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as a reliable medical source, but if used with caution the Nature paper, despite being a primary source, would probably be suitable. We could add a sentence to the article along the lines of "although not capped, hepatitis mRNA attaches to a cell-derived metabolite (flavin adenine dinucleotide) which
1469:
I am working in
Infectious Diseases in British Columbia, Canada. We see a large number of hepatitis C patients. A screening tool used to assess the severity of hepatic fibrosis in these patients is a Fibroscan. Adding this method of monitoring for both the need for treatment aswell as the progress of
1353:
Also: averaging figures given as ranges ... How is this OK? Is there some guideline regarding this, or is there some Wiki convention? When figures are given as a range, e.g. 10-50%, it could mean that these are the extremes given by various primary sources on which the secondary source draws upon, or
1328:
The CDC reference that was originally cited (archived), and which I thus checked, said 80-95%. As far as I know, if the intended reference is the current one, the archived one should not be given. Anyway, as said, the ~90% figure is given earlier, and since the following paragraph of the Wiki article
1169:
Also, relative to the question as to why this complication of the disease merits note as being "life-threatening"? The reason as to why this is beneficial to have in this article is that non-medical/scientific readers who are not familiar with varices (particularly esophageal varices) will be better
1664:
This is a really controversial subject which is not treated in that way in this article. For instance, there have been no reported reactivations of hepatitis C infection in persons who successfully have been treated against hepatitis C and that later receive immunosuppressive treatment. This is the
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is common among eukaryotes and many viruses but not hepatitis C virus. This report shows that hepatitis C virus uses a cellular product as a cap instead during the viruses replication, which has a similar function. Although this is interesting, it's sensationalising to call it a "secret strategy".
1751:
WHO's latest reports and newer data sources are now available, but updating this section may take some time. Worldwide infection, mortality and treatment numbers have been updated, as has the "infection rate by country" map. More edits to this section and possibly reorganizing paragraph/data order
1253:
Seemed like a reasonable solution but honestly as you've expressed previously liver failure and liver cancer are given to be serious. Varices not so much. Your suggested "serious" edit more or less groups varices in the same level as the two others so that essentially covers it. As a side note, I
1382:
Questioned this as well when making copy edits to simplify and add clarity. I added "Depending on a variety of patient factors," to the
Spontaneous Resolution statement that "between 15–45% of those with hepatitis C will spontaneously clear the virus within six months." These factors make the
1816:
Sherwood, A. V., Rivera-Rangel, L. R., Ryberg, L. A., Larsen, H. S., Anker, K. M., Costa, R., Vågbø, C. B., Jakljevič, E., Pham, L. V., Fernandez-Antunez, C., Indrisiunaite, G., Podolska-Charlery, A., Grothen, J. E. R., Langvad, N. W., Fossat, N., Offersgaard, A., Al-Chaer, A., Nielsen, L.,
1679:
A lot of information in this article is out of date and incorrect. Some parts are updated to current practice (DAA treatment for different genotypes) while other parts, like post-transplant treatment and research, are hopelessly out of date (seems to be written around 2011-2014).
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Yes, that sounds logical, still, in the interest of better informing our readers varices should be given due respect. Average readers are not going to be familiar with varices that do lead to death while they almost certainly will be familiar with those better known complications.
1334:"Prior to 2011, treatments consisted of a combination of pegylated interferon alpha and ribavirin for a period of 24 or 48 weeks, depending on HCV genotype. This produces cure rates of between 70 and 80% for genotype 2 and 3, respectively, and 45 to 70% for genotypes 1 and 4."
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know that you work very extensively on wikipedia and related projects and have done so for many years particularly with respect to medical articles and you deserve recognition for that, so thank you for helping to improve the project in the ways that you focus on.
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Kuśnierczyk, A., Sølund, C., Weis, N., Gottwein, J. M., Holmbeck, K., Bottaro, S., Ramirez, S., Bukh, J., Scheel, T. K. H., Vinther, J. (2023). "Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide".
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informed of this issue. This is as opposed to issues like liver failure and liver cancer that are self-evident for being fatal complications to this disease even for non-medical, non-scientific readers.
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By the way, I think it is standard practice on Wiki to add references within the brackets if all the information, and only the information given in the brackets is based on a certain inline citation.
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was a big step forward in terms of HepC treatment, and it may be worth at least suggesting this; even I have had it seared in my memory that HepC is a pain to treat/cure, and I'm on the younger side.
