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In more recent work, the Greco Lab uses stimulated emission depletion (STED) microscopy to gain three-dimensional images of cellular structures, and have been using this imaging to examine the brains of mice. In her work with hair follicles and homeostasis, Greco has also determined a link between
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Greco received her undergraduate degree in
Molecular Biology at the University of Palermo, Italy. In the final two years of her undergraduate program, Greco studied tumor suppressor genes in mitotic cell division in the lab of Aldo di Leonardo. Greco then began graduate school in 1998 and received
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Greco's research has led to notable discoveries in cell regeneration, namely the mechanism of hair and skin regeneration. Her findings show that hair germ cells are obtained from bulge stem cells, as well as suggest that hair germ cells initiate hair regeneration and stem cells drive the process.
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in mice to study cellular homeostasis, wound repair, and cancer. Her lab uses techniques such as in vivo imaging to track individual stem cells over time and understand how these cells act during homeostasis and respond to tissue injury. Her lab has worked extensively on the importance of the
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Valentino Greco was born in
Palermo, Italy, where she lived through her undergraduate program. After being denied admission to the graduate school at the University of Palermo, she was encouraged by her friend Eugenia Piddini to apply to the graduate program at the European Molecular Biology
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Laboratory. Upon completion of her PhD, Greco moved to the United States and completed her postdoctoral work. She eventually decided to start her own lab, using a high-risk/high-reward approach alongside another Yale principal investigator, Ann
Haberman.
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the lymphatic vessels of the skin and hair follicle development and organization. The ongoing work of the Greco lab is looking to determine how skin reacts to mutations and the contribution of different tissue types to homeostasis.
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spatial organization of stem cell niches and shown that these stem cells coordinate their differentiation and migration and can clear away dead cells and tumor-like growths, repairing significant faults in tissue structure.
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Park, Sangbum; Gonzalez, David G.; Guirao, Boris; Boucher, Jonathan D.; Cockburn, Katie; Marsh, Edward D.; Mesa, Kailin R.; Brown, Samara; Rompolas, Panteleimon; Haberman, Ann M.; Bellaïche, Yohanns (March 2017).
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Velasco, Mary Grace M.; Zhang, Mengyang; Antonello, Jacopo; Yuan, Peng; Allgeyer, Edward S.; May, Dennis; M’Saad, Ons; Kidd, Phylicia; Barentine, Andrew E. S.; Greco, Valentina; Grutzendler, Jaime (2019-10-02).
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Pineda, Cristiana M.; Gonzalez, David G.; Matte-Martone, Catherine; Boucher, Jonathan; Lathrop, Elizabeth; Gallini, Sara; Fons, Nathan R.; Xin, Tianchi; Tai, Karen; Marsh, Edward; Nguyen, Don X. (2019-10-07).
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as the
Carolyn Walch Slayman Professor of Genetics and is an Associate Professor in the Cell Biology and Dermatology departments. Her research focuses on the role of skin stem cells in tissue regeneration.
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The Greco lab currently studies stem cells in organ regeneration, with the goal of determining how cells are maintained despite mutation, cellular turnover, and injury. Greco focuses on the mammalian
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Rompolas, Panteleimon; Mesa, Kailin R.; Kawaguchi, Kyogo; Park, Sangbum; Gonzalez, David; Brown, Samara; Boucher, Jonathan; Klein, Allon M.; Greco, Valentina (2016-06-17).
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Greco, Valentina; Chen, Ting; Rendl, Michael; Schober, Markus; Pasolli, H. Amalia; Stokes, Nicole; Cruz-Racelis, June dela; Fuchs, Elaine (2009-02-06).
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William
Montagna Lectureship at the Society of Investigative Dermatology (SID) annual conference (2020)
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on tissue growth mechanisms. She did her postdoctoral studies at
Rockefeller University with
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734:"How Cell Biologists Work: Valentina Greco on cultivating a passionate research team"
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552:"Spatiotemporal coordination of stem cell commitment during epidermal homeostasis"
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759:"Dr. Valentina Greco Uncovers the Secrets Behind Skin and Hair Regeneration"
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Robertson Stem Cell
Investigator Award, New York Stem Cell Foundation (2015)
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studying the mechanisms for stem cell activation during hair regeneration.
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Rompolas, Panteleimon; Mesa, Kailin R.; Greco, Valentina (October 2013).
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487:"Spatial organization within a niche as a determinant of stem-cell fate"
401:"A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration"
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676:"Hair follicle regeneration suppresses Ras-driven oncogenic growth"
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308:"The thrill of scientific discovery and leadership with my group"
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Glenn Award for
Research in Biological Mechanisms of Aging (2017)
1096:"ISSCR Dr. Susan Lim Award for Outstanding Young Investigator"
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National
Institutes of Health Director's Pioneer Award (2019)
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902:"Valentina Greco, PhD | 2020 SID Annual Meeting | Speakers"
149:(EMBL/MPI-CBG) in Heidelberg, Germany working with advisor
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Max Planck
Institute of Molecular Cell Biology and Genetics
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Max Planck Institute of Molecular Cell Biology and Genetics
1023:"Valentina Greco and Bo Huang Win 2016 Early Career Award"
878:"Valentina Greco Receives the 2021 ISSCR Momentum Award"
785:"3D super-resolution deep-tissue imaging in living mice"
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Dermatology Foundation Career Development Award (2012)
1072:"NYSCF – Robertson Stem Cell Investigators Archives"
951:"Yale scientists win NIH awards for pioneering work"
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Yale Mentoring Award in the Natural Sciences (2018)
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220:Outstanding Young Investigator Award, ISSCR (2014)
214:Edward Mallinckrodt, Jr. Foundation Scholar (2015)
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128:Greco is married to fellow Yale faculty member
926:"Mentoring | Office for Postdoctoral Affairs"
202:Class of ‘61 Award, Yale Cancer Center (2017)
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820:Kam, Chen Y; Greco, Valentina (2019-10-01).
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822:"Lymph vessels find a hairy niche"
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249:Sedwick, Caitlin (2014-11-24).
211:Early Career Award, ASCB (2016)
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949:Norman, Anita (2019-10-01).
251:"Valentina Greco: Got hair?"
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975:"2016 Faculty Scholars"
576:10.1126/science.aaf7012
377:Yale School of Medicine
324:10.1091/mbc.E16-06-0373
113:Yale School of Medicine
373:"Valentina Greco, PhD"
105:Italian-born biologist
979:2016 Faculty Scholars
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40:University of Palermo
1003:glennfoundation.org
622:Nature Cell Biology
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562:(6292): 1471–1474.
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1048:"Current Awardees"
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462:"Research"
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