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by yeast and suggested in 1892 that a substance in the yeast might be responsible for speeding up the reaction. This was the first time enzymes were suggested as separate entities from organisms and talked about in chemical terms. He later studied the enzyme responsible and made the striking
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suggestion that the kinetics he observed were the result of an enzyme-substrate complex being formed during the reaction, a concept that has formed the basis of all later work on enzyme kinetics. Similar ideas had been put earlier by German chemist and Nobel laureate
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Medical School. In 1873 he returned to Burton to work as a chemist in the brewing industry for the next twenty-five years. In 1899 he left to become
Professor of Brewing and Malting at
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He was born at Burton-on-Trent, Staffordshire to Edwin Brown, a bank manager in the town. His elder brother was
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New Beer in an Old Bottle: Eduard
Buchner and the Growth of Biochemical Knowledge
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Knecht, E.; Thorpe, T. E.; Trigger, O.; Robertson, R. (1922).
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Mason
University College, now the University of Birmingham
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by comparing substrate and enzyme with a key and a lock.
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
