760:
795:
536:
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65:
969:) will travel through the systemic circulation, reach the right side of the heart, and travel through the pulmonary artery, resulting in a pulmonary embolism. Arterial thrombosis resulting from hypertension or atherosclerosis can become mobile and the resulting emboli can occlude any artery or arteriole downstream of the thrombus formation. This means that cerebral stroke, myocardial infarction, or any other organ can be affected.
685:
702:
438:, tiny thrombi (microthrombi) known as microclots can obstruct the flow of blood in the capillaries. Microclots are small clumps of blood that form within the circulation, usually as a result of a larger thrombus breaking down into smaller pieces. They can be a cause for concern as they can lead to blockages in small vessels and restrict blood flow, leading to tissue damage and potentially causing
976:
break up the thrombus and blood flow is restored to the vessel. This may be aided by fibrinolytic drugs such as Tissue
Plasminogen Activator (tPA) in instances of coronary artery occlusion. The best response to fibrinolytic drugs is within a couple of hours, before the fibrin meshwork of the thrombus
693:
A thrombus occurs when the hemostatic process, which normally occurs in response to injury, becomes activated in an uninjured or slightly injured vessel. A thrombus in a large blood vessel will decrease blood flow through that vessel (termed a mural thrombus). In a small blood vessel, blood flow may
688:
Animation of the formation of an occlusive thrombus in a vein. A few platelets attach themselves to the valve lips, constricting the opening and causing more platelets and red blood cells to aggregate and coagulate. Coagulation of unmoving blood on both sides of the blockage may propagate a clot in
855:
are used to inhibit the formation and growth of existing thrombi, with the former used for acute anticoagulation while the latter is used for long-term anticoagulation. The mechanism of action of heparin and warfarin are different as they work on different pathways of the
996:-rich thrombus. If recanalization proceeds it provides capillary-sized channels through the thrombus for continuity of blood flow through the entire thrombus but may not restore sufficient blood flow for the metabolic needs of the downstream tissue.
1811:
1796:
698:. If an embolus becomes trapped within a blood vessel, it blocks blood flow and is termed as an embolism. Embolisms, depending on their specific location, can cause more significant effects like strokes, heart attacks, or even death.
518:
it is often a result of a heart attack complication. The thrombus in this case can separate from the chamber, be carried through arteries and block a blood vessel. They appear grey-red with alternating light and dark lines (known as
547:. The three factors have been further refined to include circulatory stasis, vascular wall injury, and hypercoagulable state, all of which contribute to increased risk for venous thromboembolism and other cardiovascular diseases.
759:
794:
955:
Propagation of a thrombus occurs towards the direction of the heart and involves the accumulation of additional platelets and fibrin. This means that it is anterograde in veins or retrograde in arteries.
907:(tPA) is a different enzyme that promotes the degradation of fibrin in clots but not free fibrinogen. This drug is made by transgenic bacteria and converts plasminogen into the clot-dissolving enzyme,
871:, an enzyme needed to synthesize vitamin K dependent clotting factors II, VII, IX, and X. Bleeding time with heparin and warfarin therapy can be measured with the partial thromboplastin time (PTT) and
749:, which is a protein encoded by the F3 gene. The platelet activation can potentially cause a cascade, eventually leading to the formation of the thrombus. This process is regulated through
1854:
644:(DIC) involves widespread microthrombi formation throughout the majority of the blood vessels. This is due to excessive consumption of coagulation factors and subsequent activation of
694:
be completely cut off (termed an occlusive thrombus), resulting in death of tissue supplied by that vessel. If a thrombus dislodges and becomes free-floating, it is considered an
592:
changes (stasis, turbulence): Blood stasis promotes greater contact between platelets/coagulative factors with vascular endothelium. If rapid blood circulation (e.g., because of
543:
It was suggested over 150 years ago that thrombus formation is a result of abnormalities in blood flow, vessel wall, and blood components. This concept is now known as
915:
and enter interstitial fluid, where it then increases excitotoxicity, potentially affecting permeability of the blood–brain barrier, and causing cerebral hemorrhage.
