443:
215:
Ludwig, ML; Pattridge, KA; Metzger, AL; Dixon, MM; Eren, M; Feng, Y; Swenson, RP (11 February 1997). "Control of oxidation-reduction potentials in flavodoxin from
Clostridium beijerinckii: the role of conformation changes".
79:
move about the axis defined by the C-Cยน and N-C bond vectors of the peptide group, which are roughly parallel. As an example, the type I and type II
127:
conformation is suggested to facilitate the early stages of amyloidogenesis. Peptide plane flipping may also be significant in the early stages of
484:
143:, poor peptide-plane geometry has been described as a common problem; many structures need correction by peptide-plane flips or
332:"Pauling and Corey's ฮฑ-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid disease"
508:
503:
477:
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140:
108:
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253:"Amyloid formation may involve alpha- to beta sheet interconversion via peptide plane flipping"
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111:. For example, peptide flips have been described as significant in the catalytic cycle of
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39:. The plane flip is defined as a rotation of the dihedral angles ฯ,ฯ at amino acids
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391:"Detection of trans-cis flips and peptide-plane flips in protein structures"
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structures, where their ability to provide a low-energy pathway between
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such that the resulting angles remain in structurally stable regions of
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24:
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Milner-White, JE; Watson, JD; Qi, G; Hayward, S (September 2006).
295:(2006). "Alpha-sheet: The toxic conformer in amyloid diseases?".
35:
undergo large-scale rotations with little displacement of the
330:
Armen, RS; DeMarco, ML; Alonso, DO; Daggett, V. (2004).
458:
75:remain roughly constant; in effect, the flip is a
389:Touw, WG; Joosten, RP; Vriend, G (August 2015).
103:has been inferred in some proteins by comparing
95:The significance of peptide plane flips in the
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83:differ by a simple flip of the central
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168:"Peptide-plane flipping in proteins"
139:In protein structures determined by
51:. The key requirement is that the
457:. You can help Knowledge (XXG) by
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441:
395:Acta Crystallographica Section D
107:of the same protein in multiple
1:
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407:10.1107/S1399004715008263
270:10.1016/j.str.2006.06.016
115:and in the formation of
357:10.1073/pnas.0401781101
336:Proc Natl Acad Sci USA
17:Peptide plane flipping
141:X-ray crystallography
21:conformational change
166:Hayward, S. (2001).
348:2004PNAS..10111622A
91:In protein dynamics
509:Biochemistry stubs
135:In crystallography
123:and the so-called
105:crystal structures
49:Ramachandran space
23:that can occur in
504:Protein structure
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401:(Pt 8): 1604โ14.
309:10.1021/ar0500719
230:10.1021/bi962180o
71:angle of residue
61:angle of residue
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178:(11): 2219โ27.
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129:protein folding
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29:dihedral angles
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303:(9): 594โ602.
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109:conformations
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87:of the turn.
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85:peptide group
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27:by which the
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451:biochemistry
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297:Acc Chem Res
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218:Biochemistry
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145:peptide bond
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101:native state
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62:
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52:
44:
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31:of adjacent
16:
15:
293:Daggett, V.
172:Protein Sci
125:alpha sheet
37:side chains
33:amino acids
498:Categories
151:References
121:beta sheet
113:flavodoxin
81:beta turns
77:crankshaft
257:Structure
65:and the ฯ
425:26249342
376:15280548
317:16981675
279:16962968
202:11604529
97:dynamics
55:of the ฯ
25:proteins
416:4528797
344:Bibcode
238:9063874
193:2374056
147:flips.
117:amyloid
99:of the
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367:511030
364:
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449:This
455:stub
421:PMID
372:PMID
313:PMID
275:PMID
234:PMID
198:PMID
43:and
411:PMC
403:doi
362:PMC
352:doi
340:101
305:doi
265:doi
226:doi
188:PMC
180:doi
73:i+1
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