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Ion transporter

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220: 79: 103:(IUBMB) and are grouped according to characteristics such as the substrates being transported, the transport mechanism, the energy source used, and also by comparing the DNA sequences making up each protein. The most important unifying factor being the charged nature of the substrate which indicates the transport of an ion and not a neutral species. Ion transporters differ significantly from 6282: 138: 228: 124:. However, only ion transporters can also perform active transport, which involves moving ions against their concentration gradient. Using energy sources such as ATP, ion transporters are able to move ions against their concentration gradient which can then be used by secondary transporters or other proteins as a source of energy. 186:
ATP producing transporters run in the opposite direction of ATP Utilizing transporters. These proteins transport ions from high to low concentration with the gradient but in the process ATP is formed. Potential energy in the form of the concentration gradient is used to generate ATP. In animals, this
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Secondary transporters also transport ions (or small molecules) against the concentration gradient – from low concentration to high concentration - but unlike primary transporters which use ATP to create a concentration gradient, secondary transporters use the potential energy from the concentration
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X-ray crystallography is an incredible tool that allows the structure of proteins to be visualized, however, it is only a snapshot of one protein conformation. The structure of transport proteins allows researchers to further understand how and what the transporter does to move molecules across the
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found in the small intestine and kidney use the sodium gradient created in the cell by the sodium potassium pump (as mentioned above) to help carry glucose into the cell. This happens as sodium flows down its concentration gradient which provides enough energy to push glucose up its concentration
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A patch clamp is an electrophysiology technique used to study channels and transporters in cells by tracking the current that run through them. This technique was perfected by Hodgkin and Huxley before the existence of channels and transporters was known. Besides its groundbreaking work early on
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An electrochemical gradient or concentration gradient is a difference in concentration of a chemical molecule or ion in two separate areas. At equilibrium the concentrations of the ion in both areas will be equal, so if there is a difference in concentration the ions will seek to flow "down" the
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the protein can change the activity of the transporter. Whether the protein is activated or inhibited with the addition of the phosphate group depends on the specific protein. With allosteric inhibition, the regulatory ligand can bind into the regulatory site and either inhibit or activate the
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Fluorescence recovery after photobleaching (FRAP) is a technique used to track diffusion of lipids or proteins in a membrane. This technique is used to better understand transporters mobility in the cell and its interactions with lipid domains and lipid rafts in the cell membrane.
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Primary transporters use energy to transport ions such as Na , K, and Ca across a cells membrane and can create concentration gradients. This transport can use ATP as an energy source or it can be used to generate ATP through methods such as the electron transport chain in plants.
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to accomplish many different biological functions, including cellular communication, maintaining homeostasis, energy production, etc. There are different types of transporters including pumps, uniporters, antiporters, and symporters. Active transporters or
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transporter. Ion transporters can also be regulated by the concentration of an ion (not necessarily the ion it transfers) in solution. For example, the electron transport chain is regulated by the presence of H ions (pH) in solution.
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reactions—to potential energy by pumping an ion up its concentration gradient. This potential energy could then be used by secondary transporters, including ion carriers and ion channels, to drive vital cellular processes, such as
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Crane RK, Forstner G, Eichholz A (November 1965). "Studies on the mechanism of the intestinal absorption of sugars. X. An effect of Na+ concentration on the apparent Michaelis constants for intestinal sugar transport, in vitro".
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Förster resonance energy transfer (FRET) is a technique that uses fluorescence to track how close two proteins are to each other. This has been used in studying transporters to see how they interact with other cellular proteins.
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Ion transporters are essential for proper cell function and thus they are highly regulated by the cell and studied by researchers using a variety of methods. Some examples of cell regulations and research methods will be given.
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use ATP to convert the energy in ATP into potential energy in the form of a concentration gradient. They use the ATP to transport an ion from a low concentration to a higher concentration. Examples of proteins that use ATP are
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allows the specific ions that will fit into the channel to flow down their concentration gradient, equalizing the concentrations on either side of the cell membrane. Ion channels and ion transporters accomplish this via
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Morth JP, Pedersen BP, Buch-Pedersen MJ, Andersen JP, Vilsen B, Palmgren MG, Nissen P (January 2011). "A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps".
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patch clamping legacy continues on and is commonly used by researchers still to study ion transporters and how environments and ligands effects the function of the transporter.
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Ion transporters can be regulated in a variety of different ways such as phosphorylation, allosteric inhibition or activation, and sensitivity to ion concentration. Using
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also use the concentration gradient of one molecule to move another up its concentration gradient but the coupled molecule is transported in the opposite direction.
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to acidify vesicles or plant vacuoles during the process of photosynthesis in the chloroplasts. This process can be regulated through various methods such as pH.
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such as the sodium-glucose symporter transport an ion with its concentration gradient, and they couple the transport of a second molecule in the same direction.
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Morth JP, Pedersen BP, Toustrup-Jensen MS, SĂžrensen TL, Petersen J, Andersen JP, et al. (December 2007). "Crystal structure of the sodium-potassium pump".
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serves the opposite function as F-type ATPase and is used in plants to hydrolyze ATP to create a proton gradient. Examples of this are lysosomes that use
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Hosseinzadeh Z, Luo D, Sopjani M, Bhavsar SK, Lang F (April 2014). "Down-regulation of the epithelial Naâș channel ENaC by Janus kinase 2".
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that contain 12 families of transporters. These families are part of the Transport Classification (TC) system that is used by the
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Prebble JN (September 2010). "The discovery of oxidative phosphorylation: a conceptual off-shoot from the study of glycolysis".
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Shinoda T, Ogawa H, Cornelius F, Toyoshima C (May 2009). "Crystal structure of the sodium-potassium pump at 2.4 A resolution".
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This page is focused mainly on ion transporters acting as pumps, but transporters can also function to move molecules through
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gradient back into the cell. This is important in the small intestine and the kidney to prevent them from losing glucose.
4363: 4165: 3965: 5855: 5746: 5513: 5340: 4961: 1143:"α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter" 551:"Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms" 392: 350: 171: 5910: 2953: 6127: 5292: 5167: 3933: 430: 92: 6175: 3812: 3516: 6272: 3885: 2388: 1997: 1343: 435: 166:(ATP binding cassette transporters) that transport a broad set of molecules. Examples of the P-type ATPase include 96: 5179: 4542: 4198: 2691: 5645: 5068: 4946: 2834: 1948: 1708: 1703: 406: 200: 5840: 5237: 4730: 4996: 2818: 2585: 1301: 956:
Tikhonov AN (October 2013). "pH-dependent regulation of electron transport and ATP synthesis in chloroplasts".
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Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia AS, McNamara JO, Williams SM, eds. (2001).
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Swant J, Goodwin JS, North A, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H (December 2011).
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that transfer Na , K, and Ca ions by phosphorylation, A-type ATPases that transfer anions, and
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gradient created by the primary transporters to transport ions. For example, the
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Haumann J, Dash RK, Stowe DF, Boelens AD, Beard DA, Camara AK (August 2010).
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concentration gradient or from a high concentration to low concentration.
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Maffeo C, Bhattacharya S, Yoo J, Wells D, Aksimentiev A (December 2012).
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Marshall WS, Watters KD, Hovdestad LR, Cozzi RR, Katoh F (August 2009).
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Studies in History and Philosophy of Biological and Biomedical Sciences
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is an example of an ABC transport binding protein in the human body.
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are transporters that convert energy from various sources—including
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Transmembrane protein that moves ions across a biological membrane
828:"Visualizing the mapped ion pathway through the Na,K-ATPase pump" 6212: 6193: 6189: 6159: 6145: 5890: 5464: 5445: 4636: 4631: 4626: 2527: 1840: 5281: 5064: 4906: 4845: 4570: 4402:
System A & N, sodium-coupled neutral amino-acid transporter
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Fundamentals of biochemistry : life at the molecular level
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ATPsynthase uses a chemical (proton) gradient to generate ATP
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Takeuchi A, Reyes N, Artigas P, Gadsby DC (November 2009).
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high affinity glutamate and neutral amino-acid transporter
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Prakash S, Cooper G, Singhi S, Saier MH (December 2003).