961:
occurs when the thrombus breaks free from the vascular wall and becomes mobile, thereby traveling to other sites in the vasculature. A venous embolus (mostly from
1847:
782:
408:
Thrombi are classified into two major groups depending on their location and the relative amount of platelets and red blood cells. The two major groups are:
345:, tiny thrombi known as microclots can obstruct the flow of blood in the capillaries. This can cause a number of problems particularly affecting the
1840:
1772:
596:) occurs within vessels that have endothelial injuries, that creates disordered flow (turbulence) that can lead to the formation of thrombosis;
396:. They can restrict blood flow but usually do not block it entirely. They appear grey-red along with alternating light and dark lines (known as
1971:
641:
1042:"Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin"
1741:
1597:
1662:
Medcalf, R. (2011). "Plasminogen activation-based thrombolysis for ischaemic stroke: the diversity of targets may demand new approaches".
911:. Recent research indicates that tPA could have toxic effects in the central nervous system. In cases of severe stroke, tPA can cross the
2146:
2129:
1564:
1309:
507:. They can restrict blood flow but usually do not block it entirely. Mural thrombi are usually found in vessels already damaged by
1187:
2208:
2160:
1763:
951:
Thrombus formation can have one of four outcomes: propagation, embolization, dissolution, and organization and recanalization.
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to restore the level of clotting factors in the blood, as well as platelets and heparin to prevent further thrombi formation.
1927:
205:
2214:
2200:
2188:
2151:
2021:
1012:
904:
150:
1240:"Anatomical and Pathological Observation and Analysis of SARS and COVID-19: Microthrombosis Is the Main Cause of Death"
2341:
1917:
1133:
Karaolanis G, Moris D, Bakoyiannis C, Tsilimigras DI, Palla VV, Spartalis E, Schizas D, Georgopoulos S (August 2017).
868:
457:, resulting from reduced oxygen supply. Microclots have been found to be a characteristic feature in severe cases of
2296:
2141:
357:
resulting from reduced oxygen supply. Microclots have been found to be a characteristic feature in severe cases of
1615:"TPA modulation of the blood–brain barrier: A unifying explanation for the pleiotropic effects of tPA in the CNS?"
535:
2412:
1983:
1964:
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474:
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2125:
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154:
2165:
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2372:
599:
Common causes of stasis include anything that leads to prolonged immobility and reduced blood flow such as:
118:
2286:
2261:
2219:
823:
726:
400:) which represent bands of white blood cells and red blood cells (darker) entrapped in layers of fibrin.
2281:
2271:
2089:
924:
867:, an enzyme that acts by inactivating thrombin and factor Xa. In contrast, warfarin works by inhibiting
840:
722:
718:
27:
2037:
1932:
1922:
1135:"A critical reappraisal of the treatment modalities of normal appearing thoracic aorta mural thrombi"
962:
900:
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and clotting factors. The result is hemorrhaging and ischemic necrosis of tissue/organs. Causes are
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1942:
1815:
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827:
710:
673:
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Pretorius E, Vlok M, Venter C, Bezuidenhout JA, Laubscher GJ, Steenkamp J, Kell DB (August 2021).
2402:
2084:
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1279:
844:
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523:) which represent bands of white blood cells and red blood cells (darker) entrapped in layers of
454:
446:
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110:
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2016:
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903:. However, streptokinase causes systemic fibrinolytic state and can lead to bleeding problems.
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Composition of a fresh thrombus at microscopy, showing nuclear debris in a background of
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Singh, Davinder P.; Basit, Hajira; Malik, Ahmad; Mahajan, Kunal (5 November 2021).
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There are also some anticoagulants that come from animals that work by dissolving
773:
729:), and genetic or disease-related deficiencies in the blood's clotting abilities.
1411:
709:
Some of the conditions which increase the risk of blood clots developing include
565:(interior surface of blood vessel), causing platelet activation and aggregation;
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2047:
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857:
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653:
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562:
500:
435:
389:
342:
263:
172:
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Budzynski, A. Z. (1991). "Interaction of hementin with fibrinogen and fibrin".
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2011:
1993:
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38:
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are drugs used to prevent the formation of blood clots, reducing the risk of
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Illustration comparing normal artery with diseased artery with a blood clot.
