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Chang, GW; Stacey, M; Kwakkenbos, MJ; Hamann, J; Gordon, S; Lin, HH (Jul 17, 2003). "Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif".
64:. The domain is involved in the self-cleavage of these transmembrane receptors, and has been shown to be crucial for their function . Point mutations within the GAIN domain of PKD1 and
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94:"The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease"
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202:"Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif"
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Araç, D; Boucard, AA; Bolliger, MF; Nguyen, J; Soltis, SM; Südhof, TC; Brunger, AT (Feb 14, 2012).
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153:"A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis"
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Lin, HH; Chang, GW; Davies, JQ; Stacey, M; Harris, J; Gordon, S (Jul 23, 2004).
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36: mediates autocatalytic cleavage of adhesion GPCRs
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found in a number of cell surface receptors, including
92:Trudel, Marie; Yao, Qin; Qian, Feng (2016-01-21).
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48:(GPCR) autoproteolysis-inducing domain) is a
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56:and polycystic kidney disease proteins
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206:The Journal of Biological Chemistry
303:. You can help Knowledge (XXG) by
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255:10.1016/S0014-5793(03)00695-1
24:GPCR-Autoproteolsis INducing
380:Transmembrane receptor stubs
365:G protein-coupled receptors
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46:G-protein-coupled receptor
70:polycystic kidney disease
360:Cell adhesion proteins
299:-related article is a
297:transmembrane receptor
219:10.1074/jbc.M402974200
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169:10.1038/emboj.2012.26
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375:Signal transduction
68:are known to cause
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163:(6): 1364–78.
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301:stub
259:PMID
224:PMID
183:PMID
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116:ISSN
72:and
62:PKD2
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