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Pathogen transmission

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272:"Airborne transmission refers to infectious agents that are spread via droplet nuclei (residue from evaporated droplets) containing infective microorganisms. These organisms can survive outside the body and remain suspended in the air for long periods of time. They infect others via the upper and lower respiratory tracts." The size of the particles for airborne infections need to be < 5 ÎĽm. It includes both dry and wet aerosols and thus requires usually higher levels of isolation since it can stay suspended in the air for longer periods of time. i.e., separate ventilation systems or negative pressure environments are needed to avoid general contamination. e.g., 573: 1019:
that death rates are highest. If a disease is rapidly fatal, the host may die before the microbe can be passed along to another host. However, this cost may be overwhelmed by the short-term benefit of higher infectiousness if transmission is linked to virulence, as it is for instance in the case of cholera (the explosive diarrhea aids the bacterium in finding new hosts) or many respiratory infections (sneezing and coughing create infectious
1111:, can be transmitted both vertically and horizontally. Mixed-mode transmission can allow symbionts to have the "best of both worlds" – they can vertically infect host offspring when host density is low, and horizontally infect diverse additional hosts when a number of additional hosts are available. Mixed-mode transmission make the outcome (degree of harm or benefit) of the relationship more difficult to predict, because the 304: 743:, which lands on cow dung, contaminating its appendages with bacteria from the feces, and then lands on food prior to consumption. The pathogen never enters the body of the fly. In contrast, biological vectors harbor pathogens within their bodies and deliver pathogens to new hosts in an active manner, usually a bite. Biological vectors are often responsible for serious 1617: 796: 523:
such as HIV and hepatitis B are thought to not normally be transmitted through mouth-to-mouth contact, although it is possible to transmit some STIs between the genitals and the mouth, during oral sex. In the case of HIV, this possibility has been established. It is also responsible for the increased
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refers to acquisition of symbionts from parents (usually mothers). Vertical transmission can be intracellular (e.g. transovarial), or extracellular (for example through post-embryonic contact between parents and offspring). Both intracellular and extracellular vertical transmission can be considered
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and transmission is complex and has important consequences for the long term evolution of a pathogen. Since it takes many generations for a microbe and a new host species to co-evolve, an emerging pathogen may hit its earliest victims especially hard. It is usually in the first wave of a new disease
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A 2024 World Health Organization report standardized the terminology for the transmission modes of all respiratory pathogens in alignment with particle physics: airborne transmission; inhalation; direct deposition; and contact. But these newly standardized terms have yet to be translated to policy,
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Pathogens must have a way to be transmitted from one host to another to ensure their species' survival. Infectious agents are generally specialized for a particular method of transmission. Taking an example from the respiratory route, from an evolutionary perspective viruses or bacteria that cause
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particles pass from one person to the mouth of another person. Although it is usually discussed as a route of transmission, it is actually a specification of the entry and exit portals of the pathogen, and can operate across several of the other routes of transmission. Fecal–oral transmission is
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Direct contact occurs through skin-to-skin contact, kissing, and sexual intercourse. Direct contact also refers to contact with soil or vegetation harboring infectious organisms. Additionally, while fecal–oral transmission is primarily considered an indirect contact route, direct contact can also
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are infectious, not all infectious diseases are contagious). These diseases can also be transmitted by sharing a towel (where the towel is rubbed vigorously on both bodies) or items of clothing in close contact with the body (socks, for example) if they are not washed thoroughly between uses. For
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because patterns of contact vary between different populations and different groups of populations depending on socio-economic, cultural and other features. For example, low personal and food hygiene due to the lack of a clean water supply may result in increased transmission of diseases by the
552:, or by indirect contact such as by sharing a drinking glass or a cigarette. Infections that are known to be transmissible by kissing or by other direct or indirect oral contact include all of the infections transmissible by droplet contact and (at least) all forms of 319:, or talking. Respiratory droplet transmission is the usual route for respiratory infections. Transmission can occur when respiratory droplets reach susceptible mucosal surfaces, such as in the eyes, nose or mouth. This can also happen indirectly via contact with 225:
means that the source of infection for the spread of an illness is unknown or a link in terms of contacts between patients and other people is missing. It refers to the difficulty in grasping the epidemiological link in the community beyond confirmed cases.
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activity. It was found that the frequency of influenza-related web searches as a whole rises as the number of people sick with influenza rises. Examining space-time relationships of web queries has been shown to approximate the spread of influenza and
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of a disease agent indicates the comparative ease with which the disease agent is transmitted to other hosts. Transmission of pathogens can occur by direct contact, through contaminated food, body fluids or objects, by airborne inhalation or through
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rather than primary metabolism, for example for use in defense against pathogens, but some primary nutritional symbionts are also horizontally (environmentally) acquired. Additional examples of horizontally transmitted beneficial symbionts include
949:. To understand the spread of the vast majority of non-notifiable diseases, data either need to be collected in a particular study, or existing data collections can be mined, such as insurance company data or antimicrobial drug sales for example. 323:
when hands then touch the face. Before drying, respiratory droplets are large and cannot remain suspended in the air for long, and are usually dispersed over short distances. The size of the particles for droplet infections are > 5 ÎĽm.
