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biotype Rieter. The purpose of the absorbent is to remove anti-treponemal antibodies that are not specific for the syphilis bacteria. The pre-adsorbed patient serum is then added to the slide; if the patient has been infected by syphilis, their antibodies will bind to the bacteria.
227:
This test is not useful for following therapy, because it does not wane with successful treatment of the disease, and will continue to be positive for many years after primary exposure. FTA is nearly 100% sensitive in CSF, meaning negative CSF FTA excludes neurosyphilis.
215:(a fluorophore)-labeled anti-treponeme antibody and TRITC (another fluorophore)-labeled anti-human antibodies are added as secondary antibodies. The spirochete location is identified using the FITC staining, and the TRITC staining identifies whether the patient has anti-
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but have been shown repeatedly to be sensitive but not specific for the diagnosis of neurosyphilis in cerebrospinal fluid (CSF). In addition, FTA-ABS turns positive earlier and remains positive longer than VDRL. Other treponemes, such as
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Since the test has high negative predictive value it is very useful in both serum or CSF to exclude/rule out neurosyphilis if the FTA test result is negative. " A negative FTA in serum excludes neurosyphilis".
205:
extracted from rabbit testicular tissue. This is spread over and fixed to a slide. Patient serum is mixed with an absorbent (the "ABS" part of the test) containing an extract of a non-pathogenic treponeme,
43:
182:, may also produce a positive FTA-ABS. The ABS suffix refers particularly to a processing step used to remove nonspecific antispirochetal antibodies present in normal serum.
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The antigen for the FTA-ABS test is whole bacteria. The bacteria cannot be cultured on laboratory media, so the organisms used are a lyophilized suspension of
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species, such tests would be assumed to be more specific than non-treponemal testing such as
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As a confirmatory test for a positive result from a serum screening test (RPR for example).
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247:"Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features"
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if you can. Unsourced or poorly sourced material may be challenged and
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FTA-ABS Fluorescent treponemal antibody absorption test
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Singh, Ameeta E.; Barbara
Romanowski (1 April 1999).
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73:"Fluorescent treponemal antibody absorption test"
362:Fluorescent treponemal antibody absorption test
57:Please review the contents of the article and
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219:antibodies (binding to the same spirochete).
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153:fluorescent treponemal antibody absorption
347:Venereal Disease Research Laboratory test
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185:In general, the test has two roles:
167:. Using antibodies specific for the
730:. You can help Knowledge (XXG) by
673:. You can help Knowledge (XXG) by
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777:Infectious disease blood tests
499:Orthopoxvirus inclusion bodies
59:add the appropriate references
1:
251:Clinical Microbiology Reviews
145:diagnostic test for syphilis
44:reliable medical references
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709:
652:
451:Heterophile antibody test
163:is a diagnostic test for
50:or relies too heavily on
792:Medical diagnostic stubs
787:Infectious disease stubs
726:diagnostic article is a
593:Bloodstream infections
562:Sabin–Feldman dye test
477:Warthin–Finkeldey cell
576:Diagnosis of malaria
263:10.1128/CMR.12.2.187
208:Treponema phagedenis
549:Protozoan infection
409:Anti-streptolysin O
352:rapid plasma reagin
334:Bacterial infection
667:infectious disease
637:C-reactive protein
446:Epstein–Barr virus
434:Branched DNA assay
326:infectious disease
170:Treponema pallidum
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395:HelicoCARE direct
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16:(Redirected from
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581:SchĂĽffner's dots
494:B type inclusion
484:Inclusion bodies
463:NS1 antigen test
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357:Wassermann test
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601:Blood culture
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114:November 2021
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69:Find sources:
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40:This article
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732:expanding it
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675:expanding it
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526:yellow fever
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513:Negri bodies
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458:Dengue fever
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389:Helicobacter
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48:verification
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616:Parasitemia
539:Tzanck test
429:HIV testing
322:Blood tests
217:T. pallidum
203:T. pallidum
180:T. pertenue
42:needs more
771:Categories
375:Rickettsia
232:References
84:newspapers
197:Procedure
782:Syphilis
621:Algaemia
611:Fungemia
342:syphilis
281:10194456
165:syphilis
724:medical
630:General
606:Viremia
570:malaria
471:measles
223:Utility
157:FTA-ABS
142:Purpose
98:scholar
63:removed
18:FTA-ABS
507:rabies
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722:This
665:This
439:mChip
272:88914
105:JSTOR
91:books
728:stub
671:stub
324:for
277:PMID
213:FITC
175:VDRL
161:test
151:The
77:news
46:for
267:PMC
259:doi
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