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Thurston is best known for a massive longitudinal study of children with well-controlled seizure disorders. One hundred and forty-eight children with a diagnosis of epilepsy who had been seizure-free on medication for 4 years stopped their medication with close follow-up for the next 5-12 years. One
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After her fellowship, Thurston worked in
Edmonton as a pediatrician for several years. In 1949, Thurston returned to St. Louis to accept an appointment as instructor at the Washington University Department of Pediatrics in 1949. She was promoted to assistant professor in 1954.
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Thurston JH, Thurston DL, Hixon BB, Keller AJ. Prognosis in childhood epilepsy: additional follow-up of 148 children 15 to 23 years after withdrawal of anticonvulsant therapy. N Engl J Med. 1982 Apr 8;306(14):831-6. doi: 10.1056/NEJM198204083061403. PMID 6801511.
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Holowach J, Thurston DL, O'Leary J. Prognosis in childhood epilepsy. Follow-up study of 148 cases in which therapy had been suspended after prolonged anticonvulsant control. N Engl J Med. 1972 Jan 27;286(4):169-74. doi: 10.1056/NEJM197201272860401. PMID 4621374.
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Thurston JH, Warren SK. Permeability of the blood-brain barrier to monosodium glutamate and effects on the components of the energy reserve in newborn mouse brain. J Neurochem. 1971 Nov;18(11):2241-4. doi: 10.1111/j.1471-4159.1971.tb05084.x. PMID 5129356.
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An update, published in 1982, evaluated the same children 15-23 years after stopping medication. Again, about 28% of children had recurrence of seizures, most within the first five years after stopping medication.
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Thurston JH, Hauhard RE, Dirgo JA. Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice. Science. 1978 Aug 18;201(4356):649-51. doi: 10.1126/science.209541. PMID 209541.
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Thurston maintained an active neurochemistry laboratory until the age of 75. Her research focused on experimental neonatal asphyxia, salicylate toxicity, and the teratogenicity of valproate metabolites.
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Thurston, JH; Thurston, DL; Hixon, BB; Keller, AJ (1982). "Prognosis in childhood epilepsy: additional follow-up of 148 children 15 to 23 years after withdrawal of anticonvulsant therapy".
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Holowach, J; Thurston, DL; O'Leary, J (1972). "Prognosis in childhood epilepsy. Follow-up study of 148 cases in which therapy had been suspended after prolonged anticonvulsant control".
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In 1950, she was appointed director of the
Pediatric Convulsive Clinic, a title she held until 1962. From 1949–1961 Thurston directed the State of Missouri Premature Program.
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Thurston JH, Hauhart RE. Developmental and neurologic status of children after heart surgery. N Engl J Med. 1995 Aug 10;333(6):391; author reply 391-2. PMID 7609769.
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Thurston JH, Hauhart RE. Vitamins to prevent neural-tube defects. N Engl J Med. 1993 Jun 3;328(22):1641-2. doi: 10.1056/NEJM199306033282217. PMID 8338547.
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in four children had a recurrence of seizures, most of these in the first year after stopping medication. Relapse was more likely if children had
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HOLOWACH J, THURSTON DL. Breath-holding spells and anemia. N Engl J Med. 1963 Jan 3;268:21-3. doi: 10.1056/NEJM196301032680105. PMID 13961431.
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121:. She told a reporter from Edmonton she was "wild about" research, and would sometimes spend "24 hours at a stretch" in her lab.
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Connolly, Anne; Gurnett, Christina A.; Zempel, John (18 September 2017). "In
Memoriam: Jean Holowach Thurston, MD (1917–2017)".
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She was promoted to associate professor in 1965, full professor of pediatrics in 1975, and full professor of neurology in 1982.
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from 1949, until her retirement in 1987. In 2004, she won the first Roger and Mary
Brumback Lifetime Achievement Award from the
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148:. The two were co-authors on many of Thurston's early clinical papers - where she is listed as J. Holowach.
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In 1962, when she turned 45, Thurston took a 3-year sabbatical for a neurochemistry fellowship in the lab of
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226:"Professor Jean Holowach Thurston: Renowned and True Pioneer of Pediatric Neurology as Well as Neurochemist"
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in 1987, continuing attendance and participation in lectures and conferences. In 2003, she earned more
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22:(22 June 1917 – 29 April 2017) was an American pediatric neurologist, known for her research on
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in 1941, one of only three women in her medical school class. She worked as a pediatrician in
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in pediatrics and metabolic disorders at
Washington University School of Medicine.
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267:"Varsity Women Grads Choose Varied Careers". The Edmonton Bulletin. 9 May 1941.
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136:(CME) credits than anyone else at Washington University School of Medicine.
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Thurston's husband Donald L. Thurston was also a
Professor of Pediatrics at
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Sheppard, June (5 February 1974). "Women in
Research". Edmonton Journal.
324:"Jean Holowach Thurston: Set standards for pediatric epilepsy research"
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284:"Obituary:Jean Holowach Thurston, professor emerita, 99"
286:. Washington University School of Medicine. 10 May 2017
498:Washington University School of Medicine faculty
328:Washington University Department of Neuroscience
493:Washington University School of Medicine alumni
42:Jean Holowach Thurston was born and raised in
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307:"In Memoriam: Jean Holowach-Thurston, M.D."
50:. She received her medical degree from the
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28:Washington University School of Medicine
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26:. She was a professor of pediatrics at
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166:Thurston died on April 29, 2017, of
468:American people of Canadian descent
146:Washington University in St. Louis
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305:Rust, Robert (4 September 2023).
101:This study was published in the
98:or more than one seizure type.
385:New England Journal of Medicine
350:New England Journal of Medicine
103:New England Journal of Medicine
473:American women neuroscientists
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174:Notable Research Publications
488:University of Alberta alumni
134:Continuing Medical Education
113:Research in Brain Metabolism
397:10.1056/NEJM198204083061403
362:10.1056/NEJM197201272860401
89:Pediatric Epilepsy Research
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508:Scientists from Edmonton
478:American neuroscientists
243:10.4103/jnrp.jnrp_339_17
38:Early life and education
310:Child Neurology Society
32:Child Neurology Society
230:J Neurosci Rural Pract
224:Satyarthee GD (2017).
62:. In 1945 she went to
20:Jean Holowach Thurston
483:American neurologists
52:University of Alberta
16:American neurologist
128:Thurston moved to
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463:2017 deaths
458:1917 births
452:Categories
333:26 January
290:25 October
204:References
105:in 1972.
68:fellowship
434:Neurology
163:garden.
64:St. Louis
44:Edmonton
24:epilepsy
405:6801511
370:4621374
253:5709913
58:during
56:Calgary
48:Alberta
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153:opera
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335:2023
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161:rose
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