31:
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Gouw, A.A.; Flier, W.M.; Straaten, E.C.W.; Barkhof, F.; Ferro, J.M.; Baezner, H.; Pantoni, L.; Inzitari, D.; et al. (2006). "Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: The LADIS study".
112:
Hyperintensities are commonly divided into 3 types depending on the region of the brain where they are found. Deep white matter hyperintensities occur deep within white matter, periventricular white matter hyperintensities occur adjacent to the
104:
than control subjects. WMH volume, calculated as a potential diagnostic measure, has been shown to correlate to certain cognitive factors. Hyperintensities appear as "bright signals" (bright areas) on an MRI image and the term
323:
Habes M, Erus G, Toledo JB, Zhang T, Bryan N, Launer LJ, Rosseel Y, Janowitz D, Doshi J, Van der Auwera S, von
Sarnowski B, Hegenscheid K, Hosten N, Homuth G, Völzke H, Schminke U, Hoffmann W, Grabe H, Davatzikos C (2016).
608:
191:. Studies suggest that a combination of MTA and severe WMH showed more than a fourfold increase in the frequency of mild cognitive deficits. Severe WMH is consistently shown to be associated with
453:
Brickman, Adam M.; Meier, Irene B.; Korgaonkar, Mayuresh S.; Provenzano, Frank A.; Grieve, Stuart M.; Siedlecki, Karen L.; Wasserman, Ben T.; Williams, Leanne M.; Zimmerman, Molly E. (2012).
171:) that is consistently below 60 mmHg may be at higher risk of white matter lesions due to a decrease in cerebral perfusion (blood flow). Over half of cerebral perfusion occurs during
551:
Thomas, Alan J.; Perry, Robert; Barber, Robert; Kalaria, RAJ N.; O'Brien, John T. (2002). "Pathologies and
Pathological Mechanisms for White Matter Hyperintensities in Depression".
375:
Kempton, Matthew J.; Geddes, JR; Ettinger, U; Williams, SC; Grasby, PM (2008). "Meta-analysis, Database, and Meta-regression of 98 Structural
Imaging Studies in Bipolar Disorder".
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Spence, J David; Müller, Lucas O; Blanco, Pablo J (11 Sep 2021). "How to identify which patients should not have a systolic blood pressure target of <120 mmHg".
875:
879:
690:"Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: The LADIS study"
958:
54:
or of another mammal that reflect lesions produced largely by demyelination and axonal loss. These small regions of high intensity are observed on
604:"Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants"
59:
688:
Van Der Flier, W M; Van
Straaten, EC; Barkhof, F; Ferro, JM; Pantoni, L; Basile, AM; Inzitari, D; Erkinjuntti, T; et al. (2005).
271:"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis"
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projections have been evident. Sufficient damage to the axons that course through WMH can cause adequate interference with normal
240:
245:
89:
895:"A New Visual Rating Scale to Assess Strategic White Matter Hyperintensities Within Cholinergic Pathways in Dementia"
199:. Speed of cognitive processes and frontal skills may also be impaired in people with WMH. Pathological signs of
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disorders, impaired balance and cognitive disturbances. Certain features of gait pattern associated with WMH are:
47:
101:
55:
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Birdsill AC, Koscik RL, Jonaitis EM, Johnson SC, Okonkwo OC, Hermann BP, Larue A2, Sager MA, Bendlin BB (2014).
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88:). The volume and frequency is strongly associated with increasing age. They are also seen in a number of
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826:"Regional white matter hyperintensities: aging, Alzheimer's disease risk, and cognitive function"
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326:"White matter hyperintensities and imaging patterns of brain ageing in the general population"
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96:. For example, deep white matter hyperintensities are 2.5 to 3 times more likely to occur in
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Videbech, P. (1997). "MRI findings in patients with affective disorder: A meta-analysis".
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slight widening of the base, slowing and shortening of stride length and turning en bloc
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Hyperintensities are often seen in auto immune diseases that have effects on the brain.
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Bocti, C.; Swartz, R. H.; Gao, F.-Q.; Sahlas, D. J.; Behl, P.; Black, S. E. (2005).