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1459:
Furie, Bruce; Furie, Barbara (2008). "Mechanisms of
Thrombus Formation".
936:
895:, is one of the oldest thrombolytic drugs. This drug can be administered
852:
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628:
581:
487:, often as a result of blood stasis. They are most commonly found in the
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259:
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165:
34:
1788:
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Kushner, Abigail; West, William P.; Pillarisetty, Leela
Sharath (2020),
2377:
2336:
908:
848:
185:
106:
1395:"Hypercoagulability and thrombotic complications in hemolytic anemias"
635:) – prevents Factor V inactivation leading to increased coagulability.
2321:
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Microclots can cause a number of problems particularly affecting the
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intended to stop and prevent further bleeding, but can be harmful in
319:
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132:
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from broken bones, or other severe traumas. DIC may also be seen in
226:, regular exercise, improved blood flow, management of comorbidities
932:
768:
showing a thrombus (center of image) within a blood vessel of the
700:
683:
534:
488:
421:
or red thrombi (characterized by predominance of red blood cells).
377:
514:
A mural thrombus can affect any heart chamber. When found in the
1555:
Whalen, Karen; Finkel, Richard S.; Panavelil, Thomas A. (2015).
1337:"Venous thromboembolism (VTE) | McMaster Pathophysiology Review"
1336:
863:
Heparin works by binding to and activating the enzyme inhibitor
450:
350:
314:
protein. The substance making up a thrombus is sometimes called
73:
1836:
788:
Illustration depicting thrombus formation over arterial plaque.
1188:"Thrombus Formation – Virchow's triad & Types of Thrombi"
620:; any disorder of the blood that predisposes to thrombosis);
434:
consisting of the very small and smallest blood vessels, the
415:
or white thrombi (characterized by predominance of platelets)
368:
Mural thrombi are thrombi that adhere to the wall of a large
745:, a protein normally circulating within the vessels, to the
737:
Platelet activation occurs through injuries that damage the
341:
consisting of the very small and smallest blood vessels the
883:
Once clots have formed, other drugs can be used to promote
479:
Mural thrombi form and adhere on the inner wall of a large
26:"Clot" and "Blood clot" redirect here. For other uses, see
1613:
Fredriksson, L.; Lawrence, D. A.; Medcalf, R. L. (2016).
980:
Organization and recanalization involves the ingrowth of
1590:
Anatomy & Physiology: The Unity of Form and
Function
72:
Diagram of a thrombus (blood clot) that has blocked a
326:, when a clot obstructs blood flow through a healthy
302:. There are two components to a thrombus: aggregated
1778:
1592:(6th ed.). New York: McGraw-Hill. p. 710.
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1992:
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Muscle
Relaxing Drugs Can Reduce Lethal Blood Clots
269:
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117:
91:
79:
54:
49:
1736:(8th ed.). Philadelphia: Saunders/Elsevier.
1499:Harter, K.; Levine, M.; Henderson, S. O. (2015).
741:of the blood vessels, exposing the enzyme called
164:injury to the artery, sepsis or viral infection,
1302:Robbins & Cotran Pathologic Basis of Disease
1369:, Treasure Island (FL): StatPearls Publishing,
1559:(6th ed.). Philadelphia: Wolters Kluwer.
1300:Kumar, Vinay; Abbas, Abul; Aster, Jon (2014).
1848:
1773:Air Pollution Triggers Blood Clots – US Study
310:that form a plug, and a mesh of cross-linked
8:
1557:Lippincott Illustrated Reviews: Pharmacology
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1501:"Anticoagulation Drug Therapy: A Review"
1304:(9th ed.). Philadelphia: Elsevier.
1095:
1093:
1091:
1089:
1087:
1029:
755:
725:), extended periods of inactivity (see
1214:"Medical Definition of micro thrombus"
642:Disseminated intravascular coagulation
376:. They are most commonly found in the
318:. A thrombus is a healthy response to
1619:Seminars in Thrombosis and Hemostasis
1550:
1548:
1546:
1544:
717:), heart valve replacement, a recent
113:), and swelling in the arm and/or leg
7:
1699:Blood Coagulation & Fibrinolysis
1331:
1329:
1295:
1293:
1182:
1180:
1461:The New England Journal of Medicine
284:
1732:Kumar, Vinay; et al. (2007).