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which exhibits sensitivity to ADP and ATP concentrations
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International Union of Biochemistry and Molecular Biology
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cationic amino-acid transporter/glycoprotein-associated
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glycoprotein-associated/light or catalytic subunits of
525:(2nd ed.). Sunderland, Mass.: Sinauer Associates. 6270: 4655:
Na-independent, system-L like amino-acid transporter
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ATP synthesis takes place in the mitochondria using
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that moves ions (or other small molecules) across a
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Molecular Cell Biology 612:Nature Reviews. Molecular Cell Biology 4323:proton-coupled amino-acid transporter 2523:heterodimeric amino-acid transporters 2192:heterodimeric amino-acid transporters 916: 914: 91:Ion transporters are classified as a 7: 2788:proton coupled metal ion transporter 751: 749: 747: 745: 711: 709: 707: 705: 703: 701: 699: 697: 695: 653: 651: 544: 542: 460: 458: 456: 237:sodium-dependent glucose transporter 5129:Alternating hemiplegia of childhood 5117:Alternating hemiplegia of childhood 4364:sugar-phosphate/phosphate exchanger 3966:facilitative nucleoside transporter 1147:The Journal of Biological Chemistry 1049:The Journal of Experimental Biology 5836:Jervell and Lange-Nielsen syndrome 5775:Jervell and Lange-Nielsen syndrome 4166:type II Na-phosphate cotransporter 2379:sodium:neurotransmitter symporters 25: 4119:Vesicular glutamate transporter 1 3081:Vesicular glutamate transporter 1 2954:proton oligopeptide cotransporter 1369:F-, V-, and A-type ATPase (3.A.2) 660:"The ion transporter superfamily" 323:Förster resonance energy transfer 87:Classification and disambiguation 6280: 6246:Nephrogenic diabetes insipidus 2 5634:Congenital insensitivity to pain 5629:Paroxysmal extreme pain disorder 5557:Hypokalemic periodic paralysis 2 5408:Hypokalemic periodic paralysis 1 6138:Hypoplastic left heart syndrome 5949:Thyrotoxic periodic paralysis 2 5562:Hyperkalemic periodic paralysis 5413:Thyrotoxic periodic paralysis 1 3934:Na-coupled nucleoside transport 3813:multifunctional anion exchanger 3144:vesicular monoamine transporter 1385:H transporting, mitochondrial: 877:The Journal of Membrane Biology 6200:Erythrokeratodermia variabilis 6152:Charcot–Marie–Tooth disease X1 5856:Familial atrial fibrillation 3 5761:Spinocerebellar ataxia type-13 5747:Familial atrial fibrillation 7 5514:Familial hemiplegic migraine 3 5341:Familial hemiplegic migraine 1 1: 6046:Vitelliform macular dystrophy 5572:Potassium-aggravated myotonia 5351:Spinocerebellar ataxia type-6 4797:multidrug and toxin extrusion 3886:fatty acid transport proteins 2103:facilitative GLUT transporter 1010:Biochimica et Biophysica Acta 4543:basolateral iron transporter 4199:nucleoside-sugar transporter 2692:sodium bile salt cotransport 2293:sodium glucose cotransporter 1110:10.1113/jphysiol.2012.233411 1022:10.1016/0926-6585(65)90172-x 677:10.1016/j.bbamem.2003.10.010 351:Neurotransmitter transporter 260:to add a phosphate group or 195:. This process utilizes the 6133:Hallermann–Streiff syndrome 6128:Oculodentodigital dysplasia 5693:Pseudohypoaldosteronism 1AR 5168:Acrokeratosis verruciformis 1998:membrane transport proteins 935:10.1016/j.shpsc.2010.07.014 519:"Channels and Transporters" 431:Ion transporter superfamily 51:(ATP), sunlight, and other 6324: 6308:Integral membrane proteins 6303:Transmembrane transporters 4731:Putative sugar transporter 1795:3.A.3.5: Cu transporting: 1344:Membrane transport protein 436:Membrane transport protein 326: 311: 296: 281: 6256: 5263: 5046: 4915: 4902: 4852: 4841: 4577: 4566: 4083: 4072: 3255: 3244: 2776: 2765: 2038: 2027: 2023: 2012: 1944: 1490:H transporting, lysosomal 1098:The Journal of Physiology 978:10.1007/s11120-013-9845-y 889:10.1007/s00232-014-9636-1 720:. John Wiley & Sons. 575:10.1016/j.bpj.2010.04.069 407:Sodium-chloride symporter 393:Plasma membrane Ca ATPase 338:Table of ion transporters 201:oxidative phosphorylation 182:ATP producing transporter 5309:Diseases of ion channels 5051:solute carrier disorders 4688:Choline-like transporter 2819:electroneutral cation-Cl 1302:Medical Subject Headings 770:10.1036/1097-8542.352000 756:Scheer BT (2014-01-01). 400:Sodium-calcium exchanger 197:electron transport chain 5911:Andersen–Tawil syndrome 4589:Magnesium transporter E 2220:bicarbonate transporter 1160:10.1074/jbc.M111.241232 958:Photosynthesis Research 6176:Bart–Pumphrey syndrome 5567:Paramyotonia congenita 5452:Malignant hyperthermia 4984:Antiporter (exchanger) 606:Gadsby DC (May 2009). 386:Adenosine transporters 231: 224: 142: 83: 82:Diffusion vs Transport 49:adenosine triphosphate 6101:Mucolipidosis type IV 5646:Constitutively active 5180:Hailey–Hailey disease 4455:metal ion transporter 3565:mitochondrial carrier 3215:type III Na-phosphate 844:10.4161/chan.3.6.9775 365:Monoamine transporter 358:Glutamate transporter 299:X-ray Crystallography 293:X-ray crystallography 230: 222: 215:Secondary transporter 140: 118:facilitated diffusion 81: 65:facilitated diffusion 36:transmembrane protein 6032:Osteopetrosis A2, B4 5841:Romano–Ward syndrome 5457:Central core disease 5238:Kufor–Rakeb syndrome 426:Ion transport number 379:Glycine transporters 199:in a process called 5586:Long QT syndrome 10 4622:Ammonia transporter 3517:Na/(Ca-K) exchanger 1898:Class VI, type 11: 1265:10.1038/nature07939 1257:2009Natur.459..446S 1214:10.1038/nature06419 1206:2007Natur.450.1043M 970:2013PhoRe.116..511T 567:2010BpJ....99..997H 555:Biophysical Journal 191:otherwise known as 155:Active transporters 133:Primary transporter 120:which is a type of 40:biological membrane 18:Pump (biochemistry) 6181:Vohwinkel syndrome 6171:Ichthyosis hystrix 6060:Bartter syndrome 3 6004:Myotonia congenita 5916:Long QT syndrome 7 5897:Bartter syndrome 2 5851:Long QT syndrome 1 5808:Brugada syndrome 5 5794:Long QT syndrome 6 5780:Long QT syndrome 5 5624:Febrile seizure 3B 5605:Long QT syndrome 3 5600:Brugada syndrome 1 5538:Brugada syndrome 6 5524:Febrile seizure 3A 5427:Brugada syndrome 4 5375:Long QT syndrome 8 5370:Brugada syndrome 3 4769:Folate transporter 2190:heavy subunits of 1882:Class V, type 10: 1871:Class II, type 9: 1061:10.1242/jeb.030015 1055:(Pt 15): 2365–77. 