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Severe fever with thrombocytopenia syndrome

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In July 2017, Japanese doctors reported that a woman had died of SFTS after being bitten by a cat that may have itself been infected by a tick. The woman had no visible tick bites, leading doctors to believe that the cat — which died as well — was the transmission vector.
82:, first reported between late March and mid-July 2009 in rural areas of Hubei and Henan provinces in Central China. SFTS has fatality rates ranging from 12% to as high as 30% in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, 526: 511: 1070: 386: 580: 282: 573: 139:
SFTS occurs in China's rural areas from March to November with the majority of cases from April to July. In 2013, Japan and Korea also reported several cases with deaths.
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Yu, Xue-Jie; Liang, Mi-Fang; Zhang, Shou-Yin; Liu, Yan; Li, Jian-Dong; Sun, Yu-Lan; Zhang, Lihong; Zhang, Quan-Fu; Popov, Vsevolod L.; Li, Chuan; Qu, Jing (2011-04-21).
343: 566: 153:, more than 37 people were found with SFTS in Jiangsu province, while 23 more were found infected in Anhui province in August 2020. Seven people have died. 46: 443:
Lam, Tommy Tsan-Yuk; Liu, Wei; Bowden, Thomas A.; Cui, Ning; Zhuang, Lu; Liu, Kun; Zhang, Yao-Yun; Cao, Wu-Chun; Pybus, Oliver G. (March 2013).
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Liu, Yan; Li, Qun; Hu, Wanfu; Wu, Jiabin; Wang, Yubi; Mei, Ling; Walker, David H.; Ren, Jun; Wang, Yu (February 2012).
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vectors and animal hosts. Humans appear to be largely accidental hosts. SFTSV has been detected in
589: 62: 65:. Signs and symptoms include fever, vomiting, diarrhea, loss of consciousness and heamorrhage. 1080: 990: 969: 844: 627: 474: 311: 303: 262: 244: 200: 115:. Person-to-person transmission was not noted in early reports but has since been documented. 41: 976: 962: 869: 464: 456: 295: 252: 236: 87: 74: 742: 36:
SFTS bunyavirus isolated from patients in Central and Northeast provinces of China (red)
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The virus originated 50–150 years ago and has undergone a recent population expansion.
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In July 2013, South Korea reported a total of eight deaths since August 2012.
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Saijo, Masayuki (2019). "1. Introduction". In Saijo, Masayuki (ed.).
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Explained: What is the new tick-borne virus spreading across China?
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Seven dead, 60 infected by new infectious disease in China: Report
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Arthropod-borne viral fevers and viral haemorrhagic fevers
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Vector Borne and Zoonotic Diseases (Larchmont, N.Y.)
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Singapore: Springer. pp. 1–14. 149:In early 2020 an outbreak occurred in 850:Southern tick-associated rash illness 7: 218: 216: 173:(SFTSV) from SFTS patients’ blood. 94:(low white blood cell count), and 14: 109:(SFTSV) is a virus in the order 766:Crimean–Congo hemorrhagic fever 229:New England Journal of Medicine 776:Kemerovo tickborne viral fever 1: 680:Rocky Mountain spotted fever 461:10.1016/j.epidem.2012.09.002 96:elevated liver enzyme levels 711:Relapsing fever borreliosis 660:Spotted fever rickettsiosis 70:emerging infectious disease 1097: 433:, accessed 24 October 2020 417:, accessed 24 October 2020 701:Baggio–Yoshinari syndrome 125:Haemaphysalis longicornis 35: 26: 1045:Rhipicephalus sanguineus 670:American tick bite fever 665:Pacific Coast tick fever 806:Tick-borne encephalitis 781:Kyasanur Forest disease 941:Dermacentor variabilis 786:Omsk hemorrhagic fever 90:(low platelet count), 84:multiple organ failure 1076:Insect-borne diseases 934:Dermacentor andersoni 912:Amblyomma triguttatum 791:Powassan encephalitis 300:10.1089/vbz.2011.0758 241:10.1056/NEJMoa1010095 1027:Ornithodoros moubata 1013:Ornithodoros gurneyi 905:Amblyomma cajennense 898:Amblyomma americanum 816:Protozoan infections 801:Tete orthobunyavirus 771:Heartland bandavirus 641:Human monocytotropic 606:Bacterial infections 63:tick-borne infection 1020:Ornithodoros hermsi 761:Colorado tick fever 590:Tick-borne diseases 637:Human granulocytic 78:also known as the 47:Infectious disease 1058: 1057: 1054: 1053: 991:Ixodes scapularis 970:Ixodes holocyclus 879:Species and bites 858: 857: 845:Alpha-gal allergy 737: 736: 628:Boutonneuse fever 556: 555: 431:indianexpress.com 415:indianexpress.com 235:(16): 1523–1532. 