648:using all of the body's available
561:Endothelial injury: Injury to the
14:
2209:platelet storage pool deficiency
2161:Heparin-induced thrombocytopenia
1711:10.1097/00001721-199102000-00022
793:
781:
758:
672:. Treatment involves the use of
616:Hypercoagulability (also called
1238:Chen W, Pan JY (January 2021).
623:Common causes include: cancer (
495:in the body, more often in the
384:in the body, more often in the
1928:Activated protein C resistance
294:, is the final product of the
206:magnetic resonance angiography
19:For the sea sponge genus, see
1:
1517:10.5811/westjem.2014.12.22933
2022:Trousseau sign of malignancy
1588:Saladin, Kenneth S. (2012).
1446:Human Anatomy and Physiology
1412:10.3324/haematol.2009.013672
1244:Biological Procedures Online
1013:National Blood Clot Alliance
972:Dissolution occurs when the
935:, produces an enzyme called
905:Tissue plasminogen activator
151:Superficial thrombophlebitis
2342:Nonthrombocytopenic purpura
1918:Antithrombin III deficiency
899:to dissolve blood clots in
869:vitamin K epoxide reductase
705:Mechanism of blood clotting
123:bleeding risks from taking
2491:
2297:Congenital afibrinogenemia
2201:Glanzmann's thrombasthenia
1676:10.2174/138945011797635885
1257:10.1186/s12575-021-00142-y
1059:10.1186/s12933-021-01359-7
817:
472:
32:
25:
18:
2413:Gastrointestinal bleeding
2215:Hermansky–Pudlak syndrome
1984:Antiphospholipid syndrome
1965:Essential thrombocythemia
1875:
1448:(11th ed.). Pearson.
977:has been fully developed.
475:Left ventricular thrombus
290:), colloquially called a
273:100,000–300,000 each year
71:
62:
2383:Subconjunctival bleeding
2189:Bernard–Soulier syndrome
2152:Upshaw–Schulman syndrome
2126:Thrombocytopenic purpura
1955:Sticky platelet syndrome
1393:Ataga KI (10 May 2020).
891:, an enzyme produced by
499:, and less often in the
388:, and less often in the
245:, unfractionated heparin
155:thrombophlebitis migrans
33:Not to be confused with
2373:Intracranial hemorrhage
1734:Robbins Basic Pathology
1218:www.merriam-webster.com
1152:10.21037/atm.2017.05.15
974:fibrinolytic mechanisms
568:Common causes include:
557:of thrombus formation:
2287:Factor XIII deficiency
2267:Hypoprothrombinemia/II
2262:von Willebrand disease
2220:Gray platelet syndrome
1631:10.1055/s-0036-1586229
1009:(the tendency to clot)
893:streptococcal bacteria
824:Thrombosis prophylaxis
727:deep venous thrombosis
706:
690:
540:
127:, breathing problems,
105:, cramp-like feeling,
2282:Factor XII deficiency
2272:Factor VII deficiency
2090:Renal vein thrombosis
1473:10.1056/NEJMra0801082
925:Haementeria ghilianii
723:myocardial infarction
704:
687:
538:
473:Further information:
28:Clot (disambiguation)
2038:Deep vein thrombosis
1933:Protein S deficiency
1923:Protein C deficiency
1664:Current Drug Targets
963:deep vein thrombosis
875:(PT), respectively.
2277:Factor X deficiency
2166:May–Hegglin anomaly
1943:Prothrombin G20210A
1343:. 26 September 2012
1046:Cardiovasc Diabetol
913:blood–brain barrier
887:or clot breakdown.
858:coagulation cascade
828:Reperfusion therapy
711:atrial fibrillation
674:fresh frozen plasma
2403:Pulmonary hematoma
2310:Signs and symptoms
2085:Pulmonary embolism
1890:Bleeding diathesis
1766:2009-02-04 at the
1444:Marieb, Elaina N.