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is more common in cities in underdeveloped countries, without a clean water supply, than in cities with a good plumbing system, we might advance the theory that polio is spread by the fecal-oral route. Two routes are considered to be
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their host to develop coughing and sneezing symptoms have a great survival advantage, as they are much more likely to be ejected from one host and carried to another. This is also the reason that many microorganisms cause
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disease agent transmission from one individual to another in the same generation (peers in the same age group) by either direct contact (licking, touching, biting), or indirect contact through air – cough or sneeze
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virus. Alternatively, the vehicle may provide an environment in which the agent grows, multiplies, or produces toxin, such as improperly canned foods provide an environment that supports production of
1437: 787:. Vectors are often required in the life cycle of a pathogen. A common strategy used to control vector-borne infectious diseases is to interrupt the life cycle of a pathogen by killing the vector. 818:
primarily considered as an indirect contact route through contaminated food or water. However, it can also operate through direct contact with feces or contaminated body parts, such as through
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Vectors may be mechanical or biological. A mechanical vector picks up an infectious agent on the outside of its body and transmits it in a passive manner. An example of a mechanical vector is a
1066:. It has been argued that most organisms experience some form of vertical transmission of symbionts. Canonical examples of vertically transmitted symbionts include the nutritional symbiont 1231: 998:
etc. Most recently, data from cell phones have been shown to be able to capture population movements well enough to predict the transmission of certain infectious diseases, like rubella.
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practices - which can take various forms. Fecal oral transmission can be via foodstuffs or water that has become contaminated. This can happen when people do not adequately
67:– very small dry and wet particles that stay in the air for long periods of time allowing airborne contamination even after the departure of the host. Particle size < 5 56:
individual or group to a particular individual or group, regardless of whether the other individual was previously infected. The term strictly refers to the transmission of
249:. Differences in incidence of such diseases between different groups can also throw light on the routes of transmission of the disease. For example, if it is noted that 528:
1 (which is usually responsible for oral infections) in genital infections and the increased incidence of the type 2 virus (more common genitally) in oral infections.
77:– small and usually wet particles that stay in the air for a short period of time. Contamination usually occurs in the presence of the host. Particle size > 5 μm. 3780: 404:
this reason, contagious diseases often break out in schools, where towels are shared and personal items of clothing accidentally swapped in the changing rooms.
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agencies, on an international, national, or local level. Public health staff relies on health care workers and microbiology laboratories to report cases of
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or the fluid secreted by the excited female) which carry infectious agents that get into the partner's blood stream through tiny tears in the
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such as handkerchiefs, bedding, or surgical scalpels. A vehicle may passively carry a pathogen, as in the case of food or water may carrying
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specialists are employed, who will review medical records to analyze transmission as part of a hospital epidemiology program, for example.
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For diseases transmitted within an institution, such as a hospital, prison, nursing home, boarding school, orphanage, refugee camp, etc.,
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at certain sentinel sites of health care practitioners within a state, for example. Tools have been developed to help track influenza
1046:. Organisms can form symbioses with microbes transmitted from their parents, from the environment or unrelated individuals, or both. 232:
means that the source of the infection has been identified within the reporting location (such as within a country, region or city).
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that can be transmitted in this way include: HIV, hepatitis B and syphilis. Many mutualistic organisms are transmitted vertically.
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Diseases that can be transmitted by direct contact are called contagious (contagious is not the same as infectious; although all
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of inanimate objects. Vehicles that may indirectly transmit an infectious agent include food, water, biologic products such as
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Nussbaumer AD, Fisher CR, Bright M (May 2006). "Horizontal endosymbiont transmission in hydrothermal vent tubeworms".
344: 3544: 2957: 2697: 1403: 1134: 572: 148:(i.e. between two individuals in the same place) or may involve travel of the microorganism or the affected hosts. 145: 2119:"Using web search query data to monitor dengue epidemics: a new model for neglected tropical disease surveillance" 1666:
Whittier CA (16 April 2017). "Fecal-Oral Transmission". In Bezanson M, MacKinnon KC, Riley E, Campbell CJ (eds.).
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The mode of transmission is also an important aspect of the biology of beneficial microbial symbionts, such as
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Infections that are transmitted primarily by oral means may be caught through direct oral contact such as
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including infection control policy or the pandemic accords or updated International Health Regulations.
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Wesolowski A, Metcalf CJ, Eagle N, Kombich J, Grenfell BT, Bjørnstad ON, et al. (September 2015).
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Indirect contact transmission, also known as vehicle-borne transmission, involves transmission through
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While rare in regards to this sexual practice, some infections that can spread via manual sex include
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This refers to any infection that can be caught during sexual activity with another person, including
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that allow the transmission of the agent causing the disease without physical contact) or by
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Ebert D (2013). "The Epidemiology and Evolution of Symbionts with Mixed-Mode Transmission".
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in aphids (transovarially transmitted intracellular symbiont) and some components of the
183:, passing the agent causing the disease from parent to offspring, such as in prenatal or 2403: 2234: 2072: 2052:
Ginsberg J, Mohebbi MH, Patel RS, Brammer L, Smolinski MS, Brilliant L (February 2009).
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of infectious disease spread have been used. Human aggregation can drive transmission,
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This article is about transmission of disease-causing pathogens. For other uses, see
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of transmission have been sought. One proxy in the case of influenza is tracking of
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direct physical contact – touching an infected individual, including sexual contact
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Polgreen PM, Chen Z, Segre AM, Harris ML, Pentella MA, Rushton G (November 2009).
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of an infection, given a contact between an infected host and a noninfected host.
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indirect physical contact – usually by touching a contaminated surface, including
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of infectious diseases, such as the annual start of school, bootcamp, the annual
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Because these traditional methods are slow, time-consuming, and labor-intensive,
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Jones RM, Brosseau LM (May 2015). "Aerosol transmission of infectious disease".
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Proceedings of the National Academy of Sciences of the United States of America
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Rouet F, Nouhin J, Zheng DP, Roche B, Black A, Prak S, et al. (May 2018).
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The fecal-oral route of transmission can be a public health risk for people in
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directly from one individual to another by one or more of the following means:
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Even in developed countries there are periodic system failures resulting in a
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A common form of transmission is by way of respiratory droplets, generated by
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Kaltenpoth M, Engl T (2013). "Defensive microbial symbionts in Hymenoptera".
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of the symbiont is sometimes but not always tied to the success of the host.
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Organisms spread by droplet transmission include respiratory viruses such as
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Respiratory droplets are released through talking, coughing, or sneezing.
