Knowledge

Human maximisation test

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215:"Opinion concerning the predictive testing of potentially cutaneous sensiting cosmetic ingredients or mixtures of ingredients adopted by the SCCNFP during the 11th plenary session of 17 February 2000 | Scientific Committees" 218: 275:
Zaghi, D; Maibach, HI (2009). "The local lymph node assay compared with the human maximization test as an indicator of allergic potency in humans using patch test clinic populations".
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Basketter, D.A.; Scholes, E.W.; Kimber, I. (1994). "The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test".
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to maximise. Because of the potentially large human reaction, it is generally not considered ethical to use today. It does not have a guideline under the
214: 189: 143:"The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers" 78:
The Identification of Contact Allergens by Human Assay III. The Maximization Test: A Procedure for Screening and Rating Contact Sensitizers
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Kligman, A. M.; Epstein, W. (1975). "Updating the maximization test for identifying contact allergens".
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http://www.nature.com/jid/journal/v47/n5/abs/jid1966160a.html
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The test uses human medical volunteers (usually 25) and
32:in 1975. The first paper appeared 1966 and was a 8: 45:OECD Guidelines for the Testing of Chemicals 158: 71: 47:. It has been compared with the murine 20:(HMT) is a test method for testing for 7: 28:in 1966 and updated by Kligman and 195:from the original on 29 March 2024 112:10.1111/j.1600-0536.1975.tb05389.x 14: 221:from the original on 7 July 2024 188:. December 2, 1985. p. 18. 183:"This Week's Citation Classic" 1: 254:10.1016/0278-6915(94)90112-0 242:Food and Chemical Toxicology 24:. It was first developed by 248:(6). Elsevier BV: 543–547. 341: 289:10.1080/15569520902793627 141:Kligman, A. M. (1966). 41:sodium laureth sulphate 18:Human maximisation test 49:local lymph node assay 160:10.1038/jid.1966.160 147:J. Invest. Dermatol 277:Cutan Ocul Toxicol 100:Contact Dermatitis 85:2024-07-07 at the 22:contact allergens 332: 309: 308: 272: 266: 265: 237: 231: 230: 228: 226: 211: 205: 204: 202: 200: 194: 187: 179: 173: 172: 162: 138: 132: 131: 95: 89: 76: 34:citation classic 340: 339: 335: 334: 333: 331: 330: 329: 315: 314: 313: 312: 274: 273: 269: 239: 238: 234: 224: 222: 213: 212: 208: 198: 196: 192: 185: 181: 180: 176: 140: 139: 135: 97: 96: 92: 87:Wayback Machine 77: 73: 68: 56: 30:William Epstein 12: 11: 5: 338: 336: 328: 327: 317: 316: 311: 310: 267: 232: 206: 174: 153:(5): 393–409. 133: 106:(4): 231–239. 90: 70: 69: 67: 64: 63: 62: 55: 52: 26:Albert Kligman 13: 10: 9: 6: 4: 3: 2: 337: 326: 323: 322: 320: 306: 302: 298: 294: 290: 286: 282: 278: 271: 268: 263: 259: 255: 251: 247: 243: 236: 233: 220: 216: 210: 207: 191: 184: 178: 175: 170: 166: 161: 156: 152: 148: 144: 137: 134: 129: 125: 121: 117: 113: 109: 105: 101: 94: 91: 88: 84: 81: 75: 72: 65: 61: 58: 57: 53: 51: 50: 46: 42: 37: 35: 31: 27: 23: 19: 280: 276: 270: 245: 241: 235: 225:21 September 223:. Retrieved 209: 197:. Retrieved 177: 150: 146: 136: 103: 99: 93: 74: 38: 17: 15: 325:Allergology 283:(2): 61–4. 66:References 60:Patch test 262:0278-6915 36:in 1985. 319:Category 305:35683477 297:19514928 219:Archived 190:Archived 128:35702783 83:Archived 54:See also 169:5924294 120:1235254 303:  295:  260:  199:5 July 167:  126:  118:  301:S2CID 193:(PDF) 186:(PDF) 124:S2CID 293:PMID 258:ISSN 227:2012 201:2024 165:PMID 116:PMID 16:The 285:doi 250:doi 155:doi 108:doi 321:: 299:. 291:. 281:28 279:. 256:. 246:32 244:. 217:. 163:. 151:47 149:. 145:. 122:. 114:. 102:. 307:. 287:: 264:. 252:: 229:. 203:. 171:. 157:: 130:. 110:: 104:1

Index

contact allergens
Albert Kligman
William Epstein
citation classic
sodium laureth sulphate
OECD Guidelines for the Testing of Chemicals
local lymph node assay
Patch test
http://www.nature.com/jid/journal/v47/n5/abs/jid1966160a.html
Archived
Wayback Machine
doi
10.1111/j.1600-0536.1975.tb05389.x
PMID
1235254
S2CID
35702783
"The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers"
doi
10.1038/jid.1966.160
PMID
5924294
"This Week's Citation Classic"
Archived
"Opinion concerning the predictive testing of potentially cutaneous sensiting cosmetic ingredients or mixtures of ingredients adopted by the SCCNFP during the 11th plenary session of 17 February 2000 | Scientific Committees"
Archived
doi
10.1016/0278-6915(94)90112-0
ISSN
0278-6915

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