1192:Thrombosis Adviser
845:pulmonary embolism
715:cardiac arrhythmia
707:
691:
541:
455:respiratory system
355:respiratory system
332:circulatory system
2457:
2456:
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2292:Dysfibrinogenemia
2176:Platelet function
2098:
2097:
1977:Purpura fulminans
1830:
1829:
1743:978-1-4160-2973-1
1670:(12): 1772–1781.
1599:978-0-07-337825-1
1405:(11): 1481–1484.
1341:www.pathophys.org
751:thromboregulation
721:(also known as a
296:blood coagulation
277:
276:
224:smoking cessation
201:Diagnostic method
97:abrupt change in
44:Medical condition
21:Thrombus (sponge)
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2118:Thrombocytopenia
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2063:Lowenberg's sign
1913:Clotting factors
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901:coronary vessels
873:prothrombin time
865:antithrombin III
797:
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689:both directions.
670:pregnant females
497:descending aorta
432:microcirculation
386:descending aorta
339:microcirculation
286:
86:Vascular surgery
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2398:Hemopericardium
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2232:Clotting factor
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2043:Bancroft's sign
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2017:Virchow's triad
1988:
1938:Factor V Leiden
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1768:Wayback Machine
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1007:Thrombogenicity
1003:
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941:salivary glands
922:. For example,
881:
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818:Main articles:
816:
809:
806:red blood cells
798:
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680:Pathophysiology
664:, snake bites,
551:Virchow's triad
545:Virchow's triad
533:
509:atherosclerosis
505:abdominal aorta
477:
471:
440:ischemic events
428:
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394:abdominal aorta
308:red blood cells
194:physical trauma
178:hospitalization
109:, passing out (
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2356:
2354:
2350:
2349:
2347:
2346:
2345:
2344:
2334:
2329:
2324:
2319:
2313:
2311:
2307:
2306:
2303:
2302:
2300:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2264:
2259:
2258:
2257:
2252:
2247:
2236:
2234:
2228:
2227:
2225:
2224:
2223:
2222:
2217:
2205:
2204:
2203:
2193:
2192:
2191:
2180:
2178:
2172:
2171:
2169:
2168:
2163:
2157:
2156:
2155:
2154:
2149:
2139:
2138:
2137:
2135:Evans syndrome
2122:
2120:
2111:
2104:
2100:
2099:
2096:
2095:
2093:
2092:
2087:
2082:
2081:
2080:
2075:
2070:
2068:Peabody's sign
2065:
2060:
2055:
2050:
2045:
2034:
2032:
2028:
2027:
2025:
2024:
2019:
2014:
2009:
2004:
1998:
1996:
1990:
1989:
1987:
1986:
1981:
1980:
1979:
1969:
1968:
1967:
1962:
1960:Thrombocytosis
1957:
1947:
1946:
1945:
1940:
1935:
1930:
1925:
1920:
1909:
1907:
1900:
1896:
1895:
1893:
1892:
1887:
1882:
1876:
1873:
1872:
1862:
1860:
1859:
1852:
1845:
1837:
1828:
1827:
1824:
1823:
1808:
1792:
1787:
1786:
1784:
1783:Classification
1777:
1776:
1770:
1756:
1755:External links
1753:
1750:
1749:
1742:
1724:
1689:
1654:
1625:(2): 154–168.