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can show the spread of a disease and is at the core of the specialty of
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Main causes of fecal–oral disease transmission include lack of adequate
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Anything that reduces the rate of transmission of an infection carries
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can become infected. Another problem in some developing countries, is
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such as heroin, steroids, and hormones. This can act as a vector for
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This is the practice of intravenous drug-users by which a needle or
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infections and those infections causing sores) or from secretions (
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This is from mother to child (more rarely father to child), often
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This article incorporates text from this source, which is in the
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Some diseases that are transmissible by direct contact include
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which leads to disease transmission via the fecal-oral route.
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of infected material. Some diseases that can be transmitted
1670:. Hoboken, NJ, USA: John Wiley & Sons, Inc. p. 1. 1427:"Coronavirus disease 2019 (COVID-19) Situation Report – 47" 929:
Tracking the transmission of infectious diseases is called
767:. Biological vectors are usually, though not exclusively, 480:
Some infections transmissible by the sexual route include
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can be transmitted to humans who ingest improperly cooked
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Parasitism: The Diversity and Ecology of Animal Parasites
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infections herpes simplex virus (especially HSV-1) and
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that does not cause disease itself but that transmits
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to enter, survive and multiply in the host, while the
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Modes of Introduction of Exotic Animal Disease Agents
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bioluminescent bacteria associated with bobtail squid
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via contaminated hypodermic needles or blood products
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Here, 8: 1551:"What is Diseases contagious from droplets?" 1498:"Prevention of hospital-acquired infections" 925:Mathematical modelling of infectious disease 868:or surface water). The people who drink the 576:Brocky, Karoly - Mother and Child (1846-50) 3625: 3079: 2953: 2910: 2815: 2484: 2459: 2445: 2437: 240:The route of transmission is important to 136:or, more typically, larger pathogens like 2374: 2329: 2319: 2252: 2242: 2193: 2144: 2134: 2028: 1936: 1839: 1643:Boston University School of Public Health 1523: 1521: 164:agent can be transmitted in two ways: as 1460: 1458: 1386:"Gainers and losers in the time of nCoV" 1372:"Novel Coronavirus (COVID-19) Resources" 1002:Relationship with virulence and survival 3533:Ear-Nose-Throat/Upper respiratory tract 2706:Access to water, sanitation and hygiene 1756: 1754: 1160: 1150:Transmission coefficient (epidemiology) 1082:Some beneficial symbionts are acquired 132:). Indirect transmission could involve 4116:Infectious disease (medical specialty) 4008:Antimicrobial resistance surveillance 2302:Funkhouser LJ, Bordenstein SR (2013). 396:result in transmission through feces. 124:or fly) or an intermediate host (e.g. 2276:Graves S, Samuelson DA (March 2022). 1917:American Journal of Infection Control 1775:10.1146/annurev-ecolsys-032513-100555 1727:Great Relationships and Sex Education 1661: 1659: 1632: 1630: 1593: 1591: 1589: 1492: 1490: 7: 3363:Compartmental models in epidemiology 1191: 1189: 1107:Many microbial symbionts, including 864:can pollute drinking water sources ( 1299:"Glossary of Notifiable Conditions" 1196:Leung NH, Milton DK (3 July 2024). 1557:from the original on 16 July 2015. 