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It is also thought that WMH have a negative impact on cognition in people with
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White matter hyperintensities can be caused by a variety of factors including
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disease. In people with
Alzheimer's, higher WMH are associated with higher
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Postmortem studies combined with MRI suggest that hyperintensities are
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455:"Testing the white matter retrogenesis hypothesis of cognitive aging"
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Biochimica et
Biophysica Acta (BBA) - Molecular Basis of Disease
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atrophy (MTA) was linked with an increase in frequency of mild
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167:(ie. as measured in a peripheral artery, most commonly the
109:" is occasionally used as a synonym for a hyperintensity.
694:
Journal of
Neurology, Neurosurgery & Psychiatry
183:In most elderly people, presence of severe WMH and
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159:and the brain, or loss and deformation of the
117:and subcortical hyperintensities occur in the
661:(6). Oxford University Press (OUP): 538–539.
58:weighted MRI images (typically created using
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553:Annals of the New York Academy of Sciences
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46:is an area of high intensity on types of
602:Raz N, Yang Y, Dahle CL, Land S (2012).
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504:"Demyelination in rheumatic diseases"
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844:10.1016/j.neurobiolaging.2013.10.072
471:10.1016/j.neurobiolaging.2011.06.001
226:and reduced amyloid beta clearance.
135:caused by reduced local blood flow.
222:deposits, possibly associated with
959:Symptoms and signs: Nervous system
912:10.1161/01.STR.0000183615.07936.b6
573:10.1111/j.1749-6632.2002.tb04835.x
424:10.1111/j.1600-0447.1997.tb10146.x
34:MRI scans showing hyperintensities
25:
27:High intensity on MRI brain scans
508:J. Neurol. Neurosurg. Psychiatry
502:Theodoridou A, Settas L (2006).
241:Hypertensive leukoencephalopathy
246:Subcortical ischemic depression
412:Acta Psychiatrica Scandinavica
377:Archives of General Psychiatry
80:) or subcortical gray matter (
1:
269:Debette S, Markus HS (2010).
73:white matter hyperintensities
622:10.1016/j.bbadis.2011.08.007
82:gray matter hyperintensities
163:. People with a peripheral
129:dilated perivascular spaces
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389:10.1001/archpsyc.65.9.1017
48:magnetic resonance imaging
772:10.1007/s00415-006-0193-5
667:10.1093/eurheartj/ehab552
102:major depressive disorder
706:10.1136/jnnp.2005.064998
520:10.1136/jnnp.2005.075861
203:apoptosis and damage to
165:diastolic blood pressure
938:www.bipolardatabase.org
655:European Heart Journal
90:neurological disorders
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831:Neurobiology of Aging
459:Neurobiology of Aging
94:psychiatric illnesses
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760:Journal of Neurology
344:10.1093/brain/aww008
251:Virchow-Robin spaces
224:small vessel disease
185:medial temporal lobe
68:white matter lesions
565:2002NYASA.977..333T
338:(Pt 4): 1164–1179.
157:cerebrospinal fluid
50:(MRI) scans of the
806:has generic name (
742:has generic name (
189:cognitive deficits
115:lateral ventricles
62:) within cerebral
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289:10.1136/bmj.c3666
179:Cognitive effects
44:T2 hyperintensity
16:(Redirected from
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216:Alzheimer's
211:functions.
149:hemorrhages
948:Categories
257:References
675:0195-668X
283:: c3666.
921:16179569
862:24199958
788:34708784
780:16998647
724:16227537
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581:12480770
538:16484634
489:21783280
440:46065841
397:18762588
362:26912649
307:20660506
230:See also
209:neuronal
173:diastole
147:, micro-
145:ischemia
60:3D FLAIR
853:3880609
715:1739423
631:3245802
561:Bibcode
529:2077679
480:3222729
432:9296545
353:5006227
298:2910261
153:gliosis
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139:Causes
784:S2CID
585:S2CID
436:S2CID
331:Brain
131:, or
917:PMID
880:link
876:link
858:PMID
808:help
776:PMID
744:help
720:PMID
671:ISSN
636:PMID
614:1822
577:PMID
534:PMID
485:PMID
428:PMID
393:PMID
358:PMID
303:PMID
193:gait
100:and
92:and
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848:PMC
840:doi
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764:253
710:PMC
702:doi
663:doi
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618:doi
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516:doi
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420:doi
385:doi
348:PMC
340:doi
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293:PMC
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276:BMJ
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