1605:
1598:
1580:
1565:
1540:
1486:
1451:
1436:
1385:
1353:
1325:
1310:
1289:
1230:
1205:
1176:
1139:Ann Transl Med
1122:
1083:
1028:
1027:
1025:
1022:
1021:
1020:
1015:
1010:
1002:
999:
998:
997:
978:
970:
956:
948:
945:
880:
877:
833:Anticoagulants
815:
812:
811:
810:
799:
792:
790:
787:
780:
778:
764:
757:
734:
731:
681:
678:
639:
638:
637:
636:
614:
613:
612:
587:
586:
585:
553:describes the
532:
529:
516:left ventricle
491:, the largest
470:
467:
427:
424:
423:
422:
416:
405:
404:Classification
402:
380:, the largest
275:
274:
271:
267:
266:
253:
247:
246:
235:Anticoagulants
232:
228:
227:
221:
217:
216:
203:
197:
196:
175:
169:
168:
162:
158:
157:
148:
144:
143:
140:
136:
135:
125:anticoagulants
121:
115:
114:
95:
89:
88:
83:
77:
76:
69:
68:
60:
59:
56:
52:
51:
43:
15:
13:
10:
9:
6:
4:
3:
2:
2487:
2476:
2473:
2471:
2468:
2467:
2465:
2444:
2441:
2440:
2438:
2434:
2433:Hematosalpinx
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2410:
2408:
2404:
2401:
2399:
2396:
2394:
2391:
2390:
2388:
2384:
2381:
2379:
2376:
2374:
2371:
2369:
2366:
2364:
2361:
2360:
2358:
2357:
2355:
2351:
2343:
2340:
2339:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2318:
2315:
2314:
2312:
2308:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2256:
2253:
2251:
2248:
2246:
2243:
2242:
2241:
2238:
2237:
2235:
2233:
2229:
2221:
2218:
2216:
2213:
2212:
2211:
2210:
2206:
2202:
2199:
2198:
2197:
2194:
2190:
2187:
2186:
2185:
2182:
2181:
2179:
2177:
2173:
2167:
2164:
2162:
2159:
2158:
2153:
2150:
2148:
2145:
2144:
2143:
2140:
2136:
2133:
2132:
2131:
2127:
2124:
2123:
2121:
2119:
2115:
2112:
2108:
2105:
2101:
2091:
2088:
2086:
2083:
2079:
2076:
2074:
2071:
2069:
2066:
2064:
2061:
2059:
2058:Louvel's sign
2056:
2054:
2053:Lisker's sign
2051:
2049:
2046:
2044:
2041:
2040:
2039:
2036:
2035:
2033:
2029:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2002:Thrombophilia
2000:
1999:
1997:
1995:
1991:
1985:
1982:
1978:
1975:
1974:
1973:
1970:
1966:
1963:
1961:
1958:
1956:
1953:
1952:
1951:
1948:
1944:
1941:
1939:
1936:
1934:
1931:
1929:
1926:
1924:
1921:
1919:
1916:
1915:
1914:
1911:
1910:
1908:
1904:
1901:
1897:
1891:
1888:
1886:
1883:
1881:
1878:
1877:
1874:
1870:
1866:
1863:Disorders of
1858:
1853:
1851:
1846:
1844:
1839:
1838:
1835:
1822:
1818:
1817:
1813:
1809:
1807:
1803:
1802:
1798:
1794:
1793:
1790:
1785:
1781:
1774:
1771:
1769:
1765:
1762:
1759:
1758:
1754:
1745:
1739:
1735:
1728:
1725:
1720:
1716:
1712:
1708:
1705:(1): 149–52.
1704:
1700:
1693:
1690:
1685:
1681:
1677:
1673:
1669:
1665:
1658:
1655:
1650:
1646:
1641:
1636:
1632:
1628:
1624:
1620:
1616:
1609:
1606:
1601:
1595:
1591:
1584:
1581:
1576:
1572:
1568:
1566:9781451191776
1562:
1558:
1551:
1549:
1547:
1545:
1541:
1536:
1532:
1527:
1522:
1518:
1514:
1510:
1506:
1502:
1495:
1493:
1491:
1487:
1482:
1478:
1474:
1470:
1467:(9): 938–49.
