72:
96:
All of the tumors are unencapsulated, but are usually well defined or circumscribed. The overlying surface epithelium is not involved. The tumor shows a dual or biphasic appearance, with glandular or cystic spaces showing inner luminal secretory cells with abundant granular, eosinophilic cytoplasm
179:
The major diagnosis from which to separate ceruminous adenoma is ceruminous adenocarcinoma, which shows an infiltrative growth, pleomorphism, mitoses, necrosis, and lacks ceroid pigment granules. Other tumors which need to be excluded include a neuroendocrine adenoma of the middle ear (middle ear
62:
Ceruminous adenoma are rare tumors, accounting for less than 1% of all external ear tumors. The patients will present with a mass, perhaps associated pain, and may have changes in hearing (usually a sensorineural or a conductive hearing loss). Some patients have tinnitus. Nerve paralysis is very
53:
located within the external auditory canal. These glands are found within the outer one third to one half of the external auditory canal, more common along the posterior surface; therefore, the tumor develops within a very specific location.
391:
Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V (March–April 2008). "Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review".
196:
Patients treated with complete surgical excision can expect an excellent long term outcome without any problems. Recurrences may be seen in tumors which are incompletely excised.
592:
204:
While there is a wide age range at clinical presentation (12–85 years), most patients come to clinical attention at 55 years (mean). There is no gender difference.
78:
stained slides shows a biphasic glandular proliferation with inner apocrine cells and basal myoepithelial cells, separated by fibrous connective tissue stroma.
82:
The tumors are usually small, with a mean size of about 1.2 cm. The tumors are separated into three histologic types based on the dominant findings:
585:
970:
562:
278:
Thompson LD, Nelson BL, Barnes EL (Mar 2004). "Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature".
965:
942:
847:
578:
927:
899:
894:
694:
857:
960:
862:
516:
Lassaletta L, Patrón M, Olóriz J, Pérez R, Gavilán J (Aug 2003). "Avoiding misdiagnosis in ceruminous gland tumours".
132:
852:
1013:
639:
992:
797:
709:
777:
837:
937:
889:
802:
699:
664:
75:
71:
728:
674:
124:
477:"Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature"
348:
Hicks GW (Mar 1983). "Tumors arising from the glandular structures of the external auditory canal".
128:
782:
724:
654:
631:
745:
373:
303:
98:
909:
842:
787:
687:
644:
558:
533:
498:
457:
408:
365:
330:
295:
237:
102:
50:
932:
879:
525:
488:
447:
439:
400:
357:
287:
229:
772:
764:
127:
can be performed to confirm the biphasic nature of the tumor. All cells are positive with
428:"Ceruminous gland carcinomas: a clinicopathologic and immunophenotypic study of 17 cases"
188:
The tumors are usually removed in small pieces due to the anatomic confines of the area.
220:
Mills RG, Douglas-Jones T, Williams RG (Mar 1995). "'Ceruminoma'--a defunct diagnosis".
984:
874:
714:
605:
452:
427:
136:
529:
1007:
904:
884:
869:
833:
649:
361:
291:
164:
152:
377:
307:
914:
704:
570:
160:
404:
741:
659:
622:
682:
493:
476:
443:
233:
168:
110:
952:
807:
792:
736:
140:
537:
502:
461:
412:
334:
299:
369:
241:
118:
106:
557:. Hagerstown, MD: Lippincott Williams & Wilkins. pp. 7:42–45.
114:
601:
113:-like (cerumen) pigment granules. There is no pleomorphic, limited
613:
159:
can be positive in either population. The cells are negative with
156:
148:
144:
70:
821:
574:
555:
Diagnostic
Pathology: Head and Neck: Published by Amirsys
426:
Crain N, Nelson BL, Barnes EL, Thompson LD (Mar 2009).
180:
adenoma), paraganglioma, and endolymphatic sac tumor.
109:) secretions and will also have yellow-brown, ceroid,
49:
is a benign glandular neoplasm which arises from the
983:
951:
820:
763:
723:
673:
630:
621:
612:
29:
24:
105:. The luminal cells will often have decapitation (
553:Lester D. R. Thompson; Bruce M. Wenig (2011).
586:
8:
321:Durko T, Danilewicz M, Pajor A (2003). "".
273:
271:
826:
627:
618:
593:
579:
571:
269:
267:
265:
263:
261:
259:
257:
255:
253:
251:
143:; only the basal cells are positive with
92:Ceruminous syringocystadenoma papilliferum
21:
492:
451:
212:
971:Folliculosebaceous-apocrine hamartoma
7:
966:Folliculosebaceous cystic hamartoma
848:Multiple familial trichoepithelioma
475:Torske KR, Thompson LD (May 2002).