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It´s also suspicious that the majority of citations is from a group propagating for the existence of occult hepatitis C infection, a condition not generally accepted among hepatitis C researchers.
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the patient's over hepatic health would be very beneficial to this topic, as one does not need biopsies to assess fibrosis anymore. Thank you EDIT: Please see
Elastography Knowledge link.
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Knowing a number of patients that have died from this and having discussed it with those people and their families they absolutely were not aware of the seriousness of this complication.
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it could apply to different groups (age, ethnicity, etc.). Thus, it doesn't seem to me at least intuitively reasonable to just give averages ...
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rs12979860 CT or TT genotype), in addition to male gender, absent/mild steatosis, and lower viral load, augments antibody levels against HCV.
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Says "Over 90% of HCV infected persons can be cured of HCV infection regardless of HCV genotype, with 8-12 weeks of oral therapy"
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opposite to occult hepatitis B which is well described combined with a plausable theory of how occult infection is maintained.
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it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a
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I not needed, plus there is the concern that it implied liver failure and liver cancer are not life threatening.
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percentage spread make sense, though the ranges under No Prior
Treatment could use some explaining.
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on
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This NPR piece was quite interesting, and probably deserves mention with medical sources:
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serves a similar function" and cite the Nature paper, but this would be better placed in
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A note about the 2020 Nobel Prize in
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I recommend a total make-over of that section to improve the quality of the article.
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Hep C has a secret strategy to evade the immune system. And now we know what it is
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Interestingly, the ability to produce interferon lambda 4 (i.e., carriage of
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This was added. It is based on a primary source so not quite suitable:
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Recommendations (32) on what to do with HCV in chronic kidney disease:
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goes on to discuss treatment success rates of earlier treatments:
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Knowledge level-5 vital articles in
Biology and health sciences
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It would be better to simple refer to all of them as serious.
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please change ((Georgia)) to ((Georgia (country)|Georgia))
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This article doesn´t meet the criteria for high quality.
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would reduce clutter and make the section more engaging.
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Knowledge vital articles in Biology and health sciences
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If it is not serious it is not much of a complication.
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GA-Class vital articles in Biology and health sciences
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There can be symptoms. I will edit this in a few days
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I expanded the vaccination recommendation sentence in
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1286:% of people with chronic infection who can be cured
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clinical publications about evidence-based medicine
1074:Adding "life-threatening" to dilated blood vessels
374:Knowledge:Identifying reliable sources (medicine)
1433:Semi-protected edit request on 25 September 2019
150:for general discussion of the article's subject.
931:Semi-protected edit request on 1 September 2018
564:and that biomedical information in any article
48:If it no longer meets these criteria, you can
1512:Semi-protected edit request on 1 October 2019
1227:Thanks your most recent change works for me.
562:Manual of Style for medicine-related articles
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1295:https://www.cdc.gov/hepatitis/hcv/hcvfaq.htm
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1548:In section "Surgery": reinfetcted -: -->
399:review articles from the past five years
1944:Unknown-importance dermatology articles
1052:into a table format for better clarity?
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1091:dilated blood vessels in the esophagus
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476:It is of interest to the following
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1954:GA-Class gastroenterology articles
1789:How Hep C evades the immune system
1048:What do we think about converting
692:Medicine Collaboration of the Week
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1599:doi:10.1016/S0140-6736(19)32320-7
424:Other potential sources include:
41:. If you can improve it further,
1934:Top-importance medicine articles
1904:Knowledge level-5 vital articles
1574:, thanks for pointing it out. –
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1989:All WikiProject Medicine pages
1894:Natural sciences good articles
1747:Epidemiology Section - Updates
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1480:21:57, 25 September 2019 (UTC)
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580:Knowledge:WikiProject Medicine
33:Natural sciences good articles
29:has been listed as one of the
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1999:Top-importance virus articles
1939:GA-Class dermatology articles
1716:10.1080/00365521.2021.1922750
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1033:23:56, 30 December 2018 (UTC)
1007:09:34, 1 September 2018 (UTC)
977:07:46, 1 September 2018 (UTC)
771:Knowledge:WikiProject Viruses
765:and see a list of open tasks.
666:This article is supported by
642:This article is supported by
622:This article is supported by
583:Template:WikiProject Medicine
385:sources of information about
159:Put new text under old text.