232: 225: 150:Active transporter 143: 84: 6268: 6267: 5959: 5958: 5921:Short QT syndrome 5846:Short QT syndrome 5822:Short QT syndrome 5733:Episodic ataxia 1 5709:Potassium channel 5703: 5702: 5667:Liddle's syndrome 5486: 5485: 5389:Ocular albinism 2 5346:Episodic ataxia 2 5275: 5274: 5058: 5057: 5042: 5041: 5038: 5037: 4898: 4897: 4894: 4893: 4890: 4889: 4837: 4836: 4833: 4832: 4562: 4561: 4558: 4557: 4068: 4067: 4064: 4063: 3240: 3239: 3236: 3235: 2761: 2760: 2757: 2756: 1990:Membrane proteins 1956: 1955: 1845:Class I, type 8: 1652:Na/K transporting 1636: 1635: 483:10.1021/cr3002609 441:Transport protein 412: 411: 372:GABA transporters 345:Ion Transporters 223:Na+ Glu Symporter 122:passive transport 69:passive diffusion 16:(Redirected from 6315: 6285: 6284: 6276: 5965:Chloride channel 5882:Inward-rectifier 5714: 5497: 5365:Timothy syndrome 5322: 5302: 5295: 5288: 5279: 5255:Osteopetrosis B1 5215:Wilson's disease 5164:Darier's disease 5092:Genetic disorder 5085: 5078: 5071: 5062: 5017: 5016: 5015: 4917: 4904: 4843: 4825:Heme transporter 4579: 4568: 4085: 4074: 3257: 3246: 2926:urea transporter 2778: 2767: 2040: 2029: 2025: 2014: 1994:carrier proteins 1983: 1976: 1969: 1960: 1949:ATPase disorders 1820:Other/ungrouped: 1374: 1337: 1330: 1323: 1314: 1285: 1284: 1251:(7245): 446–50. 1240: 1234: 1233: 1200:(7172): 1043–9. 1189: 1183: 1182: 1172: 1162: 1153:(51): 43933–43. 1138: 1132: 1131: 1121: 1089: 1083: 1082: 1072: 1040: 1034: 1033: 1004: 998: 997: 953: 947: 946: 918: 909: 908: 872: 866: 865: 855: 823: 817: 816: 780: 774: 773: 753: 740: 739: 713: 690: 689: 679: 655: 646: 645: 635: 603: 597: 596: 586: 546: 537: 536: 514: 505: 504: 494: 471:Chemical Reviews 462: 421:Active transport 342: 164:ABC transporters 21: 6323: 6322: 6318: 6317: 6316: 6314: 6313: 6312: 6293: 6292: 6291: 6279: 6271: 6269: 6264: 6252: 6225: 6107: 6066: 5999:Thomsen disease 5980:Cystic fibrosis 5955: 5876: 5699: 5640: 5619:Erythromelalgia 5482: 5433: 5317:Calcium channel 5311: 5306: 5276: 5271: 5259: 5243: 5220: 5185: 5134: 5099: 5089: 5059: 5054: 5034: 5014: 5011: 5010: 5009: 5007: 4978: 4941: 4911: 4886: 4848: 4829: 4813: 4785: 4757: 4719: 4676: 4643: 4610: 4573: 4554: 4531: 4443: 4390: 4352: 4311: 4187: 4154: 4130: 4107: 4079: 4060: 3992: 3954: 3922: 3874: 3801: 3553: 3505: 3467: 3349: 3251: 3232: 3203: 3165: 3132: 3069: 2992:monocarboxylate 2980: 2942: 2914: 2871: 2807: 2772: 2753: 2680: 2607: 2586:Na/Ca exchanger 2574: 2485: 2359: 2281: 2208: 2179: 2091: 2034: 2019: 2008: 1987: 1957: 1952: 1940: 1837:Mg transporting 1750:Ca transporting 1632: 1631:found in Archea 1620: 1476: 1363: 1341: 1294: 1289: 1288: 1242: 1241: 1237: 1191: 1190: 1186: 1140: 1139: 1135: 1104:(11): 2569–70. 1091: 1090: 1086: 1042: 1041: 1037: 1006: 1005: 1001: 964:(2–3): 511–34. 955: 954: 950: 920: 919: 912: 874: 873: 869: 825: 824: 820: 797:10.1038/nrm3031 782: 781: 777: 758:"Ion transport" 755: 754: 743: 728: 715: 714: 693: 657: 656: 649: 624:10.1038/nrm2668 605: 604: 600: 561:(4): 997–1006. 548: 547: 540: 533: 516: 515: 508: 477:(12): 6250–84. 464: 463: 454: 449: 417: 340: 331: 325: 316: 310: 301: 295: 286: 280: 275: 266:dephosphorylate 258:protein kinases 254: 217: 184: 152: 135: 130: 89: 32:ion transporter 30:In biology, an 28: 23: 22: 15: 12: 11: 5: 6321: 6319: 6311: 6310: 6305: 6295: 6294: 6290: 6289: 6266: 6265: 6257: 6254: 6253: 6251: 6250: 6249: 6248: 6235: 6233: 6227: 6226: 6224: 6223: 6222: 6221: 6209: 6208: 6207: 6202: 6186: 6185: 6184: 6178: 6173: 6168: 6156: 6155: 6154: 6142: 6141: 6140: 6135: 6130: 6117: 6115: 6109: 6108: 6106: 6105: 6104: 6103: 6091: 6090: 6089: 6076: 6074: 6068: 6067: 6065: 6064: 6063: 6062: 6050: 6049: 6048: 6036: 6035: 6034: 6022: 6021: 6020: 6018:Dent's disease 6008: 6007: 6006: 6001: 5989: 5988: 5987: 5982: 5969: 5967: 5961: 5960: 5957: 5956: 5954: 5953: 5952: 5951: 5939: 5938: 5937: 5925: 5924: 5923: 5918: 5913: 5901: 5900: 5899: 5886: 5884: 5878: 5877: 5875: 5874: 5873: 5872: 5860: 5859: 5858: 5853: 5848: 5843: 5838: 5826: 5825: 5824: 5812: 5811: 5810: 5798: 5797: 5796: 5784: 5783: 5782: 5777: 5765: 5764: 5763: 5751: 5750: 5749: 5737: 5736: 5735: 5722: 5720: 5711: 5705: 5704: 5701: 5700: 5698: 5697: 5696: 5695: 5671: 5670: 5669: 5650: 5648: 5642: 5641: 5639: 5638: 5637: 5636: 5631: 5626: 5621: 5609: 5608: 5607: 5602: 5590: 5589: 5588: 5576: 5575: 5574: 5569: 5564: 5559: 5547: 5546: 5545: 5540: 5528: 5527: 5526: 5521: 5516: 5503: 5501: 5494: 5492:Sodium channel 5488: 5487: 5484: 5483: 5481: 5480: 5479: 5478: 5473: 5461: 5460: 5459: 5454: 5441: 5439: 5435: 5434: 5432: 5431: 5430: 5429: 5417: 5416: 5415: 5410: 5398: 5397: 5396: 5391: 5379: 5378: 5377: 5372: 5367: 5355: 5354: 5353: 5348: 5343: 5330: 5328: 5319: 5313: 5312: 5307: 5305: 5304: 5297: 5290: 5282: 5273: 5272: 5264: 5261: 5260: 5258: 5257: 5251: 5249: 5245: 5244: 5242: 5241: 5228: 5226: 5222: 5221: 5219: 5218: 5206: 5203:Menkes disease 5193: 5191: 5187: 5186: 5184: 5183: 5171: 5155: 5152:Brody myopathy 5142: 5140: 5136: 5135: 5133: 5132: 5120: 5107: 5105: 5101: 5100: 5090: 5088: 5087: 5080: 5073: 5065: 5056: 5055: 5047: 5044: 5043: 5040: 5039: 5036: 5035: 5033: 5032: 5027: 5022: 5021: 5020: 5012: 4994: 4988: 4986: 4980: 4979: 4977: 4976: 4975: 4974: 4969: 4959: 4954: 4949: 4944: 4939: 4935: 4929: 4927: 4913: 4912: 4907: 4900: 4899: 4896: 4895: 4892: 4891: 4888: 4887: 4885: 4884: 4879: 4874: 4869: 4864: 4859: 4853: 4850: 4849: 4846: 4839: 4838: 4835: 4834: 4831: 4830: 4828: 4827: 4821: 4819: 4815: 4814: 4812: 4811: 4810: 4809: 4804: 4793: 4791: 4787: 4786: 4784: 4783: 4782: 4781: 4776: 4765: 4763: 4759: 4758: 4756: 4755: 4754: 4753: 4748: 4743: 4738: 4727: 4725: 4721: 