101:at the periphery, adjacent to the
14:
928:Tumor of follicular infundibulum
900:Giant solitary trichoepithelioma
362:10.1288/00005537-198303000-00016
292:10.1097/00000478-200403000-00003
895:Proliferating trichilemmal cyst
695:Syringocystadenoma papilliferum
34:Adenoma of the ceruminous gland
858:Desmoplastic trichoepithelioma
89:Ceruminous pleomorphic adenoma
1:
961:Basaloid follicular hamartoma
863:Generalized trichoepithelioma
530:10.1016/S0385-8146(03)00055-5
405:10.1016/j.amjoto.2007.04.005
133:epithelial membrane antigen
1030:
853:Solitary trichoepithelioma
742:Hidradenoma or Acrospiroma
923:
829:
640:Papillary eccrine adenoma
494:10.1038/modpathol.3880561
444:10.1007/s12105-008-0095-9
234:10.1017/s0022215100129652
16:Tumor of the external ear
993:Neoplasms of the nailbed
798:Sebaceous nevus syndrome
710:Apocrine gland carcinoma
943:Birt–Hogg–Dubé syndrome
838:Malignant pilomatricoma
938:Perifollicular fibroma
890:Trichilemmal carcinoma
79:
803:Sebaceous hyperplasia
700:Papillary hidradenoma
665:Malignant acrospiroma
606:associated structures
76:Hematoxylin and eosin
74:
125:Immunohistochemistry
97:subtended by basal,
783:Sebaceous carcinoma
778:Muir–Torre syndrome
655:Syringofibroadenoma
135:; only the luminal
99:myoepithelial cells
751:Ceruminous adenoma
746:Hidradenocarcinoma
518:Auris Nasus Larynx
139:are positive with
86:Ceruminous adenoma
80:
67:Pathology findings
58:Signs and symptoms
47:ceruminous adenoma
25:Ceruminous adenoma
1001:
1000:
979:
978:
910:Trichofolliculoma
843:Trichoepithelioma
816:
815:
788:Sebaceous adenoma
759:
758:
688:Dermal cylindroma
645:Eccrine carcinoma
564:978-1-931884-61-7
103:basement membrane
51:ceruminous glands
43:
42:
19:Medical condition
1021:
1014:Benign neoplasms
933:Fibrofolliculoma
880:Fibrofolliculoma
827:
628:
619:
595:
588:
581:
572:
568:
542:
541:
513:
507:
506:
496:
472:
466:
465:
455:
432:Head Neck Pathol
423:
417:
416:
393:Am J Otolaryngol
388:
382:
381:
345:
339:
338:
318:
312:
311:
280:Am J Surg Pathol
275:
246:
245:
217:
22:
1029:
1028:
1024:
1023:
1022:
1020:
1019:
1018:
1004:
1003:
1002:
997:
975:
947:
919:
812:
773:Nevus sebaceous
765:Sebaceous gland
755:
719:
669:
608:
599:
565:
552:
550:
548:Further reading
545:
515:
514:
510:
474:
473:
469:
425:
424:
420:
390:
389:
385:
347:
346:
342:
323:Otolaryngol Pol
320:
319:
315:
277:
276:
249:
222:J Laryngol Otol
219:
218:
214:
210:
202:
194:
186:
177:
69:
60:
20:
17:
12:
11:
5:
1027:
1025:
1017:
1016:
1006:
1005:
999:
998:
996:
995:
989:
987:
981:
980:
977:
976:
974:
973:
968:
963:
957:
955:
949:
948:
946:
945:
940:
935:
930:
924:
921:
920:
918:
917:
912:
907:
902:
897:
892:
887:
882:
877:
875:Trichoblastoma
872:
867:
866:
865:
860:
855:
850:
840:
830:
824:
818:
817:
814:
813:
811:
810:
805:
800:
795:
790:
785:
780:
775:
769:
767:
761:
760:
757:
756:
754:
753:
748:
739:
733:
731:
721:
720:
718:
717:
715:Apocrine nevus
712:
707:
702:
697:
692:
691:
690:
679:
677:
671:
670:
668:
667:
662:
657:
652:
647:
642:
636:
634:
625:
616:
610:
609:
600:
598:
597:
590:
583:
575:
563:
549:
546:
544:
543:
508:
467:
418:
383:
340:
313:
247:
211:
209:
206:
201:
198:
193:
190:
185:
182:
176:
173:
129:pancytokeratin
94:
93:
90:
87:
68:
65:
59:
56:
41:
40:
31:
27:
26:
18:
15:
13:
10:
9:
6:
4:
3:
2:
1026:
1015:
1012:
1011:
1009:
994:
991:
990:
988:
986:
982:
972:
969:
967:
964:
962:
959:
958:
956:
954:
950:
944:
941:
939:
936:
934:
931:
929:
926:
925:
922:
916:
913:
911:
908:
906:
905:Trichoadenoma
903:
901:
898:
896:
893:
891:
888:
886:
885:Trichilemmoma
883:
881:
878:
876:
873:
871:
870:Trichodiscoma
868:
864:
861:
859:
856:
854:
851:
849:
846:
845:
844:
841:
839:
835:
834:Pilomatricoma
832:
831:
828:
825:
823:
819:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
770:
768:
766:
762:
752:
749:
747:
743:
740:
738:
735:
734:
732:
730:
726:
722:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
689:
686:
685:
684:
681:
680:
678:
676:
672:
666:
663:
661:
658:
656:
653:
651:
650:Eccrine nevus
648:
646:
643:
641:
638:
637:
635:
633:
629:
626:
624:
620:
617:
615:
611:
607:
603:
596:
591:
589:
584:
582:
577:
576:
573:
569:
566:
560:
556:
547:
539:
535:
531:
527:
524:(3): 287–90.
