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Estradiol/norethisterone

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Combination drug
Estradiol/norethisterone
Estradiol
Norethisterone
Combination of
EstradiolEstrogen
NorethisteroneProgestogen; Progestin
Clinical data
Other namesE2/NET; Netagen; Netagen 403
Routes of
administration		By mouth
Drug classEstrogen; Progestin; Progestogen
Legal status
Legal status
Identifiers
CAS Number

Estradiol/norethisterone (E2/NET), tentative brand name Netagen or Netagen 403, was a combination of estradiol (E2), an estrogen, and norethisterone (NET), a progestin, which was studied as a birth control pill to prevent pregnancy in women. It was taken by mouth and contained 4 mg micronized E2 and 3 mg NET per tablet. The medication was developed by Novo Pharmaceuticals in Denmark and was never marketed.

Two related formulations were Netagen 423 (4 mg estradiol, 2 mg estriol, 3 mg norethisterone) and Netasyn (50 ÎĽg ethinylestradiol, 3 mg norethisterone), were also studied but never marketed.

See also

References

  1. ^ Fruzzetti F, Bitzer J (January 2010). "Review of clinical experience with estradiol in combined oral contraceptives". Contraception. 81 (1): 8–15. doi:10.1016/j.contraception.2009.08.010. PMID 20004267.
  2. ^ Astedt B, Svanberg L, Jeppsson S, Liedholm P, Rannevik G (January 1977). "The natural oestrogenic hormone oestradiol as a new component of combined oral contraceptives". Br Med J. 1 (6056): 269. doi:10.1136/bmj.1.6056.269. PMC 1604185. PMID 319864.
  3. ^ Astedt B, Jeppsson S, Liedholm P, Rannevik G, Svanberg L (September 1979). "Clinical trial of a new oral contraceptive pill containing the natural oestrogen 17 beta-oestradiol". Br J Obstet Gynaecol. 86 (9): 732–6. doi:10.1111/j.1471-0528.1979.tb11276.x. PMID 387069. S2CID 72299078.
  4. ^ Samsioe G, Skryten A, Silfverstolpe G (1983). "Oral contraception with a nonalkylated estrogen component. Effects on lipid metabolism". Gynecol. Obstet. Invest. 15 (5): 275–82. doi:10.1159/000299421. PMID 6852647.
  5. Skouby SO, Jensen BM, KĂĽhl C, Mølsted-Pedersen L, Svenstrup B, Nielsen J (July 1985). "Hormonal contraception in diabetic women: acceptability and influence on diabetes control and ovarian function of a nonalkylated estrogen/progestogen compound". Contraception. 32 (1): 23–31. doi:10.1016/0010-7824(85)90113-1. PMID 4053603.


Related topics
Long-acting reversible
contraception (LARC)
Sterilization
Hormonal contraception
Combined
estrogen–progestogen
Progestogen-only
SERMs
Barrier Methods
Emergency Contraception
(Post-intercourse)
Spermicides
Behavioral
Including
vaginal intercourse
Avoiding
vaginal intercourse
Experimental
Androgens
Estrogens
Progestogens
First generation (estranes)
Second generation
Third generation (gonanes)
Fourth generation
Pregnanes
Miscellaneous
Estrogens
ERTooltip Estrogen receptor agonists
Progonadotropins
Antiestrogens
ERTooltip Estrogen receptor antagonists
(incl. SERMsTooltip selective estrogen receptor modulators/SERDsTooltip selective estrogen receptor downregulators)
Aromatase inhibitors
Antigonadotropins
Others
Progestogens
(and progestins)
PRTooltip Progesterone receptor agonists
Antiprogestogens
SPRMsTooltip Selective progesterone receptor modulators
PRTooltip Progesterone receptor antagonists
Androgens
(incl. AASTooltip anabolic–androgenic steroid)
ARTooltip Androgen receptor agonists
Progonadotropins
Antiandrogens
ARTooltip Androgen receptor antagonists
Steroidogenesis
inhibitors
5α-Reductase
Others
Antigonadotropins
Others
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists
ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists


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