2004:WikiProject Viruses articles
1874:08:48, 8 November 2023 (UTC)
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774:Template:WikiProject Viruses
1638:10:29, 5 October 2020 (UTC)
1588:01:24, 1 October 2019 (UTC)
1559:01:04, 1 October 2019 (UTC)
1542:to reactivate your request.
1530:has been answered. Set the
1463:to reactivate your request.
1451:has been answered. Set the
1402:20:40, 5 January 2022 (UTC)
961:to reactivate your request.
949:has been answered. Set the
897:to reactivate your request.
885:has been answered. Set the
167:New to Knowledge? Welcome!
2020:
1929:GA-Class medicine articles
1831:10.1038/s41586-023-06301-3
1784:02:30, 15 March 2022 (UTC)
1100:All are life threatening.
797:project's importance scale
669:the Translation task force
625:the Dermatology task force
606:project's importance scale
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217:Neutral point of view
39:good article criteria
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405:free review articles
381:. Here are links to
222:No original research
110:Good article nominee
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1862:Hepatitis C virus
1731:Comments welcome.
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13:
10:
9:
6:
4:
3:
2:
2016:
2005:
2002:
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1997:
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1977:
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1897:
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1866:Graham Beards
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1615:
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1609:
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1600:
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1585:
1581:
1577:
1576:Deacon Vorbis
1572:
1563:
1562:
1561:
1560:
1556:
1552:
1541:
1538:parameter to
1529:
1525:
1518:
1517:
1511:
1507:
1503:
1502:
1496:
1492:
1484:
1483:
1482:
1481:
1477:
1473:
1462:
1459:parameter to
1450:
1446:
1439:
1438:
1432:
1430:
1429:
1426:
1420:
1417:
1409:
1403:
1399:
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1376:
1375:
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1362:
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1312:
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1234:
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1218:
1214:
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1207:
1203:
1199:
1195:
1191:
1189:
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1177:
1173:
1168:
1167:
1166:
1162:
1158:
1154:
1153:
1152:
1148:
1144:
1140:
1136:
1134:
1128:
1127:
1126:
1125:
1124:
1123:
1119:
1115:
1111:
1107:
1105:
1098:
1096:
1092:
1088:
1084:
1083:liver failure
1079:
1073:
1071:
1070:
1066:
1062:
1056:
1051:
1041:
1037:
1035:
1034:
1030:
1026:
1022:
1012:
1008:
1005:
1004:
1000:
999:
995:
994:
990:with thanks,
989:
981:
980:
979:
978:
974:
970:
960:
957:parameter to
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944:
937:
936:
930:
926:
922:
918:
914:
906:
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904:
896:
893:parameter to
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880:
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866:
849:
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843:
839:
836:
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834:
833:
830:
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764:
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734:
731:
727:
726:
722:
716:
713:
710:
706:
693:
684:
680:
679:
675:
672:(assessed as
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670:
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648:(assessed as
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454:
445:
444:
435:
434:
429:
428:
423:
420:
419:
414:
413:TRIP database
410:
407:
406:
401:
400:
395:
392:
391:
388:
384:
380:
376:
375:
370:
369:Ideal sources
367:
364:
360:
359:
340:
339:
336:
332:
329:
327:
323:
322:
317:
313:
310:
307:
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296:
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289:ScienceDirect
287:
284:
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273:
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228:
227:Verifiability
225:
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215:
214:
213:
204:
200:
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186:
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170:
169:Learn to edit
166:
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127:
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114:
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111:
107:
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80:
76:
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69:
64:
60:
55:
53:
52:
44:
40:
36:
35:
34:
28:
25:
22:
18:
17:
1822:
1818:
1792:
1773:
1754:
1750:
1730:
1706:
1696:
1690:
1682:
1678:
1670:
1667:
1663:
1624:— Preceding
1619:
1597:
1570:
1547:
1539:
1528:edit request
1500:
1490:
1468:
1460:
1449:edit request
1413:
1304:
1301:
1298:
1289:
1230:
1187:
1132:
1103:
1099:
1087:liver cancer
1080:
1077:
1045:
1042:Into a Table
1016:
1002:
997:
992:
987:
966:
958:
947:edit request
912:
902:
894:
883:edit request
823:
792:
752:
667:
643:
623:
601:
569:
555:
478:WikiProjects
461:
431:
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416:
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372:
368:
324:
311:
305:
297:
291:
285:
279:
271:
263:
255:
249:
239:
211:
136:This is the
126:Good article
125:
108:
90:
89:
49:
47:
43:please do so
31:
30:
26:
1551:65.112.8.53
1549:reinfected
1061:Mwright1469
1050:Medications
1040:Medications
1038:Converting
1025:Mwright1469
915:and thanks
510:Translation
502:Dermatology
387:Hepatitis C
148:not a forum
142:Hepatitis C
27:Hepatitis C
1883:Categories
1757:Thinkinink
1687:Interferon
1532:|answered=
1501:KuyaBriBri
1453:|answered=
1394:Thinkinink
1341:Sofosbuvir
951:|answered=
887:|answered=
842:/Archive 2
838:/Archive 1
402:(limit to
96:Not listed
37:under the
1864:article.