206:978-981-13-9561-1 52: 51: 16:Medical condition 1088: 977:Ixodes pacificus 963:Ixodes cornuatus 883: 870:Tick infestation 743:Viral infections 611: 602: 592:and infestations 583: 576: 569: 560: 495: 483: 482: 472: 440: 434: 424: 418: 408: 402: 401: 399: 398: 383: 377: 376: 374: 373: 358: 352: 351: 346:. Archived from 340: 334: 333: 326: 320: 319: 285: 277: 271: 270: 260: 220: 211: 210: 190: 88:thrombocytopenia 75:Dabie bandavirus 31: 19: 1096: 1095: 1091: 1090: 1089: 1087: 1086: 1085: 1061: 1060: 1059: 1050: 1032: 996: 946: 917: 874: 854: 828: 810: 733: 715: 687: 593: 587: 557: 552: 551: 506: 492: 487: 486: 442: 441: 437: 425: 421: 413:15 August 2020 409: 405: 396: 394: 385: 384: 380: 371: 369: 360: 359: 355: 342: 341: 337: 328: 327: 323: 279: 278: 274: 222: 221: 214: 207: 192: 191: 184: 179: 167: 159: 137: 104: 17: 12: 11: 5: 1094: 1092: 1084: 1083: 1078: 1073: 1063: 1062: 1056: 1055: 1052: 1051: 1049: 1048: 1040: 1038: 1034: 1033: 1031: 1030: 1023: 1016: 1008: 1006: 998: 997: 995: 994: 987: 984:Ixodes ricinus 980: 973: 966: 958: 956: 948: 947: 945: 944: 937: 929: 927: 919: 918: 916: 915: 908: 901: 893: 891: 880: 876: 875: 873: 872: 866: 864: 860: 859: 856: 855: 853: 852: 847: 842: 840:Tick paralysis 836: 834: 833:Other diseases 830: 829: 827: 826: 820: 818: 812: 811: 809: 808: 803: 798: 793: 788: 783: 778: 773: 768: 763: 758: 753: 747: 745: 739: 738: 735: 734: 732: 731: 725: 723: 717: 716: 714: 713: 708: 703: 697: 695: 689: 688: 686: 685: 684: 683: 677: 675:rickettsialpox 672: 667: 657: 652: 630: 625: 619: 617: 608: 599: 595: 594: 588: 586: 585: 578: 571: 563: 554: 553: 550: 549: 538: 523: 507: 502: 501: 499: 498:Classification 491: 490:External links 488: 485: 484: 435: 429:7 August 2020 419: 403: 378: 353: 350:on 2013-07-05. 335: 321: 294:(2): 156–160. 272: 212: 205: 181: 180: 178: 175: 166: 163: 158: 155: 136: 133: 103: 100: 50: 49: 44: 38: 37: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 1093: 1082: 1079: 1077: 1074: 1072: 1069: 1068: 1066: 1047: 1046: 1042: 1041: 1039: 1035: 1029: 1028: 1024: 1022: 1021: 1017: 1015: 1014: 1010: 1009: 1007: 1005: 1004: 999: 993: 992: 988: 986: 985: 981: 979: 978: 974: 972: 971: 967: 965: 964: 960: 959: 957: 955: 954: 949: 943: 942: 938: 936: 935: 931: 930: 928: 926: 925: 920: 914: 913: 909: 907: 906: 902: 900: 899: 895: 894: 892: 890: 889: 884: 881: 877: 871: 868: 867: 865: 861: 851: 848: 846: 843: 841: 838: 837: 835: 831: 825: 822: 821: 819: 817: 813: 807: 804: 802: 799: 797: 794: 792: 789: 787: 784: 782: 779: 777: 774: 772: 769: 767: 764: 762: 759: 757: 756:Bourbon virus 754: 752: 749: 748: 746: 744: 740: 730: 727: 726: 724: 722: 721:Thiotrichales 718: 712: 709: 707: 704: 702: 699: 698: 696: 694: 690: 681: 678: 676: 673: 671: 668: 666: 663: 662: 661: 658: 656: 653: 650: 648: 642: 638: 634: 631: 629: 626: 624: 621: 620: 618: 616: 615:Rickettsiales 612: 609: 607: 603: 600: 596: 591: 584: 579: 577: 572: 570: 565: 564: 561: 548: 544: 543: 539: 537: 533: 532: 528: 524: 522: 518: 517: 513: 509: 508: 505: 500: 496: 489: 480: 476: 471: 466: 462: 458: 454: 450: 446: 439: 436: 432: 428: 423: 420: 416: 412: 407: 404: 392: 388: 382: 379: 367: 363: 357: 354: 349: 345: 339: 336: 331: 330:"Promed Post" 325: 322: 317: 313: 309: 305: 301: 297: 293: 289: 284: 276: 273: 268: 264: 259: 254: 250: 246: 242: 238: 234: 230: 226: 219: 217: 213: 208: 202: 198: 197: 189: 187: 183: 176: 174: 172: 164: 162: 156: 154: 152: 147: 143: 140: 134: 132: 130: 127: 126: 121: 116: 114: 113: 108: 101: 99: 97: 93: 89: 85: 81: 77: 76: 71: 66: 64: 60: 56: 48: 45: 43: 39: 34: 30: 25: 20: 1043: 1025: 1018: 1011: 1003:Ornithodoros 1001: 989: 982: 975: 968: 961: 951: 939: 932: 922: 910: 903: 896: 886: 863:Infestations 795: 751:Bhanja virus 706:Lyme disease 655:Scrub typhus 646: 633:Ehrlichiosis 623:Anaplasmosis 540: 525: 510: 452: 448: 438: 430: 422: 414: 406: 395:. 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Index


Specialty
Infectious disease
tick-borne infection
emerging infectious disease
Dabie bandavirus
multiple organ failure
thrombocytopenia
leucopenia
elevated liver enzyme levels
SFTS virus
Bunyavirales
arthropod
Haemaphysalis longicornis
ticks
East China
SFTS virus


Severe Fever with Thrombocytopenia Syndrome
ISBN
978-981-13-9561-1


"Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China"
doi
10.1056/NEJMoa1010095
ISSN
0028-4793
PMC

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