523:
519:
512:
509:
504:
500:
495:
490:
487:(5): 543–55.
486:
482:
478:
471:
468:
463:
459:
454:
449:
445:
441:
437:
433:
429:
422:
419:
414:
410:
406:
402:
398:
394:
387:
384:
379:
375:
371:
367:
363:
359:
356:(3): 326–40.
355:
351:
344:
341:
336:
332:
328:
324:
317:
314:
309:
305:
301:
297:
293:
289:
286:(3): 308–18.
285:
281:
274:
272:
270:
268:
266:
264:
262:
260:
258:
256:
254:
252:
248:
243:
239:
235:
231:
227:
223:
216:
213:
207:
205:
199:
197:
191:
189:
183:
181:
174:
172:
170:
166:
165:synaptophysin
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
120:
116:
112:
108:
104:
100:
91:
88:
85:
84:
83:
77:
73:
66:
64:
57:
55:
52:
48:
39:
35:
32:
28:
23:
915:Dilated pore
750:
705:Hidrocystoma
554:
551:
521:
517:
511:
484:
480:
470:
435:
431:
421:
399:(2): 142–6.
396:
392:
386:
353:
350:Laryngoscope
349:
343:
326:
322:
316:
283:
279:
228:(3): 180–8.
225:
221:
215:
203:
200:Epidemiology
195:
187:
178:
161:chromogranin
123:
95:
81:
61:
46:
44:
37:
33:
660:Spiradenoma
623:Sweat gland
438:(1): 1–17.
329:(1): 51–7.
30:Other names
683:Cylindroma
481:Mod Pathol
208:References
184:Management
111:lipofuscin
63:uncommon.
38:ceruminoma
953:Hamartoma
808:Mantleoma
793:Sebaceoma
737:Syringoma
192:Prognosis
175:Diagnosis
155:protein.
117:, and no
1008:Category
729:apocrine
675:Apocrine
538:12927294
503:12011260
462:20596983
413:18314029
378:31253554
335:12741144
308:27571673
300:15104293
119:necrosis
107:apocrine
725:Eccrine
632:Eccrine
453:2807538
370:6300574
242:7745330
115:mitoses
614:Glands
602:Tumors
561:
536:
501:
460:
450:
411:
376:
368:
333:
306:
298:
240:
985:Nails
374:S2CID
304:S2CID
157:CD117
145:CK5/6
137:cells
822:Hair
604:and
559:ISBN
534:PMID
499:PMID
458:PMID
409:PMID
366:PMID
331:PMID
296:PMID
238:PMID
169:CK20
167:and
153:S100
131:and
36:and
526:doi
489:doi
448:PMC
440:doi
401:doi
358:doi
288:doi
230:doi
226:109
149:p63
141:CK7
1010::
532:.
522:30
520:.
497:.
485:15
483:.
479:.
456:.
446:.
434:.
430:.
407:.
397:29
395:.
372:.
364:.
354:93
352:.
327:57
325:.
302:.
294:.
284:28
282:.
250:^
236:.
224:.
171:.
163:,
151:,
147:,
121:.
45:A
836:/
744:/
727:/
594:e
587:t
580:v
567:.
540:.
528::
505:.
491::
464:.
442::
436:3
415:.
403::
380:.
360::
337:.
310:.
290::
244:.
232::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