1838:0028-0836
1491:Not done:
1361:Jay Hodec
1305:Doc James
1231:Doc James
1188:Doc James
1133:Doc James
1104:Doc James
1021:Treatment
466:is rated
415:provides
396:provides
205:if needed
188:Be polite
138:talk page
1857:WP:MEDRS
1770:Symptoms
1724:34078234
1626:unsigned
1315:contribs
1241:contribs
1198:contribs
1143:contribs
1114:contribs
1046:Hi guys!
1017:Hi guys!
917:Cannolis
824:Archives
577:Medicine
497:Medicine
468:GA-class
326:Archives
295:Springer
260:Cochrane
173:get help
146:This is
144:article.
51:reassess
1855:passes
1846:Capped
1095:stomach
998:Vampire
867:Georgia
795:on the
768:Viruses
759:viruses
715:Viruses
604:on the
74:Process
1819:Nature
1799:Beland
1646:Beland
1584:videos
1580:carbon
474:scale.
394:PubMed
283:OpenMD
253:PubMed
115:Listed
77:Result
1697:IFNL4
1536:|ans=
1526:This
1457:|ans=
1447:This
1410:KDIGO
1319:email
1245:email
1202:email
1147:email
1118:email
1089:, or
1003:Heart
955:|ans=
945:This
891:|ans=
881:This
455:This
309:Wiley
201:Seek
1870:talk
1848:mRNA
1835:ISSN
1803:talk
1780:talk
1761:talk
1738:T@lk
1721:PMID
1650:talk
1634:talk
1607:T@lk
1571:Done
1555:talk
1476:talk
1424:T@lk
1398:talk
1365:talk
1311:talk
1260:talk
1237:talk
1217:talk
1194:talk
1176:talk
1161:talk
1139:talk
1110:talk
1093:and
1065:talk
1029:talk
993:Nici
988:Done
973:talk
921:talk
913:Done
430:and
411:The
302:Trip
276:Gale
268:DOAJ
190:and
71:Date
1853:NPR
1827:doi
1823:619
1797:--
1733:JFW
1711:doi
1602:JFW
1534:or
1455:or
1419:JFW
1097:."
953:or
889:or
787:Top
596:Top
433:CDC
316:TWL
1885::
1872:)
1833:.
1821:.
1805:)
1782:)
1763:)
1755:--
1735:|
1719:.
1709:.
1705:.
1652:)
1636:)
1604:|
1586:)
1582:•
1557:)
1540:no
1478:)
1461:no
1421:|
1400:)
1392:--
1367:)
1321:)
1317:·
1313:·
1262:)
1247:)
1243:·
1239:·
1219:)
1204:)
1200:·
1196:·
1178:)
1163:)
1149:)
1145:·
1141:·
1120:)
1116:·
1112:·
1085:,
1067:)
1031:)
975:)
959:no
923:)
895:no
840:,
676:).
652:).
508:/
504:/
500::
333:,
171:;
54:it
45:.
1868:(
1840:.
1829::
1801:(
1778:(
1759:(
1726:.
1713::
1648:(
1632:(
1578:(
1553:(
1474:(
1396:(
1363:(
1309:(
1258:(
1235:(
1215:(
1192:(
1174:(
1159:(
1137:(
1108:(
1063:(
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1027:(
971:(
919:(
799:.
694:.
628:.
608:.
574:.
480::
421:.
408:)
389:.
335:2
331:1
328::
312:·
306:·
298:·
292:·
286:·
280:·
272:·
264:·
256:·
250:·
175:.
56:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