1097:nitrogen-fixing bacteria in plants 14: 1443:from the original on 8 March 2020 1232:"Horizontal Disease Transmission" 4112:Economics of Infectious Diseases 2168:Siettos CI, Russo L (May 2013). 2123:PLOS Neglected Tropical Diseases 2009:American Journal of Epidemiology 1676:10.1002/9781119179313.wbprim0193 1615: 1140:Infectious disease: Transmission 473:(this is a more usual route for 1505:World Health Organization (WHO) 1042:-associated dinoflagellates or 971:by finding patterns in certain 704:Transmission by other organisms 521:Sexually transmitted infections 449:(see below) and rarely through 4121:Infectious disease informatics 3952:Transmission-based precautions 2376:11858/00-001M-0000-000E-B76B-E 1324:Ryan KJ, Ray CG, eds. 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The analysis of 809:In the fecal-oral route, 765:African sleeping sickness 632:Creutzfeldt–Jakob disease 616:due to medical procedures 3867:Protective sequestration 3729:Pre-exposure prophylaxis 3020:Generational difference 2573:Horizontal gene transfer 2563:Antimicrobial resistance 1253:Kurkjian KM, Little SE. 562:infectious mononucleosis 445:, less commonly through 4054:Microbial phylogenetics 3972:Wastewater surveillance 3493:Geographic distribution 3368:Critical community size 3166:Surgical site infection 3014:Iatrogenic/Medical care 2933:Microbial translocation 2929:Endogenous reactivation 2924:Normal flora overgrowth 2873:Opportunistic infection 2645:Opportunistic infection 2367:10.1111/1365-2435.12089 2244:10.1073/pnas.1423542112 1890:"Pathogens and vectors" 1639:"Common Vehicle Spread" 1415:(subscription required) 1277:"Vertical transmission" 1103:Mixed-mode transmission 1078:Horizontal transmission 881:sanitary sewer overflow 144:. Transmissions can be 95:fecal–oral transmission 4126:Microbial bioterrorism 3749:efficacy/effectiveness 3157:Surgical intervention 3049:Breakthrough infection 2671:Genetic predisposition 2655:Susceptible individual 2502:Germ theory of disease 1730:. Taylor and Francis. 1058:a form of non-genetic 1028:positive externalities 965:influenza-like illness 800: 577: 363:streptococcus pyogenes 308: 236:Routes of transmission 223:Community transmission 185:perinatal transmission 3962:Universal precautions 2920:Endogenous overgrowth 2772:Poultry and livestock 1349:Jones JH (May 2007). 1242:on 27 September 2007. 1055:Vertical transmission 1050:Vertical transmission 798: 710:Vector (epidemiology) 708:Further information: 697:Clostridium botulinum 594:(also referred to as 575: 389:Further information: 349:human metapneumovirus 321:contaminated surfaces 306: 65:airborne transmission 4164:Disease transmission 4064:Genomic reassortment 4044:Genetic epidemiology 3883:Health communication 3811:Flattening the curve 3801:Disease surveillance 3584:Systemic/Generalized 3348:Animal disease model 2828:Asymptomatic carrier 1113:evolutionary success 984:Computer simulations 931:disease surveillance 912:Ascaris lumbricoides 850:developing countries 745:blood-borne diseases 656:blood-borne diseases 526:herpes simplex virus 354:Bordetella pertussis 75:droplet transmission 50:communicable disease 44:is the passing of a 4169:Infectious diseases 4131:Pandemic prevention 4087:Viral phylodynamics 4068:Re-emerging disease 3957:Travel restrictions 3161:Postoperative wound 3130:Blood-borne disease 3112:Respiratory droplet 3024:Vertical/Congenital 3009:Nosocomial/Hospital 2966:Spillover infection 2412:10.1038/nature04793 2404:2006Natur.441..345N 2235:2015PNAS..11211114W 2229:(35): 11114–11119. 2106:on 24 October 2018. 2081:10.1038/nature07634 2073:2009Natur.457.1012G 2067:(7232): 1012–1014. 1900:on 24 January 2015. 1832:10.1093/cid/cix1071 1409:Dallas Morning News 1392:. 10 February 2020. 939:reportable diseases 604:Infectious diseases 596:perinatal infection 401:contagious diseases 333:parainfluenza virus 299:Respiratory droplet 4077:Selection pressure 3373:Force of infection 3001:Contagious disease 2936:Endogenous seeding 2833:Chain of infection 2757:Injection drug use 2668:Vaccination status 2551:Case fatality rate 2469:infectious disease 2355:Functional Ecology 2186:10.4161/viru.24041 2021:10.1093/aje/kwp270 1605:. 18 February 2019 988:seasonal variation 852:who live in urban 801: 753:viral encephalitis 578: 391:Contagious disease 309: 262:Airborne infection 230:Local transmission 162:infectious disease 140:with more complex 4151: 4150: 4141:Tropical medicine 4082:Synthetic biology 3983: 3982: 3942:Social distancing 3895:Outbreak response 3516: 3515: 3343:Agent-based model 3329: 3328: 3325: 3324: 3321: 3320: 2868:Natural reservoir 2858:Infectious period 2848:Incubation period 2805: 2804: 2761:Natural disaster 2730:Tropical diseases 2713:Biodiversity loss 2650:Risk of infection 2640:Microbiome health 2633:Immunosuppression 2398:(7091): 345–348. 