4720: 4718: 4717: 4716: 4715: 4710: 4705: 4700: 4695: 4684: 4682: 4678: 4677: 4675: 4674: 4673: 4672: 4667: 4662: 4651: 4649: 4645: 4644: 4642: 4641: 4640: 4639: 4634: 4629: 4618: 4616: 4612: 4611: 4609: 4608: 4607: 4606: 4601: 4596: 4585: 4583: 4575: 4574: 4571: 4564: 4563: 4560: 4559: 4556: 4555: 4553: 4552: 4551: 4550: 4539: 4537: 4533: 4532: 4530: 4529: 4528: 4527: 4522: 4517: 4512: 4507: 4502: 4497: 4492: 4487: 4482: 4477: 4472: 4467: 4462: 4451: 4449: 4445: 4444: 4442: 4441: 4440: 4439: 4434: 4429: 4424: 4419: 4414: 4409: 4398: 4396: 4392: 4391: 4389: 4388: 4387: 4386: 4381: 4376: 4371: 4360: 4358: 4354: 4353: 4351: 4350: 4349: 4348: 4340: 4335: 4330: 4319: 4317: 4313: 4312: 4310: 4309: 4308: 4307: 4302: 4297: 4292: 4285: 4284: 4283: 4278: 4273: 4266: 4265: 4264: 4259: 4252: 4251: 4250: 4245: 4240: 4235: 4228: 4227: 4226: 4221: 4216: 4211: 4206: 4195: 4193: 4189: 4188: 4186: 4185: 4184: 4183: 4178: 4173: 4162: 4160: 4156: 4155: 4153: 4152: 4151: 4150: 4138: 4136: 4132: 4131: 4129: 4128: 4127: 4126: 4115: 4113: 4109: 4108: 4106: 4105: 4104: 4103: 4091: 4089: 4081: 4080: 4077: 4070: 4069: 4066: 4065: 4062: 4061: 4059: 4058: 4057: 4056: 4051: 4046: 4041: 4036: 4031: 4026: 4021: 4016: 4011: 4000: 3998: 3994: 3993: 3991: 3990: 3989: 3988: 3983: 3978: 3973: 3962: 3960: 3956: 3955: 3953: 3952: 3951: 3950: 3945: 3930: 3928: 3924: 3923: 3921: 3920: 3919: 3918: 3913: 3908: 3903: 3898: 3893: 3882: 3880: 3876: 3875: 3873: 3872: 3871: 3870: 3865: 3860: 3855: 3850: 3845: 3840: 3835: 3830: 3825: 3820: 3809: 3807: 3803: 3802: 3800: 3799: 3798: 3797: 3792: 3787: 3782: 3777: 3772: 3767: 3762: 3757: 3752: 3747: 3742: 3737: 3732: 3727: 3722: 3717: 3712: 3707: 3702: 3697: 3692: 3687: 3682: 3677: 3672: 3667: 3662: 3657: 3652: 3647: 3642: 3637: 3632: 3627: 3622: 3617: 3612: 3607: 3602: 3597: 3592: 3587: 3582: 3577: 3572: 3561: 3559: 3555: 3554: 3552: 3551: 3550: 3549: 3544: 3539: 3534: 3529: 3524: 3513: 3511: 3507: 3506: 3504: 3503: 3502: 3501: 3496: 3491: 3486: 3475: 3473: 3469: 3468: 3466: 3465: 3464: 3463: 3458: 3453: 3448: 3443: 3438: 3433: 3428: 3423: 3418: 3413: 3408: 3403: 3398: 3393: 3388: 3383: 3378: 3373: 3368: 3357: 3355: 3351: 3350: 3348: 3347: 3346: 3345: 3333: 3332: 3331: 3326: 3319: 3318: 3317: 3310: 3309: 3308: 3303: 3296: 3295: 3294: 3289: 3284: 3279: 3274: 3263: 3261: 3253: 3252: 3249: 3242: 3241: 3238: 3237: 3234: 3233: 3231: 3230: 3229: 3228: 3223: 3217:cotransporter 3211: 3209: 3205: 3204: 3202: 3201: 3200: 3199: 3194: 3189: 3173: 3171: 3167: 3166: 3164: 3163: 3162: 3161: 3156: 3151: 3140: 3138: 3134: 3133: 3131: 3130: 3129: 3128: 3123: 3118: 3113: 3108: 3103: 3098: 3093: 3088: 3077: 3075: 3071: 3070: 3068: 3067: 3066: 3065: 3060: 3055: 3050: 3045: 3040: 3035: 3030: 3025: 3020: 3015: 3010: 3005: 3000: 2988: 2986: 2982: 2981: 2979: 2978: 2977: 2976: 2971: 2966: 2961: 2950: 2948: 2944: 2943: 2941: 2940: 2939: 2938: 2933: 2922: 2920: 2916: 2915: 2913: 2912: 2911: 2910: 2905: 2900: 2895: 2890: 2879: 2877: 2873: 2872: 2870: 2869: 2868: 2867: 2862: 2857: 2852: 2847: 2842: 2837: 2832: 2827: 2821:cotransporter 2815: 2813: 2809: 2808: 2806: 2805: 2804: 2803: 2795: 2784: 2782: 2774: 2773: 2770: 2763: 2762: 2759: 2758: 2755: 2754: 2752: 2751: 2746: 2741: 2736: 2731: 2730: 2729: 2724: 2719: 2714: 2709: 2704: 2699: 2688: 2686: 2682: 2681: 2679: 2678: 2677: 2676: 2671: 2666: 2661: 2656: 2651: 2646: 2641: 2636: 2631: 2626: 2619:Na/H exchanger 2615: 2613: 2609: 2608: 2606: 2605: 2604: 2603: 2598: 2593: 2582: 2580: 2576: 2575: 2573: 2572: 2571: 2570: 2565: 2560: 2555: 2550: 2545: 2540: 2535: 2530: 2519: 2518: 2517: 2512: 2507: 2502: 2493: 2491: 2487: 2486: 2484: 2483: 2482: 2481: 2476: 2471: 2466: 2461: 2456: 2451: 2446: 2441: 2436: 2431: 2426: 2421: 2416: 2411: 2406: 2401: 2396: 2391: 2386: 2367: 2365: 2361: 2360: 2358: 2357: 2356: 2355: 2350: 2345: 2340: 2335: 2330: 2325: 2320: 2315: 2310: 2305: 2300: 2289: 2287: 2283: 2282: 2280: 2279: 2278: 2277: 2272: 2267: 2262: 2257: 2252: 2247: 2242: 2237: 2232: 2227: 2216: 2214: 2210: 2209: 2207: 2206: 2205: 2204: 2199: 2187: 2185: 2181: 2180: 2178: 2177: 2176: 2175: 2170: 2165: 2160: 2155: 2150: 2145: 2140: 2135: 2130: 2125: 2120: 2115: 2110: 2099: 2097: 2093: 2092: 2090: 2089: 2088: 2087: 2082: 2077: 2072: 2067: 2062: 2057: 2046: 2044: 2036: 2035: 2032: 2021: 2020: 2017: 2010: 2009: 2001:solute carrier 1988: 1986: 1985: 1978: 1971: 1963: 1954: 1953: 1945: 1942: 1941: 1939: 1938: 1933: 1928: 1923: 1918: 1912: 1907: 1902: 1896: 1891: 1886: 1880: 1875: 1869: 1864: 1859: 1854: 1849: 1843: 1833: 1832: 1822: 1821: 1817: 1816: 1805: 1804: 1799: 1792: 1791: 1786: 1781: 1776: 1771: 1766: 1761: 1756: 1729: 1728: 1721: 1720: 1715: 1709:H/K exchanging 1706: 1699: 1698: 1693: 1688: 1683: 1678: 1673: 1668: 1663: 1658: 1647: 1645: 1638: 1637: 1634: 1633: 1630: 1628: 1622: 1621: 1619: 1618: 1612: 1611: 1606: 1601: 1596: 1591: 1586: 1581: 1576: 1571: 1566: 1561: 1556: 1551: 1546: 1541: 1536: 1531: 1526: 1521: 1516: 1511: 1506: 1501: 1496: 1486: 1484: 1478: 1477: 1475: 1474: 1469: 1464: 1459: 1454: 1449: 1444: 1439: 1434: 1429: 1424: 1419: 1414: 1409: 1404: 1399: 1394: 1389: 1382: 1380: 1371: 1365: 1364: 1342: 1340: 1339: 1332: 1325: 1317: 1311: 1310: 1305: 1293: 1292:External links 1290: 1287: 1286: 1235: 1184: 1133: 1084: 1035: 999: 948: 910: 867: 818: 775: 741: 726: 691: 647: 598: 538: 531: 506: 451: 450: 448: 445: 444: 443: 438: 433: 428: 423: 416: 413: 410: 409: 403: 402: 396: 395: 389: 388: 382: 381: 375: 374: 368: 367: 361: 360: 354: 353: 347: 346: 339: 336: 327:Main article: 324: 321: 312:Main article: 309: 306: 297:Main article: 294: 291: 282:Main article: 279: 276: 274: 271: 253: 250: 216: 213: 189:F- type ATPase 183: 180: 176:P-glycoprotein 160:P-type ATPases 151: 148: 134: 131: 129: 126: 88: 85: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 6320: 6309: 6306: 6304: 6301: 6300: 6298: 6288: 6283: 6278: 6274: 6263: 6262: 6255: 6247: 6244: 6243: 6242: 6241: 6237: 6236: 6234: 6232: 6228: 6220: 6217: 6216: 6215: 6214: 6210: 6206: 6203: 6201: 6198: 6197: 6196: 6195: 6191: 6187: 6182: 6179: 6177: 6174: 