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has its own specific chemical messenger, which are collectively referred to as acrasins. These chemicals signal that many individual cells aggregate to form a single large cell or
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60:, can be purified by inhibiting the acrasin-degrading enzyme acrasinase with alcohol, extracting with alcohol and separating with column chromatography.
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Brian
Shaffer was the first to purify acrasin, now known to be cyclic AMP, in 1954, using methanol. Glorin, the acrasin of
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Evidence for the formation of cell aggregates by chemotaxis in the development of the slime mold
Dictyostelium discoideum
138:. Mulligan, Pamela Khipple, 1953-, Stansfield, William D., 1930- (8th ed.). New York: Oxford University Press.
44:, who seduced men against their will and then transformed them into beasts. Acrasia is itself a play on the Greek
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by Brian
Shaffer, which exhibits a complex swirling-pulsating spiral pattern when forming a pseudoplasmodium.
77:- J.T.Bonner and L.J.Savage Journal of Experimental Biology Vol. 106, pp. 1, October (1947) Cell Biology
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Identification of a pterin as the acrasin of the cellular slime mold
Dictyostelium lacteum
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259:"Chemical identity of the acrasin of the cellular slime mold Polysphondylium violaceum"
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Heftmann, Erich; Wright, Barbara E.; Liddel, Gerald U. (December 1959).
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United States Vol. 79, pp. 6270–6274, October (1982) Cell
Biology
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Aggregation in cellular slime moulds: in vitro isolation of acrasin
220:"Identification of a Sterol with Acrasin Activity in a Slime Mold"
87:- B.M.Shaffer Nature Vol. 79, pp. 975, (1953) Cell Biology
37:
The term acrasin was descriptively named after
Acrasia from
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Shimomura, O.; Suthers, H. L.; Bonner, J. T. (1982-12-01).
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Shaffer, B. M. (1956-06-29). "Properties of acrasin".
24:. One of the earliest acrasins to be identified was
263:Proceedings of the National Academy of Sciences
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224:Journal of the American Chemical Society
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48:that describes loss of free will.
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189:10.1126/science.123.3209.1172
99:National Academy of Sciences
113:Smithsonian Magazine Online
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136:A dictionary of genetics
134:King, Robert C. (2013).
31:Dictyostelium discoideum
284:10.1073/pnas.79.23.7376
28:, found in the species
97:- Proceedings of the
109:Hunting Slime Moulds
275:1982PNAS...79.7376S
236:10.1021/ja01533a054
181:1956Sci...123.1172S
175:(3209): 1172–1173.
269:(23): 7376–7379.
230:(24): 6525–6526.
145:978-0-19-937686-5
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121:References
52:Extraction
26:cyclic AMP
22:plasmodium
18:slime mold
293:0027-8424
244:0002-7863
197:0036-8075
154:871046520
325:Category
205:13337336
311:6961416
271:Bibcode
177:Bibcode
169:Science
46:akrasia
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115:(2001)
64:Notes
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