2015:(10): 1300–1306. 1826:(11): 1733–1741. 1795:. 23 October 2017 1737:978-1-35118-825-8 1710:978-1-260-01202-6 1685:978-1-119-17931-3 1514:on 26 March 2020. 1335:978-0-8385-8529-0 1305:on 7 January 2010 1287:on 28 March 2007. 1265:on 15 March 2012. 954:infection control 652:intravenous drugs 638:, and many more. 52:from an infected 4176: 4136:Tropical disease 4072:Reverse zoonosis 4059:One Health Model 3888:Health education 3877:Community health 3796:Cordon sanitaire 3769:Ring vaccination 3739:Repurposed drugs 3626: 3545:Gastrointestinal 3388:Machine learning 3192:Gastrointestinal 3143:Intravenous line 3080: 2994:/Cross-infection 2981:Reverse zoonosis 2954: 2911: 2816: 2797:War and conflict 2665:Nutrition status 2628:Immunodeficiency 2485: 2461: 2454: 2447: 2438: 2432: 2431: 2387: 2381: 2380: 2378: 2350: 2344: 2343: 2333: 2323: 2299: 2293: 2292: 2282: 2273: 2267: 2266: 2256: 2246: 2214: 2208: 2207: 2197: 2165: 2159: 2158: 2148: 2138: 2114: 2108: 2107: 2105: 2099:. Archived from 2058: 2049: 2043: 2042: 2032: 2000: 1994: 1993: 1957: 1951: 1950: 1940: 1908: 1902: 1901: 1896:. Archived from 1894:MetaPathogen.com 1886: 1880: 1879: 1877: 1875: 1860: 1854: 1853: 1843: 1811: 1805: 1804: 1802: 1800: 1785: 1779: 1778: 1758: 1749: 1748: 1746: 1744: 1721: 1715: 1714: 1696: 1690: 1689: 1663: 1654: 1653: 1651: 1649: 1634: 1625: 1619: 1618: 1614: 1612: 1610: 1595: 1584: 1583: 1581: 1579: 1565: 1559: 1558: 1547: 1541: 1540: 1538: 1536: 1525: 1516: 1515: 1513: 1507:. Archived from 1502: 1494: 1485: 1484: 1482: 1480: 1474: 1462: 1453: 1452: 1450: 1448: 1442: 1431: 1423: 1417: 1416: 1413: 1400: 1394: 1393: 1390:The Manila Times 1382: 1376: 1375: 1368: 1362: 1361: 1359: 1346: 1340: 1339: 1321: 1315: 1314: 1312: 1310: 1295: 1289: 1288: 1283:. Archived from 1273: 1267: 1266: 1250: 1244: 1243: 1238:. Archived from 1228: 1222: 1221: 1193: 1184: 1183: 1165: 1109:human microbiota 1072:human microbiota 1044:human microbiota 973:web search query 841:after using the 839:wash their hands 805:Fecal–oral route 670:Indirect contact 292: 291: 268:Airborne disease 213:Transmissibility 169: 168: 126:tapeworm in pigs 4184: 4183: 4179: 4178: 4177: 4175: 4174: 4173: 4154: 4153: 4152: 4147: 4091: 4004:Antigenic shift 3999:Antigenic drift 3990: 3979: 3843:Barrier nursing 3791:Contact tracing 3782: 3775: 3620: 3618: 3611: 3522: 3512: 3413: 3407: 3398:Serial interval 3317: 3301: 3292:Cervico-vaginal 3287: 3278:Trans-placental 3273: 3257: 3225: 3187: 3123:Vascular system 3122: 3116: 3071: 3059: 3053: 2993: 2985: 2945: 2902: 2820: 2801: 2692: 2623:Immune response 2589: 2568:Drug resistance 2512:Infectious dose 2476: 2465: 2435: 2389: 2388: 2384: 2352: 2351: 2347: 2314:(8): e1001631. 2301: 2300: 2296: 2280: 2275: 2274: 2270: 2216: 2215: 2211: 2167: 2166: 2162: 2116: 2115: 2111: 2103: 2056: 2051: 2050: 2046: 2002: 2001: 1997: 1959: 1958: 1954: 1910: 1909: 1905: 1888: 1887: 1883: 1873: 1871: 1870:. 30 March 2022 1862: 1861: 1857: 1813: 1812: 1808: 1798: 1796: 1787: 1786: 1782: 1760: 1759: 1752: 1742: 1740: 1738: 1723: 1722: 1718: 1711: 1698: 1697: 1693: 1686: 1665: 1664: 1657: 1647: 1645: 1636: 1635: 1628: 1616: 1608: 1606: 1597: 1596: 1587: 1577: 1575: 1567: 1566: 1562: 1549: 1548: 1544: 1534: 1532: 1527: 1526: 1519: 1511: 1500: 1496: 1495: 1488: 1478: 1476: 1472: 1464: 1463: 1456: 1446: 1444: 1440: 1429: 1425: 1424: 1420: 1414: 1402: 1401: 1397: 1384: 1383: 1379: 1370: 1369: 1365: 1357: 1354: 1348: 1347: 1343: 1336: 1323: 1322: 1318: 1308: 1306: 1297: 1296: 1292: 1275: 1274: 1270: 1252: 1251: 1247: 1230: 1229: 1225: 1195: 1194: 1187: 1180: 1167: 1166: 1162: 1158: 1121: 1105: 1080: 1064:parental effect 1052: 1036: 1004: 927: 921: 874:open defecation 807: 793: 712: 706: 692:botulinum toxin 672: 644: 624:transplantation 612: 584: 570: 558:Cytomegalovirus 546: 534: 518: 435: 429: 393: 387: 329:influenza virus 301: 295: 289: 288: 270: 264: 242:epidemiologists 238: 166: 165: 158: 26: 17: 12: 11: 5: 4182: 4180: 4172: 4171: 4166: 4156: 4155: 4149: 4148: 4146: 4145: 4144: 4143: 4133: 4128: 4123: 4118: 4113: 4110: 4105: 4099: 4097: 4093: 4092: 4090: 4089: 4084: 4079: 4074: 4069: 4066: 4061: 