Flutamide 1367:Dienogest 1347:Canrenone 1258:clomifene 1254:tamoxifen 1107:Furazabol 821:Clostebol 772:Androgens 760:Androgens 468:1516-3180 143:testicles 135:imidazole 125:preputial 4322:Diabetes 4228:Monomers 4208:Adipates 4130:plastics 4063:See also 3950:Agonists 3923:YM-92088 3888:RU-58841 3883:RU-58642 3878:RU-57073 3873:RU-56187 3868:RU-22930 3798:ONC1-13B 3749:LGD-1331 3674:Dieldrin 3668:p,p’-DDE 3573:AZD-3514 3558:Arabilin 3489:RU-15328 3429:Metogest 3364:DU-41165 3200:S-101479 3180:RU-59063 3135:LGD-4033 3130:LGD-3303 3120:LGD-2226 3110:GSK-8698 3009:Drupanol 3004:Cl-4AS-1 2944:Tibolone 2125:Bolazine 1868:Agonists 1783:See also 1689:(incl., 1596:receptor 1222:Tibolone 903:Sustanon 899:Omnadren 800:agonists 720:19515171 679:16783690 636:19771394 597:12665522 534:18484575 486:22790552 477:10876201 427:11222865 384:20487044 328:11392371 216:such as 191:(DiBP), 177:parabens 43:in utero 4370:Dioxins 4327:Obesity 4019:-lysine 4007:(incl. 3965:calcium 3959:(incl. 3957:Cations 3754:Linuron 3694:EPI-001 3600:(e.g., 3389:EM-6537 3384:EM-5855 3379:EM-5854 3374:EM-4350 3220:MK-0773 3215:EM-9017 3195:S-40503 3050:ACP-105 3045:198RL26 2910:(e.g., 2883:(e.g., 2792:Danazol 2742:RU-2309 2682:Bolenol 1679:(e.g., 1669:(e.g., 1635:(e.g., 1280:(e.g., 1266:(e.g., 1252:(e.g., 1194:(e.g., 1182:Danazol 980:(e.g., 873:(e.g., 775:(incl. 644:5455114 554:8 April 375:2874988 195:(BBP), 187:(DBP), 121:phallus 98:areolas 82:linuron 67:puberty 20:in the 4167:(BBzP) 4136:(PHCs) 3942:GPRC6A 3918:YM-580 3848:RD-162 3739:LG-105 3090:FTBU-1 1754:WHO-EM 1721:Others 1520:Others 718:  677:  642:  634:  595:  532:  484:  474:  466:  425:  382:  372:  326:  155:is an 133:is an 4267:PBDEs 4178:(DOP) 3606:BFDGE 3602:BADGE 3548:AA560 3230:YK-11 3140:LY305 3030:SARMs 640:S2CID 4282:PFCs 4272:PCBs 4248:(in 4212:DEHA 4187:DINP 4182:DIDP 4176:DEHP 4171:DIHP 4155:DIBP 4132:and 4038:SHBG 3981:zinc 3679:DIMP 3294:BOMT 3190:S-23 3080:DTIB 762:and 716:PMID 675:PMID 632:PMID 593:PMID 556:2015 530:PMID 482:PMID 464:ISSN 423:PMID 380:PMID 324:PMID 145:and 33:and 4250:PVC 4217:DOA 4165:BBP 4160:DBP 3664:DDT 3185:S-1 3175:R-1 1292:hCG 778:AAS 706:doi 667:doi 624:doi 583:doi 579:278 520:doi 472:PMC 454:doi 450:130 413:doi 370:PMC 362:doi 314:doi 175:or 86:DDT 4423:: 4145:: 4021:, 4014:, 3979:, 3975:, 3971:, 3967:, 3963:, 3616:, 3612:, 3608:, 3604:, 2914:, 2569:) 2158:) 2059:) 1856:AR 1767:: 1709:, 1705:, 1701:, 1697:, 1693:, 1659:, 1655:, 1651:, 1647:, 1643:, 1639:, 1625:, 1621:, 1617:, 1613:, 1609:, 1321:AR 1289:, 1283:LH 1270:, 1256:, 1214:, 1210:, 1206:, 1202:, 1198:, 984:, 909:)) 905:, 901:, 897:, 889:, 885:, 881:, 877:, 793:AR 714:. 702:32 700:. 696:. 673:. 663:72 661:. 638:. 630:. 620:28 618:. 614:. 591:. 577:. 573:. 528:. 516:28 514:. 510:. 498:^ 488:. 480:. 470:. 462:. 448:. 444:. 421:. 409:60 407:. 401:. 378:. 368:. 358:33 356:. 352:. 336:^ 322:. 308:. 304:. 276:^ 256:. 149:. 115:, 111:, 80:, 76:, 69:. 4252:) 4242:) 4219:) 4210:( 4121:e 4114:t 4107:v 4028:) 4024:L 4017:L 4010:L 4003:L 3983:) 3786:N 3778:N 3770:N 3670:) 3620:) 3541:N 3539:5 2918:) 2887:) 2565:( 2349:N 2345:N 2154:( 2055:( 1836:e 1829:t 1822:v 1713:) 1683:) 1673:) 1663:) 1629:) 1601:( 1594:2 1592:D 1298:) 1274:) 1260:) 1218:) 988:) 893:( 784:) 752:e 745:t 738:v 722:. 708:: 681:. 669:: 646:. 626:: 599:. 585:: 558:. 536:. 522:: 456:: 429:. 415:: 386:. 364:: 330:. 316:: 310:2

Index

Antiandrogens
environment
industrial chemicals
phthalates
pesticides
animal experiments
in utero
endocrine disruptors
reproductive malformations
puberty
vinclozolin
procymidone
linuron
DDT
dichlorodiphenyldichloroethylene
anogenital distance
areolas
vinclozolin
sex accessory glands
hypospadias
undescended testes
phallus
preputial
Ketoconazole
imidazole
broad-spectrum
testicles
adrenal glands
Phenothrin
insecticide

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