6172: 6169: 6167: 6164: 6163: 6162: 6161: 6157: 6153: 6150: 6149: 6148: 6147: 6143: 6139: 6136: 6134: 6131: 6129: 6126: 6125: 6124: 6123: 6119: 6118: 6116: 6114: 6110: 6102: 6099: 6098: 6097: 6096: 6092: 6088: 6085: 6084: 6083: 6082: 6078: 6077: 6075: 6073: 6069: 6061: 6058: 6057: 6056: 6055: 6051: 6047: 6044: 6043: 6042: 6041: 6037: 6033: 6030: 6029: 6028: 6027: 6023: 6019: 6016: 6015: 6014: 6013: 6009: 6005: 6002: 6000: 5997: 5996: 5995: 5994: 5990: 5986: 5983: 5981: 5978: 5977: 5976: 5975: 5971: 5970: 5968: 5966: 5962: 5950: 5947: 5946: 5945: 5944: 5940: 5936: 5933: 5932: 5931: 5930: 5926: 5922: 5919: 5917: 5914: 5912: 5909: 5908: 5907: 5906: 5902: 5898: 5895: 5894: 5893: 5892: 5888: 5887: 5885: 5883: 5879: 5871: 5868: 5867: 5866: 5865: 5861: 5857: 5854: 5852: 5849: 5847: 5844: 5842: 5839: 5837: 5834: 5833: 5832: 5831: 5827: 5823: 5820: 5819: 5818: 5817: 5813: 5809: 5806: 5805: 5804: 5803: 5799: 5795: 5792: 5791: 5790: 5789: 5785: 5781: 5778: 5776: 5773: 5772: 5771: 5770: 5766: 5762: 5759: 5758: 5757: 5756: 5752: 5748: 5745: 5744: 5743: 5742: 5738: 5734: 5731: 5730: 5729: 5728: 5724: 5723: 5721: 5719: 5718:Voltage-gated 5715: 5712: 5710: 5706: 5694: 5691: 5690: 5689: 5688: 5683: 5682: 5677: 5676: 5672: 5668: 5665: 5664: 5663: 5662: 5657: 5656: 5652: 5651: 5649: 5647: 5643: 5635: 5632: 5630: 5627: 5625: 5622: 5620: 5617: 5616: 5615: 5614: 5610: 5606: 5603: 5601: 5598: 5597: 5596: 5595: 5591: 5587: 5584: 5583: 5582: 5581: 5577: 5573: 5570: 5568: 5565: 5563: 5560: 5558: 5555: 5554: 5553: 5552: 5548: 5544: 5541: 5539: 5536: 5535: 5534: 5533: 5529: 5525: 5522: 5520: 5517: 5515: 5512: 5511: 5510: 5509: 5505: 5504: 5502: 5500:Voltage-gated 5498: 5495: 5493: 5489: 5477: 5474: 5472: 5469: 5468: 5467: 5466: 5462: 5458: 5455: 5453: 5450: 5449: 5448: 5447: 5443: 5442: 5440: 5436: 5428: 5425: 5424: 5423: 5422: 5418: 5414: 5411: 5409: 5406: 5405: 5404: 5403: 5399: 5395: 5392: 5390: 5387: 5386: 5385: 5384: 5380: 5376: 5373: 5371: 5368: 5366: 5363: 5362: 5361: 5360: 5356: 5352: 5349: 5347: 5344: 5342: 5339: 5338: 5337: 5336: 5332: 5331: 5329: 5327: 5326:Voltage-gated 5323: 5320: 5318: 5314: 5310: 5303: 5298: 5296: 5291: 5289: 5284: 5283: 5280: 5270: 5269: 5262: 5256: 5253: 5252: 5250: 5246: 5239: 5235: 5234: 5230: 5229: 5227: 5223: 5216: 5212: 5211: 5207: 5204: 5200: 5199: 5195: 5194: 5192: 5188: 5181: 5177: 5176: 5172: 5169: 5165: 5161: 5160: 5156: 5153: 5149: 5148: 5144: 5143: 5141: 5137: 5130: 5126: 5125: 5121: 5118: 5114: 5113: 5109: 5108: 5106: 5102: 5097: 5093: 5086: 5081: 5079: 5074: 5072: 5067: 5066: 5063: 5053: 5052: 5045: 5031: 5028: 5026: 5023: 5019: 5003: 5000: 4999: 4998: 4995: 4993: 4990: 4989: 4987: 4985: 4981: 4973: 4970: 4968: 4965: 4964: 4963: 4960: 4958: 4955: 4953: 4950: 4948: 4945: 4943: 4936: 4934: 4931: 4930: 4928: 4926: 4925:Cotransporter 4922: 4918: 4914: 4910: 4905: 4901: 4883: 4880: 4878: 4875: 4873: 4870: 4868: 4865: 4863: 4860: 4858: 4855: 4854: 4851: 4844: 4840: 4826: 4823: 4822: 4820: 4816: 4808: 4805: 4803: 4800: 4799: 4798: 4795: 4794: 4792: 4788: 4780: 4777: 4775: 4772: 4771: 4770: 4767: 4766: 4764: 4760: 4752: 4749: 4747: 4744: 4742: 4739: 4737: 4734: 4733: 4732: 4729: 4728: 4726: 4722: 4714: 4711: 4709: 4706: 4704: 4701: 4699: 4696: 4694: 4691: 4690: 4689: 4686: 4685: 4683: 4679: 4671: 4668: 4666: 4663: 4661: 4658: 4657: 4656: 4653: 4652: 4650: 4646: 4638: 4635: 4633: 4630: 4628: 4625: 4624: 4623: 4620: 4619: 4617: 4613: 4605: 4602: 4600: 4597: 4595: 4592: 4591: 4590: 4587: 4586: 4584: 4580: 4576: 4569: 4565: 4549: 4546: 4545: 4544: 4541: 4540: 4538: 4534: 4526: 4523: 4521: 4518: 4516: 4513: 4511: 4508: 4506: 4503: 4501: 4498: 4496: 4493: 4491: 4488: 4486: 4483: 4481: 4478: 4476: 4473: 4471: 4468: 4466: 4463: 4461: 4458: 4457: 4456: 4453: 4452: 4450: 4446: 4438: 4435: 4433: 4430: 4428: 4425: 4423: 4420: 4418: 4415: 4413: 4410: 4408: 4405: 4404: 4403: 4400: 4399: 4397: 4393: 4385: 4382: 4380: 4377: 4375: 4372: 4370: 4367: 4366: 4365: 4362: 4361: 4359: 4355: 4347: 4344: 4341: 4339: 4336: 4334: 4331: 4329: 4326: 4325: 4324: 4321: 4320: 4318: 4314: 4306: 4303: 4301: 4298: 4296: 4293: 4291: 4288: 4287: 4286: 4282: 4279: 4277: 4274: 4272: 4269: 4268: 4267: 4263: 4260: 4258: 4255: 4254: 4253: 4249: 4246: 4244: 4241: 4239: 4236: 4234: 4231: 4230: 4229: 4225: 4222: 4220: 4217: 4215: 4212: 4210: 4207: 4205: 4202: 4201: 4200: 4197: 4196: 4194: 4190: 4182: 4179: 4177: 4174: 4172: 4169: 4168: 4167: 4164: 4163: 4161: 4157: 4149: 4146: 4145: 4143: 4140: 4139: 4137: 4133: 4125: 4122: 4121: 4120: 4117: 4116: 4114: 4110: 4102: 4099: 4098: 4096: 4093: 4092: 4090: 4086: 4082: 4075: 4071: 4055: 4052: 4050: 4047: 4045: 4042: 4040: 4037: 4035: 4032: 4030: 4027: 4025: 4022: 4020: 4017: 4015: 4012: 4010: 4007: 4006: 4005: 4002: 4001: 3999: 3995: 3987: 3984: 3982: 3979: 3977: 3974: 3972: 3969: 3968: 3967: 3964: 3963: 3961: 3957: 3949: 3946: 3944: 3941: 3940: 3939: 3935: 3932: 3931: 3929: 3925: 3917: 3914: 3912: 3909: 3907: 3904: 3902: 3899: 3897: 3894: 3892: 3889: 3888: 3887: 3884: 3883: 3881: 3877: 3869: 3866: 3864: 3861: 3859: 3856: 3854: 3851: 3849: 3846: 3844: 3841: 3839: 3836: 3834: 3831: 3829: 3826: 3824: 3821: 3819: 3816: 3815: 3814: 3811: 3810: 3808: 3804: 3796: 3793: 3791: 3788: 3786: 3783: 3781: 3778: 3776: 3773: 3771: 3768: 3766: 3763: 3761: 3758: 3756: 3753: 3751: 3748: 3746: 3743: 3741: 3738: 3736: 3733: 3731: 3728: 3726: 3723: 3721: 3718: 3716: 3713: 3711: 3708: 3706: 3703: 3701: 3698: 3696: 3693: 3691: 3688: 3686: 3683: 3681: 3678: 3676: 3673: 3671: 3668: 3666: 3663: 3661: 3658: 3656: 3653: 3651: 3648: 3646: 3643: 3641: 3638: 3636: 3633: 3631: 3628: 3626: 3623: 3621: 3618: 3616: 3613: 3611: 3608: 3606: 3603: 3601: 3598: 3596: 3593: 3591: 3588: 3586: 3583: 3581: 3578: 3576: 3573: 3571: 3568: 3567: 3566: 3563: 3562: 3560: 3556: 3548: 3545: 3543: 3540: 3538: 3535: 3533: 3530: 3528: 3525: 3523: 3520: 3519: 3518: 3515: 3514: 3512: 3508: 3500: 3497: 3495: 3492: 3490: 3487: 3485: 3482: 3481: 3480: 3477: 3476: 3474: 3470: 3462: 3459: 3457: 3454: 3452: 3449: 3447: 3444: 3442: 3439: 3437: 3434: 3432: 3429: 3427: 3424: 3422: 