4056: 4051: 4046: 4041: 4036: 4034:Emergent virus 4031: 4026: 4021: 4016: 4015: 4014: 4006: 4001: 3995: 3993: 3985: 3984: 3981: 3980: 3978: 3977: 3974: 3969: 3967:Vector control 3964: 3959: 3954: 3949: 3944: 3939: 3934: 3929: 3924: 3923: 3922: 3917: 3912: 3910:N95 respirator 3902: 3897: 3892: 3891: 3890: 3885: 3880: 3869: 3864: 3863: 3862: 3852: 3847: 3846: 3845: 3835: 3834: 3833: 3828: 3823: 3813: 3808: 3803: 3798: 3793: 3787: 3785: 3783:pharmaceutical 3777: 3776: 3774: 3773: 3772: 3771: 3766: 3761: 3756: 3751: 3741: 3736: 3731: 3726: 3721: 3716: 3715: 3714: 3704: 3699: 3694: 3689: 3684: 3679: 3674: 3673: 3672: 3662: 3661: 3660: 3650: 3645: 3644: 3643: 3632: 3630: 3629:Pharmaceutical 3623: 3613: 3612: 3610: 3609: 3606: 3601: 3596: 3591: 3586: 3581: 3580:Cardiovascular 3578: 3573: 3568: 3565: 3560: 3559:Nervous system 3557: 3554: 3553: 3552: 3542: 3541: 3540: 3535: 3526: 3524: 3518: 3517: 3514: 3513: 3511: 3510: 3505: 3500: 3495: 3490: 3485: 3480: 3475: 3470: 3465: 3460: 3455: 3450: 3445: 3444: 3443: 3438: 3428: 3423: 3417: 3415: 3409: 3408: 3406: 3405: 3400: 3395: 3390: 3385: 3383:Infection rate 3380: 3375: 3370: 3365: 3360: 3355: 3350: 3345: 3339: 3337: 3331: 3330: 3327: 3326: 3323: 3322: 3319: 3318: 3316: 3315: 3309: 3307: 3303: 3302: 3300: 3299: 3295: 3293: 3289: 3288: 3286: 3285: 3281: 3279: 3275: 3274: 3272: 3271: 3265: 3263: 3259: 3258: 3256: 3255: 3249: 3244: 3239: 3233: 3231: 3227: 3226: 3224: 3223: 3218: 3213: 3208: 3207: 3206: 3195: 3193: 3189: 3188: 3186: 3185: 3184: 3183: 3178: 3170: 3169: 3168: 3163: 3155: 3154: 3153: 3148: 3145: 3140: 3138:Injection site 3132: 3126: 3124: 3118: 3117: 3115: 3114: 3109: 3107:Dental aerosol 3104: 3103: 3102: 3092: 3086: 3084: 3077: 3073: 3072: 3070: 3069: 3063: 3061: 3055: 3054: 3052: 3051: 3046: 3045: 3044: 3039: 3038: 3037: 3032: 3029: 3018: 3017: 3016: 3011: 3003: 2997: 2995: 2991:Human-to-human 2987: 2986: 2984: 2983: 2978: 2973: 2968: 2962: 2960: 2951: 2947: 2946: 2944: 2943: 2937: 2934: 2931: 2926: 2921: 2917: 2915: 2908: 2904: 2903: 2901: 2900: 2895: 2890: 2888:Super-spreader 2885: 2883:Superinfection 2880: 2875: 2870: 2865: 2860: 2855: 2850: 2845: 2840: 2835: 2830: 2824: 2822: 2813: 2807: 2806: 2803: 2802: 2800: 2799: 2794: 2792:Vector control 2789: 2784: 2779: 2774: 2769: 2768: 2767: 2759: 2754: 2749: 2744: 2739: 2734: 2733: 2732: 2727: 2721:Climate zones 2719: 2717:Climate change 2714: 2711: 2708: 2702: 2700: 2694: 2693: 2691: 2690: 2689: 2688: 2685: 2682: 2681: 2680: 2672: 2669: 2666: 2663: 2660: 2652: 2647: 2642: 2637: 2636: 2635: 2630: 2620: 2615: 2610: 2605: 2599: 2597: 2591: 2590: 2588: 2587: 2582: 2581: 2580: 2575: 2570: 2560: 2559: 2558: 2553: 2548: 2543: 2533: 2531:Quorum sensing 2528: 2527: 2526: 2516: 2515: 2514: 2504: 2499: 2493: 2491: 2482: 2478: 2477: 2466: 2464: 2463: 2456: 2449: 2441: 2434: 2433: 2382: 2361:(2): 315–327. 2345: 2294: 2268: 2209: 2180:(4): 295–306. 2160: 2109: 2044: 1995: 1968:(5): 501–508. 1952: 1923:(3): 254–258. 1903: 1881: 1855: 1806: 1780: 1750: 1736: 1716: 1709: 1691: 1684: 1655: 1626: 1585: 1560: 1542: 1517: 1486: 1454: 1418: 1395: 1377: 1363: 1352: 1341: 1334: 1316: 1290: 1268: 1245: 1223: 1185: 1178: 1159: 1157: 1154: 1153: 1152: 1147: 1142: 1137: 1132: 1127: 1120: 1117: 1104: 1101: 1079: 1076: 1051: 1048: 1035: 1032: 1003: 1000: 943:aggregate data 920: 917: 870:polluted water 803:Main article: 792: 789: 757:Chagas disease 705: 702: 671: 668: 643: 642:Needle sharing 640: 628:iatrogenically 611: 608: 580:Main article: 569: 566: 554:herpes viruses 545: 542: 533: 530: 517: 514: 510:trichomoniasis 431:Main article: 428: 425: 421:conjunctivitis 409:athlete's foot 386: 385:Direct contact 383: 297:Main article: 294: 286: 266:Main article: 263: 260: 237: 234: 202:infectiousness 157: 154: 138:macroparasites 110: 109: 106: 92: 81: 78: 72: 58:microorganisms 15: 13: 10: 9: 6: 4: 3: 2: 4181: 4170: 4167: 4165: 4162: 4161: 4159: 4142: 4139: 4138: 4137: 4134: 4132: 4129: 4127: 4124: 4122: 4119: 4117: 4114: 4111: 4109: 4106: 4104: 4101: 4100: 4098: 4094: 4088: 4085: 4083: 4080: 4078: 4075: 4073: 4070: 4067: 4065: 4062: 4060: 4057: 4055: 4052: 4050: 4047: 4045: 4042: 4040: 4037: 4035: 4032: 4030: 4027: 4025: 4022: 4020: 4017: 4013: 4010: 4009: 4007: 4005: 4002: 4000: 3997: 3996: 3994: 3992: 3986: 3975: 3973: 3970: 3968: 3965: 3963: 3960: 3958: 3955: 3953: 3950: 3948: 3947:Sterilization 3945: 3943: 3940: 3938: 3935: 3933: 3930: 3928: 3925: 3921: 3918: 3916: 3915:Surgical