57:
There are several different types of DMRs. These include tissue-specific DMR (tDMR), cancer-specific DMR (cDMR), development stages (dDMRs), reprogramming-specific DMR (rDMR), allele-specific DMR (AMR), and aging-specific DMR (aDMR). DNA methylation is associated with
34:
regulation. The biological samples can be different cells/tissues within the same individual, the same cell/tissue at different times, cells/tissues from different individuals, even different alleles in the same cell.
50:. The āpā refers to the phosphate linker between them. DMR usually involves adjacent sites or a group of sites close together that have different methylation patterns between samples.
59:
31:
54:
appear to be unmethylated in most of the normal tissues, however, are highly methylated in cancer tissues.
181:
30:
status across different biological samples and regarded as possible functional regions involved in
157:
119:
149:
109:
101:
140:; Dean, W; Walter, J (Aug 10, 2001). "Epigenetic reprogramming in mammalian development".
27:
114:
89:
175:
63:
51:
153:
137:
161:
123:
43:
39:
23:
16:
Genomic region methylated differently based on tissue, time or individual
47:
105:
90:"Epigenome-wide association studies for common human diseases"
88:
Rakyan, VK; Down, TA; Balding, DJ; Beck, S (12 July 2011).
8:
83:
81:
79:
113:
75:
7:
14:
20:Differentially methylated regions
38:DNA is mostly methylated at a
1:
198:
94:Nature Reviews. Genetics
154:10.1126/science.1063443
26:regions with different
60:cell differentiation
32:gene transcriptional
148:(5532): 1089ā93.
189:
166:
165:
134:
128:
127:
117:
85:
197:
196:
192:
191:
190:
188:
187:
186:
172:
171:
170:
169:
136:
135:
131:
106:10.1038/nrg3000
87:
86:
77:
72:
28:DNA methylation
17:
12:
11:
5:
195:
193:
185:
184:
174:
173:
168:
167:
129:
74:
73:
71:
68:
46:followed by a
15:
13:
10:
9:
6:
4:
3:
2:
194:
183:
180:
179:
177:
163:
159:
155:
151:
147:
143:
139:
133:
130:
125:
121:
116:
111:
107:
103:
100:(8): 529ā41.
99:
95:
91:
84:
82:
80:
76:
69:
67:
65:
64:proliferation
61:
55:
53:
49:
45:
42:, which is a
41:
36:
33:
29:
25:
21:
145:
141:
132:
97:
93:
56:
37:
19:
18:
182:Epigenetics
52:CpG islands
22:(DMRs) are
70:References
176:Category
162:11498579
124:21747404
44:cytosine
40:CpG site
142:Science
138:Reik, W
115:3508712
48:guanine
24:genomic
160:
122:
112:
158:PMID
120:PMID
62:and
150:doi
146:293
110:PMC
102:doi
178::
156:.
144:.
118:.
108:.
98:12
96:.
92:.
78:^
66:.
164:.
152::
126:.
104::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.