3419: 3417: 3414: 3412: 3409: 3407: 3404: 3402: 3399: 3397: 3394: 3392: 3389: 3387: 3384: 3382: 3379: 3377: 3374: 3372: 3369: 3367: 3364: 3363: 3362: 3359: 3358: 3356: 3352: 3343: 3339: 3336: 3335: 3334: 3330: 3327: 3325: 3322: 3321: 3320: 3316: 3313: 3312: 3311: 3307: 3304: 3302: 3299: 3298: 3297: 3293: 3290: 3288: 3285: 3283: 3280: 3278: 3275: 3273: 3270: 3269: 3268: 3265: 3264: 3262: 3258: 3254: 3247: 3243: 3227: 3224: 3222: 3219: 3218: 3216: 3213: 3212: 3210: 3206: 3198: 3195: 3193: 3190: 3188: 3185: 3184: 3182: 3178: 3175: 3174: 3172: 3168: 3160: 3157: 3155: 3152: 3150: 3147: 3146: 3145: 3142: 3141: 3139: 3135: 3127: 3124: 3122: 3119: 3117: 3114: 3112: 3109: 3107: 3104: 3102: 3099: 3097: 3094: 3092: 3089: 3087: 3084: 3083: 3082: 3079: 3078: 3076: 3072: 3064: 3061: 3059: 3056: 3054: 3051: 3049: 3046: 3044: 3041: 3039: 3036: 3034: 3031: 3029: 3026: 3024: 3021: 3019: 3016: 3014: 3011: 3009: 3006: 3004: 3001: 2999: 2996: 2995: 2993: 2990: 2989: 2987: 2983: 2975: 2972: 2970: 2967: 2965: 2962: 2960: 2957: 2956: 2955: 2952: 2951: 2949: 2945: 2937: 2934: 2932: 2929: 2928: 2927: 2924: 2923: 2921: 2917: 2909: 2906: 2904: 2901: 2899: 2896: 2894: 2891: 2889: 2886: 2885: 2884: 2881: 2880: 2878: 2874: 2866: 2863: 2861: 2858: 2856: 2853: 2851: 2848: 2846: 2843: 2841: 2838: 2836: 2833: 2831: 2828: 2826: 2823: 2822: 2820: 2817: 2816: 2814: 2810: 2802: 2799: 2796: 2794: 2791: 2790: 2789: 2786: 2785: 2783: 2779: 2775: 2768: 2764: 2750: 2747: 2745: 2742: 2740: 2737: 2735: 2732: 2728: 2725: 2723: 2720: 2718: 2715: 2713: 2710: 2708: 2705: 2703: 2700: 2698: 2695: 2694: 2693: 2690: 2689: 2687: 2683: 2675: 2672: 2670: 2667: 2665: 2662: 2660: 2657: 2655: 2652: 2650: 2647: 2645: 2642: 2640: 2637: 2635: 2632: 2630: 2627: 2625: 2622: 2621: 2620: 2617: 2616: 2614: 2610: 2602: 2599: 2597: 2594: 2592: 2589: 2588: 2587: 2584: 2583: 2581: 2577: 2569: 2566: 2564: 2561: 2559: 2556: 2554: 2551: 2549: 2546: 2544: 2541: 2539: 2536: 2534: 2531: 2529: 2526: 2525: 2524: 2520: 2516: 2513: 2511: 2508: 2506: 2503: 2501: 2498: 2497: 2495: 2494: 2492: 2488: 2480: 2477: 2475: 2472: 2470: 2467: 2465: 2462: 2460: 2457: 2455: 2452: 2450: 2447: 2445: 2442: 2440: 2437: 2435: 2432: 2430: 2427: 2425: 2422: 2420: 2417: 2415: 2412: 2410: 2407: 2405: 2402: 2400: 2397: 2395: 2392: 2390: 2387: 2385: 2382: 2381: 2380: 2376: 2372: 2369: 2368: 2366: 2362: 2354: 2351: 2349: 2346: 2344: 2341: 2339: 2336: 2334: 2331: 2329: 2326: 2324: 2321: 2319: 2316: 2314: 2311: 2309: 2306: 2304: 2301: 2299: 2296: 2295: 2294: 2291: 2290: 2288: 2284: 2276: 2273: 2271: 2268: 2266: 2263: 2261: 2258: 2256: 2253: 2251: 2248: 2246: 2243: 2241: 2238: 2236: 2233: 2231: 2228: 2226: 2223: 2222: 2221: 2218: 2217: 2215: 2211: 2203: 2200: 2198: 2195: 2194: 2193: 2189: 2188: 2186: 2182: 2174: 2171: 2169: 2166: 2164: 2161: 2159: 2156: 2154: 2151: 2149: 2146: 2144: 2141: 2139: 2136: 2134: 2131: 2129: 2126: 2124: 2121: 2119: 2116: 2114: 2111: 2109: 2106: 2105: 2104: 2101: 2100: 2098: 2094: 2086: 2083: 2081: 2078: 2076: 2073: 2071: 2068: 2066: 2063: 2061: 2058: 2056: 2053: 2052: 2051: 2048: 2047: 2045: 2041: 2037: 2030: 2026: 2022: 2015: 2011: 2006: 2002: 1999: 1995: 1991: 1984: 1979: 1977: 1972: 1970: 1965: 1964: 1961: 1951: 1950: 1943: 1937: 1934: 1932: 1929: 1927: 1924: 1922: 1919: 1917: 1913: 1911: 1908: 1906: 1903: 1901: 1897: 1895: 1892: 1890: 1887: 1885: 1881: 1879: 1876: 1874: 1870: 1868: 1865: 1863: 1860: 1858: 1855: 1853: 1850: 1848: 1844: 1842: 1838: 1835: 1834: 1831: 1827: 1824: 1823: 1819: 1818: 1815: 1811: 1807: 1806: 1803: 1800: 1798: 1794: 1793: 1790: 1787: 1785: 1782: 1780: 1777: 1775: 1772: 1770: 1767: 1765: 1762: 1760: 1757: 1755: 1751: 1747: 1743: 1739: 1735: 1731: 1730: 1727: 1723: 1722: 1719: 1716: 1714: 1710: 1707: 1705: 1701: 1700: 1697: 1694: 1692: 1689: 1687: 1684: 1682: 1679: 1677: 1674: 1672: 1669: 1667: 1664: 1662: 1659: 1657: 1653: 1649: 1648: 1646: 1643: 1642:P-type ATPase 1639: 1629: 1627: 1623: 1617: 1614: 1613: 1610: 1607: 1605: 1602: 1600: 1597: 1595: 1592: 1590: 1587: 1585: 1582: 1580: 1577: 1575: 1572: 1570: 1567: 1565: 1562: 1560: 1557: 1555: 1552: 1550: 1547: 1545: 1542: 1540: 1537: 1535: 1532: 1530: 1527: 1525: 1522: 1520: 1517: 1515: 1512: 1510: 1507: 1505: 1502: 1500: 1497: 1495: 1491: 1488: 1487: 1485: 1483: 1479: 1473: 1470: 1468: 1465: 1463: 1460: 1458: 1455: 1453: 1450: 1448: 1445: 1443: 1440: 1438: 1435: 1433: 1430: 1428: 1425: 1423: 1420: 1418: 1415: 1413: 1410: 1408: 1405: 1403: 1400: 1398: 1395: 1393: 1390: 1388: 1384: 1383: 1381: 1379: 1375: 1372: 1370: 1366: 1361: 1357: 1353: 1349: 1345: 1338: 1333: 1331: 1326: 1324: 1319: 1318: 1315: 1309: 1306: 1303: 1299: 1296: 1295: 1291: 1282: 1278: 1274: 1270: 1266: 1262: 1258: 1254: 1250: 1246: 1239: 1236: 1231: 1227: 1223: 1219: 1215: 1211: 1207: 1203: 1199: 1195: 1188: 1185: 1180: 1176: 1171: 1166: 1161: 1156: 1152: 1148: 1144: 1137: 1134: 1129: 1125: 1120: 1115: 1111: 1107: 1103: 1099: 1095: 1088: 1085: 1080: 1076: 1071: 1066: 1062: 1058: 1054: 1050: 1046: 1039: 1036: 1031: 1027: 1023: 1019: 1016:(2): 467–77. 1015: 1011: 1003: 1000: 995: 991: 987: 983: 979: 975: 971: 967: 963: 959: 952: 949: 944: 940: 936: 932: 929:(3): 253–62. 928: 924: 917: 915: 911: 906: 902: 898: 894: 890: 886: 882: 878: 871: 868: 863: 859: 854: 849: 845: 841: 837: 833: 829: 822: 819: 814: 810: 806: 802: 798: 794: 790: 786: 779: 776: 771: 767: 763: 762:AccessScience 759: 752: 750: 748: 746: 742: 737: 733: 729: 727:9781118918401 723: 719: 712: 710: 708: 706: 704: 702: 700: 698: 696: 692: 687: 683: 678: 673: 669: 665: 661: 654: 652: 648: 643: 639: 634: 629: 625: 621: 618:(5): 344–52. 