mask 3913: 3911: 3908: 3907: 3906: 3903: 3901: 3898: 3896: 3893: 3889: 3886: 3884: 3881: 3878: 3875: 3874: 3873: 3872:Public health 3870: 3868: 3865: 3861: 3858: 3857: 3856: 3853: 3851: 3848: 3844: 3841: 3840: 3839: 3836: 3832: 3829: 3827: 3824: 3822: 3819: 3818: 3817: 3814: 3812: 3809: 3807: 3804: 3802: 3799: 3797: 3794: 3792: 3789: 3788: 3786: 3784: 3778: 3770: 3767: 3765: 3762: 3760: 3757: 3755: 3752: 3750: 3747: 3746: 3745: 3742: 3740: 3737: 3735: 3732: 3730: 3727: 3725: 3724:Phage therapy 3722: 3720: 3717: 3713: 3710: 3709: 3708: 3707:Immunotherapy 3705: 3703: 3700: 3698: 3695: 3693: 3690: 3688: 3685: 3683: 3680: 3678: 3675: 3671: 3668: 3667: 3666: 3665:Antimicrobial 3663: 3659: 3656: 3655: 3654: 3651: 3649: 3646: 3642: 3639: 3638: 3637: 3634: 3633: 3631: 3627: 3624: 3622: 3614: 3607: 3605: 3602: 3600: 3597: 3595: 3592: 3590: 3587: 3585: 3582: 3579: 3577: 3574: 3572: 3569: 3566: 3564: 3561: 3558: 3556:Genitourinary 3555: 3551: 3548: 3547: 3546: 3543: 3539: 3536: 3534: 3531: 3530: 3528: 3527: 3525: 3519: 3509: 3506: 3504: 3501: 3499: 3496: 3494: 3491: 3489: 3486: 3484: 3481: 3479: 3476: 3474: 3471: 3469: 3466: 3464: 3461: 3459: 3456: 3454: 3451: 3449: 3446: 3442: 3439: 3437: 3434: 3433: 3432: 3429: 3427: 3424: 3422: 3419: 3418: 3416: 3414:in population 3410: 3404: 3401: 3399: 3396: 3394: 3391: 3389: 3386: 3384: 3381: 3379: 3378:Herd immunity 3376: 3374: 3371: 3369: 3366: 3364: 3361: 3359: 3356: 3354: 3351: 3349: 3346: 3344: 3341: 3340: 3338: 3336: 3332: 3314: 3311: 3310: 3308: 3304: 3297: 3296: 3294: 3290: 3283: 3282: 3280: 3276: 3270: 3267: 3266: 3264: 3262:Genitourinary 3260: 3254: 3250: 3248: 3245: 3243: 3240: 3238: 3235: 3234: 3232: 3228: 3222: 3219: 3217: 3214: 3212: 3209: 3205: 3204:Contamination 3202: 3201: 3200: 3197: 3196: 3194: 3190: 3182: 3179: 3177: 3174: 3173: 3172:Vector-borne 3171: 3167: 3164: 3162: 3159: 3158: 3156: 3152: 3149: 3146: 3144: 3141: 3139: 3136: 3135: 3133: 3131: 3128: 3127: 3125: 3119: 3113: 3110: 3108: 3105: 3101: 3098: 3097: 3096: 3093: 3091: 3088: 3087: 3085: 3081: 3078: 3074: 3068: 3065: 3064: 3062: 3056: 3050: 3047: 3043: 3040: 3036: 3033: 3030: 3027: 3026: 3025: 3022: 3021: 3019: 3015: 3012: 3010: 3007: 3006: 3004: 3002: 2999: 2998: 2996: 2992: 2988: 2982: 2979: 2977: 2974: 2972: 2969: 2967: 2964: 2963: 2961: 2959: 2958:Cross-species 2955: 2952: 2948: 2941: 2938: 2935: 2932: 2930: 2927: 2925: 2922: 2919: 2918: 2916: 2912: 2909: 2905: 2899: 2898:Window period 2896: 2894: 2891: 2889: 2886: 2884: 2881: 2879: 2876: 2874: 2871: 2869: 2866: 2864: 2863:Latent period 2861: 2859: 2856: 2854: 2851: 2849: 2846: 2844: 2841: 2839: 2836: 2834: 2831: 2829: 2826: 2825: 2823: 2817: 2814: 2812: 2808: 2798: 2795: 2793: 2790: 2788: 2785: 2783: 2780: 2778: 2775: 2773: 2770: 2766: 2763: 2762: 2760: 2758: 2755: 2753: 2750: 2748: 2745: 2743: 2742:Deforestation 2740: 2738: 2735: 2731: 2728: 2726: 2723: 2722: 2720: 2718: 2715: 2712: 2709: 2707: 2704: 2703: 2701: 2699: 2695: 2687:Stress levels 2686: 2683: 2679: 2676: 2675: 2673: 2670: 2667: 2664: 2661: 2658: 2657: 2656: 2653: 2651: 2648: 2646: 2643: 2641: 2638: 2634: 2631: 2629: 2626: 2625: 2624: 2621: 2619: 2616: 2614: 2611: 2609: 2606: 2604: 2601: 2600: 2598: 2596: 2592: 2586: 2583: 2579: 2576: 2574: 2571: 2569: 2566: 2565: 2564: 2561: 2557: 2554: 2552: 2549: 2547: 2544: 2542: 2539: 2538: 2537: 2534: 2532: 2529: 2525: 2522: 2521: 2520: 2519:Pathogenicity 2517: 2513: 2510: 2509: 2508: 2505: 2503: 2500: 2498: 2495: 2494: 2492: 2490: 2486: 2483: 2479: 2474: 2470: 2462: 2457: 2455: 2450: 2448: 2443: 2442: 2439: 2429: 2425: 2421: 2417: 2413: 2409: 2405: 2401: 2397: 2393: 2386: 2383: 2377: 2372: 2368: 2364: 2360: 2356: 2349: 2346: 2341: 2337: 2332: 2327: 2322: 2317: 2313: 2309: 2305: 2298: 2295: 2290: 2286: 2279: 2272: 2269: 2264: 2260: 2255: 2250: 2245: 2240: 2236: 2232: 2228: 2224: 2220: 2213: 2210: 2205: 2201: 2196: 2191: 2187: 2183: 2179: 2175: 2171: 2164: 2161: 2156: 2152: 2147: 2142: 2137: 2132: 2128: 2124: 2120: 2113: 2110: 2102: 2098: 2094: 2090: 2086: 2082: 2078: 2074: 2070: 2066: 2062: 2055: 2048: 2045: 2040: 2036: 2031: 2026: 2022: 2018: 2014: 2010: 2006: 1999: 1996: 1991: 1987: 1983: 1979: 1975: 1971: 1967: 1963: 1956: 1953: 1948: 1944: 1939: 1934: 1930: 1926: 1922: 1918: 1914: 1907: 1904: 1899: 1895: 1891: 1885: 1882: 1869: 1865: 1859: 1856: 1851: 1847: 1842: 1837: 1833: 1829: 1825: 1821: 1817: 1810: 1807: 1794: 1790: 1784: 1781: 1776: 1772: 1768: 1764: 1757: 