1466:
1462:
1455:
1452:
1447:
1440:
1437:
1432:
1428:
1423:
1418:
1413:
1408:
1404:
1400:
1399:Haematologica
1396:
1389:
1386:
1376:
1372:
1368:
1364:
1357:
1354:
1342:
1338:
1332:
1330:
1326:
1321:
1317:
1313:
1311:9781455726134
1307:
1303:
1296:
1294:
1290:
1285:
1281:
1277:
1273:
1268:
1263:
1258:
1253:
1249:
1245:
1241:
1234:
1231:
1219:
1215:
1209:
1206:
1193:
1189:
1183:
1181:
1177:
1172:
1168:
1163:
1158:
1153:
1148:
1144:
1140:
1136:
1129:
1127:
1123:
1111:
1107:
1103:
1096:
1094:
1092:
1090:
1088:
1084:
1079:
1075:
1070:
1065:
1060:
1055:
1051:
1047:
1043:
1036:
1034:
1030:
1023:
1019:
1016:
1014:
1011:
1008:
1005:
1004:
1000:
995:
991:
987:
983:
982:smooth muscle
979:
975:
971:
968:
964:
960:
957:
954:
953:
952:
946:
944:
942:
938:
934:
931:
927:
926:
921:
916:
914:
910:
906:
902:
898:
897:intravenously
894:
890:
889:Streptokinase
886:
878:
876:
874:
870:
866:
861:
859:
854:
850:
846:
842:
838:
834:
829:
825:
821:
813:
807:
803:
796:
791:
784:
779:
775:
774:H&E stain
771:
767:
761:
756:
754:
752:
748:
747:tissue factor
744:
740:
732:
730:
728:
724:
720:
716:
712:
703:
699:
697:
686:
679:
677:
675:
671:
667:
663:
659:
655:
651:
647:
643:
634:
630:
626:
622:
621:
619:
618:thrombophilia
615:
610:
607:and extended
606:
602:
598:
597:
595:
591:
588:
583:
579:
575:
571:
567:
566:
564:
560:
559:
558:
556:
552:
548:
546:
537:
530:
528:
526:
522:
521:lines of Zahn
517:
512:
510:
506:
502:
498:
494:
490:
486:
485:heart chamber
482:
476:
469:Mural thrombi
468:
466:
464:
460:
456:
452:
448:
443:
441:
437:
433:
425:
420:
417:
414:
411:
410:
409:
403:
401:
399:
398:lines of Zahn
395:
391:
387:
383:
379:
375:
374:heart chamber
371:
366:
364:
360:
356:
352:
348:
344:
340:
335:
333:
329:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
282:
272:
268:
265:
261:
257:
254:
252:
248:
244:
240:
236:
233:
229:
225:
222:
218:
215:
211:
207:
204:
202:
198:
195:
191:
187:
183:
179:
176:
174:
170:
167:
163:
159:
156:
152:
149:
145:
142:c. 3–6 months
141:
137:
134:
130:
129:heart attacks
126:
122:
120:
119:Complications
116:
112:
108:
104:
100:
99:mental status
96:
94:
90:
87:
84:
82:
78:
75:
70:
66:
61:
57:
53:
48:
40:
36:
29:
22:
2443:Hemarthrosis
2207:
2195:
2183:
2073:Pratt's sign
2006:
1885:coagulopathy
1810:
1795:
1733:
1727:
1702:
1698:
1692:
1667:
1663:
1657:
1622:
1618:
1608:
1589:
1583:
1556:
1511:(1): 11–17.
1508:
1504:
1464:
1460:
1454:
1445:
1439:
1402:
1398:
1388:
1378:, retrieved
1366:
1356:
1345:. Retrieved
1340:
1301:
1247:
1243:
1233:
1221:. Retrieved
1217:
1208:
1196:. Retrieved
1191:
1142:
1138:
1113:. Retrieved
1049:
1045:
959:Embolization
950:
923:
917:
885:thrombolysis
882:
862:
841:heart attack
831:
820:Thrombolysis
736:
719:heart attack
708:
692:
646:fibrinolysis
640:
605:broken bones
578:hypertension
555:pathogenesis
549:
542:
513:
481:blood vessel
478:
444:
429:
407:
370:blood vessel
367:
336:
328:blood vessel
315:
291:
287:
280:
278:
173:Risk factors
2196:aggregation
2078:Rose's sign
2048:Homans sign
1880:Coagulation
1223:22 February
1145:(15): 306.
1115:11 February
990:endothelium
986:fibroblasts
967:lower limbs
739:endothelium
713:(a form of
654:septicaemia
594:tachycardia
590:Hemodynamic
563:endothelium
501:aortic arch
436:capillaries
390:aortic arch
343:capillaries
264:rivaroxaban
55:Other names
2470:Hematology
2464:Categories
2428:Hematocele
2393:Hemothorax
2368:Hemoptysis
2240:Hemophilia
2012:Thrombosis
1380:2020-06-18
1367:StatPearls
1347:2018-11-03
1194:. Bayer AG
1052:(1): 172.