617: 613: 609: 602: 599: 594: 590: 585: 580: 576: 572: 568: 564: 560: 556: 552: 545: 543: 539: 534: 532:0-87893-742-0 528: 524: 520: 513: 511: 507: 502: 498: 493: 488: 484: 480: 476: 472: 468: 461: 459: 457: 453: 446: 442: 439: 437: 434: 432: 429: 427: 424: 422: 419: 418: 414: 408: 405: 404: 401: 398: 397: 394: 391: 390: 387: 384: 383: 380: 377: 376: 373: 370: 369: 366: 363: 362: 359: 356: 355: 352: 349: 348: 344: 343: 337: 335: 330: 322: 320: 315: 307: 305: 300: 292: 290: 285: 277: 272: 270: 267: 263: 259: 251: 249: 247: 243: 238: 229: 221: 214: 212: 210: 209:V-type ATPase 206: 205:V-type ATPase 202: 198: 194: 190: 181: 179: 177: 173: 169: 165: 161: 156: 149: 147: 139: 132: 128:Energy source 127: 125: 123: 119: 114: 108: 106: 102: 98: 94: 86: 80: 76: 72: 70: 66: 61: 59: 58:ATP synthesis 54: 50: 46: 41: 37: 33: 19: 6261:ion channels 6258: 6238: 6211: 6188: 6158: 6144: 6120: 6093: 6079: 6052: 6038: 6024: 6010: 5991: 5972: 5941: 5927: 5903: 5889: 5862: 5828: 5814: 5800: 5786: 5767: 5753: 5739: 5725: 5685: 5679: 5673: 5659: 5653: 5611: 5592: 5578: 5549: 5530: 5506: 5463: 5444: 5438:Ligand gated 5419: 5400: 5381: 5357: 5333: 5265: 5231: 5208: 5196: 5173: 5157: 5145: 5122: 5110: 5094:, membrane: 5048: 4908: 4144:transporter 4097:transporter 3183:transporter 2994:transporter 2377:- dependent 1946: 1356:ATP synthase 1347: 1248: 1244: 1238: 1197: 1193: 1187: 1150: 1146: 1136: 1101: 1097: 1087: 1052: 1048: 1038: 1013: 1009: 1002: 961: 957: 951: 926: 922: 883:(4): 331–8. 880: 876: 870: 838:(6): 383–6. 835: 831: 821: 791:(1): 60–70. 788: 784: 778: 761: 717: 670:(1): 79–92. 667: 663: 615: 611: 601: 558: 554: 523:Neuroscience 522: 474: 470: 332: 317: 302: 287: 262:phosphatases 255: 233: 193:ATP synthase 185: 153: 144: 113:Ion channels 109: 105:ion channels 97:transporters 93:super family 90: 73: 62: 44: 31: 29: 6072:TRP channel 4004:zinc efflux 1808:3.A.3.8.8: 1702:3.A.3.1.2: 1650:3.A.3.1.1: 284:Patch clamp 278:Patch clamp 246:Antiporters 168:Na/K-ATPase 6297:Categories 6259:See also: 5030:Cl-oxalate 5025:Cl-formate 4952:Na/glucose 4142:Acetyl-CoA 1482:H (V-type) 1378:H (F-type) 1360:TC 3A2-3A3 447:References 304:membrane. 252:Regulation 242:Symporters 5266:see also 5098:disorders 5049:see also 4921:Symporter 4909:Ion pumps 1947:see also 1914:type 13: 1732:3.A.3.2: 1348:ion pumps 1298:Ion+pumps 1281:205216514 736:910538334 172:Ca ATPase 45:ion pumps 6113:Connexin 5018:(Band 3) 5002:Na/(Ca-K 4572:SLC41–48 4525:SLC39A14 4520:SLC39A13 4515:SLC39A12 4510:SLC39A11 4505:SLC39A10 4437:SLC38A10 4078:SLC31–40 4054:SLC30A10 3868:SLC26A11 3863:SLC26A10 3795:SLC25A46 3790:SLC25A45 3785:SLC25A44 3780:SLC25A43 3775:SLC25A42 3770:SLC25A41 3765:SLC25A40 3760:SLC25A39 3755:SLC25A38 3750:SLC25A37 3745:SLC25A36 3740:SLC25A35 3735:SLC25A34 3730:SLC25A33 3725:SLC25A32 3720:SLC25A31 3715:SLC25A30 3710:SLC25A29 3705:SLC25A28 3700:SLC25A27 3695:SLC25A26 3690:SLC25A25 3685:SLC25A24 3680:SLC25A23 3675:SLC25A22 3670:SLC25A21 3665:SLC25A20 3660:SLC25A19 3655:SLC25A18 3650:SLC25A17 3645:SLC25A16 3640:SLC25A15 3635:SLC25A14 3630:SLC25A13 3625:SLC25A12 3620:SLC25A11 3615:SLC25A10 3461:SLC22A20 3456:SLC22A19 3451:SLC22A18 3446:SLC22A17 3441:SLC22A16 3436:SLC22A15 3431:SLC22A14 3426:SLC22A13 3421:SLC22A12 3416:SLC22A11 3411:SLC22A10 3250:SLC21–30 3181:thiamine 3063:SLC16A14 3058:SLC16A13 3053:SLC16A12 3048:SLC16A11 3043:SLC16A10 2771:SLC11–20 2375:chloride 2018:By group 1810:flippase 1626:A-ATPase 1609:ATP6V0E1 1599:ATP6V0D2 1594:ATP6V0D1 1579:ATP6V0A4 1574:ATP6V0A2 1569:ATP6V0A1 1559:ATP6V1G3 1554:ATP6V1G2 1549:ATP6V1G1 1539:ATP6V1E2 1534:ATP6V1E1 1524:ATP6V1C2 1519:ATP6V1C1 1514:ATP6V1B2 1509:ATP6V1B1 1273:19458722 1222:18075585 1179:21990355 1128:22787169 1079:19617429 994:12903551 986:23695653 943:20934646 905:16015149 897:24562791 862:19806033 832:Channels 805:21179061 686:14643936 642:19339978 593:20712982 501:23035940 415:See also 6287:Biology 5543:GEFS+ 1 5519:GEFS+ 2 5402:CACNA1S 5383:CACNA1F 5359:CACNA1C 5335:CACNA1A 5233:ATP13A2 4933:Na/K,Cl 4847:SLCO1–4 4807:SLC47A2 4802:SLC47A1 4779:SLC46A2 4774:SLC46A1 4751:SLC45A4 4746:SLC54A3 4741:SLC45A2 4736:SLC45A1 4713:SLC44A5 4708:SLC44A4 4703:SLC44A3 4698:SLC44A2 4693:SLC44A1 4670:SLC43A3 4665:SLC43A2 4660:SLC43A1 4604:SLC41A3 4599:SLC41A2 4594:SLC41A1 4548:SLC40A1 4500:SLC39A9 4495:SLC39A8 4490:SLC39A7 4485:SLC39A6 4480:SLC39A5 4475:SLC39A4 4470:SLC39A3 4465:SLC39A2 4460:SLC39A1 4432:SLC38A6 4427:SLC38A5 4422:SLC38A4 4417:SLC38A3 4412:SLC38A2 4407:SLC38A1 4384:SLC37A4 4379:SLC37A3 4374:SLC37A2 4369:SLC37A1 4343:SLC36A4 4338:SLC36A3 4333:SLC36A2 4328:SLC36A1 4305:SLC35E4 4300:SLC35E3 4295:SLC35E2 4290:SLC35E1 4281:SLC35D3 4276:SLC35D2 4271:SLC35D1 4262:SLC35C2 4257:SLC35C1 4248:SLC35B4 4243:SLC35B3 4238:SLC35B2 4233:SLC35B1 4224:SLC35A5 4219:SLC35A4 4214:SLC35A3 4209:SLC35A2 4204:SLC35A1 4181:SLC34A3 4176:SLC34A2 4171:SLC34A1 4148:SLC33A1 4124:SLC32A1 4101:SLC31A1 4049:SLC30A9 4044:SLC30A8 4039:SLC30A7 4034:SLC30A6 4029:SLC30A5 4024:SLC30A4 4019:SLC30A3 4014:SLC30A2 4009:SLC30A1 3986:SLC29A4 3981:SLC29A3 3976:SLC29A2 3971:SLC29A1 3948:SLC28A3 3943:SLC28A2 3938:SLC28A1 3916:SLC27A6 3911:SLC27A5 3906:SLC27A4 3901:SLC27A3 3896:SLC27A2 3891:SLC27A1 3858:SLC26A9 3853:SLC26A8 3848:SLC26A7 3843:SLC26A6 3838:SLC26A5 3833:SLC26A4 3828:SLC26A3 3823:SLC26A2 3818:SLC26A1 3610:SLC25A9 3605:SLC25A8 3600:SLC25A7 3595:SLC25A6 3590:SLC25A5 3585:SLC25A4 3580:SLC25A3 3575:SLC25A2 3570:SLC25A1 3547:SLC24A6 3542:SLC24A5 3537:SLC24A4 3532:SLC24A3 3527:SLC24A2 3522:SLC24A1 3499:SLC23A4 3494:SLC23A3 3489:SLC23A2 3484:SLC23A1 3406:SLC22A9 3401:SLC22A8 3396:SLC22A7 3391:SLC22A6 3386:SLC22A5 3381:SLC22A4 3376:SLC22A3 3371:SLC22A2 3366:SLC22A1 3342:SLCO6A1 3338:SLCO5A1 3329:SLCO4C1 3324:SLCO4A1 3315:SLCO3A1 3306:SLCO2B1 3301:SLCO2A1 3292:SLCO1C1 3287:SLCO1B4 3282:SLCO1B3 3277:SLCO1B1 3272:SLCO1A2 3226:SLC20A2 3221:SLC20A1 3197:SLC19A3 3192:SLC19A2 3187:SLC19A1 3159:SLC18A3 3154:SLC18A2 3149:SLC18A1 3126:SLC17A9 3121:SLC17A8 3116:SLC17A7 3111:SLC17A6 3106:SLC17A5 3101:SLC17A4 3096:SLC17A3 3091:SLC17A2 3086:SLC17A1 3038:SLC16A9 3033:SLC16A8 3028:SLC16A7 3023:SLC16A6 3018:SLC16A5 3013:SLC16A4 3008:SLC16A3 3003:SLC16A2 2998:SLC16A1 2974:SLC15A4 2969:SLC15A3 2964:SLC15A2 2959:SLC15A1 2936:SLC14A2 2931:SLC14A1 2908:SLC13A5 2903:SLC13A4 2898:SLC13A3 2893:SLC13A2 2888:SLC13A1 2865:SLC12A9 2860:SLC12A8 2855:SLC12A7 2850:SLC12A6 2845:SLC12A5 2840:SLC12A4 2835:SLC12A3 2830:SLC12A2 2825:SLC12A1 2798:SLC11A2 2793:SLC11A1 2727:SLC10A7 2722:SLC10A6 2717:SLC10A5 2712:SLC10A4 2707:SLC10A3 2702:SLC10A2 2697:SLC10A1 2674:SLC9A11 