1755: 1751: 1739: 1733: 1729: 1728: 1720: 1717: 1712: 1706: 1702: 1695: 1692: 1687: 1681: 1677: 1673: 1669: 1662: 1660: 1656: 1644: 1640: 1633: 1631: 1627: 1623: 1622:public domain 1604: 1600: 1594: 1592: 1590: 1586: 1574: 1570: 1564: 1561: 1556: 1552: 1546: 1543: 1530: 1524: 1522: 1518: 1510: 1506: 1499: 1493: 1491: 1487: 1471: 1467: 1461: 1459: 1455: 1439: 1435: 1428: 1422: 1419: 1411: 1410: 1405: 1399: 1396: 1391: 1387: 1381: 1378: 1373: 1367: 1364: 1356: 1345: 1342: 1337: 1331: 1327: 1320: 1317: 1304: 1300: 1294: 1291: 1286: 1282: 1278: 1272: 1269: 1264: 1260: 1256: 1249: 1246: 1241: 1237: 1233: 1227: 1224: 1219: 1215: 1211: 1207: 1203: 1199: 1192: 1190: 1186: 1181: 1179:9780521664479 1175: 1171: 1164: 1161: 1155: 1151: 1148: 1146: 1143: 1141: 1138: 1136: 1133: 1131: 1128: 1126: 1123: 1122: 1118: 1116: 1114: 1110: 1102: 1100: 1098: 1094: 1089: 1085: 1077: 1075: 1073: 1069: 1065: 1061: 1056: 1049: 1047: 1045: 1041: 1033: 1031: 1029: 1024: 1022: 1017: 1012: 1010: 1001: 999: 997: 993: 989: 985: 981: 979: 974: 970: 966: 962: 957: 955: 950: 948: 944: 940: 936: 935:public health 932: 926: 918: 916: 914: 913: 908: 904: 903: 898: 894: 890: 886: 882: 877: 875: 871: 867: 863: 860:or untreated 859: 855: 851: 846: 844: 840: 836: 832: 827: 825: 821: 816: 812: 806: 797: 790: 788: 786: 782: 778: 774: 770: 766: 762: 758: 754: 750: 746: 742: 737: 735: 731: 728:by conveying 727: 723: 719: 718: 711: 703: 701: 699: 698: 693: 689: 685: 681: 677: 676:contamination 669: 667: 665: 661: 657: 653: 649: 641: 639: 637: 633: 629: 625: 621: 617: 614:Transmission 609: 607: 605: 601: 597: 593: 589: 583: 574: 567: 565: 563: 559: 555: 551: 543: 541: 539: 531: 529: 527: 524:incidence of 522: 515: 513: 511: 507: 503: 499: 495: 491: 490:genital warts 487: 483: 478: 476: 472: 468: 464: 460: 456: 452: 448: 444: 440: 434: 426: 424: 422: 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623–643. 1573:www.who.int 1535:28 February 1479:10 November 1351:"Notes on R 1145:Rodentology 1060:inheritance 889:hepatitis A 866:groundwater 688:hepatitis A 660:Hepatitis C 600:breast milk 498:hepatitis B 359:pneumococci 217:probability 209:organisms. 193:infectivity 142:life cycles 116:, either a 4158:Categories 3991:infections 3932:Sanitation 3900:Quarantine 3759:resistance 3677:Antiseptic 3658:Ascaricide 3648:Antifungal 3636:Antibiotic 3617:Prevention 3550:Intestinal 3483:Prevalence 3463:Inequality 3412:Occurrence 3211:Breastmilk 3095:Bioaerosol 3067:Sapronosis 3042:Horizontal 2914:Endogenous 2893:Viral load 2853:Index case 1309:3 February 1156:References 1130:Bugchasing 1125:Bioaerosol 923:See also: 902:Salmonella 831:sanitation 791:Fecal–oral 773:mosquitoes 771:, such as 769:arthropods 747:, such as 662:(HCV) and 658:, such as 610:Iatrogenic 592:childbirth 532:Manual sex 451:manual sex 367:diphtheria 341:rhinovirus 278:chickenpox 167:horizontal 99:sanitation 4103:Discovery 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177:fomites 173:vectors 103:hygiene 38:biology 4024:CRISPR 3976:Zoning 3831:Gloves 3242:Fomite 3076:Routes 2971:Vector 2838:Fomite 2819:Basic 2782:Travel 2662:Gender 2426:  2418:  2392:Nature 2338:  2328:  2261:  2251:  2202:  2192:  2153:  2143:  2097:125775 2095:  2087:  2061:Nature 2037:  2027:  1988:  1980:  1945:  1935:  1848:  1838:  1793:nhs.uk 1734:  1707:  1682:  1332:  1216:  1176:  978:dengue 909:(e.g. 905:, and 862:sewage 843:toilet 720:is an 717:vector 682:, and 508:, and 506:herpes 471:rectum 467:vagina 427:Sexual 419:, and 373:, and 207:vector 118:vector 89:fomite 36:, and 4096:Other 3604:Fetus 3599:Mouth 3594:Tooth 3589:Blood 3576:Joint 3436:Curve 3306:Other 3253:wound 3251:Open 3221:Feces 3216:Water 2907:Modes 2765:Flood 2489:Agent 2424:S2CID 2281:(PDF) 2104:(PDF) 2093:S2CID 2057:(PDF) 1986:S2CID 1512:(PDF) 1501:(PDF) 1473:(PDF) 1466:NHMRC 1441:(PDF) 1430:(PDF) 1358:(PDF) 1040:coral 893:polio 854:slums 815:fecal 781:fleas 777:ticks 680:blood 463:penis 459:semen 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Index

Transmission
medicine
public health
biology
pathogen
communicable disease
host
microorganisms
airborne transmission
ÎĽm
droplet transmission
soil
fomite
fecal–oral transmission
sanitation
hygiene
organism
vector
mosquito
tapeworm in pigs
pork
zoonoses
macroparasites
life cycles
autochthonous
infectious disease
vectors
fomites
vertical disease transmission
perinatal transmission

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