1024:References
1018:Hemorrhoid
814:Prevention
766:Micrograph
743:factor VII
666:fat emboli
631:mutation (
609:air travel
463:long COVID
426:Microclots
363:long COVID
324:thrombosis
300:hemostasis
292:blood clot
251:Medication
243:tinzaparin
220:Prevention
214:venography
210:ultrasound
182:immobility
166:immobility
103:chest pain
74:vein valve
58:Blood clot
39:Thrombosis
16:Blood clot
2418:Hemobilia
2363:Epistaxis
1950:Platelets
1575:881019575
1320:879416939
1284:255608747
992:into the
947:Prognosis
939:from its
879:Treatment
733:Formation
658:leukaemia
650:platelets
625:leukaemia
461:, and in
304:platelets
231:Treatment
190:pregnancy
81:Specialty
2475:Ischemia
2409:abdomen
2332:Petechia
2327:Hematoma
2317:Bleeding
2184:adhesion
2110:By cause
2103:Bleeding
2007:Thrombus
1906:By cause
1899:Clotting
1869:clotting
1865:bleeding
1764:Archived
1684:21707475
1649:27677179
1535:25671002
1481:18753650
1431:19880774
1375:30969519
1276:33472576
1250:(1): 4.
1198:20 March
1171:28856146
1110:30484999
1078:34425843
1001:See also
937:hementin
853:warfarin
770:placenta
656:, acute
629:factor V
582:atheroma
459:COVID-19
413:Arterial
359:COVID-19
298:step in
281:thrombus
260:edoxaban
256:apixaban
239:edoxaban
139:Duration
93:Symptoms
50:Thrombus
35:Embolism
2378:Hyphema
2353:By site
2337:Purpura
2031:By site
1719:1772982
1640:5848490
1526:4307693
1422:2770956
1267:7816139
1162:5555985
1069:8381139
984:cells,
965:in the
909:plasmin
849:Heparin
696:embolus
574:smoking
453:of the
449:in the
447:alveoli
430:In the
361:and in
353:of the
349:in the
347:alveoli
337:In the
330:in the
288:thrombi
186:obesity
111:syncope
107:fatigue
2439:joint
2389:torso
2322:Bruise
2245:A/VIII
1740:
1717:
1682:
1647:
1637:
1596:
1573:
1563:
1533:
1523:
1479:
1429:
1419:
1373:
1318:
1308:
1282:
1274:
1264:
1169:
1159:
1108:
1076:
1066:
994:fibrin
930:Amazon
920:fibrin
837:stroke
826:, and
802:fibrin
633:Leiden
601:trauma
570:trauma
525:fibrin
493:artery
419:Venous
382:artery
320:injury
312:fibrin
270:Deaths
262:, and
212:, and
161:Causes
133:stroke
2359:head
1994:Clots
1806:Xxx.x
1280:S2CID
933:leech
928:, an
662:shock
531:Cause
489:aorta
451:lungs
378:aorta
351:lungs
316:cruor
147:Types
2255:C/XI
2250:B/IX
1867:and
1816:9-CM
1738:ISBN
1715:PMID
1680:PMID
1645:PMID
1594:ISBN
1571:OCLC
1561:ISBN
1531:PMID
1477:PMID
1427:PMID
1371:PMID
1316:OCLC
1306:ISBN
1272:PMID
1225:2023
1200:2020
1167:PMID
1117:2022
1106:PMID
1074:PMID
988:and
851:and
843:and
804:and
306:and
153:and
2147:TTP
2130:ITP
1972:DIC
1821:xxx
1812:ICD
1797:ICD
1707:doi
1672:doi
1635:PMC
1627:doi
1521:PMC
1513:doi
1469:doi
1465:359
1417:PMC
1407:doi
1262:PMC
1252:doi
1157:PMC
1147:doi
1064:PMC
1054:doi
627:),
503:or
483:or
392:or
372:or
285:pl.
37:or
2466::
2142:TM
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