2669:SLC9A10 2568:SLC7A14 2563:SLC7A13 2558:SLC7A11 2553:SLC7A10 2479:SLC6A20 2474:SLC6A19 2469:SLC6A18 2464:SLC6A17 2459:SLC6A16 2454:SLC6A15 2449:SLC6A14 2444:SLC6A13 2439:SLC6A12 2434:SLC6A11 2429:SLC6A10 2033:SLC1–10 1936:ATP13A5 1931:ATP13A4 1926:ATP13A3 1921:ATP13A2 1916:ATP13A1 1644:(3.A.3) 1604:ATP6V0E 1589:ATP6V0C 1584:ATP6V0B 1564:ATP6V1H 1544:ATP6V1F 1529:ATP6V1D 1504:ATP6V1A 1499:ATP6AP2 1494:ATP6AP1 1352:ATPases 1253:Bibcode 1230:4344526 1202:Bibcode 1170:3243541 1119:3424715 1070:2712415 1030:5867548 966:Bibcode 853:2889157 813:9734181 633:2742554 584:2920628 563:Bibcode 492:3633640 6273:Portal 6095:TRPML1 6054:CLCNKB 5943:KCNJ18 5929:KCNJ11 5687:SCNN1G 5681:SCNN1B 5675:SCNN1A 5661:SCNN1G 5655:SCNN1B 5421:CACNB2 5394:CSNB2A 5268:ATPase 5175:ATP2C1 5159:ATP2A2 5147:ATP2A1 5124:ATP1A3 5112:ATP1A2 5096:ATPase 4095:copper 3177:folate 2664:SLC9A9 2659:SLC9A8 2654:SLC9A7 2649:SLC9A6 2644:SLC9A5 2639:SLC9A4 2634:SLC9A3 2629:SLC9A2 2624:SLC9A1 2601:SLC8A3 2596:SLC8A2 2591:SLC8A1 2548:SLC7A9 2543:SLC7A8 2538:SLC7A7 2533:SLC7A6 2528:SLC7A5 2515:SLC7A4 2510:SLC7A3 2505:SLC7A2 2500:SLC7A1 2424:SLC6A9 2419:SLC6A8 2414:SLC6A7 2409:SLC6A6 2404:SLC6A5 2399:SLC6A4 2394:SLC6A3 2389:SLC6A2 2384:SLC6A1 2373:- and 2371:sodium 2298:SLC5A1 2225:SLC4A1 2197:SLC3A1 2108:SLC2A1 2055:SLC1A1 1910:ATP11C 1905:ATP11B 1900:ATP11A 1894:ATP10D 1889:ATP10B 1884:ATP10A 1867:ATP8B4 1862:ATP8B3 1857:ATP8B2 1852:ATP8B1 1847:ATP8A1 1814:ATP8A2 1789:ATP2C1 1784:ATP2B4 1779:ATP2B3 1774:ATP2B2 1769:ATP2B1 1764:ATP2A3 1759:ATP2A2 1754:ATP2A1 1726:ATP12A 1696:ATP1G1 1691:ATP1B4 1686:ATP1B3 1681:ATP1B2 1676:ATP1B1 1671:ATP1A4 1666:ATP1A3 1661:ATP1A2 1656:ATP1A1 1616:TCIRG1 1462:ATP5L2 1452:ATP5J2 1432:ATP5G3 1427:ATP5G2 1422:ATP5G1 1417:ATP5F1 1402:ATP5C2 1397:ATP5C1 1387:ATP5A1 1279:  1271:  1245:Nature 1228:  1220:  1194:Nature 1177:  1167:  1126:  1116:  1077:  1067:  1028:  992:  984:  941:  903:  895:  860:  850:  811:  803:  734:  724:  684:  640:  630:  591:  581:  529:  499:  489:  6231:Porin 6087:FSGS2 6081:TRPC6 6040:BEST1 6026:CLCN7 6012:CLCN5 5993:CLCN1 5935:TNDM3 5905:KCNJ2 5891:KCNJ1 5870:BFNS1 5864:KCNQ2 5830:KCNQ1 5816:KCNH2 5802:KCNE3 5788:KCNE2 5769:KCNE1 5755:KCNC3 5741:KCNA5 5727:KCNA1 5613:SCN9A 5594:SCN5A 5580:SCN4B 5551:SCN4A 5532:SCN1B 5508:SCN1A 5476:ARVD2 5471:CPVT1 5248:Other 5225:ATP13 5210:ATP7B 5198:ATP7A 4997:Na/Ca 4947:Na/Cl 4818:(48): 4790:(47): 4762:(46): 4724:(45): 4681:(44): 4648:(43): 4615:(42): 4582:(41): 4536:(40): 4448:(39): 4395:(38): 4357:(37): 4316:(36): 4192:(35): 4159:(34): 4135:(33): 4112:(32): 4088:(31): 3997:(30): 3959:(29): 3927:(28): 3879:(27): 3806:(26): 3558:(25): 3510:(24): 3472:(23): 3354:(22): 3260:(21): 3208:(20): 3170:(19): 3137:(18): 3074:(17): 2985:(16): 2947:(15): 2919:(14): 2876:(13): 2812:(12): 2781:(11): 2685:(10): 2005:TC 2A 1878:ATP9B 1873:ATP9A 1802:ATP7B 1797:ATP7A 1738:SERCA 1718:ATP4B 1713:ATP4A 1472:ATP5S 1467:ATP5O 1457:ATP5L 1447:ATP5J 1442:ATP5I 1437:ATP5H 1412:ATP5E 1407:ATP5D 1392:ATP5B 1277:S2CID 1226:S2CID 990:S2CID 901:S2CID 809:S2CID 53:redox 34:is a 6240:AQP2 6213:GJB6 6194:GJB4 6190:GJB3 6160:GJB2 6146:GJB1 6122:GJA1 5974:CFTR 5465:RYR2 5446:RYR1 5190:ATP7 5139:ATP2 5104:ATP1 5004:) - 4992:Na/H 4962:Cl/K 4957:Na/I 4938:Na/P 4882:O4A1 4877:O431 4872:O2B1 4867:O1B3 4862:O1B1 4857:O1A2 4637:RhCG 4632:RhBG 4627:RhAG 4346:36A2 2801:11A3 2749:10A7 2744:10A3 2739:10A2 2734:10A1 2612:(9): 2579:(8): 2490:(7): 2364:(6): 2286:(5): 2213:(4): 2184:(3): 2096:(2): 2043:(1): 1841:ATP3 1826:Na/K 1748:) / 1746:SPCA 1742:PMCA 1269:PMID 1218:PMID 1175:PMID 1124:PMID 1075:PMID 1026:PMID 982:PMID 939:PMID 893:PMID 858:PMID 801:PMID 732:OCLC 722:ISBN 682:PMID 668:1618 638:PMID 589:PMID 527:ISBN 497:PMID 329:FRET 5008:HCO 5006:Cl/ 1704:H/K 1261:doi 1249:459 1210:doi 1198:450 1165:PMC 1155:doi 1151:286 1114:PMC 1106:doi 1102:590 1065:PMC 1057:doi 1053:212 1018:doi 1014:109 974:doi 962:116 931:doi 885:doi 881:247 848:PMC 840:doi 793:doi 766:doi 672:doi 628:PMC 620:doi 579:PMC 571:doi 487:PMC 479:doi 475:112 264:to 95:of 6299:: 5166:, 4923:, 2353:12 2348:11 2343:10 2275:11 2270:10 2173:14 2168:13 2163:12 2158:11 2153:10 1996:: 1992:, 1839:: 1828:– 1812:: 1752:: 1744:, 1740:, 1734:Ca 1711:: 1654:: 1492:: 1354:/ 1350:, 1346:: 1275:. 1267:. 1259:. 1247:. 1224:. 1216:. 1208:. 1196:. 1173:. 1163:. 1149:. 1145:. 1122:. 1112:. 1100:. 1096:. 1073:. 1063:. 1051:. 1047:. 1024:. 1012:. 988:. 980:. 972:. 960:. 937:. 927:41 925:. 913:^ 899:. 891:. 879:. 856:. 846:. 834:. 830:. 807:. 799:. 789:12 787:. 764:. 760:. 744:^ 730:. 694:^ 680:. 666:. 662:. 650:^ 636:. 626:. 616:10 614:. 610:. 587:. 577:. 569:. 559:99 557:. 553:. 541:^ 521:. 509:^ 495:. 485:. 473:. 469:. 455:^ 203:. 60:. 6275:: 6192:/ 6183:) 5684:/ 5678:/ 5658:/ 5301:e 5294:t 5287:v 5240:) 5236:( 5217:) 5213:( 5205:) 5201:( 5182:) 5178:( 5170:) 5162:( 5154:) 5150:( 5131:) 5127:( 5119:) 5115:( 5084:e 5077:t 5070:v 5013:3 4972:5 4967:4 4942:3 4940:i 3936:( 3344:) 3340:( 3179:/ 2338:9 2333:8 2328:7 2323:6 2318:5 2313:4 2308:3 2303:2 2265:9 2260:8 2255:7 2250:6 2245:5 2240:4 2235:3 2230:2 2202:2 2148:9 2143:8 2138:7 2133:6 2128:5 2123:4 2118:3 2113:2 2085:7 2080:6 2075:5 2070:4 2065:3 2060:2 2007:) 2003:( 1982:e 1975:t 1968:v 1830:H 1736:( 1362:) 1358:( 1336:e 1329:t 1322:v 1283:. 1263:: 1255:: 1232:. 1212:: 1204:: 1181:. 1157:: 1130:. 1108:: 1081:. 1059:: 1032:. 1020:: 996:. 976:: 968:: 945:. 933:: 907:. 887:: 864:. 842:: 836:3 815:. 795:: 772:. 768:: 738:. 688:. 674:: 644:. 622:: 595:. 573:: 565:: 535:. 503:. 481:: 20:)

Index

Pump (biochemistry)
transmembrane protein
biological membrane
adenosine triphosphate
redox
ATP synthesis
facilitated diffusion
passive diffusion

super family
transporters
International Union of Biochemistry and Molecular Biology
ion channels
Ion channels
facilitated diffusion
passive transport

Active transporters
P-type ATPases
ABC transporters
Na/K-ATPase
Ca ATPase
P-glycoprotein
F- type ATPase
ATP synthase
electron transport chain
oxidative phosphorylation
V-type ATPase
V-type ATPase

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